Detailed information for compound 654792

Basic information

Technical information
  • TDR Targets ID: 654792
  • Name: 3-bromo-4-ethoxy-N-[2-(4-methoxyphenyl)-6-met hylbenzotriazol-5-yl]benzamide
  • MW: 481.342 | Formula: C23H21BrN4O3
  • H donors: 1 H acceptors: 3 LogP: 5.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1Br)C(=O)Nc1cc2nn(nc2cc1C)c1ccc(cc1)OC
  • InChi: 1S/C23H21BrN4O3/c1-4-31-22-10-5-15(12-18(22)24)23(29)25-19-13-21-20(11-14(19)2)26-28(27-21)16-6-8-17(30-3)9-7-16/h5-13H,4H2,1-3H3,(H,25,29)
  • InChiKey: IASNMZRXNDGKCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-bromo-4-ethoxy-N-[2-(4-methoxyphenyl)-6-methyl-benzotriazol-5-yl]benzamide
  • 3-bromo-4-ethoxy-N-[2-(4-methoxyphenyl)-6-methyl-5-benzotriazolyl]benzamide
  • Oprea1_801281

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0064 0.0087
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0044 0.0191 0.0495
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0091 0.0494 0.1507
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0191 0.0506
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.003 0.0102 0.0255
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.042 0.193
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0091 0.0494 0.1507
Schistosoma mansoni microtubule-associated protein tau 0.0572 0.363 0.9785
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.042 0.1264
Loa Loa (eye worm) hypothetical protein 0.0032 0.0115 0.016
Loa Loa (eye worm) matrixin family protein 0.0914 0.5856 0.8699
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0041 0.0173 0.0165
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0067 0.0059
Echinococcus multilocularis dna polymerase kappa 0.0079 0.042 0.0413
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0176 0.1053 0.2822
Brugia malayi polk-prov protein 0.0025 0.0064 0.0084
Echinococcus granulosus survival motor neuron protein 1 0.0209 0.1263 0.1256
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0064 0.0087
Leishmania major DNA polymerase eta, putative 0.0086 0.0467 0.1418
Loa Loa (eye worm) hypothetical protein 0.003 0.0102 0.014
Echinococcus multilocularis dnaJ subfamily B 0.033 0.2052 0.2046
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.1142 0.7345 1
Echinococcus granulosus chromobox protein 1 0.0058 0.028 0.0273
Trypanosoma brucei lanosterol synthase 0.0044 0.0191 0.0506
Brugia malayi gamma-secretase subunit aph-1 0.0214 0.1298 0.1918
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0045 0.0194 0.0187
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0091 0.0494 0.0486
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0041 0.0173 0.0165
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0044 0.0191 0.0488
Toxoplasma gondii hypothetical protein 0.0259 0.1589 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0129 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0102 0.0468
Mycobacterium ulcerans aldehyde dehydrogenase 0.0105 0.059 0.1761
Brugia malayi Calcitonin receptor-like protein seb-1 0.013 0.0752 0.1107
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0055 0.007
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0167 0.0992 0.0985
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0502 0.3173 0.4707
Onchocerca volvulus 0.0041 0.0169 0.026
Brugia malayi MH2 domain containing protein 0.0104 0.0583 0.0856
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0167 0.0992 0.4554
Loa Loa (eye worm) hypothetical protein 0.0349 0.2178 0.3228
Trichomonas vaginalis chromobox protein, putative 0.0058 0.028 0.1287
Trypanosoma brucei DNA polymerase eta, putative 0.0141 0.0823 0.2595
Schistosoma mansoni DNA polymerase eta 0.0141 0.0823 0.2202
Mycobacterium leprae PROBABLE HYDROLASE 0.0502 0.3173 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.026 0.0734
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0102 0.0468
Trypanosoma brucei Aph-1 protein, putative 0.0083 0.0447 0.1352
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0282 0.1744 0.2582
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.1744 0.8005
Schistosoma mansoni lipoxygenase 0.0045 0.0194 0.0504
Brugia malayi hypothetical protein 0.003 0.0102 0.014
Brugia malayi Matrixin family protein 0.0412 0.2588 0.3837
Onchocerca volvulus 0.0034 0.0129 0.0196
Brugia malayi Matrixin family protein 0.1048 0.6731 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0079 0.042 0.0413
Loa Loa (eye worm) hypothetical protein 0.0047 0.0211 0.0302
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0191 0.0878
Echinococcus granulosus tumor protein p63 0.0277 0.1711 0.1705
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0079 0.0192
Toxoplasma gondii LsmAD domain-containing protein 0.0047 0.0211 0.1113
Echinococcus granulosus dnaJ subfamily B 0.033 0.2052 0.2046
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0079 0.0192
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0349 0.2178 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0191 0.0273
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.042 0.193
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0079 0.0106
Onchocerca volvulus 0.0043 0.0181 0.028
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.003 0.0102 0.014
Echinococcus granulosus dna polymerase kappa 0.0079 0.042 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Echinococcus granulosus GPCR family 2 0.0041 0.0173 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0064 0.0087
Trypanosoma brucei unspecified product 0.0079 0.042 0.1264
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0176 0.1053 0.1554
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0044 0.0191 0.0878
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0176 0.1053 0.1554
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0058 0.005
Mycobacterium ulcerans hypothetical protein 0.0255 0.1568 0.4879
