Detailed information for compound 661484

Basic information

Technical information
  • TDR Targets ID: 661484
  • Name: 3-[3-methoxy-4-(phenylmethoxy)phenyl]-N-(4-me thylphenyl)prop-2-enamide
  • MW: 373.444 | Formula: C24H23NO3
  • H donors: 1 H acceptors: 1 LogP: 4.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C=CC(=O)Nc2ccc(cc2)C)ccc1OCc1ccccc1
  • InChi: 1S/C24H23NO3/c1-18-8-12-21(13-9-18)25-24(26)15-11-19-10-14-22(23(16-19)27-2)28-17-20-6-4-3-5-7-20/h3-16H,17H2,1-2H3,(H,25,26)/b15-11+
  • InChiKey: BICNWJLSXSBBCC-RVDMUPIBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[3-methoxy-4-(phenylmethoxy)phenyl]-N-(4-methylphenyl)prop-2-enamide
  • 3-[4-(benzyloxy)-3-methoxy-phenyl]-N-(4-methylphenyl)acrylamide
  • (E)-3-[4-(benzyloxy)-3-methoxy-phenyl]-N-(4-methylphenyl)acrylamide
  • ZINC00951248

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0166 0.0448 0.1225
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0121 0.0795
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.0824 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0086 0.0128
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0058 0.0046
Schistosoma mansoni hypothetical protein 0.0166 0.0448 0.1225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0288 0.0819 0.2396
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0275 0.0381
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0368 0.1056
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0109 0.0169
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0063 0.0133 0.0133
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0069 0.0134
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0131 0.0119
Echinococcus granulosus GPCR family 2 0.0166 0.0448 0.1293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0088 0.013
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0312 0.0447
Plasmodium vivax importin-beta 2, putative 0.0086 0.0203 0.2265
Brugia malayi RNA binding protein 0.0066 0.0141 0.0225
Brugia malayi jmjC domain containing protein 0.0195 0.0535 0.0921
Plasmodium falciparum importin beta, putative 0.0086 0.0203 1
Schistosoma mansoni intermediate filament proteins 0.0056 0.0109 0.0211
Brugia malayi vesicular acetylcholine transporter unc-17 0.1124 0.338 0.5951
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0167 0.0383
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0029 0.0027
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0118 0.0301 0.0855
Loa Loa (eye worm) hypothetical protein 0.0166 0.0448 0.0768
Brugia malayi beta-lactamase family protein 0.0296 0.0845 0.147
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0039 0.0044
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0058 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0175 0.0284
Loa Loa (eye worm) hypothetical protein 0.0526 0.1549 0.2713
Trichomonas vaginalis Importin beta-1 subunit, putative 0.007 0.0153 0.1075
Onchocerca volvulus 0.0063 0.0131 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0296 0.0845 0.2414
Echinococcus granulosus sodium:glucose cotransporter 0.0118 0.0301 0.0855
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0131 0.0926
Onchocerca volvulus 0.0296 0.0845 0.2251
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0063 0.0133 0.0211
Echinococcus multilocularis importin subunit beta 1 0.0086 0.0203 0.019
Trichomonas vaginalis esterase, putative 0.0296 0.0845 0.5938
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0069 0.0651
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0118 0.0301 0.3078
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0039 0.0026
Loa Loa (eye worm) transcription factor SMAD2 0.0479 0.1406 0.246
Schistosoma mansoni inositol transporter 0.0118 0.0301 0.0783
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.0824 1
Schistosoma mansoni hypothetical protein 0.092 0.2757 0.8135
Echinococcus granulosus beta LACTamase domain containing family member 0.0296 0.0845 0.2473
Plasmodium vivax SET domain protein, putative 0.0063 0.0131 0.1401
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0063 0.0133 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0288 0.0819 0.2336
Loa Loa (eye worm) MH2 domain-containing protein 0.0479 0.1406 0.246
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0141 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0166 0.0448 0.0768
Schistosoma mansoni ap endonuclease 0.0039 0.0058 0.0058
Schistosoma mansoni sodium/solute symporter 0.0118 0.0301 0.0783
Entamoeba histolytica hypothetical protein 0.0074 0.0167 0.142
Schistosoma mansoni high-affinity choline transporter 0.1071 0.3218 0.9515
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0312 0.0447
