Detailed information for compound 705496

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.482 | Formula: C22H27N5O2
  • H donors: 1 H acceptors: 3 LogP: 3.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)Cn1c(=O)c(CC)c(nc1n1nc(cc1C)C)C
  • InChi: 1S/C22H27N5O2/c1-6-17-8-10-18(11-9-17)24-20(28)13-26-21(29)19(7-2)16(5)23-22(26)27-15(4)12-14(3)25-27/h8-12H,6-7,13H2,1-5H3,(H,24,28)
  • InChiKey: CHCUNXCOSWUGHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0038 0.0166
Trypanosoma brucei metacaspase 0.0019 0.0064 0.077
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0051 0.022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0021 0.0021
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0204 0.2461
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0166 0.0724
Trypanosoma brucei sugar transporter, putative 0.0045 0.0254 0.3057
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.038 0.4574
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Leishmania major protein kinase, putative 0.0097 0.0651 0.7835
Echinococcus granulosus apoptotic protease activating factor 1 0.0045 0.0255 0.0878
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0124 0.0542
Onchocerca volvulus 0.0045 0.0255 0.4759
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.038 0.457
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0166 0.0166
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0095 0.0632 0.2178
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0651 0.2837
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0831 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Echinococcus multilocularis caspase 2 0.0064 0.0399 0.1373
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0831 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0045 0.0254 0.3057
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0215
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.038 0.1309
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0656 0.2861
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Echinococcus granulosus lamin dm0 0.0027 0.0124 0.0428
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0011 0 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0211 0.2544
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0054 0.0234
Mycobacterium tuberculosis Conserved protein 0.0038 0.0204 0.1069
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.075 0.9034
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.038 0.1655
Brugia malayi major facilitator superfamily protein 0.0045 0.0254 0.1107
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0254 0.1107
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0021 0.0092
Trypanosoma cruzi metacaspase, putative 0.0019 0.0064 0.077
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0054 0.0185
Onchocerca volvulus 0.0045 0.0254 0.4722
Schistosoma mansoni cpg binding protein 0.006 0.0371 0.1279
Brugia malayi beta-lactamase 0.0038 0.0204 0.0891
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0831 0.3621
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Loa Loa (eye worm) glutathione reductase 0.0039 0.0211 0.0921
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0063 0.0753
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0054 0.0185
Loa Loa (eye worm) beta-lactamase 0.0038 0.0204 0.0891
Plasmodium falciparum metacaspase-like protein 0.0019 0.0064 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0253
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0204 0.1069
Echinococcus multilocularis caspase 0.0019 0.0064 0.022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0098 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0064 0.0399 0.1738
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0204 0.2098
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0166 0.0724
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0095 0.0632 0.2756
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.037 0.2035
Loa Loa (eye worm) hypothetical protein 0.0095 0.0632 0.2756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0011 0 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0286 0.1249
Plasmodium vivax calcium-dependent protein kinase, putative 0.0098 0.0651 0.0651
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0054 0.0234
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0063 0.0242
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Entamoeba histolytica protein kinase, putative 0.0097 0.0651 0.7835
Plasmodium falciparum calcium-dependent protein kinase 4 0.0098 0.0651 0.0651
Leishmania major histidyl-tRNA synthetase, putative 0.0011 0 0.0004
Trypanosoma cruzi metacaspase, putative 0.0019 0.0064 0.077
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0038 0.01
Toxoplasma gondii ABC1 family protein 0.0038 0.0204 0.0308
Plasmodium vivax glycine--tRNA ligase, putative 0.0018 0.0054 0.0054
Plasmodium vivax glutathione reductase, putative 0.0039 0.0211 0.0211
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0211 0.1109
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0204 0.0704
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0018 0.0054 0.0646
Onchocerca volvulus 0.0038 0.0204 0.2917
Schistosoma mansoni protein kinase 0.0097 0.0651 0.2242
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Plasmodium falciparum calcium-dependent protein kinase 2 0.0098 0.0651 0.0651
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0729 0.1099
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Schistosoma mansoni caspase-3 (C14 family) 0.0019 0.0064 0.022
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0021 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0021 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0204 0.0891
Leishmania major threonyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Giardia lamblia Prolyl-tRNA synthetase 0.0095 0.0632 1
