Detailed information for compound 690905

Basic information

Technical information
  • TDR Targets ID: 690905
  • Name: N-[2-(4-dimethylaminophenyl)-2-morpholin-4-yl ethyl]-N'-(2-fluorophenyl)oxamide
  • MW: 414.473 | Formula: C22H27FN4O3
  • H donors: 2 H acceptors: 2 LogP: 2.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)NCC(c1ccc(cc1)N(C)C)N1CCOCC1)Nc1ccccc1F
  • InChi: 1S/C22H27FN4O3/c1-26(2)17-9-7-16(8-10-17)20(27-11-13-30-14-12-27)15-24-21(28)22(29)25-19-6-4-3-5-18(19)23/h3-10,20H,11-15H2,1-2H3,(H,24,28)(H,25,29)
  • InChiKey: XZGJCBRVGRSZTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-dimethylaminophenyl)-2-morpholino-ethyl]-N'-(2-fluorophenyl)oxamide
  • N-[2-(4-dimethylaminophenyl)-2-morpholinoethyl]-N'-(2-fluorophenyl)oxamide
  • N-[2-(4-dimethylaminophenyl)-2-morpholin-4-yl-ethyl]-N'-(2-fluorophenyl)ethanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0087 0.0531
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.0811 0.3599
Schistosoma mansoni microtubule-associated protein tau 0.0697 1 1
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0575
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0454 0.1911
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0003 0.0002
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0454 0.1225
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0251 0.0545
Onchocerca volvulus 0.0027 0.0251 0.0741
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0277 0.0601
Schistosoma mansoni survival motor neuron protein 0.0049 0.0564 0.0561
Schistosoma mansoni lamin 0.0027 0.0251 0.0248
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.1667
Loa Loa (eye worm) hypothetical protein 0.0045 0.0513 0.1116
Trichomonas vaginalis rotamase, putative 0.0034 0.0346 0.0899
Brugia malayi hypothetical protein 0.0239 0.3331 0.7269
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0334 0.4095
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.005 0.0562
Echinococcus multilocularis musashi 0.0027 0.0251 0.025
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.005 0.0108
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0334 0.2115
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.005 0.0741
Echinococcus granulosus tumor protein p63 0.0341 0.4822 0.4822
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Echinococcus granulosus RUN 0.0023 0.0193 0.0191
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0811 0.2308
Loa Loa (eye worm) hypothetical protein 0.0089 0.115 0.2508
Brugia malayi CXXC zinc finger family protein 0.0029 0.0277 0.0605
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0008
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.3331 0.333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0002
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0193 0.0678
Trypanosoma cruzi metacaspase, putative 0.0054 0.0635 0.7826
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0246 0.3005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0087 0.1029
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.0454 0.5573
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0811 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0008
Trypanosoma cruzi Heat shock protein 83, putative 0.0066 0.0811 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0635 0.4042
Plasmodium falciparum metacaspase 1 0.0054 0.0635 0.277
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0201 0.2774 0.2772
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0087 0.0187
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0616 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0193 0.0191
Brugia malayi intermediate filament protein 0.0027 0.0251 0.0548
Echinococcus granulosus heat shock protein 0.0066 0.0811 0.0809
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.005 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0767 0.0763
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.0635 0.1386
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0575
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0346 0.0755
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0246 0.0727
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Entamoeba histolytica hypothetical protein 0.0036 0.0384 0.1581
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0454 0.0452
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0193 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0003 0.0002
Loa Loa (eye worm) heat shock protein 90 0.0066 0.0811 0.1766
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.005 0.029
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0246 0.3005
Schistosoma mansoni intermediate filament proteins 0.0027 0.0251 0.0248
Giardia lamblia Heat shock protein HSP 90-alpha 0.0066 0.0811 0.3599
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0067 0.0143
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0246 0.0534
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.1667
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0159 0.2164 0.2163
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.5868 0.5867
Toxoplasma gondii hypothetical protein 0.0041 0.0454 0.2878
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0346 0.0899
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.005 0.029
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0193 0.0191
Echinococcus multilocularis lamin dm0 0.0027 0.0251 0.025
Plasmodium vivax endoplasmin, putative 0.0066 0.0811 0.3599
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0246 0.0245