Echinococcus granulosus vesicular acetylcholine transporter 0.1124 0.338 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0141 0.0306
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0118 0.0301 0.0288
Schistosoma mansoni hypothetical protein 0.0059 0.0121 0.0245
Trichomonas vaginalis D-aminoacylase, putative 0.0296 0.0845 0.5938
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0118 0.0301 0.0288
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0175 0.0406
Mycobacterium tuberculosis Conserved protein 0.0296 0.0845 0.1388
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0179 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0288 0.0819 0.1424
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0121 0.0108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0166 0.0448 0.0436
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0288 0.0819 0.0808
Mycobacterium ulcerans hypothetical protein 0.0296 0.0845 1
Trichomonas vaginalis importin beta-1, putative 0.007 0.0153 0.1075
Echinococcus multilocularis vesicular acetylcholine transporter 0.1124 0.338 0.3372
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0121 0.0321
Loa Loa (eye worm) hypothetical protein 0.1872 0.5671 1
Mycobacterium tuberculosis Probable lipase LipD 0.0296 0.0845 0.1388
Loa Loa (eye worm) glutathione reductase 0.0048 0.0086 0.0128
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0141 0.0225
Echinococcus granulosus cpg binding protein 0.0093 0.0224 0.0626
Trypanosoma brucei hypothetical protein, conserved 0.0296 0.0845 0.1402
Schistosoma mansoni lamin 0.0056 0.0109 0.0211
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0275 0.0381
Mycobacterium leprae Probable lipase LipE 0.0296 0.0845 1
Brugia malayi MH2 domain containing protein 0.0479 0.1406 0.246
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0371 0.1693
Brugia malayi Pre-SET motif family protein 0.0063 0.0131 0.0208
Toxoplasma gondii ABC1 family protein 0.0296 0.0845 1
Echinococcus multilocularis snurportin 1 0.092 0.2757 0.2748
Schistosoma mansoni ran 0.0063 0.0133 0.0282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Plasmodium falciparum phd finger protein, putative 0.0059 0.0121 0.5638
Brugia malayi latrophilin 2 splice variant baaae 0.0359 0.1039 0.1813
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0086 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0296 0.0845 1
Brugia malayi MH2 domain containing protein 0.0033 0.0039 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0086 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0288 0.0819 0.0808
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1124 0.338 0.5951
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0058 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Trichomonas vaginalis penicillin-binding protein, putative 0.0296 0.0845 0.5938
Echinococcus granulosus geminin 0.0678 0.2016 0.5948
Plasmodium falciparum thioredoxin reductase 0.0048 0.0086 0.379
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0312 0.0447
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.092 0.2757 0.485
Trypanosoma brucei trypanothione reductase 0.0048 0.0086 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0131 0.0119
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0133 0.0133
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0029 0.0049
Plasmodium vivax glutathione reductase, putative 0.0048 0.0086 0.0858
Brugia malayi Calcitonin receptor-like protein seb-1 0.0526 0.1549 0.2713
Echinococcus multilocularis smad 0.0033 0.0039 0.0026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0063 0.0133 0.6295
Entamoeba histolytica hypothetical protein 0.0074 0.0167 0.142
Schistosoma mansoni vesicular acetylcholine transporter 0.1124 0.338 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0179 0.0214
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0029 0.0016
Leishmania major C-8 sterol isomerase-like protein 0.1872 0.5671 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0141 0.0225
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0121 0.0245
Loa Loa (eye worm) hypothetical protein 0.0296 0.0845 0.147
Brugia malayi MH2 domain containing protein 0.0033 0.0039 0.0044
Brugia malayi Pre-SET motif family protein 0.0426 0.1244 0.2175
Echinococcus granulosus lamin 0.0056 0.0109 0.0287
Brugia malayi Bromodomain containing protein 0.0063 0.0132 0.0208
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1124 0.338 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.003 0.0029
Onchocerca volvulus 0.0296 0.0845 0.2251
Echinococcus multilocularis lamin dm0 0.0056 0.0109 0.0097
Onchocerca volvulus Alhambra homolog 0.0059 0.0121 0.0036
Schistosoma mansoni lamin 0.0056 0.0109 0.0211
