Detailed information for compound 698161

Basic information

Technical information
  • TDR Targets ID: 698161
  • Name: N-(3-fluorophenyl)-1-[(3-fluorophenyl)methyl] -2-oxopyridine-3-carboxamide
  • MW: 340.323 | Formula: C19H14F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)NC(=O)c1cccn(c1=O)Cc1cccc(c1)F
  • InChi: 1S/C19H14F2N2O2/c20-14-5-1-4-13(10-14)12-23-9-3-8-17(19(23)25)18(24)22-16-7-2-6-15(21)11-16/h1-11H,12H2,(H,22,24)
  • InChiKey: XJBJBJHXNZBYPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-fluorophenyl)-1-[(3-fluorophenyl)methyl]-2-oxo-pyridine-3-carboxamide
  • N-(3-fluorophenyl)-1-[(3-fluorophenyl)methyl]-2-oxo-3-pyridinecarboxamide
  • 1-(3-fluorobenzyl)-N-(3-fluorophenyl)-2-keto-nicotinamide
  • ZINC05268740

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0027 0.022 0.0385
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.3037 0.4124
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0631 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0112 0.0971
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0575 0.1271
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0902 0.1268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0271 0.3759 0.5116
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0144 0.0204
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Brugia malayi RNA binding protein 0.0197 0.2684 0.3653
Schistosoma mansoni nuclear receptor 0.0128 0.1683 0.2996
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0143 0.1905 0.3392
Echinococcus granulosus ecdysone induced protein 78C 0.0271 0.3759 0.3756
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0902 0.2227
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0902 0.2227
Schistosoma mansoni hypothetical protein 0.0178 0.2412 0.4297
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0903 0.2085
Echinococcus granulosus geminin 0.0178 0.2412 0.2409
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0631 0.151
Toxoplasma gondii exonuclease III APE 0.002 0.012 0.0697
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0401 0.596
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0143 0.1905 0.3392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0271 0.3759 0.5109
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Loa Loa (eye worm) hypothetical protein 0.0089 0.1117 0.1508
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0112 0.0132
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.5608 0.5606
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.113 0.2648
Brugia malayi hypothetical protein 0.0128 0.1683 0.229
Plasmodium falciparum thioredoxin reductase 0.0046 0.0501 0.7712
Leishmania major hypothetical protein, conserved 0.0074 0.0902 0.2082
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.012 0.0088
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0112 0.0192
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1362 0.8768
Brugia malayi beta-lactamase family protein 0.0074 0.0902 0.1227
Brugia malayi Protein kinase domain containing protein 0.009 0.113 0.1538
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0144 0.0219
Schistosoma mansoni nuclear hormone receptor 0.0271 0.3759 0.6701
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0062 0.0093
Schistosoma mansoni hypothetical protein 0.0178 0.2412 0.4297
Brugia malayi beta-lactamase family protein 0.0074 0.0902 0.1227
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0074 0.0902 0.1215
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0902 0.2082
Trichomonas vaginalis set domain proteins, putative 0.0251 0.3478 0.9059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.012 0.0145
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0903 0.5462
Brugia malayi Nuclear hormone receptor-like 1 0.0143 0.1905 0.2593
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.012 1
Onchocerca volvulus 0.0074 0.0902 0.2096
Echinococcus granulosus Nuclear hormone receptor HR96 0.0128 0.1683 0.1679
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0575 0.6105
Brugia malayi CXXC zinc finger family protein 0.0028 0.0235 0.0319
Leishmania major hypothetical protein, conserved 0.0027 0.022 0.0391
Mycobacterium ulcerans hypothetical protein 0.0074 0.0902 0.2227
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1533 0.2222
Loa Loa (eye worm) glutaminase 2 0.0276 0.3833 0.5211
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.138 0.1377
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0271 0.3759 0.5116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0429 0.091
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0902 0.2227
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.022 0.0391
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0128 0.1683 0.1679
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0271 0.3759 0.3756
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.022 0.048
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0124
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0144 0.0219
Echinococcus granulosus thyroid hormone receptor alpha 0.0128 0.1683 0.1679
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0297 0.0522
Onchocerca volvulus 0.0128 0.1683 0.4256
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0501 0.523
Loa Loa (eye worm) hypothetical protein 0.0115 0.1497 0.2026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0518 0.7347 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0128 0.1683 0.2996
Schistosoma mansoni nuclear hormone receptor 0.0128 0.1683 0.2996
Brugia malayi nuclear receptor NHR-88 0.0271 0.3759 0.5116
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0124
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.012 0.015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.012 0.1027
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0143 0.1905 0.1902
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0271 0.3759 0.3756
Onchocerca volvulus Protein ultraspiracle homolog 0.0271 0.3759 1
Onchocerca volvulus 0.0251 0.3478 0.9224
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0271 0.3759 0.6701
Schistosoma mansoni hypothetical protein 0.0115 0.1497 0.2664
