Detailed information for compound 668973

Basic information

Technical information
  • TDR Targets ID: 668973
  • Name: 3,4-dichloro-N-(2-ethoxyphenyl)-1-benzothioph ene-2-carboxamide
  • MW: 366.262 | Formula: C17H13Cl2NO2S
  • H donors: 1 H acceptors: 1 LogP: 5.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)c1sc2c(c1Cl)c(Cl)ccc2
  • InChi: 1S/C17H13Cl2NO2S/c1-2-22-12-8-4-3-7-11(12)20-17(21)16-15(19)14-10(18)6-5-9-13(14)23-16/h3-9H,2H2,1H3,(H,20,21)
  • InChiKey: BNAHRJBWYZSIDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dichloro-N-(2-ethoxyphenyl)benzothiophene-2-carboxamide
  • 3,4-dichloro-N-(2-ethoxyphenyl)-2-benzothiophenecarboxamide
  • ZINC00648814
  • IVK/9230056
  • AK-968/41021619

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Echinococcus multilocularis vesicular acetylcholine transporter 0.0253 0.6348 0.6342
Schistosoma mansoni leucine aminopeptidase 0.002 0.0361 0.0346
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0102 0.246 1
Brugia malayi vesicular acetylcholine transporter unc-17 0.0253 0.6348 0.79
Brugia malayi RNA, U transporter 1 0.0082 0.1935 0.2395
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0381 0.1494
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0055 0.016
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0361 0.0346
Loa Loa (eye worm) aminopeptidase in chromosome V 0.002 0.0361 0.043
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0332 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Echinococcus multilocularis muscleblind protein 0.0319 0.8031 0.8028
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0179 0.0666
Schistosoma mansoni ferritin 0.0008 0.0055 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1177 0.1163
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.004 0.0025
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0332 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0443 0.1749
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.057 0.2267
Brugia malayi Importin beta-1 subunit 0.0029 0.0576 0.0698
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0381 0.0366
Echinococcus multilocularis muscleblind protein 1 0.0319 0.8031 0.8028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0332 0.1292
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0342
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.029 0.1123
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0576 0.0561
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0443 0.1749
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0055 0.016
Schistosoma mansoni cpg binding protein 0.0029 0.0593 0.0578
Echinococcus multilocularis ferritin 0.0008 0.0055 0.004
Echinococcus granulosus smad 0.0008 0.004 0.0025
Brugia malayi MH1 domain containing protein 0.0008 0.004 0.003
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0342
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0332 0.5822
Echinococcus multilocularis neutral alpha glucosidase AB 0.0028 0.057 0.0555
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Echinococcus multilocularis cpg binding protein 0.0029 0.0593 0.0578
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.057 0.2267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0266 0.1022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0443 0.0533
Toxoplasma gondii leucyl aminopeptidase LAP 0.0102 0.246 1
Echinococcus multilocularis Smad4 0.0008 0.004 0.0025
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.057 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.1177 0.1449
Trichomonas vaginalis sucrase-isomaltase, putative 0.0028 0.057 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1177 0.1163
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0436 0.172
Onchocerca volvulus 0.0146 0.3592 0.5648
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.057 0.0875
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0381 0.0455
Brugia malayi Smad1 0.0008 0.004 0.003
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.1177 0.1449
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.029 0.1123
Trypanosoma brucei unspecified product 0.0013 0.0179 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.057 0.2267
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0028 0.057 0.0691
Brugia malayi hypothetical protein 0.0054 0.1221 0.1503
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0028 0.057 0.2267
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Schistosoma mansoni ferritin light chain 0.0008 0.0055 0.004
Brugia malayi hypothetical protein 0.0035 0.0731 0.0892
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.002 0.0361 0.0346
Echinococcus granulosus neutral alpha glucosidase AB 0.0028 0.057 0.0555
Schistosoma mansoni ran 0.0021 0.0381 0.0366
Schistosoma mansoni alpha-glucosidase 0.0296 0.7459 0.7455
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0443 0.1749
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0332 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0381 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0576 0.229
Plasmodium vivax importin-beta 2, putative 0.0029 0.0576 0.229
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0443 0.0533
Onchocerca volvulus 0.0028 0.0552 0.0846
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0332 0.0394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.1177 0.1163
Echinococcus granulosus lysosomal alpha glucosidase 0.0296 0.7459 0.7455
Schistosoma mansoni alpha glucosidase 0.0028 0.057 0.0555
Echinococcus multilocularis leucine aminopeptidase protein 0.0102 0.246 0.2448
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0443 0.1749
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0381 0.1494
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0332 0.0394
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0253 0.6348 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0443 0.1749
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0296 0.7459 0.9286
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0332 0.1292
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0332 0.1292
Echinococcus granulosus importin subunit beta 1 0.0029 0.0576 0.0561