Brugia malayi hypothetical protein 0.0051 0.0094 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.0296 0.0845 0.5938
Mycobacterium tuberculosis Probable reductase 0.011 0.0275 0.0381
Echinococcus granulosus peregrin 0.0063 0.0132 0.0353
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0131 0.0352
Trypanosoma cruzi hypothetical protein, conserved 0.0296 0.0845 0.1402
Leishmania major GTP-binding protein, putative 0.0063 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.0088 0.0208 0.0507
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0121 0.1277
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1891 0.573 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0072 0.0159 0.0147
Brugia malayi beta-lactamase 0.0296 0.0845 0.147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0166 0.0448 0.1293
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0086 0.0074
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0039 0.0078
Echinococcus multilocularis Smad4 0.0033 0.0039 0.0026
Onchocerca volvulus 0.0088 0.0208 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0141 0.0306
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0133 0.0133
Loa Loa (eye worm) latrophilin receptor protein 2 0.0166 0.0448 0.0768
Loa Loa (eye worm) hypothetical protein 0.0059 0.0121 0.0189
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0121 0.0189
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0203 0.0258
Trichomonas vaginalis Importin beta-1 subunit, putative 0.007 0.0153 0.1075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0131 0.0276
Onchocerca volvulus 0.0485 0.1424 0.4019
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0058 0.2298
Brugia malayi hypothetical protein 0.0074 0.0167 0.0271
Entamoeba histolytica hypothetical protein 0.007 0.0153 0.124
Trypanosoma cruzi importin beta-1 subunit, putative 0.007 0.0153 0.0169
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.003 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0141 0.0306
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0179 0.1527
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0058 0.0524
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0192 0.0533
Brugia malayi PHD-finger family protein 0.0059 0.0121 0.0189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0167 0.0154
Leishmania major hypothetical protein, conserved 0.0296 0.0845 0.1402
Loa Loa (eye worm) hypothetical protein 0.0296 0.0845 0.147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0013
Schistosoma mansoni hypothetical protein 0.0166 0.0448 0.1225
Onchocerca volvulus 0.0118 0.0301 0.0585
Loa Loa (eye worm) hypothetical protein 0.0086 0.0203 0.0334
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0058 0.0079
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0315 0.0532
Brugia malayi intermediate filament protein 0.0056 0.0109 0.0169
Echinococcus granulosus high affinity choline transporter 1 0.1071 0.3218 0.9519
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0371 0.0552
Echinococcus granulosus Smad4 0.0033 0.0039 0.0078
Leishmania major importin beta-1 subunit, putative 0.007 0.0153 0.0169
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0296 0.0845 0.1388
Schistosoma mansoni cpg binding protein 0.0093 0.0224 0.0553
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0195 0.0535 0.0523
Loa Loa (eye worm) hypothetical protein 0.0078 0.0179 0.0291
Echinococcus granulosus snurportin 1 0.092 0.2757 0.8149
Mycobacterium tuberculosis Probable lipase LipE 0.0296 0.0845 0.1388
Schistosoma mansoni ap endonuclease 0.0039 0.0058 0.0058
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0381 0.1023
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0069 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0131 0.0276
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0275 0.0381
Echinococcus multilocularis beta LACTamase domain containing family member 0.0296 0.0845 0.0834
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0063 0.0133 0.0981
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0195 0.0535 0.155
Trichomonas vaginalis D-aminoacylase, putative 0.0296 0.0845 0.5938
Echinococcus multilocularis peregrin 0.0063 0.0132 0.0119
Brugia malayi Smad1 0.0033 0.0039 0.0044
Giardia lamblia PHD finger protein 15 0.0059 0.0121 0.082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Plasmodium vivax hypothetical protein, conserved 0.0296 0.0845 1
Echinococcus multilocularis GPCR, family 2 0.0166 0.0448 0.0436
Brugia malayi Importin beta-1 subunit 0.0086 0.0203 0.0334
Echinococcus multilocularis solute carrier family 5 0.0118 0.0301 0.0288
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0526 0.1549 0.2713
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.0824 1
