Detailed information for compound 695869

Basic information

Technical information
  • TDR Targets ID: 695869
  • Name: 2-[3-(3-bromophenyl)-6-oxopyridazin-1-yl]-N,N -dimethyl-3-oxobutanamide
  • MW: 378.221 | Formula: C16H16BrN3O3
  • H donors: 0 H acceptors: 3 LogP: 1.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)c1ccc(=O)n(n1)C(C(=O)N(C)C)C(=O)C
  • InChi: 1S/C16H16BrN3O3/c1-10(21)15(16(23)19(2)3)20-14(22)8-7-13(18-20)11-5-4-6-12(17)9-11/h4-9,15H,1-3H3
  • InChiKey: FHARBLCWPCBFEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(3-bromophenyl)-6-oxo-pyridazin-1-yl]-N,N-dimethyl-3-oxo-butanamide
  • 2-[3-(3-bromophenyl)-6-oxo-1-pyridazinyl]-N,N-dimethyl-3-oxobutanamide
  • 2-[3-(3-bromophenyl)-6-keto-pyridazin-1-yl]-3-keto-N,N-dimethyl-butyramide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0014 0.0035 0.0035
Schistosoma mansoni tubulin subunit gamma 0.0028 0.0199 0.0199
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0295 0.0431
Trypanosoma cruzi epsilon tubulin, putative 0.0028 0.0199 0.026
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0199 0.0291
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0087 0.0357
Schistosoma mansoni cell adhesion molecule 0.0014 0.0035 0.0035
Brugia malayi dihydrofolate reductase family protein 0.0178 0.1853 0.271
Loa Loa (eye worm) tubulin beta-2A chain 0.0028 0.0199 0.0291
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.002 0.003
Trypanosoma brucei epsilon tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0023 0.0139 0.0203
Leishmania major beta tubulin 0.0028 0.0199 0.026
Schistosoma mansoni septate junction protein 0.0014 0.0035 0.0035
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0023 0.0139 0.0171
Schistosoma mansoni septate junction protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) tubulin alpha-3 chain 0.0012 0.0022 0.0032
Schistosoma mansoni hypothetical protein 0.0171 0.1772 0.1772
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0087 0.0128
Brugia malayi Tubulin gamma chain 0.0028 0.0199 0.0291
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Schistosoma mansoni tyrosine kinase 0.03 0.3201 0.3201
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0199 0.0291
Leishmania major beta tubulin 0.0028 0.0199 0.026
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0087 0.0096
Entamoeba histolytica tubulin family protein 0.0028 0.0199 0.0166
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0199 0.0291
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.1895
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Echinococcus granulosus peroxidasin 0.0014 0.0036 0.0053
Trypanosoma brucei alpha tubulin 0.0028 0.0199 0.026
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.0295
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Echinococcus granulosus beta tubulin 0.0028 0.0199 0.0291
Brugia malayi hypothetical protein 0.0305 0.3249 0.4751
Echinococcus multilocularis tubulin alpha 1C chain 0.0028 0.0199 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Loa Loa (eye worm) TK/INSR protein kinase 0.0099 0.0979 0.1432
Leishmania major beta tubulin 0.0028 0.0199 0.026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Echinococcus granulosus tubulin alpha 1C chain 0.0028 0.0199 0.0291
Schistosoma mansoni tubulin subunit beta 0.0012 0.0022 0.0022
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni tyrosine kinase 0.0157 0.1622 0.1622
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0139 0.0171
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0035 0.0052
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0023 0.0139 0.0203
Brugia malayi Tubulin beta chain 0.0012 0.0022 0.0032
Giardia lamblia Beta tubulin 0.0028 0.0199 0.026
Echinococcus granulosus roundabout 2 0.0014 0.0035 0.0052
Brugia malayi Protein kinase domain containing protein 0.0099 0.0979 0.1432
Echinococcus granulosus alpha tubulin 0.0028 0.0199 0.0291
Echinococcus granulosus tubulin alpha chain 0.0028 0.0199 0.0291
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0199 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0092
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0062 0.0058
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0023 0.0139 0.0203
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.0139 0.0203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0063 0.0061
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0178 0.1853 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0062 0.0058
Brugia malayi alpha-tubulin 0.0028 0.0199 0.0291
Entamoeba histolytica serine/threonine protein kinase, putative 0.063 0.6839 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0062 0.009
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0062 0.0645