Schistosoma mansoni cpg binding protein 0.0057 0.0347 0.1195
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0018 0.0054 0.0196
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0656 0.7902
Schistosoma mansoni glucose transport protein 0.0317 0.2294 0.7902
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Brugia malayi glutathione reductase 0.0039 0.0211 0.0921
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0111 0.075 0.1132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0063 0.0753
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0222 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0656 0.2861
Onchocerca volvulus 0.0045 0.0254 0.4722
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0215 0.0741
Trichomonas vaginalis esterase, putative 0.0038 0.0204 0.0891
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0204 0.2461
Onchocerca volvulus 0.0045 0.0254 0.4722
Plasmodium vivax sugar transporter, putative 0.0045 0.0254 0.0254
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Plasmodium vivax hexose transporter 0.0317 0.2294 0.2294
Schistosoma mansoni caspase-7 (C14 family) 0.0019 0.0064 0.022
Echinococcus granulosus caspase 2 0.0064 0.0399 0.1373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0204 0.0704
Trichomonas vaginalis helicase, putative 0.0013 0.0017 0.0073
Onchocerca volvulus 0.0045 0.0254 0.4722
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0831 1
Echinococcus granulosus solute carrier family 22 0.0045 0.0254 0.0875
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0166 0.0251
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0052 0.018
Loa Loa (eye worm) major facilitator superfamily transporter 0.0045 0.0254 0.1107
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0 0.0001
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.006 0.037 0.2035
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0254 0.1107
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2903 1
Brugia malayi phosphofructokinase 0.0121 0.0831 0.3621
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.075 0.9034
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0166 0.0724
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.038 0.4574
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0166 0.0724
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Mycobacterium tuberculosis Conserved protein 0.0038 0.0204 0.1069
Leishmania major glucose transporter, lmgt2 0.0098 0.0656 0.7902
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0036 0.0157
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0658 0.3716
Echinococcus multilocularis caspase 8 0.0019 0.0064 0.022
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0045 0.0254 0.1358
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.038 0.1655
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Echinococcus multilocularis musashi 0.0027 0.0124 0.0428
Echinococcus multilocularis lysyl tRNA synthetase 0.0071 0.045 0.155
Echinococcus granulosus synaptic vesicle 2 protein 0.0045 0.0254 0.0875
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0124
Mycobacterium ulcerans beta-lactamase 0.0038 0.0204 0.2461
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Plasmodium falciparum glutathione reductase 0.0039 0.0211 0.0211
Plasmodium falciparum calcium-dependent protein kinase 3 0.0098 0.0651 0.0651
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0204 0.2461
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0317 0.2294 0.7902
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0021 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Leishmania major glucose transporter, lmgt1 0.0098 0.0656 0.7902
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0064 0.077
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Entamoeba histolytica hypothetical protein 0.004 0.0222 0.2667
Trypanosoma cruzi sugar transporter, putative 0.0045 0.0254 0.3057
Toxoplasma gondii thioredoxin reductase 0.0039 0.0211 0.0319
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0026 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0204 0.2461
Leishmania major lysyl-tRNA synthetase, putative 0.0071 0.045 0.5418
Echinococcus granulosus GPCR family 2 0.0015 0.0036 0.0124
Trichomonas vaginalis myo-inositol transporter, putative 0.0045 0.0254 0.1107
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0063 0.0989
Echinococcus multilocularis apoptotic protease activating factor 1 0.0045 0.0255 0.0878
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0166 0.0724
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0095 0.0632 0.7498
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0204 0.1069
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0072
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0584 0.3284
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0254 0.1107
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0204 0.1069
Onchocerca volvulus 0.0057 0.0347 0.8116
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.038 0.2093
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0215
Echinococcus multilocularis solute carrier family 22 0.0045 0.0254 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0279
Entamoeba histolytica hypothetical protein 0.0071 0.045 0.5418
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0036 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.2294 1
Brugia malayi hypothetical protein 0.0045 0.0255 0.1111
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0073
Treponema pallidum glycyl-tRNA synthetase 0.0011 0 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.066 0.2273
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0054 0.0185
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.038 0.1308
