Detailed information for compound 691199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 266.363 | Formula: C12H18N4OS
  • H donors: 1 H acceptors: 4 LogP: 3.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCSc1nnc2n1c(C)c(c(n2)O)C)C
  • InChi: 1S/C12H18N4OS/c1-7(2)5-6-18-12-15-14-11-13-10(17)8(3)9(4)16(11)12/h7H,5-6H2,1-4H3,(H,13,14,17)
  • InChiKey: SVHYZPBBATZALJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0026 0.0159 0.0458
Schistosoma mansoni hypothetical protein 0.0089 0.0869 0.0865
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.001 0.003
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Mycobacterium tuberculosis Conserved protein 0.0075 0.0706 0.1034
Trypanosoma brucei polo-like protein kinase 0.0204 0.2158 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Entamoeba histolytica hypothetical protein 0.0039 0.0297 0.0867
Brugia malayi hypothetical protein 0.0029 0.0192 0.0195
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0204 0.2158 0.215
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Brugia malayi Ets-domain containing protein 0.0079 0.0752 0.0776
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0906 0.0897
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0089 0.0395
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0106 0.0099
Treponema pallidum heat shock protein 90 0.0051 0.0437 0.1264
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.2293 0.6767
Trypanosoma brucei heat shock protein 84, putative 0.0026 0.0159 0.0719
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0059
Schistosoma mansoni patched 1 0.0093 0.0906 0.0903
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0106 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.3387 1
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Giardia lamblia Heat shock protein HSP 90-alpha 0.0064 0.0584 0.1698
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0726 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0098 0.0094
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.1604 0.1601
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.001 0.0007
Brugia malayi hypothetical protein 0.0013 0.0011 0.0007
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0051 0.0437 1
Echinococcus granulosus Niemann Pick C1 protein 0.0309 0.3335 0.3328
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0326 0.1495
Echinococcus multilocularis heat shock protein 90 0.0051 0.0437 0.0427
Brugia malayi Bromodomain containing protein 0.0032 0.022 0.0225
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.001 0.003
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0326 0.1495
Loa Loa (eye worm) hypothetical protein 0.0077 0.0726 0.0743
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0706 0.0696
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0906 0.0897
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.001 0.0007
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0098 0.0091
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0706 0.1034
Trypanosoma brucei calpain, putative 0.012 0.1213 0.5612
Brugia malayi Myosin head containing protein 0.0013 0.0011 0.0007
Leishmania major hypothetical protein, conserved 0.0075 0.0706 0.3237
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0089 0.0395
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.007 0.0068
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.001 0.0007
Brugia malayi tumor suppressor. 0.0345 0.374 0.3878
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trichomonas vaginalis heat shock protein, putative 0.0064 0.0584 0.0602
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.001 0.0007
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0752 0.0742
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0106 0.0095
Echinococcus multilocularis GPCR, family 2 0.0018 0.0067 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0098 0.0098
Toxoplasma gondii Hsp90 domain-containing protein 0.0026 0.0159 0.2074
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0051 0.0437 0.1987
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0677 0.0699
Giardia lamblia PHD finger protein 15 0.0032 0.022 0.0622
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0314 0.0304
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.007 0.0068
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.001 0.0007
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0611 0.673 0.6979
Echinococcus granulosus kelch ECH associated protein 1 0.0101 0.1002 0.0993
Brugia malayi jmjC domain containing protein 0.004 0.0314 0.0322
Brugia malayi chromobox protein homolog 3 0.0041 0.032 0.0328
Trypanosoma cruzi heat shock protein, putative 0.0026 0.0159 0.0719
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0089 0.0395
Schistosoma mansoni hypothetical protein 0.0029 0.0192 0.0188
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0314 0.3387 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0015 0.0005
Schistosoma mansoni heat shock protein 0.0026 0.0159 0.0155
Brugia malayi Ets-domain containing protein 0.0079 0.0752 0.0776
Leishmania major DNA polymerase eta, putative 0.002 0.0089 0.0366
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0506 0.0515
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0706 0.0702
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.001 0.003
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0326 0.1495
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0162 0.0449
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Schistosoma mansoni hypothetical protein 0.0102 0.1005 0.1002
Brugia malayi Patched related family protein 10 0.0013 0.0011 0.0007
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0162 0.0734