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Brugia malayi tubulin alpha-2 chain 0.0028 0.0199 0.0291
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0199 0.0291
Plasmodium vivax tubulin gamma chain, putative 0.0028 0.0199 0.2878
Brugia malayi Cell division protein ftsZ 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0359 0.3853 0.5635
Giardia lamblia Beta tubulin 0.0028 0.0199 0.026
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Echinococcus granulosus lachesin 0.0014 0.0035 0.0052
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus serine:threonine protein kinase PLK1 0.063 0.6839 1
Schistosoma mansoni cell adhesion molecule 0.0014 0.0035 0.0035
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0035 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0062 0.009
Echinococcus granulosus tubulin alpha 0.0028 0.0199 0.0291
Leishmania major hypothetical protein, conserved 0.0023 0.0139 0.0171
Echinococcus granulosus tubulin beta 1 chain 0.0028 0.0199 0.0291
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0087 0.1061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0062 0.009
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0199 0.0291
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0199 0.026
Plasmodium falciparum tubulin epsilon chain, putative 0.0028 0.0199 0.2878
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0063 0.0061
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0165 0.171 0.25
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0062 0.0217
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0068 0.0638 0.3174
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0237 0.0346
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Chlamydia trachomatis dihydrofolate reductase 0.0178 0.1853 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Echinococcus granulosus neuroglian 0.0014 0.0035 0.0052
Brugia malayi beta-tubulin, identical 0.0028 0.0199 0.0291
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Brugia malayi Dihydrofolate reductase 0.0178 0.1853 0.271
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0188 0.1963 0.287
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0237 0.0346
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0644 0.0942
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0199 0.0291
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0199 0.026
Echinococcus multilocularis tubulin beta 1 chain 0.0028 0.0199 0.0291
Echinococcus multilocularis GPCR, family 2 0.0032 0.0237 0.0346
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0126 0.1282 0.1874
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0062 0.009
Brugia malayi tubulin alpha chain - mouse 0.0028 0.0199 0.0291
Schistosoma mansoni tubulin subunit beta 0.0028 0.0199 0.0199
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0199 0.026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0064 0.0591 0.0864
Trypanosoma brucei alpha tubulin 0.0028 0.0199 0.026
Echinococcus granulosus epidermal growth factor receptor 0.03 0.3201 0.4681
Trypanosoma brucei beta tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0199 0.0291
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni hypothetical protein 0.0032 0.0237 0.0237
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0494 0.5346 0.7817
Schistosoma mansoni roundabout 0.0014 0.0035 0.0035
Brugia malayi Tubulin alpha-2 chain 0.0028 0.0199 0.0291
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0139 0.0203
Trichomonas vaginalis tubulin, putative 0.0016 0.0063 0.0061
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0178 0.1853 1
Toxoplasma gondii beta-tubulin, putative 0.0028 0.0199 0.0914
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0199 0.0291
Plasmodium falciparum phosphodiesterase gamma, putative 0.0023 0.0139 0.1895
Echinococcus granulosus tubulin alpha 3 chain 0.0028 0.0199 0.0291
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0139 0.0203
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0188 0.1963 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.063 0.6839 1
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0016 0.0067 0.0098
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Leishmania major beta tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis roundabout 2 0.0014 0.0035 0.0052
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0012 0.002 0.003
Echinococcus granulosus tubulin alpha chain 0.0028 0.0199 0.0291
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0593 0.0867
Leishmania major beta tubulin 0.0028 0.0199 0.026
Trypanosoma brucei alpha tubulin 0.0028 0.0199 0.026
Schistosoma mansoni tubulin subunit beta 0.0028 0.0199 0.0199
Echinococcus multilocularis tubulin subunit beta 0.0028 0.0199 0.0291
Loa Loa (eye worm) alpha-tubulin 0.0028 0.0199 0.0291