Plasmodium falciparum thioredoxin reductase 0.0039 0.0211 0.0211
Plasmodium vivax CDK-related protein kinase 6, putative 0.1345 1 1
Echinococcus multilocularis lamin dm0 0.0027 0.0124 0.0428
Toxoplasma gondii lysine-tRNA ligase 0.0071 0.045 0.0679
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Schistosoma mansoni glucose transport protein 0.0317 0.2294 0.7902
Brugia malayi beta-lactamase family protein 0.0038 0.0204 0.0891
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0286 0.1249
Loa Loa (eye worm) hypothetical protein 0.0097 0.0651 0.2837
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0166 0.2627
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0038 0.0166
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0166 0.0166
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0026 0.009
Onchocerca volvulus 0.0045 0.0254 0.4722
Toxoplasma gondii transporter, major facilitator family protein 0.0045 0.0254 0.0383
Onchocerca volvulus 0.0045 0.0254 0.4722
Brugia malayi Sugar transporter family protein 0.0045 0.0254 0.1107
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0011 0 0.0014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0891
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0204 0.0204
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma cruzi hexose transporter, putative 0.0054 0.0323 0.3883
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0095 0.0632 0.2756
Schistosoma mansoni caspase-7 (C14 family) 0.0064 0.0399 0.1373
Brugia malayi hypothetical protein 0.004 0.0222 0.0965
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0038 0.0459
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.038 0.457
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0026 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0831 0.3621
Echinococcus granulosus lysyl tRNA synthetase 0.0071 0.045 0.155
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.045 0.5418
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0166 0.3691
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.037 0.4189
Mycobacterium ulcerans hypothetical protein 0.0016 0.0038 0.0459
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.066 0.2273
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0021 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.045 0.155
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0018 0.0054 0.0646
Giardia lamblia Threonyl-tRNA synthetase 0.0018 0.0054 0.0849
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0098 0.0651 0.0982
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0019 0.0064
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0011 0 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0656 0.2861
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.038 0.1655
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0891
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0204 0.0891
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0052 0.018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0204 0.1069
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Brugia malayi MAP kinase sur-1 0.0061 0.038 0.1655
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0021 0.0467
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0045 0.0254 0.1358
Loa Loa (eye worm) hypothetical protein 0.0015 0.0036 0.0157
Onchocerca volvulus Cell death protein 3 homolog 0.0064 0.0399 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0071 0.045 0.1962
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0021 0.0021
Brugia malayi hypothetical protein 0.0045 0.0254 0.1107
Plasmodium falciparum calcium-dependent protein kinase 5 0.0098 0.0651 0.0651
Schistosoma mansoni glucose transporter 0.0045 0.0254 0.0875
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0171 0.0743
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0204 0.1069
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0124 0.0542
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.0632 0.2178
Plasmodium falciparum threonine--tRNA ligase 0.0018 0.0054 0.0054
Toxoplasma gondii exonuclease III APE 0.0019 0.0063 0.0094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0073
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0211 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0038 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0045 0.0254 0.0875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.066 0.2273
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0166 0.0166
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0021 0.0032
Plasmodium vivax threonine--tRNA ligase, putative 0.0018 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0279
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0011 0 0.0002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0045 0.0254 0.0254
Echinococcus granulosus solute carrier family 22 0.0045 0.0254 0.0875
Trypanosoma brucei protein kinase, putative 0.0061 0.038 0.457
Trypanosoma cruzi glucose transporter, putative 0.0045 0.0254 0.3057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0234
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0064 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Leishmania major hypothetical protein, conserved 0.0038 0.0204 0.2461
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0097 0.0651 0.2837
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0039 0.0212 0.0926
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.038 0.4574
Mycobacterium tuberculosis Probable reductase 0.0089 0.0584 0.3284
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0054 0.0234
Schistosoma mansoni glucose transport protein 0.0317 0.2294 0.7902
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Plasmodium falciparum mitogen-activated protein kinase 2 0.0512 0.376 0.376
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Brugia malayi Cell death protein 3 precursor 0.0064 0.0399 0.1738