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0706 0.1034
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.1451 0.1502
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1246 0.1283
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0162 0.0158
Onchocerca volvulus 0.0013 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0303 0.0304
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Echinococcus granulosus jumonji domain containing protein 0.0044 0.036 0.035
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.022 0.0218
Onchocerca volvulus 0.0032 0.0221 0.1009
Onchocerca volvulus 0.0013 0.0011 0.0033
Schistosoma mansoni cpg binding protein 0.003 0.0204 0.02
Onchocerca volvulus 0.0013 0.0011 0.0033
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0437 0.2011
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0033
Loa Loa (eye worm) endoplasmin 0.0064 0.0584 0.0596
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0706 0.1034
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0162 0.0152
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.0321
Trypanosoma brucei hypothetical protein 0.012 0.1213 0.5612
Trypanosoma cruzi Heat shock protein 83, putative 0.0064 0.0584 0.2692
Echinococcus multilocularis protein quaking 0.0029 0.0192 0.0181
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.0722
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0067 0.0066
Schistosoma mansoni ap endonuclease 0.0041 0.0326 0.0322
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.007 0.0068
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.032 0.1466
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.007 0.0068
Mycobacterium tuberculosis Conserved protein 0.0075 0.0706 0.1034
Leishmania major hypothetical protein, conserved 0.0077 0.0726 0.3332
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0726 0.3352
Toxoplasma gondii patched family protein 0.0013 0.0011 0.0009
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0098 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0162 0.0158
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0098 0.0098
Brugia malayi Temporarily assigned gene name protein 44 0.0029 0.0192 0.0195
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0159 0.0161
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0326 0.0935
Toxoplasma gondii heat shock protein 75, putative 0.0026 0.0159 0.2074
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0019 0.007
Mycobacterium leprae Probable lipase LipE 0.0075 0.0706 0.1034
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0098 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0726 1
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0326 0.0334
Brugia malayi Endoplasmin precursor 0.0064 0.0584 0.0602
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0706 0.1034
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0026 0.0159 0.0149
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0162 0.2232
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0437 0.045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0067 0.0057
Loa Loa (eye worm) patched family protein 0.0013 0.0011 0.0001
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0289 0.1322
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0098 0.0098
Entamoeba histolytica serine/threonine protein kinase, putative 0.0204 0.2158 0.6367
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0098 0.0088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0326 0.0316
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0067 0.0066
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0437 0.045
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0474 0.6472
Entamoeba histolytica heat shock protein 90, putative 0.0064 0.0584 0.1714
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0098 0.0088
Echinococcus granulosus heat shock protein 90 0.0051 0.0437 0.0427
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0153 0.1585 0.2343
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0186 0.0182
Echinococcus multilocularis peregrin 0.0032 0.022 0.021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trypanosoma cruzi calpain cysteine peptidase, putative 0.012 0.1213 0.5612
Echinococcus multilocularis chromobox protein 1 0.0072 0.0677 0.0667
Echinococcus granulosus muscleblind protein 0.031 0.3348 0.3341
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.007 0.0068
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1246 0.1283
Echinococcus multilocularis Kelch repeat type 1 0.0102 0.1005 0.0996
Echinococcus multilocularis muscleblind protein 0.031 0.3348 0.3341
Trypanosoma cruzi polo-like protein kinase, putative 0.0204 0.2158 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1032 0.1022
Brugia malayi CXXC zinc finger family protein 0.0029 0.0186 0.0189
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.001 0.0007
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0098 0.0094
Plasmodium falciparum heat shock protein 90 0.0064 0.0584 0.8041
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0015 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.1604 0.1601
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0162 0.0164
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0251 0.024
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.022 0.0217
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0098 0.0088
Loa Loa (eye worm) tumor suppressor 0.0345 0.374 0.3874
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0091
Toxoplasma gondii patched family protein 0.0013 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.032 0.0328
Trypanosoma brucei unspecified product 0.0014 0.0019 0.007
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.0722
