Detailed information for compound 657462

Basic information

Technical information
  • TDR Targets ID: 657462
  • Name: [3-(3,3,6,6-tetramethyl-1,8-dioxo-4,5,7,9-tet rahydro-2H-xanthen-9-yl)phenyl] N,N-dimethylc arbamate
  • MW: 437.528 | Formula: C26H31NO5
  • H donors: 0 H acceptors: 3 LogP: 3.73 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)Oc1cccc(c1)C1C2=C(OC3=C1C(=O)CC(C3)(C)C)CC(CC2=O)(C)C)C
  • InChi: 1S/C26H31NO5/c1-25(2)11-17(28)22-19(13-25)32-20-14-26(3,4)12-18(29)23(20)21(22)15-8-7-9-16(10-15)31-24(30)27(5)6/h7-10,21H,11-14H2,1-6H3
  • InChiKey: KKWOYVBXBGCBGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-dimethylcarbamic acid [3-(3,3,6,6-tetramethyl-1,8-dioxo-4,5,7,9-tetrahydro-2H-xanthen-9-yl)phenyl] ester
  • N,N-dimethylcarbamic acid [3-(1,8-diketo-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthen-9-yl)phenyl] ester
  • Oprea1_651520
  • AN-465/13395026
  • ChemDiv1_006567

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.2954 0.2754 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0067 0.0242
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0056 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0067 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0029 0.0654
Mycobacterium ulcerans hypothetical protein 0.018 0.0146 0.0531
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0051 0.0184
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0931
Mycobacterium ulcerans lipase LipD 0.0297 0.0257 0.0931
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0012 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0012 0.01
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0092 0.0064 0.021
Plasmodium vivax hypothetical protein, conserved 0.0297 0.0257 0.093
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.005 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0539
Toxoplasma gondii ABC1 family protein 0.0297 0.0257 0.0905
Brugia malayi jmjC domain containing protein 0.0051 0.0025 0.0092
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0051 0.0025 0.0069
Leishmania major basic transcription factor 3a, putative 0.0035 0.001 0.0037
Mycobacterium tuberculosis Conserved protein 0.0079 0.0051 0.0184
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0384 0.0338 0.0336
Loa Loa (eye worm) hypothetical protein 0.0079 0.0051 0.0184
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0029
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0012 0.0009
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.2876 0.268 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0056 0.0204
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0012 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0006 0.0133
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0107 0.0104
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0008 0.0176
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0012 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.0298 0.1063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0129 0.0447
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0079 0.0051 0.0048
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0079 0.0051 0.0156
Entamoeba histolytica hypothetical protein 0.0181 0.0148 1
Brugia malayi beta-lactamase family protein 0.0297 0.0257 0.0932
Trypanosoma cruzi GMP reductase 0.2954 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0013 0.0875
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0039 0.0036
Brugia malayi nuclear receptor NHR-88 0.0037 0.0012 0.0043
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0079 0.0051 0.0048
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0012 0.0006
Leishmania major mitochondrial DNA polymerase beta 0.0342 0.0298 0.1083
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0012 0.0009
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 0.042
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0067 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0012 0.0009
Toxoplasma gondii IMP dehydrogenas 0.2954 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0035 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0297 0.0257 0.5853
Schistosoma mansoni jumonji/arid domain-containing protein 0.0192 0.0158 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0025 0.0091
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.2954 0.2754 0.2752
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0056 0.003 0.0107
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1271 0.1171 0.4253
Schistosoma mansoni protein kinase subunit gamma 0.0079 0.0051 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0067 0.0064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0016 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0297 0.0257 0.0254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0297 0.0257 0.0251
Mycobacterium tuberculosis Probable esterase LipL 0.0297 0.0257 0.0931
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0079 0.0051 0.7655
Trichomonas vaginalis penicillin-binding protein, putative 0.0297 0.0257 0.5853
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.011 0.0104
Leishmania major hypothetical protein, conserved 0.0051 0.0025 0.0091
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.0382 0.1387
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0012 0.0006
Brugia malayi Pre-SET motif family protein 0.0431 0.0382 0.1388
Onchocerca volvulus 0.0297 0.0257 0.219
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0092 0.0064 0.4337
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.2954 0.2754 1
Mycobacterium tuberculosis Probable hydrolase 0.0297 0.0257 0.0931
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0079 0.0052 0.0045
