Detailed information for compound 68718

Basic information

Technical information
  • TDR Targets ID: 68718
  • Name: 2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)imidaz ol-4-yl]phenol
  • MW: 356.373 | Formula: C19H20N2O5
  • H donors: 1 H acceptors: 2 LogP: 2.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)n1cncc1c1ccc(c(c1)O)OC
  • InChi: 1S/C19H20N2O5/c1-23-16-6-5-12(7-15(16)22)14-10-20-11-21(14)13-8-17(24-2)19(26-4)18(9-13)25-3/h5-11,22H,1-4H3
  • InChiKey: DJFPFYVLJXYUSM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-methoxy-5-[3-(3,4,5-trimethoxyphenyl)-4-imidazolyl]phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Tubulin beta chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin beta chain   445 aa 439 aa 34.6 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.7 %
Dictyostelium discoideum alpha tubulin Tubulin beta chain   445 aa 446 aa 41.3 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin beta chain   445 aa 429 aa 87.4 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin beta chain   445 aa 440 aa 38.4 %
Loa Loa (eye worm) alpha-tubulin Tubulin beta chain   445 aa 440 aa 38.2 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Echinococcus multilocularis peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.0 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin beta chain   445 aa 426 aa 49.8 %
Cryptosporidium parvum alpha tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin beta chain   445 aa 461 aa 27.8 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 82.4 %
Dictyostelium discoideum gamma tubulin Tubulin beta chain   445 aa 429 aa 34.0 %
Echinococcus multilocularis tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Onchocerca volvulus 1D304 homolog Tubulin beta chain   445 aa 433 aa 40.4 %
Loa Loa (eye worm) tubulin alpha-2 chain Tubulin beta chain   445 aa 436 aa 38.5 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Leishmania mexicana epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Entamoeba histolytica tubulin gamma chain Tubulin beta chain   445 aa 428 aa 33.2 %
Brugia malayi tubulin alpha chain - mouse Tubulin beta chain   445 aa 433 aa 40.0 %
Plasmodium berghei tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Giardia lamblia Epsilon tubulin Tubulin beta chain   445 aa 442 aa 27.6 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 438 aa 34.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Entamoeba histolytica tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 35.8 %
Leishmania braziliensis alpha tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Babesia bovis tubulin, putative Tubulin beta chain   445 aa 459 aa 21.1 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin beta chain   445 aa 444 aa 28.6 %
Theileria parva Tubulin alpha chain, putative Tubulin beta chain   445 aa 439 aa 39.6 %
Plasmodium knowlesi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Babesia bovis tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 40.6 %
Schistosoma japonicum Tubulin alpha-1C chain, putative Tubulin beta chain   445 aa 438 aa 38.8 %
Echinococcus granulosus tubulin alpha 3 chain Tubulin beta chain   445 aa 439 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha Tubulin beta chain   445 aa 440 aa 30.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 427 aa 49.9 %
Trypanosoma congolense epsilon tubulin Tubulin beta chain   445 aa 464 aa 29.1 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis hypothetical protein Tubulin beta chain   445 aa 422 aa 29.9 %
Plasmodium falciparum tubulin gamma chain Tubulin beta chain   445 aa 438 aa 32.9 %
Echinococcus granulosus alpha tubulin Tubulin beta chain   445 aa 422 aa 29.9 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Theileria parva tubulin alpha chain, putative Tubulin beta chain   445 aa 452 aa 36.7 %
Leishmania major gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.0 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin beta chain   445 aa 456 aa 31.4 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin beta chain   445 aa 415 aa 33.3 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 439 aa 39.4 %
Trichomonas vaginalis tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Plasmodium falciparum alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.8 %
Plasmodium vivax tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Plasmodium berghei alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Cryptosporidium parvum gamma tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin beta chain   445 aa 445 aa 29.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Trypanosoma congolense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Trypanosoma brucei gambiense alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Entamoeba histolytica tubulin alpha-1 chain Tubulin beta chain   445 aa 439 aa 36.2 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin beta chain   445 aa 433 aa 30.7 %