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.075 0.9034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0831 0.3621
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0054 0.0234
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0891
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0097 0.0651 0.2837
Echinococcus granulosus caspase 0.0019 0.0064 0.022
Schistosoma mansoni sugar transporter 0.0045 0.0254 0.0875
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0026 0.009
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Onchocerca volvulus 0.0045 0.0254 0.4722
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0863 0.376
Onchocerca volvulus 0.0038 0.0204 0.2917
Plasmodium vivax lysine--tRNA ligase, putative 0.0071 0.045 0.045
Entamoeba histolytica hypothetical protein 0.004 0.0222 0.2667
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0584 0.3284
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0512 0.376 0.376
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.038 0.457
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0019 0.0064 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0831 0.3621
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0651 0.2242
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0038 0.0459
Echinococcus multilocularis solute carrier family 22 0.0045 0.0254 0.0875
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0064 0.0279
Schistosoma mansoni hypothetical protein 0.004 0.0222 0.0763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.066 0.2273
Echinococcus granulosus caspase 8 0.0019 0.0064 0.022
Giardia lamblia Lysyl-tRNA synthetase 0.0071 0.045 0.7117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0204 0.1069
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Echinococcus granulosus lamin 0.0027 0.0124 0.0428
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0021 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.066 0.2273
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Echinococcus granulosus histidyl tRNA synthetase 0.0011 0 0.0001
Leishmania major hypothetical protein, conserved 0.0045 0.0254 0.3057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0253
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0038 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Schistosoma mansoni sugar transporter 0.0045 0.0254 0.0875
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0253
Chlamydia trachomatis lysine--tRNA ligase 0.0071 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0286 0.1249
Chlamydia trachomatis proline--tRNA ligase 0.0034 0.0172 0.3815
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0831 0.472
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0021 0.0253
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0063 0.0273
Trypanosoma brucei Metacaspase-4 0.0019 0.0064 0.077
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0064 0.022
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0071 0.045 0.5418
Schistosoma mansoni lamin 0.0027 0.0124 0.0428
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0831 0.2861
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0011 0 0.0002
Echinococcus multilocularis solute carrier family 22 0.0045 0.0254 0.0875
Schistosoma mansoni hypothetical protein 0.0033 0.0171 0.0587
Onchocerca volvulus 0.0045 0.0254 0.4722
Loa Loa (eye worm) hypothetical protein 0.0077 0.0499 0.2174
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Brugia malayi lysyl-tRNA synthetase 0.0071 0.045 0.1962
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0347 0.1513
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0656 0.7902
Plasmodium falciparum hexose transporter 0.0317 0.2294 0.2294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Brugia malayi major facilitator superfamily protein 0.0045 0.0254 0.1107
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0831 0.2861
Onchocerca volvulus 0.0045 0.0254 0.4722
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0062 0.0385 0.1677
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0831 0.3621
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0098 0.0651 0.0651
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0658 0.3716
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0166 0.3691
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0254 0.1107
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0063 0.0753
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Schistosoma mansoni protein kinase 0.0097 0.0651 0.2242
Loa Loa (eye worm) sugar transporter 0.0045 0.0254 0.1107
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0 0.0004
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0018 0.0054 0.0081
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0831 0.3621
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.075 0.9034
Echinococcus granulosus Sugar transporter ERD6 protein 0.0045 0.0254 0.0875
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0095 0.0632 0.2756
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Onchocerca volvulus Putative transporter 0.0045 0.0254 0.4722
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.045 0.155
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0064 0.0064
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.038 0.1308
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0063 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0038 0.0166
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.038 0.457
Trichomonas vaginalis sugar transporter, putative 0.0098 0.0656 0.2861
Onchocerca volvulus 0.0045 0.0254 0.4722
Plasmodium falciparum metacaspase 1 0.0019 0.0064 0.0064
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.038 0.6003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0124 0.0542
