Detailed information for compound 671482

Basic information

Technical information
  • TDR Targets ID: 671482
  • Name: 2-bromo-3,4,5-trimethoxy-N-(6-methyl-1,3-benz othiazol-2-yl)benzamide
  • MW: 437.308 | Formula: C18H17BrN2O4S
  • H donors: 1 H acceptors: 2 LogP: 4.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C(=O)Nc2nc3c(s2)cc(cc3)C)c(c(c1OC)OC)Br
  • InChi: 1S/C18H17BrN2O4S/c1-9-5-6-11-13(7-9)26-18(20-11)21-17(22)10-8-12(23-2)15(24-3)16(25-4)14(10)19/h5-8H,1-4H3,(H,20,21,22)
  • InChiKey: PCXARBVYNOFVGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00951555

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major asparaginyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Loa Loa (eye worm) hypothetical protein 0.0051 0.0464 0.2012
Schistosoma mansoni protein kinase 0.007 0.0666 0.0836
Toxoplasma gondii glycyl-tRNA synthetase 0.0013 0.0068 0.0103
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Toxoplasma gondii anticodon binding domain-containing protein 0.0008 0.0015 0.0022
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0268 0.0337
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.0573 0.8869
Plasmodium falciparum calcium-dependent protein kinase 5 0.007 0.0666 0.0666
Loa Loa (eye worm) 63kd antigen 0.0008 0.0015 0.0063
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0008 0.0015 0.0195
Brugia malayi major facilitator superfamily protein 0.0032 0.0268 0.1163
Plasmodium falciparum asparagine--tRNA ligase 0.0008 0.0015 0.0015
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0573 0.0863
Schistosoma mansoni glucose transporter 0.0032 0.0268 0.0337
Onchocerca volvulus 0.0032 0.0268 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Plasmodium falciparum histidine--tRNA ligase, putative 0.0008 0.0015 0.0015
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0268 0.1163
Leishmania major hypothetical protein, conserved 0.0011 0.0053 0.0689
Plasmodium falciparum aspartate--tRNA ligase 0.0008 0.0015 0.0015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.062 0.0778
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0068 0.0646 0.2802
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0013 0.0068 0.1082
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0337 0.4407
Giardia lamblia Glycyl-tRNA synthetase 0.0013 0.0068 0.1055
Onchocerca volvulus 0.0032 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Treponema pallidum glycyl-tRNA synthetase 0.0008 0.0015 0.002
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0016 0.0021
Plasmodium vivax calcium-dependent protein kinase, putative 0.007 0.0666 0.0666
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0573 0.0719
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0186 1
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0268 0.0404
Echinococcus multilocularis histidyl tRNA synthetase 0.0008 0.0015 0.0019
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0464 0.0583
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0962 0.1208
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trypanosoma brucei glucose transporter 2A 0.0071 0.067 0.8771
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0008 0.0015 0.0195
Leishmania major protein kinase, putative 0.007 0.0666 0.872
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.051 0.2213
Onchocerca volvulus 0.0032 0.0268 1
Schistosoma mansoni sugar transporter 0.0032 0.0268 0.0337
Mycobacterium leprae conserved hypothetical protein 0.0011 0.0053 0.0815
Schistosoma mansoni sugar transporter 0.0032 0.0268 0.0337
Brugia malayi Cam kinase protein 1 0.007 0.0666 0.2889
Echinococcus multilocularis solute carrier family 22 0.0032 0.0268 0.0337
Onchocerca volvulus 0.0032 0.0268 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0573 0.75
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0573 0.2485
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0008 0.0015 0.0018
Echinococcus granulosus Smad4 0.0008 0.0016 0.0021
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0431 0.0649
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0068 0.0646 0.2802
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Leishmania major glucose transporter/membrane transporter D2, putative 0.0071 0.067 0.8771
Trypanosoma brucei glucose transporter 1E 0.0071 0.067 0.8771
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0431 0.0431
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0099 0.0962 0.1208
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0068 0.0646 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0227 0.0983
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0053 0.0689
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0008 0.0015 0.0065
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0008 0.0015 0.0018
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Onchocerca volvulus 0.0032 0.0268 1
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.1132 0.4912
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0646 0.0811
Schistosoma mansoni Smad4 0.0008 0.0016 0.0021
Leishmania major hypothetical protein, conserved 0.0032 0.0268 0.351
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0013 0.0068 0.0296
Schistosoma mansoni sugar transporter 0.0032 0.0268 0.0337
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0068 0.0646 0.0811
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0186 0.3815
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0008 0.0015 0.0018
Brugia malayi lysyl-tRNA synthetase 0.0051 0.0464 0.2012
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0268 0.5116
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0008 0.0015 0.0065
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0066 0.062 0.2689