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0631 0.6782
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.027 0.3743 0.3741
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.012 0.0145
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Loa Loa (eye worm) TAR-binding protein 0.0197 0.2684 0.3644
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0144 0.0124
Echinococcus multilocularis tar DNA binding protein 0.0197 0.2684 0.2681
Mycobacterium tuberculosis Conserved protein 0.0074 0.0902 0.1268
Toxoplasma gondii thioredoxin reductase 0.0046 0.0501 0.523
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0144 0.0219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0297 0.0522
Entamoeba histolytica protein kinase, putative 0.009 0.113 0.8027
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.022 0.2768
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0144 0.0296
Echinococcus granulosus dna polymerase eta 0.0019 0.0112 0.0108
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0575 0.0571
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0182
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.012 0.0069
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.022 0.1877
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0575 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0631 0.0846
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0144 0.0124
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0128 0.1683 0.1679
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0143 0.1905 0.2582
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0144 0.0182
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0501 0.0663
Schistosoma mansoni nuclear hormone receptor 0.0128 0.1683 0.2996
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0144 0.0219
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0297 0.0293
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1952 0.3476
Toxoplasma gondii ABC1 family protein 0.0074 0.0902 1
Brugia malayi MAP kinase sur-1 0.0051 0.0575 0.0782
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.012 0.0697
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0144 0.0204
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0271 0.3759 0.5116
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0575 0.1359
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0144 0.0196
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0144 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0271 0.3759 0.5109
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0902 0.5453
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.2046 0.2043
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0575 0.0571
Brugia malayi nuclear hormone receptor family member nhr-6 0.0128 0.1683 0.229
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1533 0.2222
Schistosoma mansoni DNA polymerase eta 0.0019 0.0112 0.0192
Echinococcus multilocularis thyroid hormone receptor alpha 0.0271 0.3759 0.3756
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0903 0.6238
Schistosoma mansoni nuclear receptor 0.0128 0.1683 0.2996
Echinococcus granulosus tar DNA binding protein 0.0197 0.2684 0.2681
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0062 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0363 0.5101 0.6938
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0144 0.0981
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0144 0.0296
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0495 0.0491
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0297 0.0293
Loa Loa (eye worm) hypothetical protein 0.0089 0.1117 0.1508
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Mycobacterium ulcerans glutaminase 0.0276 0.3833 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0363 0.5101 0.6942
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0112 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0271 0.3759 0.5116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.027 0.3743 0.3741
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0144 0.0204
Echinococcus multilocularis geminin 0.0178 0.2412 0.2409
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0144 0.025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.2684 0.3644
Schistosoma mansoni lamin 0.0027 0.022 0.0385
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0112 0.0152
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0903 0.1229
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0112 0.0215
Brugia malayi hypothetical protein 0.0017 0.0081 0.011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0902 0.1268
Onchocerca volvulus 0.0074 0.0903 0.2099
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0143 0.1905 0.2582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0526 0.0522
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0575 0.1271
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0575 0.1271
Schistosoma mansoni nuclear receptor nhr-48 0.0128 0.1683 0.2996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0271 0.3759 0.5109
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1893 0.1889
Echinococcus granulosus lamin dm0 0.0027 0.022 0.0216
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0271 0.3759 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2076 0.3043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0271 0.3759 0.3756
Onchocerca volvulus 0.0103 0.1318 0.3246
Echinococcus granulosus lamin 0.0027 0.022 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0271 0.3759 0.5116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0112 0.0123
Loa Loa (eye worm) oxidoreductase 0.0022 0.0144 0.0182
Entamoeba histolytica hypothetical protein 0.009 0.113 0.8027
Leishmania major DNA polymerase kappa, putative 0.0019 0.0112 0.0123
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.113 0.1526
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0903 0.223
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.1497 0.1493
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0144 0.0196
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.012 1
Schistosoma mansoni cpg binding protein 0.003 0.0258 0.0453