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.013 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0067 0.016
Mycobacterium ulcerans hypothetical protein 0.0025 0.0064 0.0084
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0079 0.0106
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0079 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.042 0.1264
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0079 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0176 0.1053 0.1046
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0229 0.1399 0.4499
Brugia malayi Matrixin family protein 0.0412 0.2588 0.3837
Leishmania major DNA polymerase kappa, putative 0.0025 0.0064 0.0087
Brugia malayi Hemopexin family protein 0.0584 0.3709 0.5505
Echinococcus multilocularis protein dispatched 1 0.004 0.0162 0.0154
Echinococcus multilocularis cpg binding protein 0.0024 0.0064 0.0056
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.013 0.0182
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0349 0.2178 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0176 0.1053 0.1046
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0103 0.0577 0.0846
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0176 0.1053 0.1046
Brugia malayi ImpB/MucB/SamB family protein 0.0141 0.0823 0.1212
Schistosoma mansoni polycystin 1-related 0.0116 0.0662 0.1767
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Schistosoma mansoni hypothetical protein 0.0041 0.0173 0.0445
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0079 0.0071
Loa Loa (eye worm) hypothetical protein 0.0077 0.0406 0.0592
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0103 0.0577 0.2647
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0105 0.059 0.1761
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0079 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Echinococcus granulosus chromobox protein 1 0.0058 0.028 0.0273
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0167 0.0992 0.2659
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.026 0.0734
Toxoplasma gondii aldehyde dehydrogenase 0.0105 0.059 0.3561
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0464 0.2926 0.7884
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0045 0.0194 0.0187
Trypanosoma cruzi DNA polymerase eta, putative 0.0141 0.0823 0.2595
Echinococcus multilocularis chromobox protein 1 0.0058 0.028 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0349 0.2178 0.2172
Echinococcus granulosus ubiquitin specific protease 41 0.003 0.0102 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.0209 0.1263 0.1866
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.013 0.0752 0.1107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0445 0.1347
Brugia malayi latrophilin 2 splice variant baaae 0.0089 0.0484 0.0708
Schistosoma mansoni aldehyde dehydrogenase 0.0105 0.059 0.1574
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0064 0.0087
Schistosoma mansoni hypothetical protein 0.033 0.2052 0.5524
Onchocerca volvulus 0.0025 0.007 0.01
Trypanosoma cruzi protein farnesyltransferase, putative 0.0103 0.0577 0.178
Entamoeba histolytica deoxycytidyl transferase, putative 0.0079 0.042 0.1786
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.155 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0105 0.059 0.0583
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0044 0.0191 0.0986
Loa Loa (eye worm) matrix metalloproteinase 0.0412 0.2588 0.3837
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0041 0.0173 0.0165
Brugia malayi hypothetical protein 0.0047 0.0211 0.0302
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0211 0.0935
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0666 0.4241 0.4237
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0349 0.2178 1
Brugia malayi CHE-14 protein 0.0035 0.013 0.0182
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.042 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Trypanosoma cruzi Aph-1 protein, putative 0.0083 0.0447 0.1352
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0167 0.0992 0.2659
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0191 0.0506
Leishmania major hypothetical protein, conserved 0.0047 0.0211 0.0571
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0082 0.0439 0.1165
Loa Loa (eye worm) hypothetical protein 0.0077 0.0406 0.0592
Brugia malayi Latrophilin receptor protein 2 0.0041 0.0173 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0115 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.042 0.1264
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0105 0.059 0.1826
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0485 0.3062 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.003 0.0102 0.0094
Mycobacterium tuberculosis Conserved hypothetical protein 0.0255 0.1568 0.4879
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0091 0.0494 0.1507
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0059 0.029 0.1298
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0086 0.0467 0.2765
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0038 0.0176
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.042 0.1264
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0068 0.0348 0.1025
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0131 0.0199
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0079 0.042 0.0614
Brugia malayi hypothetical protein 0.0077 0.0406 0.0592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0176 0.1053 0.2822
Schistosoma mansoni survival motor neuron protein 0.0043 0.0181 0.0469
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0103 0.0577 0.0569
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0068 0.0348 0.1025
Echinococcus multilocularis gamma secretase subunit aph 1 0.0214 0.1298 0.1291