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Plasmodium vivax proline--tRNA ligase, putative 0.008 0.0764 0.0764
Trypanosoma cruzi hexose transporter, putative 0.0071 0.067 0.8771
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Chlamydia trachomatis lysine--tRNA ligase 0.0051 0.0464 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Brugia malayi major facilitator superfamily protein 0.0032 0.0268 0.1163
Echinococcus multilocularis solute carrier family 22 0.0032 0.0268 0.0337
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Leishmania major glycyl tRNA synthetase, putative 0.0008 0.0015 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Brugia malayi MH2 domain containing protein 0.0008 0.0016 0.0071
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0068 0.0892
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0962 0.1208
Trichomonas vaginalis sugar transporter, putative 0.0071 0.067 0.2906
Brugia malayi Sugar transporter family protein 0.0032 0.0268 0.1163
Plasmodium falciparum calcium-dependent protein kinase 2 0.007 0.0666 0.0666
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0764 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0431 0.1868
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0268 0.0337
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0008 0.0015 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.007 0.0666 0.2889
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0573 0.2485
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0573 0.2485
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Brugia malayi MH2 domain containing protein 0.0008 0.0016 0.0071
Giardia lamblia Lysyl-tRNA synthetase 0.0051 0.0464 0.7182
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0123 0.0535
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.051 0.0641
Giardia lamblia Prolyl-tRNA synthetase 0.0068 0.0646 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.007 0.0666 0.0666
Leishmania major lysyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Trypanosoma brucei sugar transporter, putative 0.0032 0.0268 0.351
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0464 0.9066
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0123 0.0535
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0013 0.0068 0.2114
Treponema pallidum threonyl-tRNA synthetase 0.0013 0.0068 0.3127
Loa Loa (eye worm) sugar transporter 0.0032 0.0268 0.1163
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Trypanosoma cruzi sugar transporter, putative 0.0032 0.0268 0.351
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0268 0.1163
Plasmodium falciparum hexose transporter 0.0228 0.2305 0.2305
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0268 0.1163
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0068 0.0646 0.2802
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0764 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.051 0.668
Toxoplasma gondii sugar transporter ST2 0.0032 0.0268 0.0404
Plasmodium falciparum calcium-dependent protein kinase 4 0.007 0.0666 0.0666
Toxoplasma gondii Alpha-galactosidase 0.0014 0.008 0.0121
Schistosoma mansoni histidyl-tRNA synthetase 0.0008 0.0015 0.0019
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.008 0.0101
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0099 0.0962 0.1208
Plasmodium falciparum mitogen-activated protein kinase 2 0.0369 0.377 0.377
Trichomonas vaginalis sugar transport protein, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0268 0.1163
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0464 0.9066
Echinococcus multilocularis Smad4 0.0008 0.0016 0.0021
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0268 0.1163
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1621 0.7031
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Trypanosoma cruzi hexose transporter, putative 0.0071 0.067 0.8771
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.007 0.0666 0.0666
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0068 0.0646 0.9699
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Leishmania major myo-inositol/proton symporter (MIT) 0.0032 0.0268 0.351
Giardia lamblia Asparaginyl-tRNA synthetase 0.0008 0.0015 0.0225
Echinococcus granulosus Threonyl tRNA synthetase C 0.0013 0.0068 0.0086
Plasmodium falciparum calcium-dependent protein kinase 3 0.007 0.0666 0.0666
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0666 0.0836
Entamoeba histolytica protein kinase, putative 0.007 0.0666 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0053 0.0689
Plasmodium vivax hexose transporter 0.0228 0.2305 0.2305
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0013 0.0068 0.0296
Leishmania major glucose transporter, lmgt1 0.0071 0.067 0.8771
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0268 0.0337
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0123 0.2197
Schistosoma mansoni protein kinase 0.007 0.0666 0.0836
Echinococcus multilocularis smad 0.0008 0.0016 0.0021
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0068 0.0296
Loa Loa (eye worm) hypothetical protein 0.007 0.0666 0.2889
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0123 0.6351
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1621 0.2036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Leishmania major lysyl-tRNA synthetase, putative 0.0051 0.0464 0.6074
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0013 0.0068 0.0086
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0573 0.0719
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0016 0.0071
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0051 0.0464 0.7182
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.0218
Brugia malayi hypothetical protein 0.0032 0.0268 0.1163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Schistosoma mansoni threonyl-tRNA synthetase 0.0008 0.0015 0.0019