Leishmania donovani epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.3 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.1 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 436 aa 39.9 %
Onchocerca volvulus 60S ribosomal protein L13 homolog Tubulin beta chain   445 aa 430 aa 91.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium yoelii tubulin alpha chain Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania braziliensis epsilon tubulin, putative Tubulin beta chain   445 aa 465 aa 30.1 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium yoelii tubulin gamma chain Tubulin beta chain   445 aa 438 aa 33.1 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 40.8 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 39.3 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.6 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium yoelii tubulin beta chain Tubulin beta chain   445 aa 445 aa 29.7 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Leishmania infantum alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus multilocularis tubulin alpha 3 chain Tubulin beta chain   445 aa 434 aa 40.1 %
Plasmodium falciparum alpha tubulin 2 Tubulin beta chain   445 aa 434 aa 41.2 %
Trypanosoma cruzi tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Trypanosoma brucei tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.5 %
Schistosoma japonicum Tubulin alpha-1 chain, putative Tubulin beta chain   445 aa 439 aa 39.4 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Schistosoma mansoni tubulin subunit gamma Tubulin beta chain   445 aa 436 aa 33.7 %
Leishmania major epsilon tubulin, putative Tubulin beta chain   445 aa 469 aa 30.9 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Echinococcus multilocularis tubulin delta chain Tubulin beta chain   445 aa 461 aa 25.8 %
Toxoplasma gondii alpha-tubulin I, putative Tubulin beta chain   445 aa 442 aa 39.8 %
Leishmania mexicana alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin beta chain   445 aa 441 aa 29.0 %
Plasmodium berghei alpha tubulin 1 Tubulin beta chain   445 aa 434 aa 40.3 %
Trypanosoma brucei gambiense gamma tubulin Tubulin beta chain   445 aa 436 aa 33.5 %
Giardia lamblia Gamma tubulin Tubulin beta chain   445 aa 460 aa 32.4 %
Leishmania braziliensis gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.1 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin beta chain   445 aa 436 aa 34.4 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.6 %
Leishmania donovani tubulin gamma chain Tubulin beta chain   445 aa 438 aa 34.2 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 40.3 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Giardia lamblia Alpha-tubulin Tubulin beta chain   445 aa 434 aa 40.3 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin beta chain   445 aa 434 aa 38.2 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 39.0 %
Brugia malayi Tubulin gamma chain Tubulin beta chain   445 aa 440 aa 31.8 %
Brugia malayi alpha-tubulin Tubulin beta chain   445 aa 434 aa 38.7 %
Cryptosporidium hominis gamma-tubulin Tubulin beta chain   445 aa 436 aa 37.6 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Neospora caninum tubulin alpha chain, putative Tubulin beta chain   445 aa 433 aa 30.9 %
Onchocerca volvulus Tubulin beta chain   445 aa 434 aa 39.9 %
Plasmodium knowlesi alpha-tubulin II, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Trypanosoma brucei epsilon tubulin Tubulin beta chain   445 aa 443 aa 29.3 %
Neospora caninum Beta-tubulin, related Tubulin beta chain   445 aa 446 aa 35.2 %
Babesia bovis tubulin gamma chain Tubulin beta chain   445 aa 441 aa 34.0 %
Echinococcus multilocularis Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin beta chain   445 aa 438 aa 33.3 %
Trypanosoma brucei alpha tubulin Tubulin beta chain   445 aa 434 aa 40.8 %
Brugia malayi Tubulin alpha-2 chain Tubulin beta chain   445 aa 435 aa 38.4 %
Echinococcus multilocularis tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Theileria parva tubulin gamma chain, putative Tubulin beta chain   445 aa 420 aa 34.5 %
Schistosoma mansoni tubulin subunit epsilon Tubulin beta chain   445 aa 464 aa 31.7 %
Loa Loa (eye worm) tubulin alpha chain Tubulin beta chain   445 aa 432 aa 39.8 %
Leishmania infantum epsilon tubulin, putative Tubulin beta chain   445 aa 475 aa 30.3 %
Echinococcus multilocularis tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 39.9 %
Trichomonas vaginalis tubulin beta chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Schistosoma mansoni tubulin subunit alpha Tubulin beta chain   445 aa 434 aa 38.9 %
Echinococcus multilocularis tubulin alpha Tubulin beta chain   445 aa 443 aa 30.5 %
Onchocerca volvulus Tubulin beta chain   445 aa 445 aa 36.2 %
Neospora caninum tubulin alpha chain Tubulin beta chain   445 aa 440 aa 40.5 %
