Detailed information for compound 656886

Basic information

Technical information
  • TDR Targets ID: 656886
  • Name: 2-[4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-yliden e)methyl]phenoxy]acetic acid
  • MW: 279.269 | Formula: C12H9NO5S
  • H donors: 2 H acceptors: 4 LogP: 1.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)COc1ccc(cc1)/C=C\1/SC(=O)NC1=O
  • InChi: 1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5+
  • InChiKey: WXMCOLGPDOYHNK-WEVVVXLNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(E)-(2,4-dioxothiazolidin-5-ylidene)methyl]phenoxy]acetic acid
  • 2-[4-[(E)-(2,4-dioxo-5-thiazolidinylidene)methyl]phenoxy]acetic acid
  • 2-[4-[(E)-(2,4-diketothiazolidin-5-ylidene)methyl]phenoxy]acetic acid
  • 2-[4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dynamin 1 protein 0.0021 0.0075 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0714 0.1181
Loa Loa (eye worm) hypothetical protein 0.0081 0.0606 0.0606
Echinococcus granulosus snurportin 1 0.0624 0.5421 0.9015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0058 0.0042
Leishmania major importin beta-1 subunit, putative 0.0047 0.0312 0.026
Brugia malayi mbt repeat family protein 0.0046 0.03 0.0284
Loa Loa (eye worm) glutaminase 2 0.0281 0.2377 0.2377
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0331
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.03 0.0434
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0714 0.1039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0089
Echinococcus multilocularis importin subunit beta 1 0.0058 0.041 0.0595
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0546 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0624 0.5421 0.5421
Giardia lamblia Dynamin 0.0021 0.0075 0.6733
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0606 0.059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0714 0.1108
Schistosoma mansoni glutaminase 0.0281 0.2377 0.39
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0546 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0357 0.0341
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.03 0.0493
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0714 0.0714
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0005
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0085 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0058 0.0022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0058 0.0009
Loa Loa (eye worm) hypothetical protein 0.0174 0.1433 0.1433
Entamoeba histolytica hypothetical protein 0.0037 0.0219 0.3372
Onchocerca volvulus 0.0047 0.0307 0.0517
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.03 0.0415
Echinococcus multilocularis muscleblind protein 1 0.0303 0.2575 0.3766
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0714 0.0698
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0851 0.3431
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0058 0.0079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0851 0.1338
Loa Loa (eye worm) hypothetical protein 0.0583 0.5058 0.5058
Trypanosoma cruzi Emopamil binding protein, putative 0.0426 0.3668 0.3634
Schistosoma mansoni hypothetical protein 0.0624 0.5421 0.9007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0307 0.0291
Loa Loa (eye worm) hypothetical protein 0.0044 0.0278 0.0278
Echinococcus multilocularis dynamin 0.0021 0.0075 0.0103
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0053 0.0046
Toxoplasma gondii ABC1 family protein 0.0108 0.0851 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.1533 0.224
Brugia malayi beta-lactamase family protein 0.0108 0.0851 0.0835
Schistosoma mansoni dynamin 0.0021 0.0075 0.0036
Schistosoma mansoni survival motor neuron protein 0.0047 0.0307 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0714 0.1039
Brugia malayi hypothetical protein 0.023 0.1928 0.1914
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0219 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0312 0.1114
Echinococcus granulosus tumor protein p63 0.0338 0.2889 0.4801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0714 0.1108
Plasmodium vivax dynamin protein, putative 0.0021 0.0075 0.027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0052 0.0357 0.0357
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0312 0.1114
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0546 0.0495
Entamoeba histolytica Ran family GTPase 0.0022 0.0085 0.065
Mycobacterium leprae Probable lipase LipE 0.0108 0.0851 1
Onchocerca volvulus 0.0108 0.0851 0.2049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0108 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0046 0.03 0.03
Loa Loa (eye worm) inositol-1 0.0074 0.0546 0.0546
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0357 0.0517
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0851 0.1618
Brugia malayi Dynamin central region family protein 0.0021 0.0075 0.0058
Leishmania major GTP-binding protein, putative 0.0022 0.0085 0.0032
Onchocerca volvulus 0.0108 0.0851 0.2049
Brugia malayi Inositol-1 0.0074 0.0546 0.053