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0159 0.2164 0.472
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0087 0.0178
Loa Loa (eye worm) hypothetical protein 0.0159 0.2164 0.472
Trichomonas vaginalis set domain proteins, putative 0.024 0.3347 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.005 0.0562
Echinococcus granulosus dna polymerase kappa 0.0019 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0097
Schistosoma mansoni lipoxygenase 0.0097 0.1268 0.1265
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0139 0.027
Entamoeba histolytica hypothetical protein 0.0036 0.0384 0.1581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0004
Schistosoma mansoni endoplasmin 0.0066 0.0811 0.0807
Brugia malayi ecdysteroid receptor 0.001 0.0003 0.0008
Trypanosoma brucei metacaspase 0.0054 0.0635 0.7826
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0635 0.1777
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0635 0.4042
Schistosoma mansoni heat shock protein 0.0066 0.0811 0.0807
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0002
Trypanosoma brucei unspecified product 0.0013 0.0051 0.0575
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0454 0.5573
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0104
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.005 0.0048
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0087 0.0178
Brugia malayi hypothetical protein 0.0089 0.115 0.251
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.005 0.0562
Schistosoma mansoni hypothetical protein 0.0036 0.0384 0.038
Loa Loa (eye worm) hypothetical protein 0.0089 0.115 0.2508
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.005 0.0562
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0616 0.2679
Entamoeba histolytica hypothetical protein 0.0036 0.0384 0.1581
Echinococcus multilocularis microtubule associated protein 2 0.0697 1 1
Plasmodium falciparum heat shock protein 90 0.0066 0.0811 0.3599
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0003 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0454 0.5573
Brugia malayi Cell death protein 3 precursor 0.0054 0.0635 0.1386
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0454 0.5573
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.005 0.0138
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.005 0.0562
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0303 0.03
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0003 0.0002
Brugia malayi Pre-SET motif family protein 0.0031 0.0303 0.0661
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0334 0.4095
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.0454 0.0986
Onchocerca volvulus 0.0023 0.0193 0.0567
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0246 0.0245
Schistosoma mansoni cpg binding protein 0.0031 0.0301 0.0298
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0737 0.0734
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0002
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0635 0.7826
Echinococcus granulosus intermediate filament protein 0.0027 0.0251 0.025
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0159 0.2164 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0251 0.0545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0303 0.03
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0454 0.5573
Echinococcus multilocularis RUN 0.0023 0.0193 0.0191
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0454 0.5573
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0246 0.0931
Plasmodium vivax metacaspase 1, putative 0.0054 0.0635 0.277
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0003 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Brugia malayi hypothetical protein 0.0036 0.0384 0.0838
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0008
Giardia lamblia DINP protein human, muc B family 0.0019 0.0139 0.0421
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0159 0.2164 0.6413
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Brugia malayi hypothetical protein 0.0027 0.0255 0.0556
Schistosoma mansoni loxhd1 0.0023 0.0193 0.0189
Brugia malayi tumor suppressor. 0.0325 0.4583 1
Toxoplasma gondii hypothetical protein 0.0118 0.1565 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0384 0.0382
Trypanosoma brucei unspecified product 0.0019 0.0139 0.1667
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Echinococcus granulosus lamin 0.0027 0.0251 0.025
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0003 0.0008
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0246 0.0931
Loa Loa (eye worm) hypothetical protein 0.0054 0.0635 0.1383
Echinococcus granulosus dna polymerase eta 0.0045 0.0513 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0051 0.0575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0334 0.4095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0616 0.7586
Echinococcus multilocularis cpg binding protein 0.0031 0.0301 0.03
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0139 0.027
Schistosoma mansoni hypothetical protein 0.0049 0.0564 0.0561
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0003 0.0004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0303 0.1914
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0384 0.0382
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0317 0.2007
Brugia malayi hypothetical protein 0.0023 0.0193 0.0421
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0616 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.1029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0582 0.0579