Leishmania mexicana gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Echinococcus granulosus tubulin alpha chain Tubulin beta chain   445 aa 433 aa 33.5 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma mansoni alpha tubulin Tubulin beta chain   445 aa 434 aa 39.4 %
Leishmania major alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Echinococcus granulosus tubulin alpha 1C chain Tubulin beta chain   445 aa 434 aa 40.8 %
Cryptosporidium hominis alpha-tubulin Tubulin beta chain   445 aa 438 aa 40.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 441 aa 31.7 %
Trypanosoma congolense tubulin gamma chain Tubulin beta chain   445 aa 436 aa 33.3 %
Trypanosoma cruzi alpha tubulin, putative Tubulin beta chain   445 aa 434 aa 40.6 %
Toxoplasma gondii alpha tubulin TUBA1 Tubulin beta chain   445 aa 440 aa 40.5 %
Echinococcus granulosus peroxisome assembly protein 26 Tubulin beta chain   445 aa 438 aa 29.2 %
Trichomonas vaginalis tubulin epsilon chain, putative Tubulin beta chain   445 aa 434 aa 39.6 %
Leishmania donovani alpha tubulin Tubulin beta chain   445 aa 434 aa 40.6 %
Schistosoma japonicum Tubulin alpha chain, putative Tubulin beta chain   445 aa 457 aa 36.8 %
Echinococcus granulosus tubulin subunit TubB Tubulin beta chain   445 aa 441 aa 30.6 %
Leishmania infantum gamma-tubulin Tubulin beta chain   445 aa 438 aa 34.2 %
Onchocerca volvulus Tubulin beta chain   445 aa 435 aa 39.5 %
Onchocerca volvulus Tubulin beta chain   445 aa 433 aa 40.0 %
Schistosoma japonicum ko:K07374 tubulin alpha, putative Tubulin beta chain   445 aa 433 aa 40.0 %
Brugia malayi tubulin alpha-2 chain Tubulin beta chain   445 aa 440 aa 38.2 %
Echinococcus granulosus Tubulin alpha 1 chain Tubulin beta chain   445 aa 434 aa 38.9 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin beta chain   445 aa 436 aa 34.2 %
Dictyostelium discoideum hypothetical protein Tubulin beta chain   445 aa 438 aa 38.8 %
Plasmodium vivax tubulin alpha chain, putative Tubulin beta chain   445 aa 434 aa 41.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0279 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0279 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0279 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0279 1 1
Loa Loa (eye worm) Gln-2 protein 0.0154 0.4275 0.1507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0279 1 1
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0154 0.4275 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0279 1 1
Brugia malayi hypothetical protein 0.0148 0.3981 0.3204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0279 1 1
Brugia malayi conserved hypotetical protein 0.0132 0.3259 0.2389
Entamoeba histolytica glutamine synthetase, putative 0.006 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Brugia malayi Nuclear hormone receptor E75 0.0132 0.3259 0.2389
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0148 0.3981 0.3981
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0279 1 1
Brugia malayi Nuclear hormone receptor E75 0.0132 0.3259 0.2389
Onchocerca volvulus Protein ultraspiracle homolog 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0279 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0279 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Echinococcus multilocularis glutamine synthetase 0.0239 0.8178 0.7297
Echinococcus granulosus glutamine synthetase 0.0239 0.8178 0.7297
Loa Loa (eye worm) hypothetical protein 0.0148 0.3981 0.1071
Loa Loa (eye worm) hypothetical protein 0.0148 0.3981 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0279 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0279 1 1
Brugia malayi nuclear hormone receptor 0.0132 0.3259 0.2389
Schistosoma mansoni nuclear receptor 0.0132 0.3259 0.3259
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0154 0.4275 1
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0154 0.4275 1
Schistosoma mansoni thyroid hormone receptor 0.0279 1 1
Brugia malayi nuclear hormone receptor 0.0279 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0132 0.3259 0.3259
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0279 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0279 1 1
Brugia malayi steroid hormone receptor 0.0279 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0279 1 1
Leishmania major glutamine synthetase, putative 0.0239 0.8178 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0279 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0279 1 1
Onchocerca volvulus Glutamine synthetase homolog 0.0154 0.4275 0.1507
Schistosoma mansoni nuclear receptor 0.0132 0.3259 0.3259
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0279 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0148 0.3981 0.1071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0279 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0279 1 1