Loa Loa (eye worm) hypothetical protein 0.0074 0.0903 0.1216
Echinococcus multilocularis expressed conserved protein 0.01 0.1286 0.1283
Onchocerca volvulus 0.0074 0.0902 0.2096
Brugia malayi Nuclear hormone receptor E75 0.0128 0.1683 0.229
Loa Loa (eye worm) hypothetical protein 0.0518 0.7347 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1362 0.1964
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0575 0.1271
Brugia malayi hypothetical protein 0.0143 0.1905 0.2593
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0271 0.0267
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.022 0.1877
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0903 0.223
Mycobacterium ulcerans beta-lactamase 0.0074 0.0902 0.2227
Loa Loa (eye worm) beta-lactamase 0.0074 0.0902 0.1215
Echinococcus multilocularis protein dispatched 1 0.0052 0.0589 0.0585
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0112 0.0123
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0453 0.1038
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.1497 0.1493
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.113 0.2648
Loa Loa (eye worm) RNA binding protein 0.0197 0.2684 0.3644
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0093
Loa Loa (eye worm) hypothetical protein 0.0103 0.1318 0.1782
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0271 0.3759 0.5116
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0286
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.1497 0.2026
Mycobacterium tuberculosis Conserved protein 0.0074 0.0902 0.1268
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0112 0.0123
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0018 0.0014
Loa Loa (eye worm) glutaminase 0.0276 0.3833 0.5211
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.138 0.1879
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Loa Loa (eye worm) hypothetical protein 0.0074 0.0903 0.1216
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0144 0.0182
Loa Loa (eye worm) hypothetical protein 0.0055 0.0631 0.0846
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0144 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.0271 0.3759 0.5116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0271 0.3759 0.5116
Schistosoma mansoni hypothetical protein 0.0248 0.3433 0.6119
Echinococcus granulosus intermediate filament protein 0.0027 0.022 0.0216
Trichomonas vaginalis esterase, putative 0.0074 0.0902 0.2227
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0144 0.0981
Brugia malayi orphan nuclear receptor NR2E1 0.0128 0.1683 0.229
Toxoplasma gondii hypothetical protein 0.0047 0.0517 0.5421
Brugia malayi steroid hormone receptor 0.0271 0.3759 0.5116
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.012 0.0237
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0903 0.223
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1362 0.1964
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0526 0.0932
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0902 0.1268
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1362 0.1964
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0271 0.3759 0.5116
Brugia malayi Steroid receptor seven-up type 2 0.0271 0.3759 0.5116
Loa Loa (eye worm) hypothetical protein 0.0074 0.0902 0.1215
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0144 0.014
Trichomonas vaginalis ap endonuclease, putative 0.002 0.012 0.0155
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0902 0.1268
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0453 0.4661
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.2684 0.3653
Brugia malayi Latrophilin receptor protein 2 0.0115 0.1497 0.2037
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0144 0.0219
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0575 0.1359
Onchocerca volvulus 0.0271 0.3759 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0128 0.1683 0.229
Onchocerca volvulus 0.0027 0.022 0.021
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.138 0.1377
Schistosoma mansoni zinc finger protein 0.0128 0.1683 0.2996
Loa Loa (eye worm) hypothetical protein 0.0143 0.1905 0.2582
Schistosoma mansoni thyroid hormone receptor 0.0271 0.3759 0.6701
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.4096 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0501 0.0497
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0276
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0902 0.1227
Onchocerca volvulus 0.0028 0.0235 0.025
Brugia malayi glutathione reductase 0.0046 0.0501 0.0682
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0271 0.3759 0.3756
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.022 0.0286
Loa Loa (eye worm) hypothetical protein 0.0055 0.0631 0.0846
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1848 0.448
Mycobacterium ulcerans hypothetical protein 0.0074 0.0903 0.223
Brugia malayi ecdysteroid receptor 0.0271 0.3759 0.5116
Brugia malayi tailless protein 0.0128 0.1683 0.229
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0128 0.1683 0.4256
Loa Loa (eye worm) steroid hormone receptor 0.0271 0.3759 0.5109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0297 0.2795
Loa Loa (eye worm) hypothetical protein 0.0074 0.0902 0.1215
Schistosoma mansoni glutaminase 0.0276 0.3833 0.6834
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0429 0.091
Loa Loa (eye worm) DR-78 0.0128 0.1683 0.2279
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0144 0.0981
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0112 0.0132
Echinococcus multilocularis GPCR, family 2 0.0115 0.1497 0.1493
Echinococcus granulosus FTZ F1 alpha 0.0271 0.3759 0.3756
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0495 0.0491
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0453 0.4661
Entamoeba histolytica protein kinase, putative 0.009 0.113 0.8027
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.022 0.2768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0526 0.0932
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Loa Loa (eye worm) hypothetical protein 0.0074 0.0902 0.1215
Schistosoma mansoni hypothetical protein 0.0044 0.0471 0.0833
