Detailed information for compound 693164

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.38 | Formula: C15H17N3OS
  • H donors: 1 H acceptors: 2 LogP: 2.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCc2c(C1)sc(n2)NC(=O)c1ccccc1C
  • InChi: 1S/C15H17N3OS/c1-10-5-3-4-6-11(10)14(19)17-15-16-12-7-8-18(2)9-13(12)20-15/h3-6H,7-9H2,1-2H3,(H,16,17,19)
  • InChiKey: KRJFMJPQHQMPBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0295 0.0295
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.005 0.005
Plasmodium falciparum pyruvate kinase 0.0034 0.0086 0.0441
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0062 0.0283 0.0969
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0033 0.009
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Trichomonas vaginalis hypothetical protein 0.0034 0.0088 0.0194
Echinococcus multilocularis fat cadherin tumor suppressor 0.0024 0.0016 0.0016
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Echinococcus granulosus notch 0.0024 0.0016 0.0016
Echinococcus granulosus protein jagged 2 0.0024 0.0016 0.0016
Brugia malayi Calcium binding EGF domain containing protein 0.0024 0.0016 0.0055
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0129 0.0129
Onchocerca volvulus Alhambra homolog 0.0029 0.0057 0.0169
Onchocerca volvulus 0.0066 0.0311 0.0932
Schistosoma mansoni hypothetical protein 0.0607 0.4088 0.4088
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.1665 0.1665
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0072 0.0245
Brugia malayi jmjC domain containing protein 0.0161 0.0974 0.3341
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0129 0.0489
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0129 0.0129
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0038 0.0038
Schistosoma mansoni alpha glucosidase 0.004 0.0129 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0129 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.1349 0.618
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0183 0.1131 0.5167
Toxoplasma gondii calcium binding egf domain-containing protein 0.0062 0.0283 0.2391
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0086 0.0595
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0038 0.0197
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0947 0.4309
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Plasmodium vivax SET domain protein, putative 0.0064 0.0295 0.2353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Brugia malayi Pre-SET motif family protein 0.0439 0.2917 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0024 0.0024
Brugia malayi hypothetical protein 0.026 0.1665 0.5707
Brugia malayi Importin beta-1 subunit 0.0032 0.0072 0.0249
Echinococcus multilocularis tissue type plasminogen activator 0.0183 0.1131 0.1131
Echinococcus multilocularis fibropellin Ia 0.0024 0.0016 0.0016
Echinococcus granulosus cpg binding protein 0.0033 0.0084 0.0084
Echinococcus multilocularis neurogenic locus protein delta 0.0024 0.0016 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Echinococcus granulosus aspartyl aminopeptidase 0.0072 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Echinococcus multilocularis enteropeptidase 0.0095 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Brugia malayi hypothetical protein 0.0095 0.0515 0.1767
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0947 0.4271
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0033 0.009
Brugia malayi Cadherin domain containing protein 0.0024 0.0016 0.0055
Schistosoma mansoni notch 0.0024 0.0016 0.0016
Plasmodium falciparum importin beta, putative 0.0032 0.0072 0.0317
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0033 0.009
Echinococcus multilocularis pyruvate kinase 0.0027 0.0037 0.0037
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0038 0.0038
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0066 0.0311 0.2647
Brugia malayi jmjC domain containing protein 0.0102 0.0563 0.1931
Toxoplasma gondii PAN domain-containing protein 0.0066 0.0311 0.2647
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Echinococcus multilocularis neural cadherin 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Trypanosoma cruzi hypothetical protein, conserved 0.0183 0.1131 0.5167
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0038 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.1454 1 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0024 0.0016 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0202 0.0693
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0086 0.0295
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0129 0.0316
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0767 0.2629
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0033 0.0114
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0034 0.0088 0.0194
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0057 0.0057
Echinococcus granulosus Tolloid protein 1 0.0062 0.0283 0.0283
Toxoplasma gondii microneme protein, putative 0.0066 0.0311 0.2647
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Chlamydia trachomatis pyruvate kinase 0.0034 0.0086 0.5
Loa Loa (eye worm) hypothetical protein 0.0062 0.0283 0.0969
Loa Loa (eye worm) hypothetical protein 0.0439 0.2916 0.9997
Trichomonas vaginalis set domain proteins, putative 0.05 0.334 1
Giardia lamblia PHD finger protein 15 0.0029 0.0057 0.5787
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0086 0.0258
Loa Loa (eye worm) hypothetical protein 0.0062 0.0283 0.0969
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0033 0.0114
Onchocerca volvulus 0.0026 0.0033 0.0099
Echinococcus granulosus pyruvate kinase 0.0034 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0002 0.0006
Echinococcus multilocularis slit 2 protein 0.0024 0.0016 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.2917 1