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0201 0.2774 0.2772
Brugia malayi Endoplasmin precursor 0.0066 0.0811 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0303 0.03
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.0454 0.1911
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0419 0.5144
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0003 0.0004
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0139 0.1877 0.1875
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0635 0.1777
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0303 0.0301
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Schistosoma mansoni endoplasmin 0.0066 0.0811 0.0807
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.005 0.0562
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.005 0.0582 0.1267
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0454 0.5573
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0002
Trypanosoma cruzi heat shock protein 90, putative 0.0066 0.0811 1
Schistosoma mansoni DNA polymerase eta 0.0045 0.0513 0.051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0008
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Loa Loa (eye worm) tumor suppressor 0.0325 0.4583 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2924 0.6379
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Echinococcus granulosus caspase 0.0201 0.2774 0.2772
Echinococcus multilocularis caspase 2 0.0054 0.0635 0.0634
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0008
Echinococcus multilocularis caspase 3 0.0147 0.1993 0.1992
Trypanosoma cruzi metacaspase, putative 0.0054 0.0635 0.7826
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0087 0.019
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0087 0.0086
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0087 0.0084
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.005 0.0741
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0139 0.0135
Leishmania major DNA polymerase eta, putative 0.0045 0.0513 0.6311
Trypanosoma brucei metacaspase 5, putative 0.0054 0.0635 0.7826
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.0454 0.0452
Leishmania major DNA polymerase eta, putative 0.0032 0.0317 0.3885
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0384 0.038
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0246 0.0931
Schistosoma mansoni lipoxygenase 0.0139 0.1877 0.1874
Brugia malayi Hsp90 protein 0.0027 0.0246 0.0538
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0513 0.6311
Schistosoma mansoni rab6-interacting 0.0023 0.0193 0.0189
Echinococcus multilocularis heat shock protein 90 0.0066 0.0811 0.0809
Schistosoma mansoni caspase-7 (C14 family) 0.0201 0.2774 0.2771
Loa Loa (eye worm) hypothetical protein 0.0054 0.0635 0.1383
Echinococcus granulosus caspase 3 0.0147 0.1993 0.1992
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Schistosoma mansoni heat shock protein 0.0066 0.0811 0.0807
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0417
Schistosoma mansoni rotamase 0.0034 0.0346 0.0343
Echinococcus multilocularis caspase 8 0.0054 0.0635 0.0634
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0139 0.0302
Brugia malayi heat shock protein 90 0.0066 0.0811 0.1769
Echinococcus granulosus heat shock protein 90 0.0066 0.0811 0.0809
Loa Loa (eye worm) hypothetical protein 0.0027 0.0255 0.0553
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0002
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.3331 0.333
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0811 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0139 0.0299
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0159 0.2164 0.4722
Leishmania major heat shock protein, putative 0.0027 0.0246 0.3005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0081
Trypanosoma brucei metacaspase MCA3 0.0054 0.0635 0.7826
Echinococcus granulosus cpg binding protein 0.0031 0.0301 0.03
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0635 0.1777
Onchocerca volvulus 0.0049 0.0564 0.1677
Brugia malayi kinase, mitochondrial precursor 0.0013 0.005 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.0635 0.0632
Schistosoma mansoni cpg binding protein 0.0031 0.0301 0.0298
Schistosoma mansoni hypothetical protein 0.0023 0.0193 0.0189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0193 0.0417
Toxoplasma gondii heat shock protein HSP90 0.0066 0.0811 0.5165
Trypanosoma brucei metacaspase MCA2 0.0054 0.0635 0.7826
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.1029
Onchocerca volvulus 0.0041 0.0454 0.1346
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.005 0.0138
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.005 0.0048
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0193 0.0191
Trypanosoma brucei Heat shock protein 83, putative 0.0066 0.0811 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0246 0.1552
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0003 0.0008
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0118 0.1565 0.4598
Schistosoma mansoni hypothetical protein 0.0027 0.0255 0.0251
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0317 0.3885
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0255 0.0556
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0334 0.4095
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0087 0.0531
Trichomonas vaginalis rotamase, putative 0.0033 0.0334 0.0864
Plasmodium vivax heat shock protein, putative 0.0027 0.0246 0.0931