Trypanosoma brucei protein kinase, putative 0.0051 0.0575 0.1352
Onchocerca volvulus 0.0027 0.022 0.021
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0144 0.0124
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0182
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0501 0.0497
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0453 0.1038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0271 0.3759 0.6701
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0144 0.0196
Brugia malayi nuclear hormone receptor 0.0271 0.3759 0.5116
Echinococcus multilocularis dna polymerase eta 0.0019 0.0112 0.0108
Brugia malayi nuclear receptor RXR 0.0143 0.1905 0.2593
Schistosoma mansoni hypothetical protein 0.0044 0.0471 0.0833
Echinococcus granulosus dual specificity 0.009 0.113 0.1126
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0128 0.1683 0.2279
Brugia malayi nuclear receptor NHR-88 0.0128 0.1683 0.229
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0903 0.223
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2684 0.4782
Echinococcus multilocularis musashi 0.0027 0.022 0.0216
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0902 0.0898
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0271 0.3759 0.3756
Echinococcus granulosus expressed conserved protein 0.01 0.1286 0.1283
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0018 0.0014
Mycobacterium tuberculosis Conserved protein 0.0074 0.0902 0.1268
Loa Loa (eye worm) hypothetical protein 0.0074 0.0903 0.1216
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0112 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.4096 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0144 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0588 0.0794
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0112 0.0215
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0903 0.2085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0271 0.3759 0.5109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0271 0.3759 0.5109
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2684 0.4782
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0631 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0495 0.066
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Loa Loa (eye worm) hypothetical protein 0.0248 0.3433 0.4664
Loa Loa (eye worm) nuclear hormone receptor 0.0128 0.1683 0.2279
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0903 0.1229
Schistosoma mansoni hypothetical protein 0.0115 0.1497 0.2664
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0271 0.3759 0.3756
Schistosoma mansoni RAR-like nuclear receptor 0.0271 0.3759 0.6701
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.113 0.2716
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0903 0.1229
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0144 0.0124
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0144 0.0219
Trichomonas vaginalis glutaminase, putative 0.0276 0.3833 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0128 0.1683 0.1679
Loa Loa (eye worm) hypothetical protein 0.0046 0.0495 0.066
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0903 0.127
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0631 0.086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0271 0.3759 0.5109
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0902 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0575 0.1271
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0902 0.2156
Brugia malayi intermediate filament protein 0.0027 0.022 0.0299
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.022 0.0391
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0902 0.1602
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0903 0.2085
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.1318 0.2344
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0143 0.1905 0.1902
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.012 0.0145
Echinococcus multilocularis tumor protein p63 0.0701 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0271 0.3759 0.5116
Schistosoma mansoni ap endonuclease 0.002 0.012 0.0207
Brugia malayi glutaminase DH11.1 0.0276 0.3833 0.5218
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0144 0.0204
Schistosoma mansoni steroid hormone receptor ad4bp 0.0271 0.3759 0.6701
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0902 0.0898
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0903 0.6238
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.012 0.0116
Mycobacterium leprae Probable lipase LipE 0.0074 0.0902 0.5453
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0495 0.0491
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0501 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0271 0.3759 0.5116
Echinococcus multilocularis ecdysone induced protein 78C 0.0271 0.3759 0.3756
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.138 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0902 0.1602
Leishmania major DNA polymerase eta, putative 0.0019 0.0112 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0144 0.0257
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Schistosoma mansoni ap endonuclease 0.002 0.012 0.0207
Trypanosoma brucei trypanothione reductase 0.0046 0.0501 0.1172
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0429 0.091
Brugia malayi Nuclear hormone receptor-like 1 0.0143 0.1905 0.2593
Brugia malayi nuclear hormone receptor 0.0128 0.1683 0.229
Echinococcus granulosus dnaJ subfamily B 0.0398 0.5608 0.5606
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1533 1
Echinococcus multilocularis lamin dm0 0.0027 0.022 0.0216
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0144 0.0219
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0575 0.0769
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.4096 1
Brugia malayi TAR-binding protein 0.0197 0.2684 0.3653
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0575 0.1271
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0271 0.3759 0.6701
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.012 0.0155
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0401 0.662
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0144 0.0219
