Detailed information for compound 705823

Basic information

Technical information
  • TDR Targets ID: 705823
  • Name: N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]eth yl]-3-fluorobenzenesulfonamide
  • MW: 396.887 | Formula: C17H14ClFN2O2S2
  • H donors: 1 H acceptors: 3 LogP: 4.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1scc(n1)CCNS(=O)(=O)c1cccc(c1)F
  • InChi: 1S/C17H14ClFN2O2S2/c18-13-6-4-12(5-7-13)17-21-15(11-24-17)8-9-20-25(22,23)16-3-1-2-14(19)10-16/h1-7,10-11,20H,8-9H2
  • InChiKey: IKQGAMZCCAZATR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[2-(4-chlorophenyl)thiazol-4-yl]ethyl]-3-fluoro-benzenesulfonamide
  • N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-3-fluorobenzenesulfonamide
  • N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]-3-fluoro-benzenesulfonamide
  • ZINC05137598

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Smad4 0.0016 0.0159 0.0058
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0305 0.0305
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0164 0.0065
Brugia malayi Dopamine receptor protein 2 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0928 0.3369
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0164 0.0065
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0063 0.0063
Leishmania major trypanothione reductase 0.0047 0.0824 0.2942
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1207 0.1313
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0312 0.0242
Leishmania major hypothetical protein, conserved 0.0051 0.0928 0.3342
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Trypanosoma brucei unspecified product 0.0026 0.0376 0.1214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Brugia malayi Smad1 0.0016 0.0159 0.0159
Echinococcus granulosus smad 0.0016 0.0159 0.0058
Brugia malayi Cathepsin L-like precursor 0.0034 0.0552 0.0552
Brugia malayi Cathepsin L-like precursor 0.0034 0.0552 0.0552
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0312 0.0481
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0144 0.0144
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0611 0.6343
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0634 0.0627
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0611 0.2151
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0634 0.0627
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0611 0.06
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0552 0.0529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Echinococcus granulosus lamin dm0 0.0029 0.0438 0.0393
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.5017 0.5017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0312 0.0481
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0164 0.0135
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0601 0.0588
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0824 0.0855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0552 0.566
Brugia malayi hypothetical protein 0.0033 0.053 0.053
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0164 0.0065
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0517 0.1116
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0601 0.926
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0157 0.1677
Echinococcus multilocularis somatostatin receptor 0.0016 0.0164 0.0065
Schistosoma mansoni amine GPCR 0.0016 0.0164 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.8462 1
Echinococcus granulosus cysteine protease 0.0018 0.0189 0.0095
Plasmodium falciparum thioredoxin reductase 0.0016 0.0157 0.1108
Loa Loa (eye worm) glutathione reductase 0.0047 0.0824 0.0824
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.2408 0.905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0611 0.6386
Echinococcus granulosus dnaJ subfamily B 0.0396 0.8462 1
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0634 0.0976
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0552 0.8159
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0164 0.0065
Plasmodium falciparum glutathione reductase 0.0016 0.0157 0.1108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0634 0.2208
Schistosoma mansoni myosin xvIII 0.0016 0.0164 0.0135
Plasmodium vivax vivapain-3 0.0018 0.0189 0.1574
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0189 0.053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0164 0.0135
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1207 0.3254
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0135
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0164 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0164 0.0065
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0634 0.2208
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0634 0.2208
Loa Loa (eye worm) hypothetical protein 0.0049 0.088 0.088
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0824 0.8816
Brugia malayi glutathione reductase 0.0047 0.0824 0.0824
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0928 0.7569
Schistosoma mansoni neuropeptide receptor 0.0016 0.0164 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0061 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0601 0.0769
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0061 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni amine GPCR 0.0016 0.0164 0.0135
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0552 0.8159
Echinococcus multilocularis lamin dm0 0.0029 0.0438 0.0393
Echinococcus multilocularis serotonin receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0164 0.0065
Onchocerca volvulus 0.0029 0.0438 0.7073
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0135
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0312 0.0428
Brugia malayi neuropeptide F receptor 0.0016 0.0164 0.0164
Onchocerca volvulus 0.0023 0.0305 0.3619
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0305 0.2596
Plasmodium vivax DNA repair protein REV1, putative 0.0012 0.0061 0.0117
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0634 0.0976
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0634 0.0634
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0159 0.0128
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Brugia malayi Cathepsin L-like precursor 0.0023 0.0305 0.0305
Echinococcus granulosus lamin 0.0029 0.0438 0.0393
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma brucei trypanothione reductase 0.0047 0.0824 0.2942
Leishmania major cathepsin L-like protease 0.0034 0.0552 0.1892
Leishmania major cathepsin L-like protease 0.0034 0.0552 0.1892
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0312 0.0312
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0159 0.0058
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0164 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0634 0.2238
Brugia malayi G-protein coupled receptor 0.0016 0.0164 0.0164
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0634 0.2238
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0164 0.0065
Brugia malayi Thioredoxin reductase 0.0047 0.0824 0.0824
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0164 0.0065
Echinococcus granulosus allatostatin A receptor 0.0016 0.0164 0.0065
Leishmania major DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus granulosus hypothetical protein 0.0016 0.0164 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0552 0.1924
Echinococcus granulosus intermediate filament protein 0.0029 0.0438 0.0393
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0611 0.0611
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0438 0.0438
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0164 0.0164
