Detailed information for compound 699637

Basic information

Technical information
  • TDR Targets ID: 699637
  • Name: 2-(2-ethoxyethyl)-6-(2-methoxyphenyl)-4,7-dim ethylpurino[7,8-a]imidazole-1,3-dione
  • MW: 397.428 | Formula: C20H23N5O4
  • H donors: 0 H acceptors: 3 LogP: 2.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCn1c(=O)n(C)c2c(c1=O)n1cc(n(c1n2)c1ccccc1OC)C
  • InChi: 1S/C20H23N5O4/c1-5-29-11-10-23-18(26)16-17(22(3)20(23)27)21-19-24(16)12-13(2)25(19)14-8-6-7-9-15(14)28-4/h6-9,12H,5,10-11H2,1-4H3
  • InChiKey: WSXXGBQUUQXVBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-ethoxyethyl)-6-(2-methoxyphenyl)-4,7-dimethyl-purino[7,8-a]imidazole-1,3-dione
  • 2-(2-ethoxyethyl)-6-(2-methoxyphenyl)-4,7-dimethyl-purino[7,8-a]imidazole-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0187 0.0299
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.0085
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0187 0.0299
Giardia lamblia Transglutaminase/protease, putative 0.0413 0.3402 0.6805
Mycobacterium tuberculosis Conserved protein 0.0038 0.0205 0.058
Leishmania major DNA polymerase kappa, putative 0.002 0.0046 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Echinococcus multilocularis dna polymerase eta 0.002 0.0046 0.0037
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0186 0.0643
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0055 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0175 0.0167
Schistosoma mansoni hypothetical protein 0.0035 0.0175 0.0167
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.021 0.0457
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0186 0.0417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0652 0.1462
Schistosoma mansoni DNA polymerase eta 0.002 0.0046 0.0037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Echinococcus multilocularis caspase 3 0.0531 0.4412 0.4407
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.023 0.0831
Trypanosoma brucei metacaspase MCA3 0.0338 0.2765 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0597 0.4979 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0338 0.2765 0.6263
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0186 0.0643
Echinococcus multilocularis caspase 2 0.0449 0.3709 0.3703
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0013 0.0004
Brugia malayi beta-lactamase 0.0038 0.0205 0.0447
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0143 0.0134
Schistosoma mansoni hypothetical protein 0.0046 0.0273 0.0265
Loa Loa (eye worm) beta-lactamase 0.0038 0.0205 0.0447
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.0085
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0869 0.7299 0.7296
Schistosoma mansoni hypothetical protein 0.011 0.0821 0.0814
Echinococcus multilocularis lamin dm0 0.0057 0.0366 0.0358
Entamoeba histolytica hypothetical protein 0.0035 0.0175 0.0262
Onchocerca volvulus Cell death protein 3 homolog 0.0449 0.3709 0.4475
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0278
Trypanosoma brucei glucosidase, putative 0.0036 0.0187 0.0647
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0447
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.127 0.1262
Echinococcus multilocularis apoptotic protease activating factor 1 0.011 0.0821 0.0814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0652 0.0644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0205 0.0197
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0169 0.0161
Schistosoma mansoni hypothetical protein 0.1185 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0055 0.0046
Entamoeba histolytica hypothetical protein 0.0035 0.0175 0.0262
Plasmodium falciparum phd finger protein, putative 0.0028 0.0119 0.0429
Echinococcus multilocularis caspase 8 0.0338 0.2765 0.2759
Trypanosoma cruzi metacaspase, putative 0.0338 0.2765 1
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2765 0.5519
Trypanosoma brucei metacaspase 0.0338 0.2765 1
Schistosoma mansoni caspase-7 (C14 family) 0.0869 0.7299 0.7296
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0055 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0338 0.2765 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0139 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0187 0.0647
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1012 0.2877
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0046 0.0085
Leishmania major metacaspase, putative 0.0338 0.2765 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0013 0.0004
Schistosoma mansoni alpha-glucosidase 0.014 0.1076 0.1068
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0375 0.0832
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0065 0.0056
Treponema pallidum fructose-bisphosphate aldolase 0.0597 0.4979 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0187 0.0405
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.127 0.1262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0652 0.0644
Loa Loa (eye worm) hypothetical protein 0.0178 0.1402 0.3167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0447
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0046 0.0037
Schistosoma mansoni caspase-3 (C14 family) 0.0869 0.7299 0.7296
Onchocerca volvulus 0.0057 0.0366 0.0308
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.023 0.0803
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0447
Schistosoma mansoni lamin 0.0057 0.0366 0.0358
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.1012 0.1004
Echinococcus granulosus lamin 0.0057 0.0366 0.0358
Echinococcus multilocularis muscleblind protein 0.0146 0.1122 0.1115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0413 0.3402 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0153 0.0427
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0338 0.2765 1