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0072 0.0357 0.1553
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0177 0.0715
Toxoplasma gondii kringle domain-containing protein 0.0183 0.1131 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0095 0.0515 0.1767
Schistosoma mansoni hypothetical protein 0.0416 0.2751 0.2751
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0129 0.3323
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.1101 0.1101
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1101 0.1101
Toxoplasma gondii microneme protein MIC17B 0.0066 0.0311 0.2647
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0086 0.0595
Schistosoma mansoni pyruvate kinase 0.0034 0.0086 0.0086
Toxoplasma gondii hypothetical protein 0.0066 0.0311 0.2647
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0161 0.0974 0.0974
Echinococcus granulosus importin subunit beta 1 0.0032 0.0072 0.0072
Echinococcus multilocularis protein jagged 1 0.0024 0.0016 0.0016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0038 0.0066
Echinococcus granulosus Mastin 0.0095 0.0515 0.0515
Brugia malayi Trypsin family protein 0.0095 0.0515 0.1767
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Mycobacterium ulcerans hypothetical protein 0.0026 0.0033 0.009
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Brugia malayi Calcium binding EGF domain containing protein 0.0062 0.0283 0.0969
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0016 0.0016
Loa Loa (eye worm) trypsin family protein 0.0095 0.0515 0.1767
Toxoplasma gondii PAN domain-containing protein 0.0066 0.0311 0.2647
Brugia malayi Bromodomain containing protein 0.0029 0.0057 0.0194
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Brugia malayi notch-like transmembrane receptor 0.0024 0.0016 0.0055
Onchocerca volvulus 0.0066 0.0311 0.0932
Onchocerca volvulus Arrow homolog 0.0062 0.0283 0.0846
Onchocerca volvulus 0.0416 0.2751 0.8238
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.013
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0947 0.4309
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0024 0.0016 0.0055
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0295 0.0295
Echinococcus multilocularis protein jagged 1 0.0024 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0053 0.0221 0.0221
Onchocerca volvulus 0.0066 0.0311 0.0932
Echinococcus multilocularis laminin 0.0062 0.0283 0.0283
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0248 0.1047
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0072 0.0507
Brugia malayi Pre-SET motif family protein 0.0064 0.0295 0.1012
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0072 0.0357 0.0357
Schistosoma mansoni hypothetical protein 0.0095 0.0515 0.0515
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0091 0.0313
Onchocerca volvulus 0.0104 0.0574 0.1719
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0274 0.0274
Brugia malayi Cadherin domain containing protein 0.0024 0.0016 0.0055
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0072 0.0357 0.1553
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0767 0.2629
Schistosoma mansoni hypothetical protein 0.0183 0.1131 0.1131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0033 0.009
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Echinococcus multilocularis lysine specific demethylase 5A 0.01 0.0551 0.0551
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0038 0.013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0449 0.2988 0.2988
Brugia malayi SEA domain containing protein 0.0416 0.2751 0.9432
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Toxoplasma gondii PAN domain-containing protein 0.0066 0.0311 0.2647
Echinococcus granulosus protein jagged 2 0.0024 0.0016 0.0016
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Echinococcus granulosus protein jagged 1 0.0024 0.0016 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0033 0.0529
Plasmodium vivax importin-beta 2, putative 0.0032 0.0072 0.0317
Schistosoma mansoni septate junction protein 0.0024 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.1349 0.618
Onchocerca volvulus 0.0416 0.2751 0.8238
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0095 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0038 0.0038
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0038 0.0038
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0038 0.0038
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0072 0.0357 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0088 0.0194
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0295 0.0295
Brugia malayi Protein kinase domain containing protein 0.0183 0.1131 0.3879
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0062 0.0283 0.0969
Schistosoma mansoni cpg binding protein 0.0033 0.0084 0.0084
Onchocerca volvulus 0.0066 0.0311 0.0932
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0086 0.0188
Loa Loa (eye worm) Notch2 0.0024 0.0016 0.0055
Echinococcus multilocularis transmembrane protease serine 3 0.0095 0.0515 0.0515
Toxoplasma gondii PAN/Apple domain-containing protein 0.0066 0.0311 0.2647
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Onchocerca volvulus 0.0064 0.0295 0.0884
Loa Loa (eye worm) hypothetical protein 0.0183 0.1131 0.3879
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.013
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0033 0.0529
Loa Loa (eye worm) notch protein 0.0024 0.0016 0.0055
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.0563 0.0563
Brugia malayi Trypsin-like protease protein 5 0.0095 0.0515 0.1767
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0114
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0033 0.0044