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0584 0.3284
Trypanosoma cruzi histidyl-tRNA synthetase 0.0011 0 0.0004
Chlamydia trachomatis threonine--tRNA ligase 0.0018 0.0054 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.066 0.2273
Brugia malayi intermediate filament protein 0.0027 0.0124 0.0542
Schistosoma mansoni hypothetical protein 0.0317 0.2294 0.7902
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0215 0.0741
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0021 0.0253
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0064 0.022
Brugia malayi beta-lactamase family protein 0.0038 0.0204 0.0891
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0279
Loa Loa (eye worm) hypothetical protein 0.0071 0.045 0.1962
Mycobacterium leprae Probable lipase LipE 0.0038 0.0204 0.2098
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0656 0.7902
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0021 0.0253
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0063 0.0753
Schistosoma mansoni sugar transporter 0.0045 0.0254 0.0875
Leishmania major hypothetical protein, conserved 0.0016 0.0038 0.0459
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.003 0.0129
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0254 0.1107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0036 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0204 0.0891
Onchocerca volvulus 0.0045 0.0254 0.4722
Schistosoma mansoni cpg binding protein 0.006 0.0371 0.1279
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0658 0.3716
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0204 0.0704
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0054 0.019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0891
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0063 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.066 0.2876
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0064 0.0096
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.038 0.0573
Onchocerca volvulus 0.0045 0.0254 0.4722
Echinococcus granulosus calcium dependent protein kinase 0.0091 0.0602 0.2074
Schistosoma mansoni histidyl-tRNA synthetase 0.0011 0 0.0001
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0064 0.077
Chlamydia trachomatis histidine--tRNA ligase 0.0011 0 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0166 0.0724
Trypanosoma brucei metacaspase MCA2 0.0019 0.0064 0.077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0891
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.038 0.1309
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.066 0.2876
Brugia malayi CXXC zinc finger family protein 0.0057 0.0347 0.1513
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0063 0.0753
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0097 0.0651 0.7835
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0204 0.2461
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0584 0.3284
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0016 0.0038 0.0459
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0021 0.0092
Plasmodium vivax proline--tRNA ligase, putative 0.0111 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0124 0.0542
Leishmania major glucose transporter, lmgt3 0.0098 0.0656 0.7902
Echinococcus multilocularis lamin 0.0027 0.0124 0.0428
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0063 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0651 0.2242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0254 0.1107
Onchocerca volvulus 0.0045 0.0254 0.4722
Leishmania major glycyl tRNA synthetase, putative 0.0011 0 0.0004
Echinococcus granulosus solute carrier family 22 0.0045 0.0254 0.0875
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.038 0.457
Brugia malayi 6-phosphofructokinase 0.0121 0.0831 0.3621
Loa Loa (eye worm) hypothetical protein 0.0045 0.0255 0.1111
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.038 0.1308
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0831 1
Plasmodium falciparum protein kinase 7 0.0895 0.6631 0.6631
Schistosoma mansoni hypothetical protein 0.0398 0.2903 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0166 0.0166
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0831 0.2861
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0831 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0019 0.0064
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0222 0.0763
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0098 0.0651 0.0982
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0054 0.0234
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0052 0.0228
Leishmania major glucose transporter/membrane transporter D2, putative 0.0098 0.0656 0.7902
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0171 0.0743
Brugia malayi MH2 domain containing protein 0.0126 0.0863 0.376
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.075 0.9034
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Mycobacterium tuberculosis Conserved protein 0.0038 0.0204 0.1069
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0863 0.376
Toxoplasma gondii sugar transporter ST3 0.0045 0.0254 0.0383
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0095 0.0632 0.7613
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0204 0.0704
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0286 0.1249
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.066 0.2273
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma brucei glucose transporter 1E 0.0098 0.0656 0.7902
Toxoplasma gondii glycyl-tRNA synthetase 0.0018 0.0054 0.0081
Brugia malayi Sugar transporter family protein 0.0045 0.0254 0.1107
Trichomonas vaginalis glucose transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0036 0.0124
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0018 0.0054 0.2114