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1533 0.2222
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.012 0.0116
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0903 0.223
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0144 0.0981
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0235 0.0306
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1952 0.1949
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.012 0.1141
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0453 0.4661
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0271 0.3759 0.5109
Brugia malayi photoreceptor-specific nuclear receptor 0.0271 0.3759 0.5116
Brugia malayi Pre-SET motif family protein 0.0221 0.3037 0.4133
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0501 0.1089
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0903 0.223
Onchocerca volvulus 0.0032 0.0297 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Plasmodium vivax SET domain protein, putative 0.0032 0.0297 0.2795
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2684 0.4782
Brugia malayi CHE-14 protein 0.0046 0.0495 0.0673
Echinococcus multilocularis nuclear receptor nhr 48 0.0128 0.1683 0.1679
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0144 0.014
Echinococcus granulosus dna polymerase kappa 0.0019 0.0112 0.0108
Schistosoma mansoni patched 1 0.0046 0.0495 0.0875
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0112 0.0192
Brugia malayi nuclear receptor NHR-67 0.0128 0.1683 0.229
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0285
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Brugia malayi Thioredoxin reductase 0.0046 0.0501 0.0682
Schistosoma mansoni retinoic acid receptor RXR 0.0271 0.3759 0.6701
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0112 0.0152
Loa Loa (eye worm) hypothetical protein 0.0107 0.138 0.1867
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0062 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0526 0.0522
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0297 0.0293
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0271 0.3759 0.3756
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0112 0.0075
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Brugia malayi Pre-SET motif family protein 0.0032 0.0297 0.0404
Brugia malayi nuclear hormone receptor family member odr-7 0.0128 0.1683 0.229
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0902 0.2227
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0112 0.0215
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0575 0.0571
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0453 0.0449
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0903 0.6238
Loa Loa (eye worm) hypothetical protein 0.0143 0.1905 0.2582
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0112 0.0075
Echinococcus multilocularis protein patched 0.0046 0.0495 0.0491
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0128 0.1683 0.1679
Echinococcus granulosus nuclear receptor nhr 48 0.0128 0.1683 0.1679
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0429 0.0995
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.022 0.0299
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0271 0.3759 0.6701
Brugia malayi beta-lactamase 0.0074 0.0902 0.1227
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0271 0.3759 0.3756
Schistosoma mansoni coup transcription factor 0.0271 0.3759 0.6701
Entamoeba histolytica protein kinase domain containing protein 0.009 0.113 0.8027
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0575 0.1359
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0902 0.2227
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1848 0.4429
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0271 0.3759 0.3756
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0575 0.0571
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0112 0.0215
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0038 0.0038
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0038 0.0052
Loa Loa (eye worm) hypothetical protein 0.0055 0.0631 0.0846
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0902 0.2227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0112 0.0123
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0112 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0575 0.1018
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0112 0.0123
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1952 0.2657
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0128 0.1683 0.1679
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0902 0.1215
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0144 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0526 0.0716
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0144 0.0219
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0112 0.0132
Trichomonas vaginalis ap endonuclease, putative 0.002 0.012 0.0155
Echinococcus multilocularis FTZ F1 alpha 0.0271 0.3759 0.3756
Onchocerca volvulus 0.0128 0.1683 0.4256
Schistosoma mansoni hypothetical protein 0.0398 0.5608 1
Brugia malayi hypothetical protein 0.0143 0.1905 0.2593
Plasmodium falciparum glutathione reductase 0.0046 0.0501 0.7712
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.056 0.1235
Loa Loa (eye worm) hypothetical protein 0.0032 0.0297 0.039
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0112 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0903 0.5462
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.6683 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0588 0.0794
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0271 0.3759 0.3756
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0575 0.1359
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.2046 0.2043
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0144 0.0204
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0271 0.3759 0.6701
Schistosoma mansoni hypothetical protein 0.0115 0.1497 0.2664
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0128 0.1683 0.1679
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0588 0.0794