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Toxoplasma gondii hypothetical protein 0.0066 0.0311 0.2647
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0033 0.009
Echinococcus granulosus tissue type plasminogen activator 0.0183 0.1131 0.1131
Schistosoma mansoni microtubule-associated protein tau 0.1454 1 1
Toxoplasma gondii PAN domain-containing protein 0.0066 0.0311 0.2647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0034 0.0091 0.0091
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.0311 0.1067
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0072 0.0357 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0283 0.0969
Echinococcus granulosus phd:f box containing protein 0.0027 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.0693
Loa Loa (eye worm) hypothetical protein 0.0062 0.0283 0.0969
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0072 0.0357 0.1497
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0095 0.0515 0.0515
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0137 0.0137
Onchocerca volvulus 0.0095 0.0515 0.1543
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.2212 0.7583
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0202 0.0693
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0129 0.0441
Echinococcus granulosus glycoprotein Antigen 5 0.0095 0.0515 0.0515
Echinococcus multilocularis protein jagged 2 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0034 0.0086 0.0295
Brugia malayi Trypsin family protein 0.0095 0.0515 0.1767
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0129 0.0316
Giardia lamblia Pyruvate kinase 0.0034 0.0086 1
Echinococcus multilocularis Tolloid protein 1 0.0062 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0295 0.0295
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0057 0.0057
Echinococcus granulosus protein jagged 1 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0095 0.0515 0.0515
Echinococcus granulosus fibropellin Ia 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0072 0.0357 0.1497
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.2167 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0086 0.0188
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0086 0.1637
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0129 0.3323
Schistosoma mansoni slit 0.0024 0.0016 0.0016
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0129 0.0316
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.2988 0.2988
Plasmodium falciparum cysteine repeat modular protein 1 0.0183 0.1131 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0072 0.0163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0295 0.2504
Echinococcus granulosus X box binding protein 1 0.0607 0.4088 0.4088
Echinococcus multilocularis neurogenic locus notch protein 4 0.0024 0.0016 0.0016
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Schistosoma mansoni cpg binding protein 0.0032 0.0072 0.0072
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0072 0.0072
Toxoplasma gondii microneme protein MIC17C 0.0066 0.0311 0.2647
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0177 0.0715
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0033 0.009
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0129 0.0316
Brugia malayi Trypsin family protein 0.0095 0.0515 0.1767
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Brugia malayi Calcium binding EGF domain containing protein 0.0024 0.0016 0.0055
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0062 0.0283 0.0969
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0033 0.0044
Onchocerca volvulus 0.0066 0.0311 0.0932
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.0311 0.1067
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0038 0.0038
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0024 0.0016 0.0016
Onchocerca volvulus 0.0024 0.0016 0.0048
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.2167 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Entamoeba histolytica aminopeptidase, putative 0.0072 0.0357 1
Onchocerca volvulus 0.0439 0.2916 0.8731
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0086 0.0291
Brugia malayi Fibulin-1 precursor 0.0062 0.0283 0.0969
Schistosoma mansoni cpg binding protein 0.0033 0.0084 0.0084
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0024 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0161 0.0974 0.0974
Schistosoma mansoni hypothetical protein 0.0095 0.0515 0.0515
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0072 0.0357 0.2916
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.1101 0.3774
Echinococcus multilocularis neurogenic locus protein delta 0.0024 0.0016 0.0016
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0034 0.0088 0.0194
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0031 0.0021
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0029 0.0057 0.0057
Onchocerca volvulus 0.0066 0.0311 0.0932
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0031 0.0021
Schistosoma mansoni notch 0.0024 0.0016 0.0016
Brugia malayi jmjC domain containing protein 0.0027 0.0038 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.2167 1
Leishmania major importin beta-1 subunit, putative 0.0026 0.0031 0.0032
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.0311 0.1067
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.0311 0.1067
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0034 0.0088 0.0194
Schistosoma mansoni notch 0.0024 0.0016 0.0016
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0015 0.0052
Loa Loa (eye worm) aspartyl aminopeptidase 0.0072 0.0357 0.1223
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0114
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Onchocerca volvulus 0.0024 0.0016 0.0048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0335 0.0335