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Mycobacterium ulcerans integral membrane transport protein 0.0045 0.0254 0.3057
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0656 0.7902
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0831 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0584 0.3284
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0017 0.0073
Plasmodium falciparum lysine--tRNA ligase 0.0071 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Echinococcus granulosus solute carrier family 22 0.0045 0.0254 0.0875
Mycobacterium ulcerans lipase LipD 0.0038 0.0204 0.2461
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Echinococcus multilocularis synaptic vesicle 2 protein 0.0045 0.0254 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0831 0.3621
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2903 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0021 0.0828
Toxoplasma gondii sugar transporter ST2 0.0045 0.0254 0.0383
Schistosoma mansoni sugar transporter 0.0045 0.0254 0.0875
Trypanosoma cruzi metacaspase, putative 0.0019 0.0064 0.077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0063 0.0753
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0011 0 0.0004
Leishmania major myo-inositol/proton symporter (MIT) 0.0045 0.0254 0.3057
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0166 0.0724
Echinococcus granulosus cpg binding protein 0.006 0.0371 0.1279
Trypanosoma brucei histidyl-tRNA synthetase 0.0011 0 0.0004
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0512 0.376 0.567
Leishmania major metacaspase, putative 0.0019 0.0064 0.077
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0584 0.6892
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.003 0.0129
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.038 0.457
Loa Loa (eye worm) hypothetical protein 0.0038 0.0204 0.0891
Brugia malayi hypothetical protein 0.0045 0.0254 0.1107
Trypanosoma cruzi hexose transporter, putative 0.0045 0.0254 0.3057
Plasmodium vivax metacaspase 1, putative 0.0019 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus multilocularis histidyl tRNA synthetase 0.0011 0 0.0001
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.0656 0.7902
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0036 0.0124
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0098 0.0651 0.0982
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0826 0.2844
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Giardia lamblia Sugar-proton symporter 0.0045 0.0254 0.4016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0204 0.0891
Entamoeba histolytica hypothetical protein 0.004 0.0222 0.2667
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.045 0.5418
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0045 0.0254 0.3057
Mycobacterium ulcerans sugar transporter 0.0045 0.0254 0.3057
Schistosoma mansoni threonyl-tRNA synthetase 0.0011 0 0.0001
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0831 1
Trypanosoma brucei trypanothione reductase 0.0039 0.0211 0.2544
Plasmodium falciparum glutathione reductase 0.0013 0.0021 0.0021
Schistosoma mansoni lamin 0.0027 0.0124 0.0428
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.038 0.4574
Echinococcus granulosus General substrate transporter 0.0272 0.196 0.6752
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.038 0.1655
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0064 0.077
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0021 0.0092
Onchocerca volvulus 0.0045 0.0254 0.4722
Echinococcus granulosus intermediate filament protein 0.0027 0.0124 0.0428
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Giardia lamblia Glycyl-tRNA synthetase 0.0018 0.0054 0.0849
Leishmania major trypanothione reductase 0.0039 0.0211 0.2544
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0166 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.038 0.1655
Giardia lamblia Hexose transporter 0.0045 0.0254 0.4016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0021 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0073
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0222 0.0763
Toxoplasma gondii facilitative glucose transporter GT1 0.0317 0.2294 0.346
Plasmodium falciparum thioredoxin reductase 0.0013 0.0021 0.0021
Toxoplasma gondii sugar transporter ST1 0.0045 0.0254 0.0383
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0045 0.0254 1
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0166 0.0251
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0021 0.0253
Brugia malayi Major Facilitator Superfamily protein 0.0045 0.0254 0.1107
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.038 0.0572
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0656 0.2861
Plasmodium falciparum proline--tRNA ligase 0.0111 0.075 0.075
Trypanosoma cruzi metacaspase, putative 0.0019 0.0064 0.077
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Treponema pallidum NADH oxidase 0.0013 0.0021 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0831 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0204 0.2461
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.038 0.1308
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Brugia malayi Cam kinase protein 1 0.0097 0.0651 0.2837
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0204 0.0891
Onchocerca volvulus 0.0038 0.0204 0.2917
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0279
Trypanosoma cruzi hexose transporter, putative 0.0098 0.0656 0.7902
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Plasmodium falciparum calcium-dependent protein kinase 1 0.0098 0.0651 0.0651
Brugia malayi Thioredoxin reductase 0.0039 0.0211 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0254 0.1107
Treponema pallidum threonyl-tRNA synthetase 0.0018 0.0054 0.0646