Chlamydia trachomatis Mg++ transporter 0.0079 0.0051 0.3713
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0297 0.0257 0.0931
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0092 0.0064 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0005
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0052 0.0165
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0029
Mycobacterium ulcerans esterase/lipase LipP 0.0297 0.0257 0.0931
Echinococcus granulosus jumonji domain containing 1A 0.0051 0.0025 0.0023
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0036 0.0128
Schistosoma mansoni transcription factor LCR-F1 0.0181 0.0148 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0012 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0029 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0538
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0008 0.0029
Echinococcus multilocularis geminin 0.0171 0.0138 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0067 0.0065
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0931
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.0298 0.1063
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0028 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0012 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0012 0.0006
Brugia malayi glutathione reductase 0.0095 0.0067 0.0242
Brugia malayi ancient conserved domain protein 2 0.0079 0.0051 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0539
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.0073 0.0264
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0006 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0008 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0035 0.0033
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0008 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0297 0.0257 0.0931
Brugia malayi beta-lactamase family protein 0.0297 0.0257 0.0932
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.001 0.0015
Plasmodium vivax JmjC domain containing protein 0.0051 0.0025 0.0064
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0012 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0079 0.0052 0.0049
Schistosoma mansoni hypothetical protein 0.0049 0.0023 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0035 0.0029
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 0.0447
Schistosoma mansoni jumonji domain containing protein 0.0192 0.0158 0.0152
Schistosoma mansoni hypothetical protein 0.0171 0.0138 0.0132
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0079 0.0051 0.0048
Schistosoma mansoni intermediate filament proteins 0.0056 0.003 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0012 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0025 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0008 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.005 0.0156
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0022 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0122 0.0443
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0042 0.0122
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0931
Brugia malayi hypothetical protein 0.005 0.0024 0.0088
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0012 0.0009
Brugia malayi beta-NAC-like protein 0.0035 0.001 0.0038
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0384 0.0338 0.0336
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.0073 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0012 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0012 0.0042
Toxoplasma gondii CBS domain-containing protein 0.0079 0.0051 0.0156
Leishmania major trypanothione reductase 0.0095 0.0067 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0035 0.0029
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0242 0.0204 0.0741
Echinococcus granulosus neuropeptide receptor A26 0.0488 0.0436 0.0434
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0012 0.01
Loa Loa (eye worm) chloride channel protein 7 0.0079 0.0051 0.0184
Schistosoma mansoni phd/f-box containing protein 0.0051 0.0025 0.0019
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.1349 0.1245 0.4521
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.0073 0.0264
Toxoplasma gondii CBS domain-containing protein 0.0079 0.0051 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0029 0.0654
Brugia malayi chloride channel protein 7 0.0079 0.0051 0.0185
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.0181 0.0658
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.001 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0064 0.1453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Mycobacterium leprae conserved hypothetical protein 0.0297 0.0257 0.0931
Onchocerca volvulus 0.0079 0.0051 0.0433
Loa Loa (eye worm) hypothetical protein 0.0084 0.0056 0.0203
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0297 0.0257 0.0931
Brugia malayi Thioredoxin reductase 0.0095 0.0067 0.0242
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.0052 0.1171
Mycobacterium ulcerans beta-lactamase 0.0297 0.0257 0.0931
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0067 0.0242
Mycobacterium tuberculosis Conserved protein 0.0297 0.0257 0.0931
Echinococcus granulosus neuropeptide s receptor 0.0488 0.0436 0.0434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0384 0.0338 0.0332
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0079 0.0051 0.0045
Entamoeba histolytica hypothetical protein 0.0181 0.0148 1
Echinococcus multilocularis neuropeptide s receptor 0.0488 0.0436 0.0434
Echinococcus granulosus lamin dm0 0.0056 0.003 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0029 0.0642
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0931