Schistosoma mansoni nuclear hormone receptor 0.0279 1 1
Schistosoma mansoni coup transcription factor 0.0279 1 1
Brugia malayi nuclear receptor RXR 0.0132 0.3259 0.2389
Schistosoma mansoni thyroid hormone receptor 0.0279 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0132 0.3259 0.2389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Schistosoma mansoni zinc finger protein 0.0132 0.3259 0.3259
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3981 0.1071
Brugia malayi orphan nuclear receptor NR2E1 0.0132 0.3259 0.2389
Mycobacterium ulcerans glutamine synthetase 0.0154 0.4275 1
Onchocerca volvulus Bile acid receptor homolog 0.0279 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0279 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0279 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0132 0.3259 0.2389
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0148 0.3981 0.1071
Trypanosoma cruzi glutamine synthetase, putative 0.0239 0.8178 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0279 1 1
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0239 0.8178 0.8178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0279 1 1
Trichomonas vaginalis glutamine synthetase, putative 0.006 0 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0132 0.3259 0.3259
Brugia malayi hypothetical protein 0.0132 0.3259 0.2389
Brugia malayi nuclear receptor NHR-88 0.0279 1 1
Entamoeba histolytica glutamine synthetase, putative 0.006 0 0.5
Plasmodium vivax glutamine synthetase, putative 0.0154 0.4275 0.5
Echinococcus granulosus FTZ F1 alpha 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0279 1 1
Schistosoma mansoni nuclear hormone receptor 0.0132 0.3259 0.3259
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0279 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0279 1 1
Brugia malayi hypothetical protein 0.0132 0.3259 0.2389
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.006 0 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0279 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0279 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0279 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0279 1 1
Plasmodium falciparum glutamine synthetase, putative 0.0154 0.4275 0.5
Brugia malayi nuclear receptor NHR-88 0.0132 0.3259 0.2389
Trypanosoma brucei glutamine synthetase, putative 0.0239 0.8178 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.3981 0.1071
Brugia malayi nuclear receptor RXR 0.0148 0.3981 0.3204
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0279 1 1
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.006 0 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0148 0.3981 0.1071
Brugia malayi hypothetical protein 0.0148 0.3981 0.3204
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0279 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0279 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0279 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0279 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0279 1 1
Trypanosoma cruzi glutamine synthetase, putative 0.0239 0.8178 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0279 1 1
Brugia malayi ecdysone receptor 0.0132 0.3259 0.2389
Brugia malayi tailless protein 0.0132 0.3259 0.2389
Onchocerca volvulus 0.0279 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0148 0.3981 0.3204
Loa Loa (eye worm) hypothetical protein 0.0148 0.3981 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0279 1 1
Toxoplasma gondii glutamine synthetase, type I, putative 0.0154 0.4275 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0279 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0279 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0148 0.3981 0.3981
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0132 0.3259 0.3259
Schistosoma mansoni nuclear hormone receptor 0.0132 0.3259 0.3259
Brugia malayi Nuclear hormone receptor-like 1 0.0148 0.3981 0.3204
Brugia malayi nuclear hormone receptor family member odr-7 0.0132 0.3259 0.2389
Brugia malayi nuclear receptor NHR-67 0.0132 0.3259 0.2389

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 61 nM Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth ChEMBL. 11931625
IC50 (functional) = 61 nM Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth ChEMBL. 11931625
IC50 (functional) = 89 nM Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth ChEMBL. 11931625
IC50 (functional) = 89 nM Inhibition of human HCT-15 (human colon adenocarcinoma, MDR positive) cell growth ChEMBL. 11931625
IC50 (functional) = 7.6 uM Concentration needed to inhibit tubulin polymerization by 50% ChEMBL. 11931625
IC50 (functional) = 7.6 uM Concentration needed to inhibit tubulin polymerization by 50% ChEMBL. 11931625

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11931625

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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