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.1895
Echinococcus granulosus tubulin alpha chain 0.0028 0.0199 0.0291
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0063 0.0586 0.0857
Trichomonas vaginalis tubulin, putative 0.0016 0.0063 0.0061
Trypanosoma cruzi beta tubulin, putative 0.0028 0.0199 0.026
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1214 0.1776
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0199 0.0199
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0028 0.0199 0.026
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0199 0.0291
Loa Loa (eye worm) raf kinase 0.0213 0.2236 0.3269
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Loa Loa (eye worm) hypothetical protein 0.0028 0.0199 0.0291
Leishmania major beta tubulin 0.0028 0.0199 0.026
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0199 0.0199
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Loa Loa (eye worm) hypothetical protein 0.01 0.0995 0.1456
Entamoeba histolytica tubulin family protein 0.0028 0.0199 0.0166
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.2184 0.3172
Schistosoma mansoni tyrosine kinase 0.0099 0.0979 0.0979
Loa Loa (eye worm) tubulin beta chain 0.0028 0.0199 0.0291
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0593 0.0837
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni nephrin 0.0014 0.0035 0.0035
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0023 0.0139 0.0203
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0062 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0139 0.0171
Giardia lamblia Beta tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis peroxisome assembly protein 26 0.0028 0.0199 0.0291
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.1895
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.063 0.6839 1
Schistosoma mansoni tubulin subunit beta 0.0028 0.0199 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0014 0.0035 0.0052
Leishmania major hypothetical protein, conserved 0.0023 0.0139 0.0171
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0139 0.0203
Plasmodium vivax phosphodiesterase gamma, putative 0.0023 0.0139 0.1895
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.2184 0.3172
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0087 1
Plasmodium vivax tubulin alpha chain, putative 0.0028 0.0199 0.2878
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0199 0.026
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0995 0.1456
Echinococcus multilocularis peroxidasin 0.0014 0.0036 0.0053
Echinococcus multilocularis roundabout 2 0.0014 0.0035 0.0052
Schistosoma mansoni alpha tubulin 0.0028 0.0199 0.0199
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0068 0.0638 0.0904
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0063 0.0061
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0295 0.0431
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0139 0.0203
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0237 0.0346
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.0139 0.0139
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0014 0.0035 0.0052
Plasmodium falciparum alpha tubulin 2 0.0028 0.0199 0.2878
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0644 0.0942
Toxoplasma gondii exonuclease III APE 0.0018 0.0087 0.0337
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0199 0.0291
Schistosoma mansoni hypothetical protein 0.0171 0.1772 0.1772
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Brugia malayi Tubulin alpha chain 0.0028 0.0199 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0139 0.0171
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Loa Loa (eye worm) tubulin alpha-2 chain 0.0028 0.0199 0.0291
Trypanosoma brucei beta tubulin 0.0028 0.0199 0.026
Echinococcus granulosus contactin 0.0014 0.0035 0.0052
Trypanosoma brucei beta tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis tubulin epsilon chain 0.0028 0.0199 0.0291
Brugia malayi Furin-like cysteine rich region family protein 0.03 0.3201 0.4681
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0087 0.0096
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0028 0.0199 0.0291
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0062 0.009
Schistosoma mansoni alpha tubulin 0.0028 0.0199 0.0199
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0035 0.0052
Giardia lamblia Kinase, PLK 0.063 0.6839 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0139 0.0203
Echinococcus granulosus beta tubulin 0.0028 0.0199 0.0291
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0062 0.0062
Echinococcus granulosus insulin receptor 0.0099 0.0979 0.1432
Onchocerca volvulus 0.0346 0.3701 0.5388
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0237 0.0346