Loa Loa (eye worm) glutathione reductase 0.0095 0.0067 0.0242
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0052 0.0165
Plasmodium vivax SET domain protein, putative 0.0062 0.0035 0.0101
Mycobacterium tuberculosis Conserved protein 0.0297 0.0257 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0052 0.1171
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0538
Plasmodium falciparum glutathione reductase 0.0095 0.0067 0.0219
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0079 0.0051 0.0156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0012 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0006 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0012 0.0042
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0068 0.0246
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0013 0.0876
Mycobacterium ulcerans hypothetical protein 0.0079 0.0051 0.0184
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0079 0.0051 0.0184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0012 0.0043
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0036 0.0033
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0012 0.0043
Brugia malayi CBS domain containing protein 0.0079 0.0051 0.0185
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0005 0.0019
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.2954 0.2754 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Mycobacterium leprae Probable lipase LipE 0.0297 0.0257 0.0931
Schistosoma mansoni lamin 0.0056 0.003 0.0023
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.001 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0421 0.0373 0.0367
Echinococcus multilocularis musashi 0.0056 0.003 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0039 0.0032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.19 0.1763 0.6401
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.0123 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Echinococcus multilocularis ubiquitin specific protease 41 0.0079 0.0052 0.0049
Brugia malayi jmjC domain containing protein 0.0051 0.0025 0.0092
Loa Loa (eye worm) RNA binding protein 0.0065 0.0039 0.014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.003 0.0107
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0036 0.0128
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0079 0.0051 0.0045
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0008 0.0176
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0035 0.0033
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.0123 0.0121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0012 0.0006
Echinococcus granulosus intermediate filament protein 0.0056 0.003 0.0027
Plasmodium vivax glutathione reductase, putative 0.0095 0.0067 0.0219
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0297 0.0257 0.0931
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.0181 0.0658
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0079 0.0052 0.1171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0067 0.0065
Schistosoma mansoni hypothetical protein 0.0049 0.0023 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0076 0.0277
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0028 0.0101
Schistosoma mansoni phosphatidylserine receptor 0.0051 0.0025 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0022 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0012 0.0043
Mycobacterium ulcerans hypothetical protein 0.0297 0.0257 0.0931
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.0181 0.0658
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0046 0.0168
Leishmania major inosine-5-monophosphate dehydrogenase 0.2954 0.2754 1
Onchocerca volvulus 0.0096 0.0068 0.0576
Trichomonas vaginalis D-aminoacylase, putative 0.0297 0.0257 0.5853
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0051 0.0025 0.0063
Mycobacterium tuberculosis Conserved protein 0.0079 0.0051 0.0184
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0079 0.0051 0.0156
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0016 0.0363
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0297 0.0257 0.0931
Plasmodium falciparum JmjC domain-containing protein, putative 0.0051 0.0025 0.0064
Mycobacterium tuberculosis Probable lipase LipD 0.0297 0.0257 0.0931
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0079 0.0051 0.0184
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0006 0.0022
Treponema pallidum hemolysin (tlyC) 0.0079 0.0051 0.3713
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.0748 0.0746
Onchocerca volvulus 0.0037 0.0012 0.01
Trypanosoma cruzi chloride channel protein, putative 0.0079 0.0051 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0539
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0123 0.042
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0051 0.0025 0.0069
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0012 0.0043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0122 0.0443
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0092 0.0064 0.0232
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0158 0.0155
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.2954 0.2754 1
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.2876 0.268 1
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0067 0.0219
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0051 0.0025 0.0069
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0079 0.0052 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0012 0.0042
Trypanosoma brucei GMP reductase 0.2954 0.2754 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0012 0.01
Loa Loa (eye worm) hypothetical protein 0.0055 0.0029 0.0104
Toxoplasma gondii CBS family protein 0.0079 0.0051 0.0156