Onchocerca volvulus 0.0032 0.0072 0.0214
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0086 0.063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0102 0.0563 0.1931
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Trypanosoma brucei hypothetical protein, conserved 0.0215 0.1349 0.6155
Loa Loa (eye worm) hypothetical protein 0.0062 0.0283 0.0969
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Schistosoma mansoni pyruvate kinase 0.0034 0.0086 0.0086
Onchocerca volvulus 0.0416 0.2751 0.8238
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Onchocerca volvulus 0.0095 0.0515 0.1543
Schistosoma mansoni notch 0.0024 0.0016 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0129 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0033 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0129 0.0316
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0095 0.0515 0.0515
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0072 0.0163
Echinococcus granulosus survival motor neuron protein 1 0.026 0.1665 0.1665
Brugia malayi Muscle positioning protein 4 0.0439 0.2916 0.9997
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.1101 0.3774
Schistosoma mansoni jumonji/arid domain-containing protein 0.0102 0.0563 0.0563
Plasmodium falciparum phd finger protein, putative 0.0029 0.0057 0.0171
Echinococcus granulosus lysine specific demethylase 5A 0.0102 0.0563 0.0563
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0202 0.0693
Leishmania major pyruvate kinase 0.0034 0.0086 0.0291
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Echinococcus granulosus enteropeptidase 0.0095 0.0515 0.0515
Loa Loa (eye worm) TK/ROR protein kinase 0.0183 0.1131 0.3879
Leishmania major pyruvate kinase 0.0034 0.0086 0.0291
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0072 0.0357 0.1004
Echinococcus multilocularis Mastin 0.0095 0.0515 0.0515
Toxoplasma gondii hypothetical protein 0.0054 0.0225 0.1874
Toxoplasma gondii subtilisin SUB12 0.0066 0.0311 0.2647
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0016 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0183 0.1131 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0091 0.0313
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Onchocerca volvulus 0.0095 0.0515 0.1543
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0086 0.0227
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0285 0.241
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0086 0.0295
Echinococcus multilocularis glycoprotein Antigen 5 0.0095 0.0515 0.0515
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0086 0.0295
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0033 0.009
Entamoeba histolytica hypothetical protein 0.0026 0.0031 0.0456
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0038 0.0038
Echinococcus multilocularis pyruvate kinase 0.0034 0.0086 0.0086
Schistosoma mansoni egf-like domain protein 0.0062 0.0283 0.0283
Toxoplasma gondii calcium binding egf domain-containing protein 0.0062 0.0283 0.2391
Leishmania major hypothetical protein, conserved 0.0027 0.0038 0.0066
Loa Loa (eye worm) hypothetical protein 0.0068 0.0323 0.1109
Onchocerca volvulus 0.0066 0.0311 0.0932
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Brugia malayi PAN domain containing protein 0.0066 0.0311 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0088 0.0194
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Onchocerca volvulus Neurogenic locus notch homolog 0.0024 0.0016 0.0048
Toxoplasma gondii PAN domain-containing protein 0.0066 0.0311 0.2647
Schistosoma mansoni survival motor neuron protein 0.0053 0.0221 0.0221
Schistosoma mansoni cell polarity protein 0.0024 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0057 0.0171
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0033 0.0044
Onchocerca volvulus 0.0024 0.0016 0.0048
Loa Loa (eye worm) PAN domain-containing protein 0.0066 0.0311 0.1067
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0129 0.0316
Echinococcus multilocularis cpg binding protein 0.0033 0.0084 0.0084
Onchocerca volvulus 0.0066 0.0311 0.0932
Echinococcus multilocularis fibrillin 1 0.0062 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0095 0.0515 0.1767
Brugia malayi GCC2 and GCC3 family protein 0.0024 0.0016 0.0055
Toxoplasma gondii microneme protein MIC4 0.0066 0.0311 0.2647
Brugia malayi Trypsin family protein 0.0095 0.0515 0.1767
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0137 0.0137
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0086 0.0441
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0086 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0114
Onchocerca volvulus 0.0095 0.0515 0.1543
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0072 0.0357 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0416 0.2751 0.9432
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0221 0.0758
Echinococcus multilocularis notch 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.0295 0.1012
Echinococcus granulosus neurogenic locus protein delta 0.0024 0.0016 0.0016
Onchocerca volvulus 0.0095 0.0515 0.1543
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0072 0.0357 0.1553
Loa Loa (eye worm) hypothetical protein 0.0072 0.0357 0.1223
Echinococcus granulosus neural cadherin 0.0024 0.0016 0.0016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0031 0.0021
Schistosoma mansoni notch 0.0024 0.0016 0.0016
Schistosoma mansoni alpha-glucosidase 0.0154 0.0927 0.0927
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0086 0.0295
Schistosoma mansoni hypothetical protein 0.0338 0.2212 0.2212
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0129 0.101
Brugia malayi MH2 domain containing protein 0.0131 0.0767 0.2629
Echinococcus multilocularis snurportin 1 0.0338 0.2212 0.2212