Echinococcus granulosus orexin receptor type 2 0.0016 0.0164 0.0065
Echinococcus multilocularis musashi 0.0029 0.0438 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0157 0.037
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0164 0.0065
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0189 0.0095
Loa Loa (eye worm) Smad1 0.0016 0.0159 0.0159
Echinococcus granulosus serotonin receptor 0.0016 0.0164 0.0065
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0164 0.0065
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0111
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0164 0.0135
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Leishmania major cathepsin L-like protease 0.013 0.2655 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0634 0.1478
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0157 0.1212
Trypanosoma brucei unspecified product 0.0026 0.0376 0.1214
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0164 0.0065
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0164 0.3383 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2132 0.5927
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Onchocerca volvulus 0.0034 0.0552 1
Brugia malayi ORL1-like opioid receptor 0.0016 0.0164 0.0164
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0164 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2132 0.6123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.295 0.34
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Brugia malayi MH1 domain containing protein 0.0016 0.0159 0.0159
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0552 0.566
Loa Loa (eye worm) hypothetical protein 0.0029 0.0427 0.0427
Brugia malayi MH2 domain containing protein 0.0016 0.0159 0.0159
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0238 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0144 0.0041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0164 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0376 0.1214
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0157 0.0126
Onchocerca volvulus 0.0034 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0164 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.0408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1207 0.1313
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0189 0.0164
Leishmania major cathepsin L-like protease 0.013 0.2655 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Schistosoma mansoni ap endonuclease 0.002 0.0238 0.0223
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2132 0.6123
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0051 0.0051
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0164 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0164 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.295 0.34
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0305 0.0255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus granulosus GPCR family 2 0.0016 0.0144 0.0041
Brugia malayi CXXC zinc finger family protein 0.0028 0.0412 0.0412
Echinococcus granulosus cathepsin l1 0.0034 0.0552 0.0529
Echinococcus multilocularis cysteine protease 0.0034 0.0552 0.0529
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0159 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0098 0.0098
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0159 0.0058
Toxoplasma gondii thioredoxin reductase 0.0047 0.0824 0.6662
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0135
Echinococcus granulosus g protein coupled receptor 0.0016 0.0164 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0611 0.2151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0164 0.0164
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0552 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.295 0.3447
Brugia malayi hypothetical protein 0.0051 0.0928 0.0928
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2392 0.6929
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0312 0.0242
Plasmodium vivax unspecified product 0.0018 0.0189 0.1574
Onchocerca volvulus 0.0034 0.0552 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0305 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Toxoplasma gondii exonuclease III APE 0.002 0.0238 0.1544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Schistosoma mansoni hypothetical protein 0.0023 0.0308 0.0306
Brugia malayi Cathepsin L-like precursor 0.0034 0.0552 0.0552
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0164 0.0065
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0238 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.2045 0.7656
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Echinococcus granulosus somatostatin receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0312 0.0242
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0634 0.0826
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.088 0.088
Plasmodium vivax vivapain-2 0.0034 0.0552 0.5711
Schistosoma mansoni Smad4 0.0016 0.0159 0.0128
Schistosoma mansoni cpg binding protein 0.0029 0.0446 0.047
Echinococcus granulosus cathepsin L 0.0018 0.0189 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0634 0.0693
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.088 0.088
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0928 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0164 0.0135
Schistosoma mansoni hypothetical protein 0.0396 0.8462 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0164 0.0065
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1207 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0308 0.0237
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Plasmodium falciparum thioredoxin reductase 0.0047 0.0824 0.8802
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus granulosus dna polymerase eta 0.0038 0.0634 0.0627
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0164 0.0065
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0312 0.0428
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0238 0.014
Schistosoma mansoni biogenic amine receptor 0.0016 0.0164 0.0135
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0164 0.0164
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0157 0.037
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0164 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0189 0.0055
Loa Loa (eye worm) cysteine protease 0.0034 0.0552 0.0552
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0164 0.0164
Brugia malayi Serotonin receptor 0.0016 0.0164 0.0164
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0164 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0312 0.0428
Mycobacterium ulcerans hypothetical protein 0.0164 0.3383 0.566
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0061 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0552 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0376 0.1214
Loa Loa (eye worm) fibroinase 0.0034 0.0552 0.0552
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0164 0.0164
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0111
Echinococcus multilocularis cysteine protease 0.0034 0.0552 0.0529
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0157 0.037
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0634 0.2208
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Schistosoma mansoni DNA polymerase eta 0.0038 0.0634 0.0693
Echinococcus granulosus dna polymerase kappa 0.0038 0.0634 0.0627
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0164 0.0164
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0164 0.0164
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0634 0.0826
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0164 0.0065