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0033 0.0253 0.0339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Schistosoma mansoni ap endonuclease 0.0018 0.0087 0.0087
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0028 0.0199 0.0914
Schistosoma mansoni hypothetical protein 0.0069 0.0644 0.0644
Schistosoma mansoni hypothetical protein 0.0032 0.0237 0.0237
Schistosoma mansoni alpha tubulin 0.0028 0.0199 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0139 0.0171
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.0139 0.0203
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0199 0.026
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0593 0.0593
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0199 0.0291
Schistosoma mansoni tubulin subunit epsilon 0.0028 0.0199 0.0199
Leishmania major beta tubulin 0.0028 0.0199 0.026
Loa Loa (eye worm) tubulin alpha chain 0.0028 0.0199 0.0291
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0286 0.0419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0995 0.1456
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0199 0.0291
Echinococcus granulosus tubulin alpha chain 0.0028 0.0199 0.0291
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Toxoplasma gondii beta tubulin 0.0028 0.0199 0.0914
Echinococcus granulosus dihydrofolate reductase 0.0178 0.1853 0.271
Brugia malayi Tubulin beta chain 0.0016 0.0063 0.0092
Echinococcus granulosus epidermal growth factor receptor 0.0163 0.169 0.2472
Giardia lamblia Hypothetical protein 0.0023 0.0139 0.0171
Entamoeba histolytica tubulin alpha-1 chain 0.0028 0.0199 0.0166
Toxoplasma gondii beta-1 tubulin, putative 0.0028 0.0199 0.0914
Echinococcus granulosus tubulin alpha 1C chain 0.0028 0.0199 0.0291
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0068 0.0638 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0165 0.171 0.25
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Entamoeba histolytica tubulin alpha chain, putative 0.0028 0.0199 0.0166
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0062 0.0645
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0139 0.0171
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0062 0.0058
Loa Loa (eye worm) dihydrofolate reductase 0.0178 0.1853 0.271
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0087 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0237 0.0346
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0023 0.0139 0.0171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Onchocerca volvulus Tyrosine kinase homolog 0.0358 0.3835 0.5586
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.0295
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0087 0.0128
Echinococcus multilocularis epidermal growth factor receptor 0.0163 0.169 0.2472
Leishmania major beta tubulin 0.0028 0.0199 0.026
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0199 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0139 0.0171
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0199 0.0291
Leishmania major beta tubulin 0.0028 0.0199 0.026
Leishmania major beta tubulin 0.0028 0.0199 0.026
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0165 0.171 0.25
Brugia malayi MH2 domain containing protein 0.012 0.1214 0.1776
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0188 0.1963 0.287
Echinococcus granulosus roundabout 2 0.0014 0.0035 0.0052
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0593 0.0837
Schistosoma mansoni ap endonuclease 0.0018 0.0087 0.0087
Leishmania major beta tubulin 0.0028 0.0199 0.026
Echinococcus granulosus geminin 0.0171 0.1772 0.2591
Echinococcus multilocularis hemicentin 1 0.0014 0.0035 0.0052
Echinococcus multilocularis beta tubulin 0.0028 0.0199 0.0291
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus multilocularis tubulin alpha 1C chain 0.0028 0.0199 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Brugia malayi serine/threonine-protein kinase plk-2 0.063 0.6839 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0139 0.0203
Loa Loa (eye worm) tubulin alpha chain 0.0028 0.0199 0.0291
Schistosoma mansoni dihydrofolate reductase 0.0178 0.1853 0.1853
Schistosoma mansoni tyrosine kinase 0.0099 0.0979 0.0979
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0087 0.0096
Loa Loa (eye worm) tubulin beta chain 0.0012 0.0022 0.0032
Trypanosoma brucei polo-like protein kinase 0.063 0.6839 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0237 0.0346
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0099 0.0979 0.1432
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0199 0.026
Brugia malayi Blistered cuticle protein 3 0.0033 0.0253 0.037
Echinococcus multilocularis hemicentin 1 0.0014 0.0035 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0023 0.0139 0.0139
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0188 0.1963 0.2847