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0902 0.2082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Onchocerca volvulus 0.0074 0.0902 0.2096
Loa Loa (eye worm) glutathione reductase 0.0046 0.0501 0.0669
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0297 0.0522
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0271 0.3759 0.3756
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0526 0.0703
Schistosoma mansoni thyroid hormone receptor 0.0271 0.3759 0.6701
Leishmania major trypanothione reductase 0.0046 0.0501 0.1089
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2684 0.4782
Loa Loa (eye worm) hypothetical protein 0.0128 0.1683 0.2279
Loa Loa (eye worm) hypothetical protein 0.0143 0.1905 0.2582
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.012 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0128 0.1683 0.1679
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0903 0.127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0144 0.0124
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.01 0.0058
Echinococcus multilocularis cpg binding protein 0.003 0.0258 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0903 0.223
Trypanosoma brucei unspecified product 0.0019 0.0112 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0271 0.3759 0.5116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0297 0.0522
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0144 0.0219
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0144 0.0219
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.4096 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1362 0.1964
Schistosoma mansoni cpg binding protein 0.003 0.0258 0.0453
Echinococcus granulosus cpg binding protein 0.003 0.0258 0.0254
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0144 0.0196
Brugia malayi conserved hypotetical protein 0.0128 0.1683 0.229
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.113 0.2648
Mycobacterium tuberculosis Probable reductase 0.0106 0.1362 0.1964
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0401 0.2283
Brugia malayi latrophilin 2 splice variant baaae 0.0248 0.3433 0.4672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0526 0.0932
Brugia malayi nuclear receptor RXR 0.0128 0.1683 0.229
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0128 0.1683 0.4256
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0271 0.3759 0.5116
Loa Loa (eye worm) hypothetical protein 0.0074 0.0902 0.1215
Schistosoma mansoni serine/threonine protein kinase 0.009 0.113 0.2009
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0144 0.0219
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1848 0.4429
Loa Loa (eye worm) hypothetical protein 0.0055 0.0631 0.0846
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0902 0.1268
Loa Loa (eye worm) nuclear receptor NHR-67 0.0128 0.1683 0.2279
Onchocerca volvulus Bile acid receptor homolog 0.0271 0.3759 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0112 0.0108
Schistosoma mansoni intermediate filament proteins 0.0027 0.022 0.0385
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0144 0.0196
Loa Loa (eye worm) hypothetical protein 0.0271 0.3759 0.5109
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0144 0.0124
Brugia malayi ecdysone receptor 0.0128 0.1683 0.229
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0902 0.1268
Loa Loa (eye worm) hypothetical protein 0.0056 0.0644 0.0864
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0144 0.1447
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0495 0.1148
Brugia malayi hypothetical protein 0.0027 0.022 0.0299
Loa Loa (eye worm) hypothetical protein 0.0074 0.0902 0.1215
Echinococcus multilocularis dual specificity 0.009 0.113 0.1126
Mycobacterium ulcerans hypothetical protein 0.0155 0.2076 0.5341
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0128 0.1683 0.1679
Loa Loa (eye worm) hypothetical protein 0.0143 0.1905 0.2582
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0588 0.0794
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0112 0.0108
Schistosoma mansoni hypothetical protein 0.0044 0.0471 0.0833
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0271 0.3759 0.3756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0526 0.0522
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0667 0.72
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0575 0.1352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0271 0.3759 0.5116
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.001
Brugia malayi Nuclear hormone receptor E75 0.0128 0.1683 0.229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0112 0.0215
Plasmodium vivax glutathione reductase, putative 0.0046 0.0501 0.523
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1404 0.2499
Echinococcus granulosus GPCR family 2 0.0115 0.1497 0.1493
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0526 0.0522
Schistosoma mansoni hypothetical protein 0.0115 0.1497 0.2664
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2684 0.4782
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0062 0.0103
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.1497 0.2037
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1362 0.1964
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0128 0.1683 0.2996
Brugia malayi hypothetical protein 0.0128 0.1683 0.229
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0902 0.1268
Mycobacterium ulcerans lipase LipD 0.0074 0.0902 0.2227
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0902 0.2227
Loa Loa (eye worm) intermediate filament protein 0.0027 0.022 0.0286
Schistosoma mansoni hypothetical protein 0.0044 0.0471 0.0833
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0271 0.3759 0.3756
Loa Loa (eye worm) acetyltransferase 0.0146 0.1952 0.2647
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0144 0.0204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0271 0.3759 0.6701
Schistosoma mansoni cpg binding protein 0.0028 0.0235 0.0411
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0706 0.1253
Echinococcus multilocularis lamin 0.0027 0.022 0.0216

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.