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0454 0.5573
Echinococcus granulosus endoplasmin 0.0052 0.0616 0.0614
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0246 0.0931
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0513 0.6311
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0671 0.4271
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.0454 0.0452
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0303 0.03
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0104
Treponema pallidum heat shock protein 90 0.0052 0.0616 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0251 0.0545
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0139 0.0137
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0454 0.0452
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0303 0.0658
Leishmania major DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0008
Echinococcus multilocularis heat shock protein 0.0066 0.0811 0.0809
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.005 0.029
Onchocerca volvulus 0.005 0.0582 0.173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0004
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.005 0.0108
Trypanosoma brucei Metacaspase-4 0.0054 0.0635 0.7826
Brugia malayi Doublecortin family protein 0.0023 0.0193 0.0421
Echinococcus granulosus hypothetical protein 0.0027 0.0255 0.0253
Leishmania major metacaspase, putative 0.0054 0.0635 0.7826
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.005 0.0562
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0193 0.0678
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.0454 0.5573
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0139 0.1573
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.005 0.0046
Echinococcus granulosus dnaJ subfamily B 0.0413 0.5868 0.5867
Echinococcus granulosus protein quaking 0.0027 0.0255 0.0253
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.0635 0.0632
Schistosoma mansoni cpg binding protein 0.0029 0.0277 0.0274
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.005 0.0562
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0139 0.0137
Echinococcus multilocularis dna polymerase eta 0.0045 0.0513 0.0512
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0087 0.1029
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0159 0.2164 0.2163
Brugia malayi Probable DNA topoisomerase II 0.0013 0.005 0.0108
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0008
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.005 0.0104
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0334 0.1347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0004
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0616 0.1718
Echinococcus granulosus heat shock protein 90 0.0052 0.0616 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0635 0.1777
Schistosoma mansoni polycystin 1-related 0.0023 0.0193 0.0189
Loa Loa (eye worm) hypothetical protein 0.0239 0.3331 0.7268
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0139 0.1667
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.005 0.0562
Trichomonas vaginalis heat shock protein, putative 0.004 0.0441 0.1188
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0303 0.0301
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.005 0.5
Echinococcus granulosus caspase 2 0.0054 0.0635 0.0634
Toxoplasma gondii heat shock protein 90, putative 0.0066 0.0811 0.5165
Plasmodium vivax heat shock protein 86, putative 0.0066 0.0811 0.3599
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0008
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.005 0.0562
Echinococcus multilocularis endoplasmin 0.0052 0.0616 0.0614
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0046 0.0045
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0193 0.0191
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.005 0.0562
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.1667
Schistosoma mansoni hypothetical protein 0.0027 0.0255 0.0251
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0003 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0067 0.0147
Echinococcus multilocularis heat shock protein 90 0.0052 0.0616 0.0614
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0616 0.7586
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0616 0.0614
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0087 0.0664
Giardia lamblia Rab geranylgeranyltransferase 0.0159 0.2164 1
Trypanosoma brucei unspecified product 0.0013 0.0051 0.0575
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0193 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0454 0.5573
Loa Loa (eye worm) endoplasmin 0.0066 0.0811 0.1766
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.0635 0.189
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.005 0.0562
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0139 0.1573
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0104
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0616 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Echinococcus multilocularis expressed protein 0.0034 0.0346 0.0344
Echinococcus multilocularis tumor protein p63 0.0341 0.4822 0.4822
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0251 0.0548
Schistosoma mansoni hypothetical protein 0.0413 0.5868 0.5867
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0346 0.0752
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0003 0.0002
Schistosoma mansoni DNA topoisomerase II 0.0013 0.005 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0635 0.1777