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.041 0.0404
Loa Loa (eye worm) hypothetical protein 0.0026 0.012 0.012
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0851 0.1409
Schistosoma mansoni lamin 0.0026 0.0124 0.012
Entamoeba histolytica hypothetical protein 0.0037 0.0219 0.3372
Loa Loa (eye worm) hypothetical protein 0.023 0.1928 0.1928
Echinococcus multilocularis dna polymerase eta 0.0044 0.0278 0.04
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0546 0.1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0606 0.0881
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0058 0.009
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0312 0.1114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.041 0.4744
Leishmania major DNA polymerase kappa, putative 0.0019 0.0058 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0851 0.1338
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0163 0.1797
Echinococcus granulosus dna polymerase kappa 0.0019 0.0058 0.009
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0085 0.0867
Onchocerca volvulus 0.0426 0.3668 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0851 0.0851
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.2147 0.2147
Schistosoma mansoni importin beta-1 0.0058 0.041 0.0599
Loa Loa (eye worm) hypothetical protein 0.1141 1 1
Entamoeba histolytica dynamin-1-like protein, putative 0.0021 0.0075 0.0437
Trypanosoma cruzi Emopamil binding protein, putative 0.0426 0.3668 0.3634
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0058 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0124 0.0124
Trichomonas vaginalis mgm1, putative 0.0021 0.0075 0.0093
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0085 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0714 0.1181
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0851 0.1338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0714 0.1108
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0058 0.0011
Loa Loa (eye worm) glutaminase 0.0281 0.2377 0.2377
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0053 0.0037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0851 0.1338
Trypanosoma brucei unspecified product 0.0019 0.0058 0.0052
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0278 0.0226
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0606 0.059
Brugia malayi Importin beta-1 subunit 0.0058 0.041 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0851 0.3431
Trichomonas vaginalis esterase, putative 0.0108 0.0851 0.3431
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0085 0.0032
Echinococcus multilocularis dynamin 1 0.0022 0.0089 0.0124
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0278 0.0271
Echinococcus multilocularis lamin dm0 0.0026 0.0124 0.0176
Schistosoma mansoni hypothetical protein 0.0081 0.0606 0.0927
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0606 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0058 0.0009
Onchocerca volvulus 0.005 0.0331 0.0583
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0058 0.0005
Entamoeba histolytica hypothetical protein 0.0037 0.0219 0.3372
Plasmodium vivax importin-beta 2, putative 0.0058 0.041 0.4476
Schistosoma mansoni hypothetical protein 0.0081 0.0606 0.0927
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0606 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Trichomonas vaginalis dynamin, putative 0.0021 0.0075 0.0093
Echinococcus granulosus intermediate filament protein 0.0026 0.0124 0.02
Loa Loa (eye worm) DRP-1 protein 0.0021 0.0075 0.0075
Mycobacterium ulcerans lipase LipD 0.0108 0.0851 0.1618
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0851 0.3431
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.03 0.0497
Entamoeba histolytica hypothetical protein 0.0047 0.0312 0.5256
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0851 0.1338
Brugia malayi RNA, U transporter 1 0.0166 0.1365 0.1351
Trichomonas vaginalis dynamin, putative 0.0021 0.0075 0.0093
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0851 0.1338
Echinococcus granulosus dynamin 0.0021 0.0075 0.0117
Schistosoma mansoni hypothetical protein 0.0532 0.4603 0.7635
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1928 0.2818
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0546 0.0495
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0053 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0085 0.0119
Echinococcus multilocularis snurportin 1 0.0624 0.5421 0.7935
Schistosoma mansoni inositol monophosphatase 0.0074 0.0546 0.0827
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0219 0.0315
Schistosoma mansoni hypothetical protein 0.0532 0.4603 0.7635
Leishmania major hypothetical protein, conserved 0.0426 0.3668 0.3634
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.03 0.03
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1928 0.3201
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0124 0.0108
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0357 0.0587
Loa Loa (eye worm) MBCTL1 0.0052 0.0357 0.0357
