Detailed information for compound 652998

Basic information

Technical information
  • TDR Targets ID: 652998
  • Name: 1-(1,3-benzodioxol-5-yl)-N-[(3-methylphenyl)m ethyl]methanamine
  • MW: 255.312 | Formula: C16H17NO2
  • H donors: 1 H acceptors: 0 LogP: 2.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)CNCc1ccc2c(c1)OCO2
  • InChi: 1S/C16H17NO2/c1-12-3-2-4-13(7-12)9-17-10-14-5-6-15-16(8-14)19-11-18-15/h2-8,17H,9-11H2,1H3
  • InChiKey: ZBTXVYBPJZGWDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-benzodioxol-5-ylmethyl-(3-methylbenzyl)amine
  • Oprea1_205962
  • STK194597

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0137 0.0708 0.0708
Loa Loa (eye worm) matrixin family protein 0.0201 0.1144 0.1675
Loa Loa (eye worm) AStacin protease 0.0438 0.2754 0.4037
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0006 0.0006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0069 0.0504
Loa Loa (eye worm) hypothetical protein 0.0672 0.4348 0.6376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0006 0.0003
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0078 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.1501 1 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0059 0.0176 0.0249
Brugia malayi Pre-SET motif family protein 0.0035 0.0009 0.0008
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0006 0.0003
Schistosoma mansoni hypothetical protein 0.0059 0.0176 0.0173
Onchocerca volvulus 0.0059 0.0176 0.0254
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0235 0.0232
Loa Loa (eye worm) RNA binding protein 0.0068 0.0235 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0749 0.0746
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0235 0.034
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0078 0.2324
Echinococcus granulosus dna polymerase kappa 0.0045 0.0078 0.0078
Echinococcus multilocularis CUB 0.0059 0.0176 0.0173
Schistosoma mansoni DNA polymerase eta 0.0075 0.028 0.0277
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.0049
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0111 0.053 0.053
Schistosoma mansoni lipoxygenase 0.0137 0.0708 0.0705
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0052 0.0052
Leishmania major DNA polymerase eta, putative 0.0075 0.028 0.0403
Toxoplasma gondii ABC1 family protein 0.0034 0.0006 0.0023
Schistosoma mansoni lipoxygenase 0.0096 0.0426 0.0423
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0296 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0296 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0078 0.0108
Brugia malayi jmjC domain containing protein 0.0111 0.053 0.0773
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0203 0.1155 0.1691
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0749 0.0746
Brugia malayi Matrixin family protein 0.0083 0.0339 0.0493
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0134 0.0192
Onchocerca volvulus 0.0035 0.0009 0.0008
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0088 0.037 0.0539
Schistosoma mansoni jumonji domain containing protein 0.0088 0.0374 0.0371
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0749 0.0749
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0296 1
Onchocerca volvulus 0.0059 0.0176 0.0254
Brugia malayi CUB domain containing protein 0.0059 0.0176 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0006 0.0004
Brugia malayi beta-lactamase family protein 0.0034 0.0006 0.0004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0006 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0078 0.0078
Onchocerca volvulus 0.0034 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0075 0.028 0.0407
Onchocerca volvulus 0.0034 0.0006 0.0004
Onchocerca volvulus Matrilysin homolog 0.0083 0.0339 0.0493
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0094 0.0091
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0303 0.1836 0.1833
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0059 0.0176 0.0249
Echinococcus multilocularis cubilin 0.0059 0.0176 0.0173
Onchocerca volvulus Matrilysin homolog 0.0185 0.1031 0.1508
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0075 0.0072
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0176 0.0173
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0078 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0235 0.0232
Loa Loa (eye worm) matrixin family protein 0.0185 0.1031 0.1508
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.07 0.4542 0.454
Onchocerca volvulus 0.0034 0.0006 0.0004
Loa Loa (eye worm) bone morphogenetic protein 1b 0.07 0.4542 0.6661
Trichomonas vaginalis lipase containing protein, putative 0.1034 0.6817 1
Brugia malayi jmjC domain containing protein 0.0041 0.0052 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0078 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0235 0.0232
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0059 0.0176 0.0254
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0012 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.1034 0.6817 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0235 0.0232
Loa Loa (eye worm) hypothetical protein 0.0058 0.0169 0.0243
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0296 0.043
Brugia malayi Lectin C-type domain containing protein 0.0059 0.0176 0.0254
Loa Loa (eye worm) CUB domain-containing protein 0.0059 0.0176 0.0254
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0226 0.131 0.1918
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0296 0.0293
Echinococcus multilocularis dna polymerase eta 0.0075 0.028 0.0277
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0296 0.0425
Onchocerca volvulus Arrow homolog 0.0203 0.1155 0.1691
Brugia malayi CUB domain containing protein 0.0059 0.0176 0.0254
Echinococcus granulosus CUB 0.0059 0.0176 0.0176