Loa Loa (eye worm) tubulin beta-1 chain 0.0028 0.0199 0.0291
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0165 0.171 0.25
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0593 0.0867
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.0295
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0062 0.0205
Schistosoma mansoni tyrosine kinase 0.0157 0.1622 0.1622
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0068 0.0638 0.0904
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0023 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0203
Echinococcus multilocularis tubulin gamma 1 chain 0.0028 0.0199 0.0291
Leishmania major epsilon tubulin, putative 0.0028 0.0199 0.026
Schistosoma mansoni tubulin subunit delta 0.0012 0.0022 0.0022
Trypanosoma brucei beta tubulin 0.0028 0.0199 0.026
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0062 0.009
Echinococcus multilocularis beta tubulin 0.0028 0.0199 0.0291
Echinococcus granulosus raf serine:threonine protein kinase 0.0219 0.2304 0.337
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0494 0.5346 0.7817
Onchocerca volvulus Serine\/threonine kinase homolog 0.063 0.6839 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0139 0.0203
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus multilocularis tubulin alpha 0.0028 0.0199 0.0291
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0063 0.0586 0.0857
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0087 0.0096
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.1895
Echinococcus granulosus hemicentin 1 0.0014 0.0035 0.0052
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1214 0.1776
Toxoplasma gondii alpha-tubulin I, putative 0.0028 0.0199 0.0914
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0014 0.0035 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0139 0.0171
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0062 0.0205
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0163 0.169 0.2472
Brugia malayi Protein kinase domain containing protein 0.0063 0.0586 0.0857
Echinococcus granulosus tubulin alpha chain 0.0028 0.0199 0.0291
Leishmania major beta tubulin 0.0028 0.0199 0.026
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni tubulin subunit beta 0.0028 0.0199 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0062 0.0058
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0199 0.026
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0139 0.0171
Plasmodium falciparum tubulin gamma chain 0.0028 0.0199 0.2878
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0035 0.0052
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus tubulin subunit beta 0.0028 0.0199 0.0291
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0062 0.009
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0023 0.0139 0.0203
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0199 0.0291
Brugia malayi Raf kinase 0.0212 0.2222 0.3249
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0593 0.0867
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0593 0.0837
Trypanosoma cruzi alpha tubulin, putative 0.0028 0.0199 0.026
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0099 0.0979 0.1432
Echinococcus multilocularis geminin 0.0171 0.1772 0.2591
Schistosoma mansoni hypothetical protein 0.0032 0.0237 0.0237
Brugia malayi Tubulin beta-1 chain 0.0028 0.0199 0.0291
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0033 0.0253 0.0339
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0188 0.1963 0.287
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.063 0.6839 1
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0139 0.1895
Echinococcus multilocularis tyrosine protein kinase otk 0.0014 0.0035 0.0052
Plasmodium vivax tubulin alpha chain, putative 0.0028 0.0199 0.2878
Giardia lamblia Gamma tubulin 0.0028 0.0199 0.026
Onchocerca volvulus 0.0016 0.0063 0.0041
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Echinococcus multilocularis neuroglian 0.0014 0.0035 0.0052
Echinococcus granulosus tubulin gamma 1 chain 0.0028 0.0199 0.0291
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0053
Echinococcus granulosus roundabout 2 0.0014 0.0035 0.0052
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Toxoplasma gondii alpha tubulin TUBA1 0.0028 0.0199 0.0914
Schistosoma mansoni hypothetical protein 0.0032 0.0237 0.0237
Loa Loa (eye worm) beta-tubulin 0.0028 0.0199 0.0291
Echinococcus multilocularis roundabout 2 0.0014 0.0035 0.0052
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0286 0.0419
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0286 0.0286
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0014 0.0035 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0995 0.1456
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0139 0.0171
