Detailed information for compound 690859

Basic information

Technical information
  • TDR Targets ID: 690859
  • Name: N-[2-(4-dimethylaminophenyl)-2-pyrrolidin-1-y lethyl]-N'-(3-fluorophenyl)oxamide
  • MW: 398.474 | Formula: C22H27FN4O2
  • H donors: 2 H acceptors: 2 LogP: 3.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)NC(=O)C(=O)NCC(c1ccc(cc1)N(C)C)N1CCCC1
  • InChi: 1S/C22H27FN4O2/c1-26(2)19-10-8-16(9-11-19)20(27-12-3-4-13-27)15-24-21(28)22(29)25-18-7-5-6-17(23)14-18/h5-11,14,20H,3-4,12-13,15H2,1-2H3,(H,24,28)(H,25,29)
  • InChiKey: JBZWDJIIJBEURC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-dimethylaminophenyl)-2-pyrrolidin-1-yl-ethyl]-N'-(3-fluorophenyl)oxamide
  • N-[2-(4-dimethylaminophenyl)-2-1-pyrrolidinylethyl]-N'-(3-fluorophenyl)oxamide
  • N-[2-(4-dimethylaminophenyl)-2-pyrrolidin-1-yl-ethyl]-N'-(3-fluorophenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0659 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0111
Brugia malayi beta-lactamase family protein 0.0036 0.0364 0.1251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0032 0.0018
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0102 0.012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0364 0.1199
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0102 0.0085
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0156 0.0211
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0728 0.2456
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0292
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0032 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.1199
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0639 0.0623
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0217 0.0297
Echinococcus multilocularis geminin 0.0171 0.2061 0.2047
Leishmania major hypothetical protein, conserved 0.0016 0.0102 0.1399
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0639 0.0623
Toxoplasma gondii ABC1 family protein 0.0036 0.0364 0.5783
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0111
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.022 0.1892
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0103 0.0002
Schistosoma mansoni hypothetical protein 0.0171 0.2061 0.2426
Mycobacterium ulcerans thioesterase 0.0021 0.0165 0.0223
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0032 0.0038
Schistosoma mansoni survival motor neuron protein 0.0049 0.052 0.0612
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.1199
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0364 0.0494
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.1199
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.037 0.0507
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0242 0.0777
Schistosoma mansoni hypothetical protein 0.0011 0.0047 0.0056
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0236 0.0321
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.0038
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0587 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0178
Echinococcus multilocularis musashi 0.0027 0.0242 0.0225
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0165 0.0221
Echinococcus granulosus lamin dm0 0.0027 0.0242 0.0265
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0008 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0102 0.01
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0032 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0032 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0032 0.0111
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0032 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.008 0.0218
Brugia malayi jmjC domain containing protein 0.0016 0.0102 0.035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0015
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0103 0.0355
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0196 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0156
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0002 0.0007
Schistosoma mansoni nuclear hormone receptor 0.001 0.0032 0.0038
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0728 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0111
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0364 0.0499
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0364 0.0499
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0217 0.0291
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0728 0.0857
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0659 0.2217
Echinococcus granulosus microtubule associated protein 2 0.0682 0.8496 1
Onchocerca volvulus 0.0049 0.052 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.022 0.1892
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0728 0.5
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0108 0.0853
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0587 0.7296 1
Schistosoma mansoni hypothetical protein 0.0049 0.052 0.0612
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0659 0.0757
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0364 0.0348
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0673
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2913 0.3415
Loa Loa (eye worm) hypothetical protein 0.0026 0.0236 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0032 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0052
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0587 0.7296 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0032 0.0015
Brugia malayi beta-lactamase 0.0036 0.0364 0.1251
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0049 0.011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0101
Giardia lamblia Methyltransferase like 2 0.0007 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0032 0.0111
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.8496 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0032 0.0015
Treponema pallidum hypothetical protein 0.0587 0.7296 0.5
Schistosoma mansoni thyroid hormone receptor 0.001 0.0032 0.0038
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0587 0.7296 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.1199
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0364 0.0499
Onchocerca volvulus 0.0036 0.0364 0.681
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0364 0.0409
Echinococcus multilocularis lamin dm0 0.0027 0.0242 0.0225
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0102 0.0085
Mycobacterium ulcerans polyketide synthase 0.0025 0.0217 0.0294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0018
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0364 0.0499
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0086