Mycobacterium tuberculosis Probable esterase LipL 0.0296 0.0845 0.1388
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0109 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0288 0.0819 0.2336
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0275 0.0381
Brugia malayi RNA, U transporter 1 0.0245 0.069 0.1195
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0203 0.0258
Onchocerca volvulus 0.0296 0.0845 0.2251
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.0824 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0296 0.0845 0.1388
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0288 0.0819 0.2396
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0072 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.0517 0.1431
Loa Loa (eye worm) hypothetical protein 0.0118 0.0301 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0131 0.0276
Mycobacterium ulcerans esterase/lipase LipP 0.0296 0.0845 1
Leishmania major trypanothione reductase 0.0048 0.0086 0.0049
Loa Loa (eye worm) Smad1 0.0033 0.0039 0.0044
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0021 0.0025
Echinococcus granulosus sodium:myo inositol cotransporter 0.0118 0.0301 0.0855
Brugia malayi beta-lactamase family protein 0.0296 0.0845 0.147
Plasmodium falciparum glutathione reductase 0.0048 0.0086 0.379
Brugia malayi Thioredoxin reductase 0.0048 0.0086 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0131 0.0276
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0063 0.0133 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0109 0.0169
Trichomonas vaginalis D-aminoacylase, putative 0.0296 0.0845 0.5938
Echinococcus granulosus intermediate filament protein 0.0056 0.0109 0.0287
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0039 0.0044
Schistosoma mansoni hypothetical protein 0.0166 0.0448 0.1225
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0141 0.0306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0008
Loa Loa (eye worm) beta-lactamase 0.0296 0.0845 0.147
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0086 0.0858
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0008
Brugia malayi glutathione reductase 0.0048 0.0086 0.0128
Schistosoma mansoni ran 0.0063 0.0133 0.0282
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0381 0.0369
Loa Loa (eye worm) hypothetical protein 0.0063 0.0131 0.0208
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0058 0.041
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0063 0.0133 0.1425
Brugia malayi CXXC zinc finger family protein 0.0088 0.0208 0.0344
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0063 0.0133 0.0951
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1872 0.5671 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0086 0.0218
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0179 0.8705
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0069 0.0484
Mycobacterium ulcerans lipase LipD 0.0296 0.0845 1
Echinococcus multilocularis cpg binding protein 0.0093 0.0224 0.0211
Echinococcus granulosus tar DNA binding protein 0.0066 0.0141 0.0381
Trypanosoma brucei C-8 sterol isomerase, putative 0.1872 0.5671 1
Entamoeba histolytica Ran family GTPase 0.0063 0.0133 0.0981
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0121 0.0795
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0296 0.0845 0.1388
Echinococcus granulosus importin subunit beta 1 0.0086 0.0203 0.0565
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0141 0.0225
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0141 0.0129
Schistosoma mansoni importin beta-1 0.0086 0.0203 0.0491
Schistosoma mansoni hypothetical protein 0.0678 0.2016 0.5916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0288 0.0819 0.2336
Loa Loa (eye worm) hypothetical protein 0.0296 0.0845 0.147
Schistosoma mansoni hypothetical protein 0.0678 0.2016 0.5916
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0039 0.0026
Echinococcus granulosus smad 0.0033 0.0039 0.0078
Loa Loa (eye worm) hypothetical protein 0.0296 0.0845 0.147
Loa Loa (eye worm) hypothetical protein 0.0056 0.0109 0.0169
Schistosoma mansoni cpg binding protein 0.0093 0.0224 0.0553
Loa Loa (eye worm) hypothetical protein 0.0359 0.1039 0.1813
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0312 0.0656
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0192 0.018
Trichomonas vaginalis ran, putative 0.0063 0.0133 0.0936
Mycobacterium ulcerans beta-lactamase 0.0296 0.0845 1
Schistosoma mansoni inositol transporter 0.0118 0.0301 0.0783
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0021 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0086 0.0203 0.1837
Brugia malayi GH02984p 0.1071 0.3218 0.5665