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0349 0.2178 0.5864
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0103 0.0577 0.0569
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0214 0.1298 0.1918
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0064 0.0087
Giardia lamblia DINP protein human, muc B family 0.0079 0.042 0.1786
Loa Loa (eye worm) hypothetical protein 0.0141 0.0823 0.1212
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0091 0.0494 0.2239
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.003 0.0102 0.0255
Onchocerca volvulus 0.0091 0.0494 0.0786
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0091 0.0494 0.1507
Schistosoma mansoni eyes absent homolog 0.0077 0.0406 0.1075
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0064 0.0261
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.013 0.0598
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0167 0.0992 0.1464
Leishmania major mitochondrial DNA polymerase beta 0.0485 0.3062 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0349 0.2178 0.3228
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0105 0.059 0.0583
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0079 0.0134
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0102 0.0211
Trichomonas vaginalis chaperonin, putative 0.0027 0.0079 0.0362
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0191 0.0845
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0349 0.2178 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0079 0.042 0.0413
Toxoplasma gondii hypothetical protein 0.0078 0.0414 0.2421
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0091 0.0494 0.0486
Trypanosoma cruzi lanosterol synthase, putative 0.0044 0.0191 0.0506
Schistosoma mansoni hypothetical protein 0.0041 0.0173 0.0445
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0091 0.0494 0.1507
Loa Loa (eye worm) pigment dispersing factor receptor c 0.013 0.0752 0.1107
Loa Loa (eye worm) hypothetical protein 0.0089 0.0484 0.0708
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0064 0.0261
Trypanosoma brucei hypothetical protein, conserved 0.0091 0.0494 0.1507
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1176 0.54
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0079 0.0189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0176 0.1053 0.1046
Schistosoma mansoni hypothetical protein 0.0584 0.3709 1
Mycobacterium ulcerans hydrolase 0.0502 0.3173 1
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0038 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0081 0.0431 0.0423
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0494 0.1507
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0171 0.1021 0.1506
Echinococcus granulosus geminin 0.0135 0.0786 0.0779
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0041 0.0173 0.0245
Brugia malayi Heterochromatin protein 1 0.0058 0.028 0.0405
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0044 0.0191 0.0845
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.1744 0.8005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0068 0.0348 0.1025
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0103 0.0577 0.2647
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0091 0.0494 0.1507
Brugia malayi CXXC zinc finger family protein 0.0023 0.0055 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Plasmodium vivax geranylgeranyltransferase, putative 0.0044 0.0191 0.0845
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.1111 0.1784
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0349 0.2178 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0191 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0044 0.0191 0.0184
Schistosoma mansoni hypothetical protein 0.0135 0.0786 0.2103
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0102 0.0211
Echinococcus granulosus Niemann Pick C1 protein 0.0081 0.0431 0.0423
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0245
Plasmodium vivax SET domain protein, putative 0.0025 0.0067 0.0274
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0349 0.2178 1
Echinococcus multilocularis survival motor neuron protein 1 0.0209 0.1263 0.1256
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0167 0.0992 0.0985
Plasmodium falciparum geranylgeranyltransferase, putative 0.0044 0.0191 0.0845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.042 0.1264
Schistosoma mansoni hypothetical protein 0.0135 0.0786 0.2103
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Echinococcus granulosus Niemann Pick C1 protein 0.0116 0.0657 0.0649
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0485 0.3062 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0211 0.0571
Echinococcus granulosus microtubule associated protein 2 0.0572 0.363 0.3625
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0349 0.2178 0.2172
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.1744 0.8005
Schistosoma mansoni hypothetical protein 0.0033 0.0122 0.0309
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.013 0.0752 0.1107
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0064 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0211 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0115 0.0528
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1176 0.54
Brugia malayi hypothetical protein 0.0209 0.1263 0.1866
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0038 0.014
Schistosoma mansoni hypothetical protein 0.0033 0.0122 0.0309
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.006 0.0293 0.0771
Schistosoma mansoni cpg binding protein 0.0024 0.0064 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Toxoplasma gondii hypothetical protein 0.0091 0.0494 0.2938
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0064 0.0087
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0167 0.0992 0.4457