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.0722
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.001 0.0144
Echinococcus multilocularis cpg binding protein 0.003 0.0204 0.0194
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.022 0.2934
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Toxoplasma gondii patched family protein 0.0013 0.0011 0.0009
Echinococcus multilocularis dna polymerase eta 0.002 0.0089 0.0079
Onchocerca volvulus 0.0075 0.0706 0.3257
Brugia malayi Hsp90 protein 0.0026 0.0159 0.0161
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0098 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1451 0.1447
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0706 0.1034
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.0722
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0026 0.0159 0.0719
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0091
Brugia malayi hypothetical protein 0.0039 0.0297 0.0305
Giardia lamblia Fructose-bisphosphate aldolase 0.0314 0.3387 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0706 0.0728
Loa Loa (eye worm) TAR-binding protein 0.0141 0.1451 0.1496
Loa Loa (eye worm) patched family protein 0.0013 0.0011 0.0001
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.001 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0326 0.4491
Echinococcus granulosus heat shock protein 0.0064 0.0584 0.0574
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0706 0.0722
Brugia malayi heat shock protein 90 0.0064 0.0584 0.0602
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Echinococcus multilocularis protein patched 0.0093 0.0906 0.0897
Echinococcus granulosus expressed conserved protein 0.0203 0.2146 0.2137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0091
Brugia malayi hypothetical protein 0.0021 0.0098 0.0098
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0098 0.0088
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0098 0.0088
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Echinococcus granulosus protein quaking 0.0029 0.0192 0.0181
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0706 0.0722
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0089 0.0395
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0089 0.0082
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0098 0.0088
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0051 0.0437 0.0635
Loa Loa (eye worm) hypothetical protein 0.0093 0.0906 0.093
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0132 0.0594
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0326 0.0328
Plasmodium vivax patched family protein, putative 0.0013 0.0011 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1451 0.1447
Giardia lamblia DINP protein human, muc B family 0.002 0.0089 0.0233
Brugia malayi Fli-1 protein 0.024 0.2559 0.2652
Plasmodium vivax endoplasmin, putative 0.0064 0.0584 0.8041
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Brugia malayi hypothetical protein 0.0075 0.0702 0.0725
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.001 0.0144
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.036 0.035
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.001 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0314 0.0315
Entamoeba histolytica hypothetical protein 0.0021 0.0098 0.0279
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0098 0.0094
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Brugia malayi beta-lactamase 0.0075 0.0706 0.0728
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.001 0.5
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.001 0.0144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0091
Brugia malayi hypothetical protein 0.0013 0.0011 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0906 0.0936
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0098 0.0098
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0999 0.1033
Trypanosoma brucei calpain-like protein, putative 0.012 0.1213 0.5612
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0089 0.0251
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.001 0.003
Mycobacterium ulcerans beta-lactamase 0.0075 0.0706 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0187 0.0189
Onchocerca volvulus 0.0013 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0706 0.3257
Brugia malayi jmjC domain containing protein 0.0104 0.1032 0.1067
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0999 0.1033
Echinococcus multilocularis dna polymerase kappa 0.002 0.0089 0.0079
Brugia malayi Heterochromatin protein 1 0.0072 0.0677 0.0699
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0726 0.3352
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0019 0.007
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.2293 0.2376
Toxoplasma gondii exonuclease III APE 0.0041 0.0326 0.4411
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0098 0.0091
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0098 0.0091
Schistosoma mansoni hypothetical protein 0.0029 0.0192 0.0188
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0098 0.0088
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.022 0.2934
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0098 0.0088
Brugia malayi protein C24B5.3 0.0013 0.0011 0.0007
Onchocerca volvulus 0.0075 0.0706 0.3257
Brugia malayi TAR-binding protein 0.0141 0.1451 0.1502
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0326 0.0334
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0162 0.0706
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0611 0.673 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0098 0.0094
Schistosoma mansoni gabp alpha 0.0079 0.0752 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0098 0.0098