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0731 0.1642
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0366 0.0812
Schistosoma mansoni hypothetical protein 0.0413 0.3402 0.3397
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0187 0.0299
Trypanosoma brucei metacaspase 5, putative 0.0338 0.2765 1
Onchocerca volvulus 0.0038 0.0205 0.0108
Trichomonas vaginalis esterase, putative 0.0038 0.0205 0.0336
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0186 0.0297
Echinococcus granulosus survival motor neuron protein 1 0.0531 0.441 0.4405
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0013 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Leishmania major DNA polymerase eta, putative 0.002 0.0046 0.0136
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0055 0.0198
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.1126 0.2539
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0187 0.0299
Echinococcus granulosus caspase 2 0.0449 0.3709 0.3703
Mycobacterium tuberculosis Hypothetical protein 0.0413 0.3402 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.0205 0.0159
Schistosoma mansoni lamin 0.0057 0.0366 0.0358
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0114 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0133 0.019
Trypanosoma cruzi metacaspase 5, putative 0.0338 0.2765 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0205 0.0336
Loa Loa (eye worm) hypothetical protein 0.01 0.0731 0.1642
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0205 0.0447
Onchocerca volvulus 0.0045 0.0262 0.0179
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0453 0.0838
Brugia malayi hypothetical protein 0.0531 0.441 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0292 0.237 0.6821
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0205 0.0475
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0186 0.0297
Plasmodium falciparum metacaspase 1 0.0338 0.2765 1
Schistosoma mansoni hypothetical protein 0.0346 0.2831 0.2825
Entamoeba histolytica hypothetical protein 0.0035 0.0175 0.0262
Brugia malayi Bromodomain containing protein 0.0032 0.0148 0.0317
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0108 0.01
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0119 0.0429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.1809 0.4091
Trypanosoma brucei unspecified product 0.002 0.0046 0.0136
Loa Loa (eye worm) hypothetical protein 0.0057 0.0366 0.0812
Schistosoma mansoni cpg binding protein 0.0088 0.0629 0.0621
Loa Loa (eye worm) inositol-1 0.0036 0.0186 0.0403
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.023 0.0221
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0008 0.003
Brugia malayi Cell death protein 3 precursor 0.0449 0.3709 0.8407
Echinococcus granulosus caspase 0.0869 0.7299 0.7296
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.1126 0.2539
Loa Loa (eye worm) hypothetical protein 0.0146 0.1122 0.253
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0187 0.0179
Schistosoma mansoni cpg binding protein 0.0083 0.0589 0.0581
Schistosoma mansoni alpha-glucosidase 0.014 0.1076 0.1068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0205 0.058
Mycobacterium ulcerans hypothetical protein 0.0413 0.3402 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0338 0.2765 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0108 0.01
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0119 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0338 0.2765 0.2759
Brugia malayi beta-lactamase family protein 0.0038 0.0205 0.0447
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.1012 0.1004
Trypanosoma brucei Metacaspase-4 0.0338 0.2765 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.021 0.0201
Schistosoma mansoni hypothetical protein 0.0046 0.0273 0.0265
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0869 0.7299 0.7296
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0133 0.019
Brugia malayi beta-lactamase family protein 0.0038 0.0205 0.0447
Echinococcus multilocularis geminin 0.0346 0.2831 0.2825
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0666 0.0658
Brugia malayi CXXC zinc finger family protein 0.0083 0.0589 0.1319
Loa Loa (eye worm) hypothetical protein 0.0338 0.2765 0.6263
Schistosoma mansoni intermediate filament proteins 0.0057 0.0366 0.0358
Mycobacterium leprae Conserved hypothetical protein 0.0413 0.3402 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.023 0.0386
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0187 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0187 0.0647
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0225 0.0376
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0338 0.2765 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0168 0.0609
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0168 0.016
Onchocerca volvulus 0.0083 0.0589 0.0586
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0273 0.0601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0652 0.0644
Brugia malayi intermediate filament protein 0.0057 0.0366 0.0812
Brugia malayi Pre-SET motif family protein 0.0034 0.0168 0.0363
Trypanosoma cruzi metacaspase, putative 0.0338 0.2765 1
Loa Loa (eye worm) hypothetical protein 0.0531 0.441 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0205 0.0742
Schistosoma mansoni hypothetical protein 0.0046 0.0273 0.0265
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.023 0.0386
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0168 0.058
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0186 0.0177
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0055 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0133 0.019
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0225 0.0132