Brugia malayi Lipase family protein 0.1034 0.6817 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0235 0.034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0134 0.0192
Onchocerca volvulus 0.0083 0.0339 0.0493
Loa Loa (eye worm) hypothetical protein 0.0285 0.1715 0.2512
Loa Loa (eye worm) hypothetical protein 0.0083 0.0339 0.0493
Trichomonas vaginalis lipase containing protein, putative 0.1034 0.6817 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0226 0.131 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0296 0.0296
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0012 0.0012
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0749 0.1095
Onchocerca volvulus 0.1034 0.6817 1
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0078 0.0108
Schistosoma mansoni hypothetical protein 0.0059 0.0176 0.0173
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0094 0.0094
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0296 0.0293
Echinococcus multilocularis muscleblind protein 0.016 0.0864 0.0861
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0006 0.5458
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0059 0.0176 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Schistosoma mansoni hypothetical protein 0.0059 0.0176 0.0173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0012 0.0009
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0012 0.0009
Echinococcus multilocularis cubilin 0.0059 0.0176 0.0173
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0176 0.0173
Loa Loa (eye worm) hypothetical protein 0.0082 0.0331 0.0481
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0012 0.0009
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0111 0.053 0.0527
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0078 0.011
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0235 0.0232
Brugia malayi Hemopexin family protein 0.0118 0.0577 0.0842
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0059 0.0176 0.0173
Loa Loa (eye worm) hypothetical protein 0.016 0.0864 0.1263
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.1425 0.2086
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0176 0.0249
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0296 0.0425
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0296 0.043
Onchocerca volvulus Matrix metalloproteinase homolog 0.0185 0.1031 0.1508
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0059 0.0176 0.0254
Loa Loa (eye worm) beta-lactamase 0.0034 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0083 0.0339 0.0493
Leishmania major DNA polymerase eta, putative 0.0044 0.0069 0.0092
Loa Loa (eye worm) hypothetical protein 0.0083 0.0339 0.0493
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0078 0.0106
Brugia malayi Matrixin family protein 0.0201 0.1144 0.1675
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0078 0.0106
Mycobacterium ulcerans hydrolase 0.0101 0.0463 0.0684
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Brugia malayi CUB domain containing protein 0.0059 0.0176 0.0254
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0078 0.011
Schistosoma mansoni hypothetical protein 0.0118 0.0577 0.0574
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0059 0.0176 0.0249
Echinococcus granulosus Tolloid protein 1 0.07 0.4542 0.4542
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Brugia malayi Kelch motif family protein 0.0059 0.0176 0.0254
Echinococcus granulosus peregrin 0.0034 0.0003 0.0003
Schistosoma mansoni egf-like domain protein 0.0203 0.1155 0.1152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0749 0.0746
Loa Loa (eye worm) hypothetical protein 0.0203 0.1155 0.1691
Leishmania major DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Echinococcus multilocularis Tolloid protein 1 0.07 0.4542 0.454
Brugia malayi CUB domain containing protein 0.0059 0.0176 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0749 0.0749
Echinococcus multilocularis fibrillin 1 0.0226 0.131 0.1307
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0004
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0147 0.0771 0.0768
Brugia malayi RNA binding protein 0.0068 0.0235 0.034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0009 0.0042
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.1034 0.6817 0.6816
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0052 0.0072
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0006 0.0003
Echinococcus multilocularis muscleblind protein 1 0.016 0.0864 0.0861
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0749 0.1095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0749 0.0746
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.028 0.0407
Schistosoma mansoni inositol monophosphatase 0.0035 0.0012 0.0009
Giardia lamblia DINP protein human, muc B family 0.0045 0.0078 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0006
Echinococcus multilocularis laminin 0.0226 0.131 0.1307
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0004
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0083 0.0339 0.0336
Brugia malayi Pre-SET motif family protein 0.0243 0.1425 0.2086
Schistosoma mansoni hypothetical protein 0.0059 0.0176 0.0173
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0134 0.0192
Brugia malayi Matrixin family protein 0.0083 0.0339 0.0493
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0069 0.0092
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0088 0.037 0.0539
Loa Loa (eye worm) hypothetical protein 0.0226 0.131 0.1918
Loa Loa (eye worm) hypothetical protein 0.0203 0.1155 0.1691
Trypanosoma brucei lipase domain protein, putative 0.1034 0.6817 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0203 0.1155 0.1691