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0008 0.0015 0.0063
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0268 0.1163
Onchocerca volvulus 0.0032 0.0268 1
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0013 0.0068 0.2114
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1573 0.1976
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0573 0.75
Toxoplasma gondii aspartate-tRNA ligase 0.0008 0.0015 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0053 0.0689
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Brugia malayi Sugar transporter family protein 0.0228 0.2305 1
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0008 0.0015 0.0007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0123 0.1853
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Toxoplasma gondii exonuclease III APE 0.0018 0.0123 0.0186
Echinococcus multilocularis solute carrier family 22 0.0032 0.0268 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0268 0.1163
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0764 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0123 0.0535
Chlamydia trachomatis histidine--tRNA ligase 0.0008 0.0015 0.0008
Trypanosoma cruzi hexose transporter 0.0071 0.067 0.8771
Plasmodium falciparum asparagine--tRNA ligase 0.0008 0.0015 0.0015
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0016 0.0071
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0764 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0369 0.377 0.377
Schistosoma mansoni microtubule-associated protein tau 0.0773 0.7962 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0123 0.1911
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0123 0.1616
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Brugia malayi MH2 domain containing protein 0.0115 0.1132 0.4912
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0389 0.6027
Brugia malayi Sugar transporter family protein 0.0032 0.0268 0.1163
Plasmodium vivax asparagine--tRNA ligase, putative 0.0008 0.0015 0.0015
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0369 0.377 0.5681
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Trichomonas vaginalis sugar transporter, putative 0.0071 0.067 0.2906
Brugia malayi hypothetical protein 0.0032 0.0268 0.1163
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0962 0.1208
Leishmania major aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Onchocerca volvulus 0.0032 0.0268 1
Trypanosoma brucei protein kinase, putative 0.0061 0.0573 0.75
Trichomonas vaginalis glucose transporter, putative 0.0071 0.067 0.2906
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0068 0.0646 0.2802
Onchocerca volvulus 0.0032 0.0268 1
Onchocerca volvulus Putative transporter 0.0032 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0513 0.2224
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Trichomonas vaginalis sugar transporter, putative 0.0071 0.067 0.2906
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Echinococcus granulosus solute carrier family 22 0.0032 0.0268 0.0337
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0021
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.007 0.0666 0.1004
Echinococcus granulosus glycyl tRNA synthetase 0.0013 0.0068 0.0086
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.051 0.0641
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0053 0.0689
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0053 0.0228
Loa Loa (eye worm) Smad1 0.0008 0.0016 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0573 0.0719
Giardia lamblia Aspartyl-tRNA synthetase 0.0008 0.0015 0.0225
Schistosoma mansoni hypothetical protein 0.0228 0.2305 0.2895
Onchocerca volvulus 0.0032 0.0268 1
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0389 0.0389
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.062 0.0778
Schistosoma mansoni histidyl-tRNA synthetase 0.0008 0.0015 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0053 0.0228
Onchocerca volvulus 0.0032 0.0268 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.007 0.0666 0.0836
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0016 0.0021
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0016 0.0021
Trypanosoma cruzi glucose transporter, putative 0.0032 0.0268 0.351
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0051 0.0464 0.6074
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.007 0.0666 0.2889
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.007 0.0666 0.1004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0389 0.5846
Entamoeba histolytica protein kinase, putative 0.007 0.0666 1
Plasmodium falciparum threonine--tRNA ligase 0.0013 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Onchocerca volvulus 0.0032 0.0268 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0268 0.5116
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0464 0.0583
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.007 0.0666 0.1004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0431 0.0541
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0573 0.2485
Echinococcus granulosus General substrate transporter 0.0196 0.1972 0.2477
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0008 0.0015 0.0223
Leishmania major histidyl-tRNA synthetase, putative 0.0008 0.0015 0.0195
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0008 0.0015 0.0018
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0268 0.5116
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0384 0.5947
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0431 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.067 0.2906
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0573 0.75