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0119 0.025
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0187 0.0299
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0299 0.0291
Brugia malayi CHD4 protein 0.0016 0.0013 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0139 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.021 0.0201
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1012 0.2877
Loa Loa (eye worm) hypothetical protein 0.0048 0.029 0.0641
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0187 0.0286
Mycobacterium ulcerans lipase LipD 0.0038 0.0205 0.0475
Giardia lamblia Fructose-bisphosphate aldolase 0.0597 0.4979 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0187 0.0647
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1022 0.2303
Leishmania major hypothetical protein, conserved 0.0038 0.0205 0.0714
Schistosoma mansoni caspase-7 (C14 family) 0.0449 0.3709 0.3703
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0186 0.0297
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0205 0.0197
Echinococcus multilocularis survival motor neuron protein 1 0.0531 0.441 0.4405
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0065 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2765 0.5519
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0106 0.0136
Echinococcus multilocularis tumor protein p63 0.0337 0.2753 0.2747
Trichomonas vaginalis conserved hypothetical protein 0.0174 0.136 0.2675
Echinococcus multilocularis dna polymerase kappa 0.002 0.0046 0.0037
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0008 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0366 0.0812
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0205 0.0197
Toxoplasma gondii exonuclease III APE 0.0021 0.0055 0.0168
Loa Loa (eye worm) hypothetical protein 0.0056 0.0357 0.0792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Brugia malayi hypothetical protein 0.011 0.0821 0.1847
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0055 0.0198
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.0085
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.127 0.2865
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0047 0.0016
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.02 0.0313
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0178 0.1402 0.3167
Trypanosoma cruzi metacaspase 5, putative 0.0338 0.2765 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1122 0.253
Onchocerca volvulus 0.0057 0.0366 0.0308
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.025
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0597 0.4979 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0162 0.1264 0.4554
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0453 0.0838
Giardia lamblia PHD finger protein 15 0.0028 0.0119 0.0147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0273 0.0601
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0168 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0652 0.0644
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0055 0.0032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0187 0.0286
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0168 0.016
Echinococcus granulosus chromobox protein 1 0.0067 0.0453 0.0445
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0205 0.058
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0114 0.0105
Onchocerca volvulus 0.0049 0.0299 0.0225
Trypanosoma cruzi metacaspase, putative 0.0338 0.2765 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0186 0.0643
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0046 0.0136
Schistosoma mansoni hypothetical protein 0.0046 0.0273 0.0265
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.127 0.1262
Mycobacterium tuberculosis Conserved hypothetical protein 0.0413 0.3402 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0447
Trichomonas vaginalis set domain proteins, putative 0.0257 0.2073 0.4118
Loa Loa (eye worm) hypothetical protein 0.0038 0.0205 0.0447
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0205 0.0336
Mycobacterium ulcerans hypothetical protein 0.0413 0.3402 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0652 0.0644
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0046 0.011
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0187 0.0299
Echinococcus multilocularis cpg binding protein 0.0088 0.0629 0.0621
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0013 0.001
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0046 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0273 0.0601
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0363
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0366 0.0812
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0205 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0136
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0186 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0652 0.0644
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1012 0.1004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0652 0.0644
Echinococcus granulosus apoptotic protease activating factor 1 0.011 0.0821 0.0814
Schistosoma mansoni inositol monophosphatase 0.0036 0.0186 0.0177
Echinococcus multilocularis musashi 0.0057 0.0366 0.0358
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0108 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0168 0.016
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0504 0.0496
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0133 0.019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1968 0.5774
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0273 0.0601
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0119 0.04