Trypanosoma brucei glucosidase, putative 0.004 0.0129 0.0426
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0275 0.0943
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Onchocerca volvulus 0.0024 0.0016 0.0048
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0016 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0033 0.0529
Brugia malayi Kringle domain containing protein 0.0183 0.1131 0.3879
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0129 0.0316
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0072 0.0357 0.2916
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1101 0.1101
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0038 0.013
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0177 0.0653
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0086 0.0227
Echinococcus granulosus slit 2 protein 0.0024 0.0016 0.0016
Onchocerca volvulus 0.0183 0.1131 0.3387
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0072 0.0357 0.1004
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.2167 1
Onchocerca volvulus 0.0066 0.0311 0.0932
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0038 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0295 0.0295
Schistosoma mansoni notch 0.0024 0.0016 0.0016
Brugia malayi Delta serrate ligand family protein 0.0024 0.0016 0.0055
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0033 0.0114
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0072 0.0357 0.3178
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0072 0.0357 0.1004
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0129 0.0316
Echinococcus granulosus laminin 0.0062 0.0283 0.0283
Schistosoma mansoni importin beta-1 0.0032 0.0072 0.0072
Schistosoma mansoni jumonji domain containing protein 0.0141 0.0836 0.0836
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0057 0.0194
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0066 0.0311 0.1067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0295 0.0295
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0129 0.0489
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Echinococcus multilocularis X box binding protein 1 0.0607 0.4088 0.4088
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0062 0.0283 0.0969
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0086 0.0295
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0038 0.0038
Onchocerca volvulus 0.05 0.334 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0062 0.0283 0.0283
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0057 0.0364
Echinococcus granulosus transmembrane protease serine 3 0.0095 0.0515 0.0515
Brugia malayi EGF-like domain containing protein 0.0024 0.0016 0.0055
Brugia malayi RNA, U transporter 1 0.009 0.048 0.1646
Brugia malayi CXXC zinc finger family protein 0.0032 0.0072 0.0245
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0057 0.0364
Echinococcus granulosus dnaJ subfamily B 0.0449 0.2988 0.2988
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0033 0.009
Onchocerca volvulus Slit protein homolog 0.0024 0.0016 0.0048
Loa Loa (eye worm) hypothetical protein 0.0072 0.0357 0.1223
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0129 0.0441
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.1071 1
Echinococcus granulosus peregrin 0.0029 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.0095 0.0515 0.4694
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0249
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0031 0.0032
Onchocerca volvulus Putative cubilin 0.0024 0.0016 0.0048
Loa Loa (eye worm) hypothetical protein 0.026 0.1665 0.5707
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0055
Onchocerca volvulus 0.0066 0.0311 0.0932
Brugia malayi Calcium binding EGF domain containing protein 0.0024 0.0016 0.0055
Echinococcus granulosus snurportin 1 0.0338 0.2212 0.2212
Onchocerca volvulus 0.0066 0.0311 0.0932
Echinococcus multilocularis aspartyl aminopeptidase 0.0072 0.0357 0.0357
Schistosoma mansoni alpha-glucosidase 0.0154 0.0927 0.0927
Schistosoma mansoni hypothetical protein 0.0024 0.0016 0.0016
Toxoplasma gondii microneme protein MIC17A 0.0066 0.0311 0.2647
Echinococcus multilocularis pyruvate kinase 0.0034 0.0086 0.0086
Onchocerca volvulus 0.0095 0.0515 0.1543
Onchocerca volvulus 0.0416 0.2751 0.8238
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0095 0.0515 0.0515
Schistosoma mansoni cercarial elastase (S01 family) 0.0095 0.0515 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0088 0.0194
Loa Loa (eye worm) hypothetical protein 0.0416 0.2751 0.9432
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0038 0.013
Onchocerca volvulus 0.0053 0.0221 0.0662
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0194
Mycobacterium ulcerans hypothetical protein 0.0175 0.1071 1
Echinococcus granulosus delta-like protein 1 0.0024 0.0016 0.0016
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0086 0.0258
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0024 0.0016 0.0048
Leishmania major hypothetical protein, conserved 0.0215 0.1349 0.618
Brugia malayi PHD-finger family protein 0.0029 0.0057 0.0194
Echinococcus granulosus pyruvate kinase 0.0034 0.0086 0.0086
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0086 0.0258
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0038 0.0197
Echinococcus multilocularis peregrin 0.0029 0.0057 0.0057
Toxoplasma gondii PAN domain-containing protein 0.0066 0.0311 0.2647
Brugia malayi Aspartyl aminopeptidase 0.0072 0.0357 0.1223
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0057 0.0057
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.005 0.005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0177 0.0715

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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