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0013 0.0068 0.1055
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0764 1
Toxoplasma gondii sugar transporter ST3 0.0032 0.0268 0.0404
Plasmodium falciparum proline--tRNA ligase 0.008 0.0764 0.0764
Entamoeba histolytica hypothetical protein 0.0051 0.0464 0.6965
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0013 0.0068 0.0296
Schistosoma mansoni ap endonuclease 0.0018 0.0123 0.0155
Schistosoma mansoni smad1 5 8 and 0.0008 0.0016 0.0021
Mycobacterium ulcerans hypothetical protein 0.0011 0.0053 0.0768
Plasmodium falciparum glycine--tRNA ligase 0.0008 0.0015 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0573 0.2485
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0123 0.0535
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0384 0.7529
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Echinococcus granulosus solute carrier family 22 0.0032 0.0268 0.0337
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.007 0.0666 0.0666
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.007 0.0666 0.2889
Plasmodium vivax sugar transporter, putative 0.0032 0.0268 0.0268
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0011 0.0053 0.0079
Plasmodium vivax lysine--tRNA ligase, putative 0.0051 0.0464 0.0464
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0384 0.7529
Onchocerca volvulus 0.0032 0.0268 1
Brugia malayi MH1 domain containing protein 0.0008 0.0016 0.0071
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.067 0.2906
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0068 0.0646 0.0811
Leishmania major aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0008 0.0015 0.0218
Plasmodium vivax CDK-related protein kinase 6, putative 0.097 1 1
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Echinococcus multilocularis lysyl tRNA synthetase 0.0051 0.0464 0.0583
Onchocerca volvulus 0.0032 0.0268 1
Echinococcus multilocularis General substrate transporter 0.0196 0.1972 0.2477
Mycobacterium tuberculosis Conserved hypothetical protein 0.0011 0.0053 0.1031
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0228 0.2305 0.2895
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0008 0.0015 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0268 0.1163
Schistosoma mansoni sugar transporter 0.0032 0.0268 0.0337
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0008 0.0015 0.0014
Schistosoma mansoni glucose transport protein 0.0228 0.2305 0.2895
Trichomonas vaginalis glucose transporter, putative 0.0071 0.067 0.2906
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0053 0.0228
Trypanosoma cruzi histidyl-tRNA synthetase 0.0008 0.0015 0.0195
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0268 0.1163
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0268 0.0337
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0008 0.0015 0.0065
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0013 0.0068 0.0103
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Toxoplasma gondii facilitative glucose transporter GT1 0.0228 0.2305 0.3473
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0123 0.0155
Loa Loa (eye worm) hypothetical protein 0.0013 0.0068 0.0296
Echinococcus granulosus histidyl tRNA synthetase 0.0008 0.0015 0.0019
Schistosoma mansoni smad 0.0008 0.0016 0.0021
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.007 0.0666 0.0666
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0616 0.0773
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0008 0.0015 0.0063
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0013 0.0068 0.1023
Echinococcus granulosus smad 0.0008 0.0016 0.0021
Echinococcus multilocularis solute carrier family 22 0.0032 0.0268 0.0337
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.051 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.051 0.0641
Toxoplasma gondii sugar transporter ST1 0.0032 0.0268 0.0404
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0123 0.4294
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0013 0.0068 0.1336
Onchocerca volvulus 0.0032 0.0268 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0068 0.0892
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0011 0.0053 0.0689
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Brugia malayi MH1 domain containing protein 0.0008 0.0016 0.0071
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0573 0.0719
Plasmodium vivax histidine--tRNA ligase, putative 0.0008 0.0015 0.0015
Onchocerca volvulus 0.0032 0.0268 1
Plasmodium falciparum protein kinase 7 0.0646 0.6637 0.6637
Chlamydia trachomatis threonine--tRNA ligase 0.0013 0.0068 0.1193
Brugia malayi Aspartyl-tRNA synthetase 0.0008 0.0015 0.0063
Plasmodium vivax threonine--tRNA ligase, putative 0.0013 0.0068 0.0068
Trichomonas vaginalis myo-inositol transporter, putative 0.0032 0.0268 0.1163
Leishmania major glucose transporter, lmgt3 0.0071 0.067 0.8771
Echinococcus multilocularis calcium activated potassium channel 0.0009 0.0023 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0123 0.1616
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.067 0.8771
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.007 0.0666 0.872
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trypanosoma cruzi hexose transporter, putative 0.0071 0.067 0.8771
Brugia malayi hypothetical protein 0.0032 0.0268 0.1163
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0268 0.0337
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0471 0.2045
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0268 0.1163
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0032 0.0268 0.5255
Loa Loa (eye worm) sugar transporter 0.0228 0.2305 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0032 0.0268 0.0268