Entamoeba histolytica hypothetical protein 0.0181 0.0148 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.2954 0.2754 0.2752
Echinococcus granulosus lysine specific demethylase 6a 0.0051 0.0025 0.0023
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0079 0.0051 0.0163
Onchocerca volvulus 0.049 0.0438 0.374
Mycobacterium ulcerans hypothetical protein 0.0079 0.0051 0.0184
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0217 0.0181 0.0658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0067 0.0061
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0005 0.0019
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0092 0.0064 0.021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.0181 0.0658
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0067 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0421 0.0373 0.0367
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0008 0.0006
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0039 0.014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0023 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0006 0.0133
Brugia malayi jmjC domain containing protein 0.0051 0.0025 0.0092
Mycobacterium ulcerans cystathionine beta-synthase 0.0079 0.0051 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0046 0.1047
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0036 0.0129
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0013 0.0018
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1349 0.1245 0.4521
Trypanosoma cruzi hypothetical protein, conserved 0.0297 0.0257 0.0911
Loa Loa (eye worm) hypothetical protein 0.0051 0.0025 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0297 0.0257 0.0911
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0051 0.0025 0.0063
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0006 0.0004
Schistosoma mansoni lamin 0.0056 0.003 0.0023
Leishmania major chloride channel protein, putative 0.0079 0.0051 0.0184
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0342 0.0298 0.1063
Echinococcus granulosus tumor protein p63 0.1671 0.1548 0.1546
Schistosoma mansoni jumonji/arid domain-containing protein 0.0192 0.0158 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0539
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0067 0.0064
Onchocerca volvulus 0.0056 0.003 0.0252
Chlamydia trachomatis CBS domain-containing protein 0.0079 0.0051 0.3713
Loa Loa (eye worm) GMP reductase 0.1271 0.1171 0.4253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0035 0.0029
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.0123 0.0447
Plasmodium falciparum thioredoxin reductase 0.0095 0.0067 0.0219
Echinococcus multilocularis lysine specific demethylase 5A 0.0192 0.0158 0.0155
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0035 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0008 0.0007
Echinococcus granulosus tar DNA binding protein 0.0065 0.0039 0.0036
Echinococcus granulosus ubiquitin specific protease 41 0.0079 0.0052 0.0049
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0079 0.0052 0.0049
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0013 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0297 0.0257 0.5853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0036 0.0799
Echinococcus granulosus phd:f box containing protein 0.0051 0.0025 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0421 0.0373 0.037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0033 0.0031
Mycobacterium ulcerans transcriptional regulator 0.0079 0.0051 0.0184
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0006 0.0022
Brugia malayi steroid hormone receptor 0.0037 0.0012 0.0043
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0079 0.0052 0.0165
Loa Loa (eye worm) hypothetical protein 0.0051 0.0025 0.0091
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.0129 0.0447
Loa Loa (eye worm) hypothetical protein 0.0027 0.0003 0.0008
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.1605 0.1486 0.5395
Onchocerca volvulus 0.0056 0.003 0.0252
Schistosoma mansoni coup transcription factor 0.0037 0.0012 0.0006
Loa Loa (eye worm) IMP dehydrogenase 1 0.2954 0.2754 1
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0079 0.0051 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Onchocerca volvulus 0.0062 0.0035 0.0299
Loa Loa (eye worm) beta-lactamase 0.0297 0.0257 0.0931
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0007
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0079 0.0051 0.0184
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0008 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.0146 0.0531
Trichomonas vaginalis esterase, putative 0.0297 0.0257 0.5853
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0036 0.0128
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0008 0.0029
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.0181 0.0658
Leishmania major chloride channel protein, putative 0.0079 0.0051 0.0184
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0079 0.0051 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0025 0 0.0001
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0056 0.0054
Trypanosoma cruzi GMP reductase 0.2954 0.2754 1
Schistosoma mansoni hypothetical protein 0.0181 0.0148 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0007
Brugia malayi Probable ClpP-like protease 0.0156 0.0123 0.0448
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0079 0.0051 0.0184
Plasmodium falciparum protein MAM3, putative 0.0079 0.0051 0.016
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.001 0.0007
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.2954 0.2754 0.2749
Echinococcus multilocularis lamin 0.0056 0.003 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0012 0.0043