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0851 0.0851
Toxoplasma gondii dynamin-related protein DRPB 0.0021 0.0075 0.0743
Leishmania major DNA polymerase eta, putative 0.0044 0.0278 0.0226
Echinococcus granulosus lamin 0.0026 0.0124 0.02
Brugia malayi mbt repeat family protein 0.0046 0.03 0.0284
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0851 0.1338
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0085 0.0897
Brugia malayi beta-lactamase family protein 0.0108 0.0851 0.0835
Schistosoma mansoni DNA polymerase eta 0.0044 0.0278 0.0377
Echinococcus granulosus GPCR family 2 0.0081 0.0606 0.1001
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0058 0.0052
Mycobacterium ulcerans hypothetical protein 0.0108 0.0851 0.1618
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0546 0.212
Echinococcus granulosus importin subunit beta 1 0.0058 0.041 0.0675
Loa Loa (eye worm) hypothetical protein 0.0108 0.0851 0.0851
Trypanosoma brucei Emopamil binding protein, putative 0.0426 0.3668 0.3664
Loa Loa (eye worm) hypothetical protein 0.0108 0.0851 0.0851
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0163 0.0111
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.1923 0.1923
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0219 0.0279
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0546 0.6365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0005
Brugia malayi Dynamin 0.0022 0.0089 0.0072
Leishmania major GTP-binding protein, putative 0.0021 0.0075 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.03 0.0415
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0851 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0058 0.0106
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0477 0.0712
Entamoeba histolytica hypothetical protein 0.0037 0.0219 0.3372
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0606 0.0606
Mycobacterium tuberculosis Conserved protein 0.0108 0.0851 0.1338
Trichomonas vaginalis ran, putative 0.0022 0.0085 0.0138
Onchocerca volvulus 0.0108 0.0851 0.2049
Leishmania major hypothetical protein, conserved 0.0108 0.0851 0.0802
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0058 0.0011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0546 0.212
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0053 0.0081
Schistosoma mansoni inositol monophosphatase 0.0074 0.0546 0.0827
Mycobacterium tuberculosis Probable oxidoreductase 0.0575 0.4981 0.8266
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0058 0.0052
Onchocerca volvulus 0.0046 0.03 0.0497
Mycobacterium tuberculosis Conserved protein 0.0108 0.0851 0.1338
Schistosoma mansoni hypothetical protein 0.0284 0.2406 0.3948
Echinococcus multilocularis GPCR, family 2 0.0081 0.0606 0.0881
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0851 0.3431
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0546 0.212
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.03 0.0493
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0075 0.0068
Brugia malayi glutaminase DH11.1 0.0281 0.2377 0.2365
Entamoeba histolytica dynamin-like protein 0.0021 0.0075 0.0437
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0058 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0851 0.1338
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.041 0.0404
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0851 0.0802
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0851 0.124
Giardia lamblia DINP protein human, muc B family 0.0019 0.0058 0.1629
Leishmania major DNA polymerase eta, putative 0.0031 0.0163 0.0111
Schistosoma mansoni microtubule-associated protein tau 0.0691 0.6012 1
Echinococcus multilocularis geminin 0.0532 0.4603 0.6737
Brugia malayi hypothetical protein 0.0037 0.0219 0.0203
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.03 0.0434
Brugia malayi follicle stimulating hormone receptor 0.0229 0.1923 0.1909
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0124 0.0124
Echinococcus multilocularis musashi 0.0026 0.0124 0.0176
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0546 0.0794
Trichomonas vaginalis dynamin, putative 0.0021 0.0075 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0851 0.0844
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0085 0.0135
Loa Loa (eye worm) hypothetical protein 0.0303 0.2575 0.2575
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0058 0.0005
Brugia malayi Dynamin 0.0022 0.0089 0.0072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0851 0.0835
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.1533 0.2544
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0085 0.0078
Echinococcus multilocularis microtubule associated protein 2 0.0691 0.6012 0.8802
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0058 0.0058
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0546 0.0495
Schistosoma mansoni ran 0.0022 0.0085 0.0054
Schistosoma mansoni hypothetical protein 0.0081 0.0606 0.0927
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.1433 0.1419