Plasmodium falciparum lysine--tRNA ligase 0.0051 0.0464 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0573 0.75
Echinococcus granulosus lysyl tRNA synthetase 0.0051 0.0464 0.0583
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.067 0.8771
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0013 0.0068 0.1023
Echinococcus granulosus microtubule associated protein 2 0.0773 0.7962 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0268 0.1163
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0099 0.0962 0.1208
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.008 0.0764 0.1151
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0666 0.2889
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.2305 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0068 0.0892
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0573 0.75
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0123 0.0155
Schistosoma mansoni ap endonuclease 0.0018 0.0123 0.0155
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0016 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771
Plasmodium vivax aspartate--tRNA ligase, putative 0.0008 0.0015 0.0015
Giardia lamblia Hexose transporter 0.0032 0.0268 0.415
Loa Loa (eye worm) hypothetical protein 0.0068 0.0646 0.2802
Loa Loa (eye worm) hypothetical protein 0.0066 0.062 0.2689
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0013 0.0068 0.1082
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0186 0.3459
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.067 0.8771
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.1132 0.4912
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Toxoplasma gondii melibiase subfamily protein 0.0099 0.0962 0.145
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0616 0.0773
Echinococcus granulosus solute carrier family 22 0.0032 0.0268 0.0337
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0008 0.0015 0.019
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0051 0.0464 0.2012
Onchocerca volvulus 0.0032 0.0268 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0068 0.0892
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.051 1
Giardia lamblia Threonyl-tRNA synthetase 0.0013 0.0068 0.1055
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Echinococcus multilocularis glycyl tRNA synthetase 0.0013 0.0068 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1621 0.2036
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0573 0.0719
Plasmodium vivax asparagine--tRNA ligase, putative 0.0008 0.0015 0.0015
Brugia malayi Melibiase family protein 0.0066 0.062 0.2689
Leishmania major hypothetical protein, conserved 0.0011 0.0053 0.0689
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0068 0.0646 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0268 0.1163
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0268 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0013 0.0068 0.0296
Schistosoma mansoni glucose transport protein 0.0228 0.2305 0.2895
Mycobacterium ulcerans sugar transporter 0.0032 0.0268 0.5116
Brugia malayi glycyl-tRNA synthetase 0.0013 0.0068 0.0296
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0068 0.0892
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0573 0.75
Echinococcus granulosus calcium activated potassium channel 0.0009 0.0023 0.0029
Giardia lamblia Sugar-proton symporter 0.0032 0.0268 0.415
Plasmodium vivax glycine--tRNA ligase, putative 0.0013 0.0068 0.0068
Echinococcus granulosus solute carrier family 22 0.0032 0.0268 0.0337
Schistosoma mansoni protein kinase 0.007 0.0666 0.0836
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0268 0.351
Leishmania major glucose transporter, lmgt2 0.0071 0.067 0.8771
Loa Loa (eye worm) acetyltransferase 0.0162 0.1621 0.7031
Toxoplasma gondii protein kinase, putative 0.0646 0.6637 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0431 0.1868
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0228 0.2305 0.2895
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.051 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0032 0.0268 0.351
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0573 0.75
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0051 0.0464 0.6074
Schistosoma mansoni glucose transport protein 0.0228 0.2305 0.2895
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.0962 0.1208
Schistosoma mansoni aspartyl-tRNA synthetase 0.0008 0.0015 0.0018
Trypanosoma brucei histidyl-tRNA synthetase 0.0008 0.0015 0.0195
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0399 0.1729
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0008 0.0015 0.0018
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0008 0.0015 0.0018
Brugia malayi MAP kinase sur-1 0.0061 0.0573 0.2485
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0666 0.0836
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0123 0.1616
Echinococcus multilocularis microtubule associated protein 2 0.0773 0.7962 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0123 0.2419
Brugia malayi Smad1 0.0008 0.0016 0.0071
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0032 0.0268 0.5255
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0123 0.0123
Toxoplasma gondii lysine-tRNA ligase 0.0051 0.0464 0.0699
Loa Loa (eye worm) hypothetical protein 0.0032 0.0268 0.1163
Schistosoma mansoni glycyl-tRNA synthetase 0.0013 0.0068 0.0086
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0016 0.0021
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0123 0.1616
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0008 0.0015 0.0063
Trypanosoma brucei glucose transporter, putative 0.0071 0.067 0.8771

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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