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.0073 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0064 0.1453
Loa Loa (eye worm) hypothetical protein 0.0154 0.0122 0.0442
Schistosoma mansoni hypothetical protein 0.0096 0.0068 0.0061
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0079 0.0051 0.0184
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0008 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.005 0.0158
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0079 0.0051 0.0048
Leishmania major CBS domain protein, conserved 0.0079 0.0051 0.0184
Schistosoma mansoni chloride channel protein 0.0079 0.0051 0.0045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0023 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0242 0.0204 0.0741
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0018 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 1
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0012 0.0009
Giardia lamblia Hypothetical protein 0.0079 0.0051 0.7655
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1271 0.1171 0.4253
Echinococcus multilocularis GPCR, family 2 0.0049 0.0023 0.002
Mycobacterium ulcerans hypothetical protein 0.0079 0.0051 0.0184
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.005 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0012 0.0043
Schistosoma mansoni hypothetical protein 0.0105 0.0076 0.007
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0079 0.0052 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0012 0.0043
Leishmania major guanosine monophosphate reductase 0.2954 0.2754 1
Brugia malayi jmjC domain containing protein 0.0051 0.0025 0.0092
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0079 0.0052 0.35
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0122 0.0442
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0105 0.0076 0.0276
Onchocerca volvulus 0.0245 0.0207 0.1767
Brugia malayi TAR-binding protein 0.0065 0.0039 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0039 0.0032
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0092 0.0064 0.0058
Echinococcus multilocularis JmjC domain containing protein 4 0.0051 0.0025 0.0023
Leishmania major hypothetical protein, conserved 0.0079 0.0051 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0245 0.0207 0.0751
Loa Loa (eye worm) chloride channel 3 0.0079 0.0051 0.0184
Loa Loa (eye worm) jmjC domain-containing protein 0.0192 0.0158 0.0573
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0012 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0007
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.2954 0.2754 1
Echinococcus granulosus geminin 0.0171 0.0138 0.0136
Toxoplasma gondii NAC domain-containing protein 0.0035 0.001 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.0064 0.0233
Schistosoma mansoni hypothetical protein 0.0049 0.0023 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.005 0.0156
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1605 0.1486 0.5395
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.011 0.0108
Toxoplasma gondii hypothetical protein 0.0054 0.0028 0.007
Loa Loa (eye worm) hypothetical protein 0.0079 0.0052 0.0187
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0012 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0012 0.0006
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0079 0.0051 0.0163
Echinococcus multilocularis microtubule associated protein 2 1.0663 1 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0079 0.0052 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.001 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0064 0.1453
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0008 0.003
Schistosoma mansoni microtubule-associated protein tau 1.0663 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0181 0.0148 0.0145
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0079 0.0051 0.3713
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.005 0.0152
Loa Loa (eye worm) hypothetical protein 0.0079 0.0051 0.0184
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0129 0.0468
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0022 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0034 0.0756
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0079 0.0051 0.0048
Echinococcus granulosus transcription factor btf3 0.0035 0.001 0.0008
Giardia lamblia GTOR 0.0092 0.0064 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0092 0.0064 0.0232
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0297 0.0257 0.0931
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0123 0.042
Onchocerca volvulus 0.0297 0.0257 0.219
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0025 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0012 0.0009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0008 0.0029
Echinococcus granulosus GPCR family 2 0.0049 0.0023 0.002
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.2954 0.2754 1
Brugia malayi GMP reductase 0.1271 0.1171 0.4253
Echinococcus granulosus lamin 0.0056 0.003 0.0027
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0092 0.0064 0.0062
Brugia malayi hypothetical protein 0.0181 0.0148 0.0536
Echinococcus granulosus lysine specific demethylase 5A 0.0192 0.0158 0.0155
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0079 0.0051 0.7655
Brugia malayi RNA binding protein 0.0065 0.0039 0.0141
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0046 0.0146
Brugia malayi loechrig isoform VII 0.0079 0.0051 0.0185
Brugia malayi beta-lactamase 0.0297 0.0257 0.0932
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0012 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0012 0.0042