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0046 0.011
Mycobacterium leprae Conserved hypothetical protein 0.0413 0.3402 1
Brugia malayi Thioredoxin family protein 0.0413 0.3402 0.7711
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0453 0.101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.1012 0.3639
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0136
Mycobacterium tuberculosis Conserved protein 0.0038 0.0205 0.058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0133 0.019
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0175 0.0167
Echinococcus multilocularis caspase 0.0869 0.7299 0.7296
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0168 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0133 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0652 0.1462
Onchocerca volvulus 0.0968 0.8141 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0178 0.1396 0.1388
Echinococcus granulosus geminin 0.0346 0.2831 0.2825
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0262 0.0254
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0046 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0055 0.0105
Plasmodium vivax metacaspase 1, putative 0.0338 0.2765 1
Onchocerca volvulus 0.011 0.0821 0.0876
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0046 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0273 0.0265
Brugia malayi chromobox protein homolog 3 0.0038 0.02 0.0436
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0065 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0273 0.0265
Trichomonas vaginalis peptide N-glycanase, putative 0.0413 0.3402 0.6809
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.021 0.0201
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0186 0.0283
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0292 0.237 0.6957
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0802 0.1804
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0055 0.0168
Mycobacterium ulcerans hypothetical protein 0.0038 0.0205 0.0475
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0046 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2765 0.5519
Echinococcus multilocularis dnaJ subfamily B 0.1185 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0187 0.0299
Mycobacterium ulcerans transglutaminase family protein 0.0413 0.3402 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.02 0.0102
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0046 0.0037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0205 0.058
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0136
Echinococcus granulosus chromobox protein 1 0.0067 0.0453 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0059 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0136
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0205 0.0447
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0187 0.0647
Brugia malayi PHD-finger family protein 0.0028 0.0119 0.025
Echinococcus granulosus dna polymerase kappa 0.002 0.0046 0.0037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0119 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0055 0.0168
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0136
Schistosoma mansoni alpha glucosidase 0.0036 0.0187 0.0179
Brugia malayi Muscleblind-like protein 0.0146 0.1122 0.253
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0175 0.0167
Onchocerca volvulus 0.0094 0.0683 0.0703
Schistosoma mansoni hypothetical protein 0.0108 0.0802 0.0795
Loa Loa (eye worm) hypothetical protein 0.0146 0.1126 0.2539
Brugia malayi MH2 domain containing protein 0.0134 0.1022 0.2303
Echinococcus multilocularis chromobox protein 1 0.0067 0.0453 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0205 0.0714
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0205 0.0714
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.127 0.2865
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0187 0.0405
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0213 0.0205
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0119 0.011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0055 0.0026
Brugia malayi jmjC domain containing protein 0.0092 0.0666 0.1493
Echinococcus granulosus GPCR family 2 0.0046 0.0273 0.0265
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0205 0.058
Mycobacterium tuberculosis Conserved protein 0.0038 0.0205 0.058
Onchocerca volvulus 0.0108 0.0802 0.0852
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0065 0.0056
Loa Loa (eye worm) CXXC zinc finger family protein 0.0083 0.0589 0.1319
Onchocerca volvulus 0.0038 0.0205 0.0108
Echinococcus granulosus Transglutaminase 0.0413 0.3402 0.3397
Echinococcus multilocularis chromobox protein 1 0.0067 0.0453 0.0445
Brugia malayi jmjC domain containing protein 0.0039 0.021 0.0457
Loa Loa (eye worm) hypothetical protein 0.0038 0.02 0.0436
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0046 0.0037
Trypanosoma brucei metacaspase MCA2 0.0338 0.2765 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0133 0.019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0273 0.0265
Brugia malayi Heterochromatin protein 1 0.0067 0.0453 0.101
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0046 0.0136
Brugia malayi Pre-SET motif family protein 0.0226 0.1809 0.4091
Schistosoma mansoni chromobox protein 0.0067 0.0453 0.0445
Onchocerca volvulus 0.0038 0.0205 0.0108
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0205 0.058
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1022 0.2303
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0186 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0119 0.04
Loa Loa (eye worm) hypothetical protein 0.011 0.0821 0.1847
Echinococcus granulosus caspase 3 0.0531 0.4412 0.4407