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0851 0.3431
Loa Loa (eye worm) hypothetical protein 0.0108 0.0851 0.0851
Loa Loa (eye worm) beta-lactamase 0.0108 0.0851 0.0851
Plasmodium falciparum dynamin-like protein 0.0021 0.0075 0.0604
Loa Loa (eye worm) hypothetical protein 0.0255 0.2147 0.2147
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0331 0.0466
Plasmodium falciparum importin beta, putative 0.0058 0.041 1
Echinococcus granulosus geminin 0.0532 0.4603 0.7654
Echinococcus granulosus lamin dm0 0.0026 0.0124 0.02
Trichomonas vaginalis dynamin, putative 0.0021 0.0075 0.0093
Schistosoma mansoni hypothetical protein 0.0174 0.1433 0.2316
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0426 0.3668 0.3634
Trichomonas vaginalis glutaminase, putative 0.0281 0.2377 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0546 0.054
Brugia malayi intermediate filament protein 0.0026 0.0124 0.0108
Mycobacterium ulcerans glutaminase 0.0281 0.2377 0.4716
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0058 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0851 1
Echinococcus multilocularis lamin 0.0026 0.0124 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0312 0.026
Echinococcus multilocularis tumor protein p63 0.0338 0.2889 0.4226
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.03 0.0415
Brugia malayi beta-lactamase 0.0108 0.0851 0.0835
Schistosoma mansoni lamin 0.0026 0.0124 0.012
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0085 0.0401
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0058 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0851 0.0802
Trichomonas vaginalis dynamin, putative 0.0021 0.0075 0.0093
Brugia malayi Muscleblind-like protein 0.0303 0.2575 0.2563
Plasmodium vivax dynamin-like protein, putative 0.0021 0.0075 0.027
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1141 1 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0851 0.0851
Echinococcus granulosus microtubule associated protein 2 0.0691 0.6012 1
Trypanosoma cruzi dynamin-1-like protein 0.0021 0.0075 0.0022
Leishmania major C-8 sterol isomerase-like protein 0.1141 1 1
Toxoplasma gondii dynamin-related protein DRPA 0.0021 0.0075 0.0743
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0053 0.0072
Schistosoma mansoni hypothetical protein 0.0037 0.0219 0.0279
Schistosoma mansoni dynamin 0.0022 0.0089 0.006
Echinococcus granulosus dynamin 1 0.0022 0.0089 0.0141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.6015 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0851 0.1618
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0546 0.0902
Mycobacterium ulcerans short chain dehydrogenase 0.0575 0.4981 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0357 0.051
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0851 0.1338
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.683 1
Echinococcus multilocularis muscleblind protein 0.0303 0.2575 0.3766
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.2147 0.2134
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0085 0.0032
Echinococcus granulosus muscleblind protein 0.0303 0.2575 0.4279
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0357 0.0517
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.2147 0.2134
Trypanosoma brucei C-8 sterol isomerase, putative 0.1141 1 1
Loa Loa (eye worm) hypothetical protein 0.0303 0.2575 0.2575
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0426 0.3668 0.3634
Mycobacterium tuberculosis Conserved protein 0.0108 0.0851 0.1338
Loa Loa (eye worm) hypothetical protein 0.0058 0.041 0.041
Mycobacterium ulcerans beta-lactamase 0.0108 0.0851 0.1618
Trichomonas vaginalis interferon-induced GTP-binding protein mx, putative 0.0021 0.0075 0.0093
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0426 0.3668 0.3634
Trypanosoma brucei dynamin-1-like protein 0.0021 0.0075 0.0068
Toxoplasma gondii exonuclease III APE 0.0018 0.0053 0.0485
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0357 0.0587
Schistosoma mansoni ran 0.0022 0.0085 0.0054
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0017 0.0017
Echinococcus granulosus dna polymerase eta 0.0044 0.0278 0.0455
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0278 0.0261
Echinococcus multilocularis dynamin 1 protein 0.0021 0.0075 0.0103
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0085 0.0085
Schistosoma mansoni dynamin 0.0022 0.0089 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Plasmodium falciparum dynamin-like protein 0.0021 0.0075 0.0604
Trichomonas vaginalis dynamin, putative 0.0021 0.0075 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0058 0.0052
Schistosoma mansoni intermediate filament proteins 0.0026 0.0124 0.012
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0058 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0047 0.0307 0.0427
Schistosoma mansoni hypothetical protein 0.0081 0.0606 0.0927
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0606 0.0881

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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