Echinococcus multilocularis tubulin alpha 3 chain 0.0028 0.0199 0.0291
Leishmania major gamma-tubulin 0.0028 0.0199 0.026
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Trypanosoma cruzi polo-like protein kinase, putative 0.063 0.6839 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0199 0.0199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0063 0.0061
Schistosoma mansoni serine/threonine protein kinase 0.063 0.6839 0.6839
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0139 0.0203
Trichomonas vaginalis tubulin, putative 0.0028 0.0199 0.026
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0087 0.1061
Schistosoma mansoni tyrosine kinase 0.0157 0.1622 0.1622
Brugia malayi Tubulin alpha-2 chain 0.0028 0.0199 0.0291
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Loa Loa (eye worm) tubulin alpha 2 0.0016 0.0063 0.0092
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus multilocularis tubulin alpha 3 chain 0.0028 0.0199 0.0291
Brugia malayi hypothetical protein 0.0036 0.0286 0.0419
Loa Loa (eye worm) tubulin beta-4 chain 0.0028 0.0199 0.0291
Giardia lamblia Alpha-tubulin 0.0028 0.0199 0.026
Schistosoma mansoni tyrosine kinase 0.0163 0.169 0.169
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Trypanosoma cruzi epsilon tubulin, putative 0.0028 0.0199 0.026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0139 0.0602
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2304 0.2304
Onchocerca volvulus 0.0305 0.3249 0.4724
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0063 0.0061
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni neuroglian 0.0014 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0036 0.0286 0.0286
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0012 0.002 0.003
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0087 0.0357
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0068 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0359 0.3853 0.5635
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Loa Loa (eye worm) hypothetical protein 0.0188 0.1963 0.287
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis lachesin 0.0014 0.0035 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Loa Loa (eye worm) PDE1B protein 0.0023 0.0139 0.0203
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0188 0.1963 0.287
Brugia malayi Tubulin alpha chain 0.0012 0.0022 0.0032
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0139 0.0171
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0199 0.0291
Echinococcus granulosus tubulin alpha 3 chain 0.0028 0.0199 0.0291
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Entamoeba histolytica hypothetical protein 0.0036 0.0286 0.0295
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0023 0.0139 0.0203
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0593 0.0867
Echinococcus multilocularis epidermal growth factor receptor 0.03 0.3201 0.4681
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0199 0.0291
Schistosoma mansoni tubulin subunit alpha 0.0012 0.0022 0.0022
Schistosoma mansoni titin 0.0014 0.0035 0.0035
Leishmania major beta tubulin 0.0028 0.0199 0.026
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus multilocularis tubulin subunit TubB 0.0028 0.0199 0.0291
Schistosoma mansoni tyrosine kinase 0.002 0.0104 0.0104
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0203
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0199 0.0291
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0014 0.0035 0.0035
Onchocerca volvulus Dual oxidase homolog 0.0033 0.0253 0.032
Trypanosoma brucei tubulin gamma chain 0.0028 0.0199 0.026
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0188 0.1963 0.1963
Entamoeba histolytica tubulin gamma chain 0.0028 0.0199 0.0166
Schistosoma mansoni tubulin subunit beta 0.0028 0.0199 0.0199
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.1895
Plasmodium vivax tubulin epsilon chain, putative 0.0028 0.0199 0.2878
Echinococcus granulosus tubulin epsilon chain 0.0028 0.0199 0.0291
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0139 0.0171
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0139 0.0139
Leishmania major beta tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0199 0.0291
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0199 0.0291
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0139 0.0203
Echinococcus multilocularis insulin receptor 0.0099 0.0979 0.1432
Trichomonas vaginalis CAMK family protein kinase 0.063 0.6839 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0593 0.0749
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0178 0.1853 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0062 0.0058
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0023 0.0139 0.0171
Brugia malayi Peroxidasin 0.0014 0.0036 0.0053