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.031 0.3348 0.3466
Brugia malayi beta-lactamase family protein 0.0075 0.0706 0.0728
Schistosoma mansoni hypothetical protein 0.0903 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0064 0.0584 0.2692
Onchocerca volvulus 0.0013 0.0011 0.0033
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0204 0.2158 0.215
Loa Loa (eye worm) hypothetical protein 0.0216 0.2293 0.2371
Echinococcus multilocularis muscleblind protein 1 0.031 0.3348 0.3341
Trypanosoma brucei heat shock protein 90, putative 0.0064 0.0584 0.2692
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Echinococcus multilocularis endoplasmin 0.0051 0.0437 0.0427
Schistosoma mansoni chromobox protein 0.0072 0.0677 0.0673
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0354 0.0364
Entamoeba histolytica hypothetical protein 0.0039 0.0297 0.0867
Echinococcus granulosus chromobox protein 1 0.0072 0.0677 0.0667
Loa Loa (eye worm) RNA binding protein 0.0141 0.1451 0.1496
Echinococcus granulosus hypothetical protein 0.0029 0.0192 0.0181
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Echinococcus granulosus tar DNA binding protein 0.0141 0.1451 0.1442
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0162 0.0734
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0079 0.0078
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0089 0.0366
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0098 0.0094
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0098 0.0088
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0098 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0726 0.3352
Brugia malayi kinase, mitochondrial precursor 0.0013 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.007 0.0068
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0098 0.0098
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Echinococcus granulosus kelch ECH associated protein 1 like 0.0101 0.1002 0.0993
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0089 0.0085
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0026 0.0159 0.0149
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.001 0.0144
Brugia malayi CHE-14 protein 0.0093 0.0906 0.0937
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0098 0.0088
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0437 0.045
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Brugia malayi Patched related family protein 4 0.0013 0.0011 0.0007
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.012 0.1213 0.5612
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0075 0.0702 0.0692
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0204 0.2158 0.223
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0204 0.2158 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0295 0.0285
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0089 0.0085
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.001 0.0144
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.0722
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0547 0.0543
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0089 0.0395
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0326 0.7396
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0314 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Brugia malayi glutaminase DH11.1 0.0871 0.9639 1
Trichomonas vaginalis chaperonin, putative 0.0027 0.0162 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0089 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1451 0.1447
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.06 0.0612
Trypanosoma brucei unspecified product 0.002 0.0089 0.0395
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0706 0.1034
Loa Loa (eye worm) beta-lactamase 0.0075 0.0706 0.0722
Brugia malayi CHD4 protein 0.0013 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Brugia malayi protein C24B5.3 0.0013 0.0011 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0506 0.0521
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0098 0.0088
Echinococcus multilocularis expressed conserved protein 0.0203 0.2146 0.2137
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0706 0.3257
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0218
Brugia malayi hypothetical protein 0.0077 0.0726 0.0749
Echinococcus multilocularis tar DNA binding protein 0.0141 0.1451 0.1442
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0162 0.0467
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0098 0.0088
Schistosoma mansoni hypothetical protein 0.0089 0.0869 0.0865
Echinococcus granulosus chromobox protein 1 0.0072 0.0677 0.0667
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Brugia malayi hypothetical protein 0.0021 0.0098 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0706 0.3257
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0326 0.0334
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0067 0.0057
Loa Loa (eye worm) heat shock protein 75 0.0026 0.0159 0.0154
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0098 0.0088
Brugia malayi Patched protein homolog 1 0.0013 0.0011 0.0007
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.001 0.003
Trichomonas vaginalis hypothetical protein 0.0036 0.0272 0.0278
Brugia malayi serine/threonine-protein kinase plk-2 0.0204 0.2158 0.2235
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Echinococcus granulosus GPCR family 2 0.0018 0.0067 0.0057
Schistosoma mansoni endoplasmin 0.0064 0.0584 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0187 0.0189
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0098 0.0098
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0752 0.077
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.001 0.003