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0204 0.0891
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0021 0.0253
Trypanosoma brucei glucose transporter, putative 0.0098 0.0656 0.7902
Trichomonas vaginalis glucose transporter, putative 0.0098 0.0656 0.2861
Leishmania major hypothetical protein, conserved 0.0016 0.0038 0.0459
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0279
Echinococcus multilocularis GPCR, family 2 0.0015 0.0036 0.0124
Echinococcus multilocularis General substrate transporter 0.0272 0.196 0.6752
Entamoeba histolytica protein kinase, putative 0.0097 0.0651 0.7835
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0018 0.0054 0.2114
Loa Loa (eye worm) sugar transporter 0.0317 0.2294 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.038 0.1309
Trypanosoma brucei glucose transporter 2A 0.0098 0.0656 0.7902
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0034 0.0172 0.2067
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0098 0.0651 0.0651
Onchocerca volvulus 0.0045 0.0254 0.4722
Toxoplasma gondii protein kinase, putative 0.0895 0.6631 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0073
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0011 0 0.0004
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0019 0.0064 0.0096
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0054 0.0185
Brugia malayi 6-phosphofructokinase 0.0121 0.0831 0.3621
Treponema pallidum prolyl-tRNA synthetase 0.0034 0.0172 0.2067
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0204 0.1069
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0021 0.0021
Onchocerca volvulus 0.0045 0.0254 0.4722
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.038 0.1309
Trichomonas vaginalis sugar transport protein, putative 0.0045 0.0254 0.1107
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0071 0.045 0.5418
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0026 0.009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0063 0.0215
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0072
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0063 0.0753
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0045 0.0254 0.0875
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0063 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0036 0.0157
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0064 0.0279
Toxoplasma gondii anticodon binding domain-containing protein 0.0011 0 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0017 0.0073
Schistosoma mansoni hypothetical protein 0.0045 0.0255 0.0878
Loa Loa (eye worm) hypothetical protein 0.0095 0.0632 0.2756
Brugia malayi Sugar transporter family protein 0.0317 0.2294 1
Entamoeba histolytica hypothetical protein 0.004 0.0222 0.2667
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.038 0.1308
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0166 0.2
Echinococcus multilocularis calcium dependent protein kinase 0.0091 0.0602 0.2074
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0021 0.0021
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0054 0.0185
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0021 0.0828
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0204 0.0891
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0097 0.0651 0.2837
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0063 0.2463
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0095 0.0632 0.2178
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0018 0.0054 0.0234
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0071 0.045 0.5197
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0063 0.0273
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.1736 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0658 0.7827
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0017 0.0073
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0831 0.2861
Schistosoma mansoni intermediate filament proteins 0.0027 0.0124 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0279
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Schistosoma mansoni protein kinase 0.0097 0.0651 0.2242
Brugia malayi hypothetical protein 0.0045 0.0254 0.1107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0097 0.0651 0.2242
Trichomonas vaginalis sugar transporter, putative 0.0045 0.0254 0.1107
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0656 0.2861
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0211 0.0921
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0016 0.0038 0.0058
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0254 0.1107
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.038 0.457
Trypanosoma brucei metacaspase MCA3 0.0019 0.0064 0.077
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0045 0.0254 0.3057
Trypanosoma cruzi hexose transporter 0.0098 0.0656 0.7902
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0831 1
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0124
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0018 0.0054 0.0646
Echinococcus multilocularis solute carrier family 22 0.0045 0.0254 0.0875
Echinococcus multilocularis cpg binding protein 0.006 0.0371 0.1279
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0036 0.0157
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0124
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0021 0.0253
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0166 0.2
Loa Loa (eye worm) hypothetical protein 0.0027 0.0121 0.0526
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0317 0.2294 0.7902
Loa Loa (eye worm) hypothetical protein 0.0045 0.0254 0.1107
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.0632 0.2178

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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