Loa Loa (eye worm) hypothetical protein 0.0957 0.2868 0.5046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0141 0.0225
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0371 0.3976
Toxoplasma gondii thioredoxin reductase 0.0048 0.0086 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0179 0.0214
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0013 0.0001
Echinococcus granulosus solute carrier family 5 0.0118 0.0301 0.0855
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0058 0.0004
Echinococcus granulosus lamin dm0 0.0056 0.0109 0.0287
Loa Loa (eye worm) hypothetical protein 0.0296 0.0845 0.147
Echinococcus multilocularis musashi 0.0056 0.0109 0.0097
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0058 0.041
Loa Loa (eye worm) hypothetical protein 0.0055 0.0106 0.0163
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0058 0.2314
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0119 0.0314
Loa Loa (eye worm) hypothetical protein 0.0296 0.0845 0.147
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0046 0.01
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0296 0.0845 0.2414
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0167 0.0458
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0166 0.0448 0.1293
Trypanosoma cruzi hypothetical protein, conserved 0.0296 0.0845 0.1402
Brugia malayi hypothetical protein 0.0078 0.0179 0.0291
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0046 0.0034
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0118 0.0301 0.0288
Mycobacterium leprae conserved hypothetical protein 0.0296 0.0845 1
Leishmania major hypothetical protein, conserved 0.0078 0.0179 0.0214
Brugia malayi Sodium:solute symporter family protein 0.0118 0.0301 0.0507
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0166 0.0448 0.0768
Loa Loa (eye worm) acetyltransferase 0.0144 0.0381 0.0649
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1872 0.5671 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0526 0.1549 0.2713
Echinococcus granulosus GTP binding nuclear protein Ran 0.0063 0.0133 0.0358
Brugia malayi MH1 domain containing protein 0.0033 0.0039 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0275 0.0381
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0179 0.1971
Schistosoma mansoni jumonji domain containing protein 0.0155 0.0412 0.1118
Brugia malayi TAR-binding protein 0.0066 0.0141 0.0225
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0296 0.0845 0.147
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0039 0.0078
Trichomonas vaginalis set domain proteins, putative 0.0485 0.1424 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.0824 0.5787
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.1244 0.2175
Mycobacterium tuberculosis Conserved protein 0.0296 0.0845 0.1388
Toxoplasma gondii histone lysine methyltransferase SET1 0.0172 0.0467 0.519
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0069 0.0134
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0023
Echinococcus multilocularis lamin 0.0056 0.0109 0.0097
Echinococcus granulosus sodium:glucose cotransporter 2 0.0118 0.0301 0.0855
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0058 0.0136
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0179 0.8705
Mycobacterium tuberculosis Conserved protein 0.0296 0.0845 0.1388
Echinococcus multilocularis high affinity choline transporter 1 0.1071 0.3218 0.321
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0381 0.0649
Schistosoma mansoni hypothetical protein 0.0074 0.0167 0.0383
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.0175 0.0481
Entamoeba histolytica hypothetical protein 0.0074 0.0167 0.142
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0058 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.0175 0.0406
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0208 0.0344
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0296 0.0845 0.147
Brugia malayi MH1 domain containing protein 0.0033 0.0039 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.0296 0.0845 0.1388
Brugia malayi jmjC domain containing protein 0.0077 0.0175 0.0284
Entamoeba histolytica hypothetical protein 0.0074 0.0167 0.142
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0069 0.0167
Echinococcus multilocularis geminin 0.0678 0.2016 0.2005
Schistosoma mansoni hypothetical protein 0.0359 0.1039 0.2994
Loa Loa (eye worm) hypothetical protein 0.1071 0.3218 0.5665
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0288 0.0819 0.1424
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0166 0.0448 0.0436
Loa Loa (eye worm) hypothetical protein 0.0102 0.0251 0.0419

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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