Leishmania major beta tubulin 0.0028 0.0199 0.026
Trypanosoma brucei beta tubulin 0.0028 0.0199 0.026
Echinococcus granulosus tubulin beta 4A class IVa 0.0028 0.0199 0.0291
Loa Loa (eye worm) tubulin gamma chain 0.0028 0.0199 0.0291
Brugia malayi isocitrate dehydrogenase 0.0016 0.0062 0.009
Loa Loa (eye worm) blistered cuticle protein 3 0.0033 0.0253 0.037
Trypanosoma brucei alpha tubulin 0.0028 0.0199 0.026
Leishmania major beta tubulin 0.0028 0.0199 0.026
Giardia lamblia hypothetical protein 0.0023 0.0139 0.0171
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0237 0.0346
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0593 0.0837
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0087 0.0128
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0199 0.026
Giardia lamblia Alpha-tubulin 0.0028 0.0199 0.026
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0139 0.1895
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Loa Loa (eye worm) alpha-tubulin 0.0028 0.0199 0.0291
Trypanosoma cruzi polo-like protein kinase, putative 0.063 0.6839 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0023 0.0139 0.1895
Trypanosoma brucei epsilon tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis hypothetical protein 0.0028 0.0199 0.0291
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0014 0.0035 0.0052
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Leishmania major ferric reductase, putative 0.0033 0.0253 0.0339
Echinococcus granulosus tubulin subunit TubB 0.0028 0.0199 0.0291
Plasmodium falciparum alpha tubulin 1 0.0028 0.0199 0.2878
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0199 0.0291
Trypanosoma brucei alpha tubulin, putative 0.0016 0.0063 0.0061
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0016 0.0063 0.0092
Loa Loa (eye worm) tubulin alpha 2 0.0016 0.0063 0.0092
Loa Loa (eye worm) TK protein kinase 0.0012 0.002 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0139 0.0171
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0023 0.0139 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0087 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0087 0.0096
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0033 0.0253 0.0339
Echinococcus granulosus GPCR family 2 0.0032 0.0237 0.0346
Echinococcus multilocularis tubulin delta chain 0.0012 0.0022 0.0032
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0199 0.0291
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0023 0.0139 0.0171
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0199 0.026
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0023 0.0139 0.0203
Loa Loa (eye worm) TK/EGFR protein kinase 0.03 0.3201 0.4681
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0052
Trypanosoma cruzi tubulin gamma chain 0.0028 0.0199 0.026
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0063 0.0061
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0023 0.0139 0.0171
Leishmania major beta tubulin 0.0028 0.0199 0.026
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.0139 0.0171
Trypanosoma brucei epsilon tubulin 0.0028 0.0199 0.026
Echinococcus granulosus peroxisome assembly protein 26 0.0028 0.0199 0.0291
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0199 0.0291
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Echinococcus granulosus tyrosine protein kinase otk 0.0014 0.0035 0.0052
Echinococcus multilocularis raf serine:threonine protein kinase 0.0219 0.2304 0.337
Loa Loa (eye worm) hypothetical protein 0.0305 0.3249 0.4751
Leishmania major alpha tubulin 0.0028 0.0199 0.026
Plasmodium vivax tubulin beta chain, putative 0.0028 0.0199 0.2878
Echinococcus granulosus tubulin delta chain 0.0012 0.0022 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0139 0.0171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0139 0.0171
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0068 0.0638 0.0904
Echinococcus multilocularis 0.0092 0.0896 0.1311
Brugia malayi Prion-like- 0.0014 0.0035 0.0052
Plasmodium falciparum tubulin beta chain 0.0028 0.0199 0.2878
Schistosoma mansoni tyrosine kinase 0.0163 0.169 0.169
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0012 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0139 0.0203
Leishmania major beta tubulin 0.0028 0.0199 0.026
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0087 0.0128
Echinococcus multilocularis dihydrofolate reductase 0.0178 0.1853 0.271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0237 0.0346
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0035 0.0052
Schistosoma mansoni tubulin subunit beta 0.0028 0.0199 0.0199
Schistosoma mansoni cell adhesion molecule 0.0014 0.0035 0.0035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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