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0092 0.0064 0.021
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0079 0.0052 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0012 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Echinococcus granulosus H:Cl exchange transporter 3 0.0079 0.0051 0.0048
Brugia malayi jmjC domain containing protein 0.0192 0.0158 0.0574
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0036 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0012 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0023 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0006 0.0133
Echinococcus granulosus beta LACTamase domain containing family member 0.0297 0.0257 0.0254
Echinococcus granulosus survival motor neuron protein 1 0.0472 0.0421 0.0418
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0931
Loa Loa (eye worm) hypothetical protein 0.0297 0.0257 0.0931
Onchocerca volvulus 0.0297 0.0257 0.219
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0079 0.0051 0.7655
Trichomonas vaginalis set domain proteins, putative 0.049 0.0438 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0067 0.0061
Brugia malayi ecdysteroid receptor 0.0037 0.0012 0.0043
Mycobacterium tuberculosis Probable oxidoreductase 0.0242 0.0204 0.0741
Schistosoma mansoni hypothetical protein 0.0049 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0079 0.0051 0.0184
Brugia malayi hypothetical protein 0.0472 0.0421 0.1528
Echinococcus granulosus H:Cl exchange transporter 4 0.0079 0.0051 0.0048
Brugia malayi ancient conserved domain protein 4 0.0079 0.0051 0.0185
Brugia malayi intermediate filament protein 0.0056 0.003 0.0108
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0079 0.0052 0.7793
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0079 0.0051 0.0163
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0079 0.0051 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0039 0.0032
Loa Loa (eye worm) loechrig isoform VII 0.0079 0.0051 0.0184
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0025 0.0019
Echinococcus multilocularis lamin dm0 0.0056 0.003 0.0027
Toxoplasma gondii thioredoxin reductase 0.0095 0.0067 0.0213
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0008 0.0006
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0051 0.0025 0.0023
Onchocerca volvulus Putative GMP reductase 0.1271 0.1171 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0012 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0012 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0008 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0008 0.0007
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0046 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0029 0.0642
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0012 0.0042
Leishmania major hypothetical protein, conserved 0.0077 0.005 0.018
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0012 0.0006
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0028 0.168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0002 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 0.0447
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0079 0.0052 0.0045
Schistosoma mansoni hypothetical protein 0.0035 0.001 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0006 0.0023
Echinococcus multilocularis neuropeptide receptor A26 0.0488 0.0436 0.0434
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0242 0.0204 0.0741
Echinococcus multilocularis phd:f box containing protein 0.0051 0.0025 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.0297 0.0257 0.0911
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.2954 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0051 0.0184
Treponema pallidum Mg2+ transport protein (mgtE) 0.0079 0.0051 0.3713
Brugia malayi jmjC domain containing protein 0.0192 0.0158 0.0574
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0092 0.0064 0.0062
Brugia malayi hypothetical protein 0.0077 0.005 0.0181
Brugia malayi CLC chloride channel protein 0.0079 0.0051 0.0185
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.2876 0.268 0.9732
Entamoeba histolytica hypothetical protein 0.0181 0.0148 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0036 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0012 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0035 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.001 0.0227
Trichomonas vaginalis D-aminoacylase, putative 0.0297 0.0257 0.5853
Loa Loa (eye worm) intermediate filament protein 0.0056 0.003 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0042 0.0944
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.001 0.0692
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.005 0.0158
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0039 0.0141
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.0123 0.0121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0012 0.0042
Loa Loa (eye worm) acetyltransferase 0.0142 0.011 0.04
Loa Loa (eye worm) hypothetical protein 0.0156 0.0123 0.0447
Brugia malayi Voltage gated chloride channel family protein 0.0079 0.0051 0.0185
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0028 0.0072
Trypanosoma brucei trypanothione reductase 0.0095 0.0067 0.022
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0079 0.0051 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0022 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0039 0.0032
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.003 0.0108
Brugia malayi nuclear hormone receptor 0.0037 0.0012 0.0043
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.0073 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0024 0.0538
Trypanosoma cruzi chloride channel protein, putative 0.0079 0.0051 0.0163