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.001 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0089 0.0117
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.001 0.003
Schistosoma mansoni tsg101-related 0.0062 0.0562 0.0558
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Brugia malayi hypothetical protein 0.0162 0.1685 0.1745
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.001 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4448 0.4442
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0098 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0098 0.0098
Mycobacterium tuberculosis Conserved protein 0.0075 0.0706 0.1034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.007 0.0068
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0051 0.0434 0.1271
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0089 0.0088
Plasmodium vivax heat shock protein 90, putative 0.0026 0.0159 0.2188
Schistosoma mansoni ap endonuclease 0.0041 0.0326 0.0322
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0305 0.0313
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0706 0.0728
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Schistosoma mansoni DNA topoisomerase II 0.0013 0.001 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0067 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.1213 0.5598
Toxoplasma gondii heat shock protein 90, putative 0.0064 0.0584 0.8012
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0106 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0051 0.0437 0.0635
Brugia malayi MH2 domain containing protein 0.0123 0.1246 0.1289
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0297 0.0287
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0098 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Echinococcus granulosus peregrin 0.0032 0.022 0.021
Onchocerca volvulus 0.0013 0.0011 0.0033
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0162 0.0157
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0326 0.0328
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0303 0.031
Onchocerca volvulus Serine\/threonine kinase homolog 0.0204 0.2158 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0162 0.0152
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0098 0.0094
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.031 0.3348 0.3466
Leishmania major heat shock protein, putative 0.0026 0.0159 0.0691
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0098 0.0098
Schistosoma mansoni glutaminase 0.0871 0.9639 0.9638
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0677 0.0699
Leishmania major hypothetical protein, conserved 0.0024 0.0132 0.0565
Loa Loa (eye worm) glutaminase 2 0.0871 0.9639 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.006 0.0056
Echinococcus granulosus kelch ECH associated protein 1 like 0.0101 0.1002 0.0993
Brugia malayi hypothetical protein 0.0013 0.0011 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0186 0.0182
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Plasmodium falciparum endoplasmin, putative 0.0039 0.0305 0.4207
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.022 0.021
Echinococcus granulosus dna polymerase eta 0.002 0.0089 0.0079
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0706 0.0728
Echinococcus granulosus dna polymerase kappa 0.002 0.0089 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0726 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0354 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Schistosoma mansoni hypothetical protein 0.0089 0.0869 0.0865
Trypanosoma cruzi polo-like protein kinase, putative 0.0204 0.2158 1
Schistosoma mansoni hypothetical protein 0.0018 0.0067 0.0063
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0132 0.0594
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0706 0.0728
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0089 0.0395
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0098 0.0098
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.5241 0.7785
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0906 0.0897
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.001 0.0007
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0089 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0089 0.0395
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0159 0.2188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.1604 0.1596
Loa Loa (eye worm) glutaminase 0.0871 0.9639 1
Brugia malayi Probable DNA topoisomerase II 0.0013 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Loa Loa (eye worm) patched family protein 0.0013 0.0011 0.0001
Onchocerca volvulus 0.0029 0.0186 0.0844
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Plasmodium vivax heat shock protein, putative 0.0026 0.0159 0.2188
Schistosoma mansoni hypothetical protein 0.0034 0.0251 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0019 0.007
Trichomonas vaginalis esterase, putative 0.0075 0.0706 0.0728
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.1604 0.1596
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Trypanosoma brucei unspecified product 0.0014 0.0019 0.007
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.001 0.003
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Echinococcus multilocularis kelch ECH associated protein 1 0.0101 0.1002 0.0993
Onchocerca volvulus Protein patched homolog 0.0013 0.0011 0.0033
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0437 0.1264
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.1213 0.5598
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0354 0.1627
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0584 0.2692
Onchocerca volvulus 0.0013 0.0011 0.0033
Schistosoma mansoni endoplasmin 0.0064 0.0584 0.058
Mycobacterium ulcerans heat shock protein 90 0.0051 0.0437 0.0443