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.02 0.0313
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0055 0.0136
Echinococcus multilocularis lamin 0.0057 0.0366 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0168 0.016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Echinococcus granulosus muscleblind protein 0.0146 0.1122 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2765 0.5519
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1074 0.1066
Echinococcus multilocularis peregrin 0.0032 0.0148 0.014
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Onchocerca volvulus 0.003 0.0131 0.0015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.1126 0.2539
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0219
Schistosoma mansoni survival motor neuron protein 0.0108 0.0802 0.0795
Mycobacterium ulcerans beta-lactamase 0.0038 0.0205 0.0475
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0133 0.019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0055 0.0168
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Echinococcus multilocularis GPCR, family 2 0.0046 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0049 0.0299 0.066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0143 0.0135
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0055 0.0105
Echinococcus granulosus peregrin 0.0032 0.0148 0.014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0666 0.0658
Giardia lamblia Hypothetical protein 0.0413 0.3402 0.6805
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0187 0.0179
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1074 0.242
Schistosoma mansoni cpg binding protein 0.0088 0.0629 0.0621
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0055 0.0018
Toxoplasma gondii ABC1 family protein 0.0038 0.0205 0.0714
Entamoeba histolytica hypothetical protein 0.0035 0.0175 0.0262
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.104 0.1033
Schistosoma mansoni hypothetical protein 0.0028 0.0119 0.011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.023 0.0803
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0273 0.0265
Echinococcus multilocularis Transglutaminase 0.0413 0.3402 0.3397
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2765 0.5519
Schistosoma mansoni ap endonuclease 0.0021 0.0055 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0205 0.0336
Mycobacterium ulcerans putative transglutaminase-like protein 0.0413 0.3402 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0205 0.0336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0597 0.4979 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0186 0.0643
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0186 0.0643
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0205 0.0197
Loa Loa (eye worm) acetyltransferase 0.014 0.1074 0.242
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0205 0.0336
Brugia malayi Inositol-1 0.0036 0.0186 0.0403
Brugia malayi hypothetical protein 0.0035 0.0175 0.0378
Mycobacterium tuberculosis Conserved protein 0.0413 0.3402 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.02 0.0326
Schistosoma mansoni hypothetical protein 0.0346 0.2831 0.2825
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0292 0.237 0.6923
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1012 0.2877
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1074 0.1066
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0106 0.0136
Echinococcus granulosus caspase 8 0.0338 0.2765 0.2759
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0184 0.0399
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0059 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0338 0.2765 0.5519
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0338 0.2765 0.5519
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.02 0.0725
Echinococcus granulosus cpg binding protein 0.0088 0.0629 0.0621
Echinococcus granulosus intermediate filament protein 0.0057 0.0366 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0205 0.0475
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0205 0.058
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0205 0.0714
Schistosoma mansoni ap endonuclease 0.0021 0.0055 0.0046
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0213 0.0205
Schistosoma mansoni inositol monophosphatase 0.0036 0.0186 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.02 0.0326
Echinococcus granulosus tumor protein p63 0.0337 0.2753 0.2747
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.1012 0.3639
Loa Loa (eye worm) hypothetical protein 0.0028 0.0114 0.0239
Echinococcus granulosus dna polymerase eta 0.002 0.0046 0.0037
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.1012 0.2956
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Loa Loa (eye worm) hypothetical protein 0.0449 0.3709 0.8407
Schistosoma mansoni hypothetical protein 0.01 0.0731 0.0723
Trypanosoma cruzi metacaspase, putative 0.0338 0.2765 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0187 0.0299
Plasmodium falciparum metacaspase-like protein 0.0338 0.2765 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0225 0.0376
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0205 0.058
Onchocerca volvulus 0.0257 0.2073 0.2437
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1012 0.1004
Schistosoma mansoni chromobox protein 0.0067 0.0453 0.0445
Echinococcus granulosus lamin dm0 0.0057 0.0366 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0136
Mycobacterium tuberculosis Long conserved protein 0.0413 0.3402 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0055 0.0032
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1122 0.1115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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