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0054 0.0246
Echinococcus multilocularis expressed conserved protein 0.0076 0.0399 0.0391
Trypanosoma brucei unspecified product 0.0055 0.026 0.0734
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0494 0.1507
Brugia malayi Niemann-Pick C1 protein precursor 0.0081 0.0431 0.0629
Loa Loa (eye worm) latrophilin receptor protein 2 0.0041 0.0173 0.0245
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.0467 0.1418
Trypanosoma brucei unspecified product 0.0055 0.026 0.0734
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0041 0.0173 0.0165
Leishmania major DNA polymerase eta, putative 0.0141 0.0823 0.2595
Schistosoma mansoni aldehyde dehydrogenase 0.0105 0.059 0.1574
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0088
Schistosoma mansoni hypothetical protein 0.0041 0.0173 0.0445
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0044 0.0191 0.0715
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.003 0.0102 0.0468
Leishmania major DNA polymerase kappa, putative 0.0079 0.042 0.1264
Mycobacterium tuberculosis Conserved hypothetical protein 0.0079 0.042 0.1219
Schistosoma mansoni hypothetical protein 0.0089 0.0484 0.1286
Leishmania major farnesyltransferase beta subunit 0.0103 0.0577 0.178
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0191 0.0506
Giardia lamblia Rab geranylgeranyltransferase 0.0091 0.0494 0.2129
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0103 0.0577 0.0846
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.0181 0.0258
Echinococcus multilocularis microtubule associated protein 2 0.0572 0.363 0.3625
Echinococcus granulosus expressed conserved protein 0.0076 0.0399 0.0391
Echinococcus multilocularis protein patched 0.0035 0.013 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.0067 0.0059
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0038 0.003
Onchocerca volvulus 0.0195 0.1174 0.1886
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0131 0.0602
Onchocerca volvulus Matrilysin homolog 0.0966 0.6195 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.023 0.06
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0064 0.0169
Trichomonas vaginalis chromobox protein, putative 0.0058 0.028 0.1287
Echinococcus multilocularis geminin 0.0135 0.0786 0.0779
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0091 0.0494 0.2239
Schistosoma mansoni patched 1 0.0035 0.013 0.0331
Trypanosoma cruzi Aph-1 protein, putative 0.0083 0.0447 0.1352
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0064 0.0087
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0091 0.0494 0.1507
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0091 0.0494 0.0486
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0079 0.0362
Onchocerca volvulus Matrilysin homolog 0.0412 0.2588 0.417
Schistosoma mansoni ap endonuclease 0.0021 0.0038 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0092
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.003 0.0102 0.0298
Leishmania major DNA damage repair protein, putative 0.0025 0.0064 0.0087
Brugia malayi Matrixin family protein 0.0412 0.2588 0.3837
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0038 0.0176
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0191 0.0986
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0079 0.0071
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0103 0.0577 0.1536
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0091 0.0494 0.0723
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0091 0.0494 0.2267
Echinococcus multilocularis Niemann Pick C1 protein 0.0116 0.0657 0.0649
Brugia malayi Pre-SET motif family protein 0.0025 0.0067 0.0088
Echinococcus granulosus Protein patched homolog 1 0.0035 0.013 0.0122
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0103 0.0577 0.178
Echinococcus granulosus cpg binding protein 0.0024 0.0064 0.0056
Schistosoma mansoni hypothetical protein 0.0041 0.0173 0.0445
Loa Loa (eye worm) hypothetical protein 0.0081 0.0431 0.0629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0176 0.1053 0.2822
Brugia malayi Pre-SET motif family protein 0.0171 0.1021 0.1506
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0259 0.1589 0.7293
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.1744 0.8005
Giardia lamblia Prenyltransferase 0.0103 0.0577 0.2515
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0084
Loa Loa (eye worm) hypothetical protein 0.0041 0.0169 0.0239
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0064 0.0087
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0079 0.0189
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.003 0.0102 0.0094
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0038 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0067 0.016
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0091 0.0494 0.0486
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0103 0.0577 0.2647
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0196 0.1017
Schistosoma mansoni cpg binding protein 0.0024 0.0064 0.0151
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0282 0.1744 0.2582
Echinococcus multilocularis dna polymerase eta 0.0141 0.0823 0.0816
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.0182
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.003 0.0102 0.0094
Giardia lamblia DNA damage repair protein 0.0025 0.0064 0.0123
Brugia malayi Matrixin family protein 0.0412 0.2588 0.3837
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0054 0.0246
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.042 0.1264
Loa Loa (eye worm) matrixin family protein 0.1048 0.6731 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0042 0.0034
Schistosoma mansoni cpg binding protein 0.0023 0.0055 0.0128
Giardia lamblia Rab geranylgeranyltransferase 0.0044 0.0191 0.0715