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0075 0.0702 0.0692
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0089 0.0079
Loa Loa (eye worm) hypothetical protein 0.0075 0.0706 0.0722
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0726 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0051 0.0437 0.0427
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0584 0.2692
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0706 0.0728
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0159 0.2188
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0792 0.0788
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0153 0.1585 0.1635
Loa Loa (eye worm) fli-1 protein 0.024 0.2559 0.2647
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0153 0.1585 0.2343
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0706 0.1034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0297 0.0287
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0326 0.0935
Loa Loa (eye worm) hypothetical protein 0.0114 0.1141 0.1174
Echinococcus granulosus endoplasmin 0.0051 0.0437 0.0427
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0155 0.1604 0.1661
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.1604 0.1596
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0326 0.147
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0611 0.673 1
Trypanosoma cruzi heat shock protein 85, putative 0.0064 0.0584 0.2692
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.1604 0.1601
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0314 0.031
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0326 0.047
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0906 0.093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0221 0.0219
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Brugia malayi Muscleblind-like protein 0.031 0.3348 0.3471
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0506 0.0521
Toxoplasma gondii ABC1 family protein 0.0075 0.0706 0.9713
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0098 0.0094
Onchocerca volvulus 0.0075 0.0706 0.3257
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Loa Loa (eye worm) hypothetical protein 0.0054 0.0475 0.0483
Echinococcus multilocularis Niemann Pick C1 protein 0.0309 0.3335 0.3328
Schistosoma mansoni hypothetical protein 0.0018 0.0067 0.0063
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Schistosoma mansoni kinase 0.0104 0.103 0.1026
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0706 0.0728
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0067 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.1604 0.1596
Echinococcus multilocularis expressed protein 0.0407 0.4429 0.4424
Trichomonas vaginalis glutaminase, putative 0.0871 0.9639 1
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1451 0.1447
Plasmodium vivax hypothetical protein, conserved 0.0013 0.001 0.0144
Brugia malayi RNA binding protein 0.0141 0.1451 0.1502
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0106 0.0102
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Mycobacterium ulcerans hypothetical protein 0.0075 0.0706 0.0722
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0015 0.0005
Giardia lamblia Kinase, PLK 0.0204 0.2158 0.636
Schistosoma mansoni tsg101-related 0.0051 0.0434 0.043
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0752 0.0742
Onchocerca volvulus 0.0162 0.1685 0.7806
Schistosoma mansoni ets-related 0.024 0.2559 0.2556
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0089 0.0082
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0706 0.0702
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0091
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0297 0.0294
Entamoeba histolytica heat shock protein 90, putative 0.0064 0.0584 0.1714
Brugia malayi beta-lactamase family protein 0.0075 0.0706 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0098 0.0098
Brugia malayi hypothetical protein 0.005 0.042 0.0432
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.001 0.0007
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.001 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0089 0.0088
Loa Loa (eye worm) heat shock protein 90 0.0064 0.0584 0.0596
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0677 0.0692
Mycobacterium ulcerans glutaminase 0.0871 0.9639 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0706 0.1034
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0098 0.0094
Schistosoma mansoni heat shock protein 0.0064 0.0584 0.058
Toxoplasma gondii heat shock protein HSP90 0.0064 0.0584 0.8012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0067 0.0057
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0706 0.0722
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Echinococcus multilocularis kelch ECH associated protein 1 0.0101 0.1002 0.0993
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0106 0.0102
Giardia lamblia Grp94/Hsp90 0.0051 0.0437 0.1264
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.022 0.021
Loa Loa (eye worm) hypothetical protein 0.0068 0.0623 0.0636
Schistosoma mansoni hypothetical protein 0.0032 0.022 0.0217
Schistosoma mansoni hypothetical protein 0.0089 0.0869 0.0865
Entamoeba histolytica hypothetical protein 0.0021 0.0098 0.0279
Treponema pallidum fructose-bisphosphate aldolase 0.0314 0.3387 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0036 0.0033
Schistosoma mansoni heat shock protein 0.0064 0.0584 0.058
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.012 0.1213 0.5612
Echinococcus granulosus heat shock protein 90 0.0064 0.0584 0.0574
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.001 0.003
Leishmania major DNA polymerase kappa, putative 0.002 0.0089 0.0366