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.002 0.0361 0.043
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0381 0.0366
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0332 0.1292
Brugia malayi MH2 domain containing protein 0.0115 0.2804 0.3479
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.057 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0458 0.0443
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1352 0.1338
Echinococcus multilocularis dna polymerase eta 0.0019 0.0332 0.0317
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.004 0.003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0436 0.7654
Chlamydia trachomatis cytosol aminopeptidase 0.0102 0.246 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1177 0.1163
Brugia malayi CXXC zinc finger family protein 0.0028 0.0552 0.0669
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0266 0.1022
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0381 0.1494
Loa Loa (eye worm) hypothetical protein 0.0319 0.8031 1
Brugia malayi hypothetical protein 0.0146 0.3592 0.4462
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.002 0.0361 0.0346
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.1221 0.4929
Leishmania major DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Loa Loa (eye worm) hypothetical protein 0.0024 0.0443 0.0533
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.119 0.4804
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0436 0.7654
Loa Loa (eye worm) hypothetical protein 0.0024 0.0443 0.0533
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0458 0.0443
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.0361 0.043
Entamoeba histolytica hypothetical protein 0.0023 0.0436 0.7586
Loa Loa (eye worm) Smad1 0.0008 0.004 0.003
Leishmania major importin beta-1 subunit, putative 0.0023 0.0436 0.172
Schistosoma mansoni smad1 5 8 and 0.0008 0.004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0576 0.0698
Schistosoma mansoni ferritin light chain 0.0008 0.0055 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1221 0.4929
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.057 1
Echinococcus multilocularis expressed protein 0.0008 0.0055 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0552 0.0669
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.002 0.0361 0.043
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0332 0.5822
Schistosoma mansoni alpha-glucosidase 0.0296 0.7459 0.7455
Brugia malayi Glycosyl hydrolases family 31 protein 0.0296 0.7459 0.9286
Schistosoma mansoni smad1 5 8 and 0.0008 0.004 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0443 0.7715
Schistosoma mansoni apoferritin-2 0.0008 0.0055 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.1221 0.4929
Trichomonas vaginalis ran, putative 0.0021 0.0381 0.6685
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0443 0.1749
Echinococcus granulosus leucine aminopeptidase protein 0.0102 0.246 0.2448
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0443 0.1749
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0266 0.1022
Brugia malayi cytosol aminopeptidase 0.002 0.0361 0.043
Plasmodium falciparum M17 leucyl aminopeptidase 0.0102 0.246 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1177 0.1163
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0381 0.0455
Mycobacterium ulcerans leucyl aminopeptidase 0.0102 0.246 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Schistosoma mansoni ferritin 0.0008 0.0055 0.004
Entamoeba histolytica Ran family GTPase 0.0021 0.0381 0.6589
Leishmania major hypothetical protein, conserved 0.0054 0.1221 0.4929
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0102 0.246 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0443 0.1749
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0102 0.246 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.7711 0.96
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0332 0.0317
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.004 0.0025
Schistosoma mansoni ferritin 0.0008 0.0055 0.004
Trypanosoma brucei glucosidase, putative 0.0028 0.057 0.2267
Trypanosoma brucei unspecified product 0.0019 0.0332 0.1292
Schistosoma mansoni hypothetical protein 0.0395 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Onchocerca volvulus 0.0024 0.0443 0.0675
Echinococcus granulosus muscleblind protein 0.0319 0.8031 0.8028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Echinococcus multilocularis lysosomal alpha glucosidase 0.0296 0.7459 0.7455
Echinococcus granulosus dna polymerase kappa 0.0019 0.0332 0.0317
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0361 0.0346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.1177 0.1163
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.057 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0332 0.1292
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0443 0.7715
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.004 0.0025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0443 0.1749
Echinococcus granulosus cpg binding protein 0.0029 0.0593 0.0578
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0381 0.1494
Echinococcus granulosus vesicular acetylcholine transporter 0.0253 0.6348 0.6342
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.057 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0576 0.229
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0102 0.246 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0332 0.0317
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.057 0.0691
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0443 0.1749
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0179 0.0666
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Schistosoma mansoni cpg binding protein 0.0028 0.0552 0.0537
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0342
Loa Loa (eye worm) hypothetical protein 0.0018 0.029 0.0342
Schistosoma mansoni importin beta-1 0.0029 0.0576 0.0561
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0443 0.1749
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0102 0.246 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0436 0.7654