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0079 0.0134
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.003 0.0102 0.0298
Onchocerca volvulus Matrix metalloproteinase homolog 0.0914 0.5856 0.9453
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.042 0.1264
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0042 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0105 0.059 0.1761
Onchocerca volvulus 0.0584 0.3709 0.5983
Mycobacterium ulcerans aldehyde dehydrogenase 0.0105 0.059 0.1761
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0115 0.0173
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0131 0.0602
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0064 0.0153
Schistosoma mansoni hypothetical protein 0.0043 0.0181 0.0469
Giardia lamblia Rab geranylgeranyltransferase 0.0349 0.2178 1
Brugia malayi chromobox protein homolog 3 0.0032 0.0115 0.016
Schistosoma mansoni ap endonuclease 0.0021 0.0038 0.0082
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0258
Schistosoma mansoni hypothetical protein 0.0033 0.0122 0.0309
Echinococcus multilocularis GPCR, family 2 0.0041 0.0173 0.0165
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0079 0.0327
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0103 0.0577 0.262
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0091 0.0494 0.0723
Loa Loa (eye worm) heterochromatin protein 1 0.0058 0.028 0.0405
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.003 0.0102 0.0211
Schistosoma mansoni hypothetical protein 0.0033 0.0122 0.0309
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0079 0.042 0.1264
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.0583 0.0856
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0091 0.0494 0.2129
Loa Loa (eye worm) hypothetical protein 0.0464 0.2926 0.4341
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0038 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0229 0.1399 0.4499
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0485 0.3062 1
Trypanosoma cruzi lanosterol synthase, putative 0.0044 0.0191 0.0506
Echinococcus granulosus dna polymerase eta 0.0141 0.0823 0.0816
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0167 0.0992 0.1464
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0079 0.042 0.1219
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.017 0.101 0.2707
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0502 0.3173 1
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0044 0.0191 0.0273
Schistosoma mansoni chromobox protein 0.0058 0.028 0.0736
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0079 0.0261
Echinococcus multilocularis ubiquitin specific protease 41 0.003 0.0102 0.0094
Echinococcus multilocularis tumor protein p63 0.0277 0.1711 0.1705
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0103 0.0577 0.2647
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.0583 0.0856
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0038 0.014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.0067 0.0059
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0229 0.1399 0.4499
Onchocerca volvulus 0.0412 0.2588 0.417
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0044 0.0191 0.0506
Leishmania major geranylgeranyltransferase, putative 0.0044 0.0191 0.0506
Schistosoma mansoni gamma-secretase subunit aph-1 0.0214 0.1298 0.3485
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0068 0.0348 0.1025
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0211 0.0571
Loa Loa (eye worm) hypothetical protein 0.0412 0.2588 0.3837
Loa Loa (eye worm) hypothetical protein 0.0502 0.3173 0.4707
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0103 0.0577 0.3472
Schistosoma mansoni chromobox protein 0.0058 0.028 0.0736
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.042 0.1264
Trichomonas vaginalis set domain proteins, putative 0.0195 0.1174 0.5391
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.042 0.1219
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0079 0.0106
Trypanosoma cruzi protein farnesyltransferase, putative 0.0103 0.0577 0.178
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0038 0.0045
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0103 0.0577 0.2647
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0064 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1111 0.5101
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0103 0.0577 0.262
Schistosoma mansoni terminal deoxycytidyl transferase 0.0079 0.042 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.026 0.0734
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.042 0.1219
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0081 0.0431 0.1834
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.003 0.0102 0.0094
Echinococcus granulosus gamma secretase subunit aph 1 0.0214 0.1298 0.1291
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.013 0.0122
Trypanosoma brucei PAB1-binding protein , putative 0.0047 0.0211 0.0571
Onchocerca volvulus 0.0023 0.0055 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0067 0.016
Plasmodium vivax ataxin-2 like protein, putative 0.0047 0.0211 0.0935
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0103 0.0577 0.2647
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.1744 0.8005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.003 0.0102 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.1744 0.8005
Echinococcus multilocularis chromobox protein 1 0.0058 0.028 0.0273
Schistosoma mansoni cellular tumor antigen P53 0.0041 0.0169 0.0435
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0349 0.2178 0.3228
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0103 0.0577 0.2515
Loa Loa (eye worm) hypothetical protein 0.0412 0.2588 0.3837

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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