Onchocerca volvulus 0.024 0.3347 1
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0635 0.1777
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0139 0.1573
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0003 0.0008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0139 0.1573
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0635 0.277
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0529
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0616 0.1718
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.005 0.029
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0159 0.2164 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.005 0.0048
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.005 0.0741
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0004
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Schistosoma mansoni lamin 0.0027 0.0251 0.0248
Plasmodium falciparum metacaspase-like protein 0.0054 0.0635 0.277
Echinococcus multilocularis caspase 0.0201 0.2774 0.2772
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0635 0.4042
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.0454 0.1911
Echinococcus granulosus FTZ F1 alpha 0.001 0.0003 0.0002
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.0454 0.1911
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0564 0.1231
Trypanosoma cruzi metacaspase, putative 0.0054 0.0635 0.7826
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0159 0.2164 0.6413
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0303 0.0301
Brugia malayi isocitrate dehydrogenase 0.0016 0.0087 0.019
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.0811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Echinococcus multilocularis lamin 0.0027 0.0251 0.025
Schistosoma mansoni caspase-3 (C14 family) 0.0201 0.2774 0.2771
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.0811 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0139 0.1877 0.1875
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Leishmania major DNA topoisomerase ii 0.0013 0.005 0.0562
Brugia malayi hypothetical protein 0.0023 0.0193 0.0421
Onchocerca volvulus 0.0023 0.0193 0.0567
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0616 1
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0513 0.112
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0139 0.0421
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0278 0.0276
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0139 0.0137
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.005 0.0562
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0193 0.0417
Onchocerca volvulus 0.0031 0.0303 0.0896
Trichomonas vaginalis endoplasmin, putative 0.004 0.0441 0.1188
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0616 0.7586
Brugia malayi Pre-SET motif family protein 0.0211 0.2924 0.638
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0008
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Echinococcus granulosus caspase 8 0.0054 0.0635 0.0634
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0002
Leishmania major hypothetical protein, conserved 0.0013 0.005 0.0562
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0246 0.1552
Plasmodium vivax SET domain protein, putative 0.0031 0.0303 0.1199
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0159 0.2164 0.2161
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0159 0.2164 0.6413
Onchocerca volvulus 0.0027 0.0251 0.0741
Schistosoma mansoni heat shock protein 0.0027 0.0246 0.0243
Brugia malayi steroid hormone receptor 0.001 0.0003 0.0008
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.005 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0004
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.005 0.5
Schistosoma mansoni eyes absent homolog 0.0089 0.115 0.1147
Onchocerca volvulus 0.0029 0.0277 0.0819
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0008
Schistosoma mansoni rab6-interacting 0.0023 0.0193 0.0189
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0159 0.2164 1
Trypanosoma cruzi metacaspase, putative 0.0054 0.0635 0.7826
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0616 0.1718
Echinococcus multilocularis protein quaking 0.0027 0.0255 0.0253
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.0811 0.3599
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0811 1
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0635 0.7826
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0003 0.0002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0046 0.0045
Leishmania major heat shock protein 83-1 0.0066 0.0811 1
Plasmodium falciparum endoplasmin, putative 0.004 0.0441 0.1852
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.1029
Giardia lamblia Grp94/Hsp90 0.0052 0.0616 0.2679
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0002
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.0454 0.099
Entamoeba histolytica hypothetical protein 0.0036 0.0384 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0008
Trypanosoma brucei heat shock protein, putative 0.0066 0.0811 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1667
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0246 0.0597
Echinococcus granulosus expressed protein 0.0034 0.0346 0.0344
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0635 0.1777
Echinococcus granulosus lamin dm0 0.0027 0.0251 0.025

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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