Brugia malayi ecdysteroid receptor 0.001 0.0032 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0063 0.0156
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0016 0.0054
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0217 0.0294
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0102 0.0085
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0103 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0364 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0382 0.0366
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0728 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0364 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.022 0.0165
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.022 0.1892
Brugia malayi beta-lactamase family protein 0.0036 0.0364 0.1251
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0032 0.0018
Schistosoma mansoni lamin 0.0027 0.0242 0.0285
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0102 0.0292
Mycobacterium tuberculosis Conserved protein 0.0036 0.0364 0.0499
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0083 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0364 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0364 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.037 0.0507
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0069 0.0051
Echinococcus granulosus FTZ F1 alpha 0.001 0.0032 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0047 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0659 0.0776
Echinococcus multilocularis cpg binding protein 0.003 0.0285 0.0268
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0236 0.0321
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0032 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0102 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0292
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0122 0.0124
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0382 0.043
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0103 0.0297
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2831 0.388
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0587 0.7296 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0102 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0032 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0364 0.0499
Mycobacterium tuberculosis Conserved protein 0.0036 0.0364 0.0499
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0217 0.0294
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0364 0.0497
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0032 0.0038
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0639 0.0752
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0032 0.0044
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0103 0.0769
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0236 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0364 0.419
Schistosoma mansoni intermediate filament proteins 0.0027 0.0242 0.0285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0665 0.0783
Onchocerca volvulus 0.0036 0.0364 0.681
Brugia malayi jmjC domain containing protein 0.0016 0.0102 0.035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0032 0.0111
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2913 0.2901
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0236 0.0318
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0217 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0032 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0242 0.0777
Mycobacterium ulcerans polyketide synthase 0.0026 0.0236 0.0321
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0103 0.0023
Brugia malayi isocitrate dehydrogenase 0.0016 0.0103 0.0355
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0069 0.0061
Trichomonas vaginalis esterase, putative 0.0036 0.0364 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0364 0.419
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0086 0.0297
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0217 0.0743
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0242 0.0777
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0112 0.0148
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0364 0.419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0052
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0004 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0584 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0032 0.0052
Echinococcus multilocularis lamin 0.0027 0.0242 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0364 0.0429
Onchocerca volvulus 0.0027 0.0242 0.4306
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0102 0.01
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0032 0.0038
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0102 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0728 0.25
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0032 0.0111
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.8496 0.8494
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.022 0.3018
Mycobacterium leprae Probable lipase LipE 0.0036 0.0364 0.0494
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.052 0.1785
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0728 0.0712
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0103 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0032 0.0111
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0103 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0032 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.1199
Brugia malayi hypothetical protein 0.0025 0.022 0.0757
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0122 0.0105
Brugia malayi steroid hormone receptor 0.001 0.0032 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0111
Schistosoma mansoni lamin 0.0027 0.0242 0.0285
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0236 0.0318
Brugia malayi hypothetical protein 0.0016 0.0109 0.0375
Echinococcus granulosus phd:f box containing protein 0.0016 0.0102 0.01
Brugia malayi jmjC domain containing protein 0.0016 0.0102 0.035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0032 0.0111
Mycobacterium ulcerans hypothetical protein 0.0036 0.0364 0.0497
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0207 0.0284
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.022 0.0165
Loa Loa (eye worm) hypothetical protein 0.0041 0.0427 0.1416
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0103 0.1418
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0112 0.015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0728 1
Echinococcus granulosus geminin 0.0171 0.2061 0.241