Echinococcus granulosus JmjC domain containing protein 4 0.0051 0.0025 0.0023
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0092 0.0064 0.0232
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0158 0.0155
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0051 0.0025 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0181 0.0148 0.0145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0067 0.0243
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0023 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0051 0.1163
Mycobacterium tuberculosis Conserved protein 0.0297 0.0257 0.0931
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0079 0.0051 0.0184
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0016 0.003
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0472 0.0421 0.1527
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0012 0.0009
Mycobacterium tuberculosis Probable reductase 0.0217 0.0181 0.0658
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0079 0.0051 0.0045
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0016 0.0363
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0051 0.0025 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0023 0.0084
Schistosoma mansoni cellular tumor antigen P53 0.0245 0.0207 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0046 0.1047
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.0123 0.0431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0008 0.0007
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.001 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0006 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0046 0.1047
Echinococcus multilocularis lysine specific demethylase 6a 0.0051 0.0025 0.0023
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0006 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0012 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0007
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0092 0.0064 0.4337
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0079 0.0051 0.0184
Schistosoma mansoni hypothetical protein 0.0171 0.0138 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0067 0.0061
Toxoplasma gondii hypothetical protein 0.0055 0.0029 0.0076
Echinococcus multilocularis jumonji domain containing 1A 0.0051 0.0025 0.0023
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.2954 0.2754 1
Brugia malayi Pre-SET motif family protein 0.0062 0.0035 0.0128
Leishmania major hypothetical protein, conserved 0.0297 0.0257 0.0931
Echinococcus multilocularis survival motor neuron protein 1 0.0472 0.0421 0.0418
Echinococcus multilocularis tumor protein p63 0.1671 0.1548 0.1546
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0297 0.0257 0.0251
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.001 0.0008
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0079 0.0051 0.0163
Trypanosoma cruzi chloride channel protein, putative 0.0079 0.0051 0.0163
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.2954 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0012 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0067 0.0244
Brugia malayi AMP-binding enzyme family protein 0.0025 0 0.0001
Schistosoma mansoni survival motor neuron protein 0.0096 0.0068 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.001 0.0227
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0012 0.0009
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0123 0.0431
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0023 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0012 0.0043
Mycobacterium tuberculosis Conserved protein 0.0079 0.0051 0.0184
Loa Loa (eye worm) ICD-1 protein 0.0035 0.001 0.0037
Echinococcus granulosus H:Cl exchange transporter 7 0.0079 0.0051 0.0048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0012 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0046 0.1047
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.011 0.0401
Onchocerca volvulus 0.0084 0.0056 0.0478
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0016 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0023 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0039 0.0032
Echinococcus multilocularis transcription factor btf3 0.0035 0.001 0.0008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0008 0.0002
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0079 0.0051 0.0163
Schistosoma mansoni transcription factor btf3 0.0035 0.001 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0046 0.1047
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0079 0.0051 0.0048
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0032 0.0094
Entamoeba histolytica hypothetical protein 0.0035 0.001 0.0692
Schistosoma mansoni chloride channel protein 0.0079 0.0051 0.0045
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.001 0.0007
Schistosoma mansoni chloride channel protein 0.0079 0.0051 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0012 0.0043
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0297 0.0257 0.0932
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0039 0.014
Brugia malayi AMP-binding enzyme family protein 0.0025 0 0.0001
Schistosoma mansoni protein phosphatase 2C 0.0051 0.0025 0.0019
Loa Loa (eye worm) hypothetical protein 0.0077 0.005 0.018
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0016 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0023 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0028 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0025 0.0091
Trypanosoma cruzi chloride channel protein, putative 0.0079 0.0051 0.0163

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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