Toxoplasma gondii calcium binding egf domain-containing protein 0.0226 0.131 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0303 0.1836 0.1836
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1102 0.7277 1
Brugia malayi Fibulin-1 precursor 0.0226 0.131 0.1918
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0059 0.0176 0.0173
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0749 0.0746
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0009 0.0006
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.1034 0.6817 0.6817
Echinococcus multilocularis microtubule associated protein 2 0.1501 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0009 0.0006
Leishmania major hypothetical protein, conserved 0.1034 0.6817 1
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.1015 0.6689 1
Brugia malayi hypothetical protein 0.0059 0.0176 0.0254
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0012 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.1034 0.6817 1
Brugia malayi Matrixin family protein 0.0083 0.0339 0.0493
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0012 0.0009
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0235 0.034
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0052 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Schistosoma mansoni inositol monophosphatase 0.0035 0.0012 0.0009
Trypanosoma brucei unspecified product 0.0045 0.0078 0.0106
Brugia malayi beta-lactamase family protein 0.0034 0.0006 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.028 0.0403
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.028 0.0403
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0059 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0006 0.0004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0012 0.007
Loa Loa (eye worm) hypothetical protein 0.0101 0.0463 0.0675
Brugia malayi Inositol-1 0.0035 0.0012 0.0013
Brugia malayi Nematode astacin protease protein 30 0.0088 0.037 0.0539
Onchocerca volvulus 0.0059 0.0176 0.0254
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0019 0.0024
Brugia malayi CUB domain containing protein 0.0059 0.0176 0.0254
Onchocerca volvulus 0.0276 0.1653 0.2421
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0009 0.0006
Echinococcus granulosus dna polymerase eta 0.0075 0.028 0.028
Onchocerca volvulus Putative cubilin 0.0082 0.0331 0.0481
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0078 0.0075
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0101 0.0463 0.0695
Trichomonas vaginalis set domain proteins, putative 0.0276 0.1653 0.2418
Onchocerca volvulus 0.0088 0.037 0.0539
Loa Loa (eye worm) hypothetical protein 0.016 0.0864 0.1263
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0078 0.0106
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0059 0.0176 0.0173
Loa Loa (eye worm) DPY-31 protein 0.0088 0.037 0.0539
Brugia malayi Matrixin family protein 0.0083 0.0339 0.0493
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.025 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Brugia malayi Nematode astacin protease protein 30 0.0088 0.037 0.0539
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0088 0.037 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0009 0.0006
Mycobacterium leprae PROBABLE HYDROLASE 0.0101 0.0463 1
Echinococcus granulosus cubilin 0.0059 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0036 0.0019 0.0016
Loa Loa (eye worm) inositol-1 0.0035 0.0012 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0078 0.011
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0059 0.0176 0.0254
Loa Loa (eye worm) CUB domain-containing protein 0.0059 0.0176 0.0254
Onchocerca volvulus 0.0118 0.0577 0.0842
Echinococcus granulosus laminin 0.0226 0.131 0.131
Brugia malayi astacin protease protein 30 0.0088 0.037 0.0539
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0134 0.0192
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Plasmodium vivax SET domain protein, putative 0.0035 0.0009 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.0235 0.0235
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0137 0.0708 0.0705
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0078 0.0075
Brugia malayi TAR-binding protein 0.0068 0.0235 0.034
Trypanosoma brucei lipase domain protein, putative 0.1034 0.6817 1
Plasmodium falciparum phd finger protein, putative 0.0034 0.0003 0.5
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0075 0.0075
Brugia malayi Muscleblind-like protein 0.016 0.0864 0.1263
Echinococcus granulosus cubilin 0.0059 0.0176 0.0176
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0078 0.011
Loa Loa (eye worm) lipase 0.1034 0.6817 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0106
Mycobacterium tuberculosis 4,9-DHSA hydrolase 0.0999 0.6578 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0019 0.0024
Schistosoma mansoni polycystin 1-related 0.012 0.0588 0.0585
Echinococcus granulosus muscleblind protein 0.016 0.0864 0.0864
Brugia malayi Calcium binding EGF domain containing protein 0.0082 0.0331 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0235 0.0232
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0012 0.0009
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0012 0.0009
Brugia malayi Calcium binding EGF domain containing protein 0.0226 0.131 0.1918
Brugia malayi beta-lactamase 0.0034 0.0006 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.022 0.127 0.1923
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0059 0.0176 0.0254
Loa Loa (eye worm) hypothetical protein 0.0088 0.037 0.0539
Loa Loa (eye worm) matrix metalloproteinase 0.0083 0.0339 0.0493
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0101 0.0463 0.0675

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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