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0103 0.0769
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0236 0.3313
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0086 0.0239
Echinococcus granulosus dnaJ subfamily B 0.0404 0.4998 0.5874
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0236 0.0318
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0004 0.0003
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0465 0.888
Schistosoma mansoni hypothetical protein 0.0171 0.2061 0.2426
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0032 0.0111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0364 0.1251
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0032 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0364 0.0365
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0364 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0165 0.0226
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0112 0.015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0364 0.1199
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0364 0.0499
Brugia malayi nuclear hormone receptor 0.001 0.0032 0.0111
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0032 0.0111
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0103 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Echinococcus granulosus intermediate filament protein 0.0027 0.0242 0.0265
Leishmania major hypothetical protein, conserved 0.0025 0.022 0.3026
Onchocerca volvulus 0.0027 0.0242 0.4306
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0032 0.0018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0196 0.0618
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Loa Loa (eye worm) beta-lactamase 0.0036 0.0364 0.1199
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0111
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0292
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0156 0.0211
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.4998 0.4989
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0728 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0364 0.0497
Loa Loa (eye worm) hypothetical protein 0.0239 0.2913 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Schistosoma mansoni coup transcription factor 0.001 0.0032 0.0038
Onchocerca volvulus 0.0036 0.0364 0.681
Brugia malayi jmjC domain containing protein 0.006 0.0659 0.2263
Brugia malayi CXXC zinc finger family protein 0.0028 0.0264 0.0907
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0127 0.1229
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0103 0.0023
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0102 0.0742
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0032 0.0038
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.037 0.0502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0032 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0032 0.0052
Schistosoma mansoni cpg binding protein 0.0028 0.0264 0.0311
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0103 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0032 0.0052
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0207 0.0284
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0217 0.0297
Schistosoma mansoni cpg binding protein 0.003 0.0285 0.0335
Brugia malayi jmjC domain containing protein 0.0058 0.0639 0.2193
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0242 0.0832
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0032 0.0038
Schistosoma mansoni hypothetical protein 0.0404 0.4998 0.5882
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0236 0.0323
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0217 0.0291
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0047 0.003
Echinococcus granulosus lamin 0.0027 0.0242 0.0265
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0103 0.0086
Onchocerca volvulus 0.0023 0.0196 0.3359
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0639 0.0733
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0102 0.0742
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0129 0.0177
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0018
Brugia malayi intermediate filament protein 0.0027 0.0242 0.0832
Brugia malayi hypothetical protein 0.0239 0.2913 1
Onchocerca volvulus 0.0028 0.0264 0.4754
Brugia malayi nuclear receptor NHR-88 0.001 0.0032 0.0111
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0494 0.1696
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0103 0.0142
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0102 0.012
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0102 0.012
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0102 0.01
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0364 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0217 0.0294
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0217 0.0294
Mycobacterium ulcerans beta-lactamase 0.0036 0.0364 0.0497
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0102 0.012
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0032 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0364 0.0497
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0212 0.0674
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0702
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0102 0.0292
Leishmania major hypothetical protein, conserved 0.0036 0.0364 0.5003
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0103 0.0122
Echinococcus granulosus cpg binding protein 0.003 0.0285 0.0315
Mycobacterium tuberculosis Conserved protein 0.0036 0.0364 0.0499
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0032 0.0015
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0236 0.0323
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.016 0.0219
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.022 0.0165
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0032 0.0038
Schistosoma mansoni cpg binding protein 0.003 0.0285 0.0335
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0165 0.0223
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0052
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0728 0.0839
Brugia malayi jmjC domain containing protein 0.0016 0.0102 0.035
Onchocerca volvulus 0.0043 0.0446 0.8485
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0264 0.0853
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0032 0.0015
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0156 0.0208
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0364 0.0499
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.037 0.0504

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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