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.057 0.0691
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0055 0.016
Schistosoma mansoni hypothetical protein 0.0306 0.7711 0.7707
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0179 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1221 0.4929
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0443 0.7715
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.1221 0.4929
Loa Loa (eye worm) hypothetical protein 0.0146 0.3592 0.4462
Leishmania major DNA polymerase eta, putative 0.0019 0.0332 0.1292
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.057 1
Echinococcus granulosus ferritin 0.0008 0.0055 0.004
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.057 0.2267
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.057 1
Trypanosoma brucei aminopeptidase, putative 0.002 0.0361 0.1411
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0443 0.1749
Loa Loa (eye worm) hypothetical protein 0.0028 0.057 0.0691
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0281
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0443 0.0533
Echinococcus multilocularis smad 0.0008 0.004 0.0025
Leishmania major alpha glucosidase II subunit, putative 0.0028 0.057 0.2267
Trypanosoma brucei unspecified product 0.0013 0.0179 0.0666
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.029 0.1123
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.057 1
Schistosoma mansoni ran 0.0021 0.0381 0.0366
Schistosoma mansoni hypothetical protein 0.0024 0.0458 0.0443
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0055 0.016
Schistosoma mansoni cpg binding protein 0.0029 0.0593 0.0578
Plasmodium falciparum importin beta, putative 0.0029 0.0576 0.229
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0361 0.0346
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.0361 0.1411
Schistosoma mansoni smad 0.0008 0.004 0.0025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0332 0.1292
Echinococcus multilocularis lysosomal alpha glucosidase 0.0296 0.7459 0.7455
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.057 0.2267
Mycobacterium ulcerans hypothetical protein 0.0024 0.0443 0.1749
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0443 0.0533
Echinococcus granulosus leucyl aminopeptidase 0.002 0.0361 0.0346
Brugia malayi MH2 domain containing protein 0.0008 0.004 0.003
Echinococcus granulosus dna polymerase eta 0.0019 0.0332 0.0317
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0332 0.1292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.029 0.1123
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2804 0.3479
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0332 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0266 0.1022
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0443 0.1749
Leishmania major GTP-binding protein, putative 0.0021 0.0381 0.1494
Schistosoma mansoni DNA polymerase eta 0.0019 0.0332 0.0317
Loa Loa (eye worm) aminopeptidase in chromosome III 0.002 0.0361 0.043
Schistosoma mansoni smad1 5 8 and 0.0008 0.004 0.0025
Brugia malayi MH2 domain containing protein 0.0008 0.004 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0332 0.1292
Echinococcus multilocularis dnaJ subfamily B 0.0395 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0576 0.229
Leishmania major glycosyl hydrolase-like protein 0.0028 0.057 0.2267
Schistosoma mansoni apoferritin-2 0.0008 0.0055 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0332 0.1292
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0381 0.1494
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.004 0.0025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Echinococcus multilocularis snurportin 1 0.0306 0.7711 0.7707
Loa Loa (eye worm) hypothetical protein 0.0054 0.1221 0.1503
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1221 0.4929
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0102 0.246 1
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0055 0.5
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0055 0.016
Schistosoma mansoni Smad4 0.0008 0.004 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.004 0.003
Trichomonas vaginalis ferritin, putative 0.0008 0.0055 0.0968
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0381 0.1494
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1221 0.4929
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0332 0.1292
Echinococcus granulosus snurportin 1 0.0306 0.7711 0.7707
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0016 0.0281
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2804 0.3479
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0054
Schistosoma mansoni ferritin 0.0008 0.0055 0.004
Echinococcus granulosus leucyl aminopeptidase 0.002 0.0361 0.0346
Loa Loa (eye worm) hypothetical protein 0.0319 0.8031 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0332 0.0394
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.004 0.0025
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0443 0.1749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.1177 0.1163
Onchocerca volvulus 0.0199 0.4959 0.7807
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0332 0.5702
Schistosoma mansoni vesicular acetylcholine transporter 0.0253 0.6348 0.6342
Echinococcus granulosus Smad4 0.0008 0.004 0.0025
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0056 0.005
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0253 0.6348 0.79
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0332 0.1292
Brugia malayi MH1 domain containing protein 0.0008 0.004 0.003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.057 1
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0102 0.246 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Brugia malayi Muscleblind-like protein 0.0319 0.8031 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.057 1
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0102 0.246 1
Echinococcus granulosus expressed protein 0.0008 0.0055 0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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