Entamoeba histolytica hypothetical protein 0.0039 0.0297 0.0867
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.2293 0.2285
Loa Loa (eye worm) hypothetical protein 0.0075 0.0702 0.0718
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0162 0.0164
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0098 0.0088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0155 0.1604 0.1655
Schistosoma mansoni hypothetical protein 0.0018 0.0067 0.0063
Echinococcus multilocularis geminin 0.0903 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0204 0.0194
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.001 0.003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0089 0.0088
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Schistosoma mansoni cpg binding protein 0.003 0.0204 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.2158 0.2235
Onchocerca volvulus Protein patched homolog 0.0013 0.0011 0.0033
Plasmodium falciparum phd finger protein, putative 0.0032 0.022 0.3036
Loa Loa (eye worm) patched family protein 0.0013 0.0011 0.0001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0251 0.024
Brugia malayi PXA domain containing protein 0.0021 0.0098 0.0098
Mycobacterium ulcerans lipase LipD 0.0075 0.0706 0.0722
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.0011 0.0153
Brugia malayi PXA domain containing protein 0.0021 0.0098 0.0098
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0326 0.0316
Schistosoma mansoni hypothetical protein 0.0018 0.0067 0.0063
Schistosoma mansoni niemann-pick C1 (NPC1) 0.022 0.2331 0.2328
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0314 0.3387 0.3511
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0162 0.2232
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1451 0.1447
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.012 0.1213 0.5612
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.1451 0.1496
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1032 0.1022
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.032 0.0328
Entamoeba histolytica hypothetical protein 0.0039 0.0297 0.0867
Toxoplasma gondii patched family protein 0.0013 0.0011 0.0009
Onchocerca volvulus Alhambra homolog 0.0032 0.022 0.1005
Brugia malayi Patched related family protein 12 0.0013 0.0011 0.0007
Plasmodium vivax heat shock protein 86, putative 0.0064 0.0584 0.8041
Echinococcus multilocularis heat shock protein 0.0064 0.0584 0.0574
Brugia malayi PHD-finger family protein 0.0032 0.022 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0032 0.022 0.3036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.007 0.0068
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0706 0.0696
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0031 0.0028
Schistosoma mansoni tsg101-related 0.0062 0.0562 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Echinococcus multilocularis chromobox protein 1 0.0072 0.0677 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0089 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0089 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0395
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0089 0.0395
Loa Loa (eye worm) patched family protein 0.0013 0.0011 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0326 0.0952
Loa Loa (eye worm) hypothetical protein 0.0057 0.0506 0.0515
Brugia malayi hypothetical protein 0.0013 0.0011 0.0007
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0305 0.0313
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0326 0.4491
Echinococcus multilocularis protein dispatched 1 0.0106 0.1054 0.1044
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.012 0.1213 0.5612
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0089 0.0082
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0106 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0082
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4448 0.4442
Trypanosoma brucei heat shock protein 90, putative 0.0064 0.0584 0.2692
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.2293 0.2285
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.012 0.1213 0.5598
Echinococcus granulosus expressed protein 0.0407 0.4429 0.4424
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0098 0.0088
Leishmania major heat shock protein 83-1 0.0064 0.0584 0.267
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0437 0.2011
Schistosoma mansoni DNA polymerase eta 0.002 0.0089 0.0085
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0015 0.0011
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0162 0.2119
Schistosoma mansoni hypothetical protein 0.0408 0.4448 0.4446
Trypanosoma cruzi heat shock protein 90, putative 0.0064 0.0584 0.2692
Schistosoma mansoni chromobox protein 0.0072 0.0677 0.0673
Schistosoma mansoni hypothetical protein 0.0039 0.0303 0.0299
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0706 0.9717
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0001
Toxoplasma gondii hypothetical protein 0.0013 0.0011 0.0009
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0162 0.0158
Entamoeba histolytica hypothetical protein 0.0021 0.0098 0.0279
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0162 0.0164
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0162 0.1685 0.1739
Schistosoma mansoni hypothetical protein 0.0903 1 1
Brugia malayi Patched family protein 0.0013 0.0011 0.0007
Schistosoma mansoni hypothetical protein 0.0039 0.0297 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.2158 0.2155
Trypanosoma brucei heat shock protein, putative 0.0064 0.0584 0.2692
Echinococcus multilocularis heat shock protein 90 0.0064 0.0584 0.0574

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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