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0601 1
Onchocerca volvulus 0.0034 0.0552 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0144 0.0144
Echinococcus multilocularis cpg binding protein 0.0029 0.0446 0.0403
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.088 0.088
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0634 0.2238
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0552 0.0552
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0164 0.0135
Schistosoma mansoni lamin 0.0029 0.0438 0.0461
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0189 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0552 0.0684
Trichomonas vaginalis glutaminase, putative 0.028 0.5929 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0164 0.0065
Echinococcus multilocularis Smad4 0.0016 0.0159 0.0058
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0164 0.3383 0.5588
Echinococcus multilocularis dna polymerase eta 0.0038 0.0634 0.0627
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0238 0.0719
Leishmania major DNA polymerase eta, putative 0.0038 0.0634 0.2208
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0164 0.0065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0189 0.0164
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0147 0.3029 0.3029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Onchocerca volvulus 0.0034 0.0552 1
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0111
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0611 0.212
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0144 0.0144
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.2655 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0601 0.2112
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0238 0.0153
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0552 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0189 0.0055
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1207 0.1374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0601 0.0769
Brugia malayi polk-prov protein 0.0012 0.0061 0.0061
Echinococcus multilocularis lamin 0.0029 0.0438 0.0393
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0164 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0164 0.0065
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Schistosoma mansoni cpg binding protein 0.0029 0.0446 0.047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0312 0.2192
Brugia malayi Augmenter of liver regeneration 0.0037 0.0611 0.0611
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0539 0.0539
Schistosoma mansoni smad 0.0016 0.0159 0.0128
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0164 0.0135
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Echinococcus granulosus cpg binding protein 0.0029 0.0446 0.0403
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0164 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0164 0.0065
Schistosoma mansoni neuropeptide receptor 0.0016 0.0164 0.0135
Brugia malayi sulfakinin receptor protein 0.0016 0.0164 0.0164
Brugia malayi MH1 domain containing protein 0.0016 0.0159 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0164 0.0065
Brugia malayi Serotonin receptor 0.0016 0.0164 0.0164
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0552 0.1892
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0308 0.0237
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0238 0.0682
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0312 0.0481
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Echinococcus granulosus g protein coupled receptor 0.0016 0.0164 0.0065
Echinococcus granulosus g protein coupled receptor 0.0016 0.0164 0.0065
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0164 0.0164
Brugia malayi Melatonin receptor type 1A 0.0016 0.0164 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0634 0.0634
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0438 0.0438
Loa Loa (eye worm) ctsf protein 0.0034 0.0552 0.0552
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0157 0.037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.0408
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0601 0.2112
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0164 0.0065
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0189 0.053
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0164 0.0065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0412 0.0412
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0164 0.0065
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0157 0.1108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0238 0.1103
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Echinococcus multilocularis cathepsin L 0.0018 0.0189 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Brugia malayi Cathepsin L-like precursor 0.0034 0.0552 0.0552
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0238 0.014
Schistosoma mansoni histamine h1 receptor 0.0016 0.0164 0.0135
Brugia malayi larval opioid receptor 0.0016 0.0164 0.0164
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0189 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0159 0.0159
Echinococcus granulosus fmrfamide receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis sex peptide receptor 0.0016 0.0164 0.0065
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1207 0.1374
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0157 0.1212
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Onchocerca volvulus 0.0034 0.0552 1
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0312 0.2896
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0601 0.092
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0824 0.297
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0164 0.0164
Schistosoma mansoni inositol monophosphatase 0.0036 0.0601 0.0654
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0157 0.0157
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0164 0.0065
Entamoeba histolytica cysteine protease, putative 0.0034 0.0552 0.8159
Echinococcus multilocularis GPCR, family 2 0.0016 0.0144 0.0041
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.2655 1
Brugia malayi Inositol-1 0.0036 0.0601 0.0601
Brugia malayi G-protein coupled receptor 0.0016 0.0164 0.0164
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0634 0.0634
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0164 0.0065
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0312 0.298
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0312 0.0428
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0164 0.0164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0955 0.7805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0552 0.0529
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0312 0.0242
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.295 0.295
Leishmania major cathepsin L-like protease 0.0034 0.0552 0.1892
Trypanosoma cruzi DNA damage repair protein, putative 0.0012 0.0061 0.0039
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0164 0.3383 0.566
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0312 1
Schistosoma mansoni adenoreceptor 0.0016 0.0164 0.0135
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0438 0.0438
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0157 0.0838
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0634 0.2238
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.2655 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus granulosus Aminotransferase class III 0.0023 0.0312 0.0242
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2392 0.6929
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0238 0.0153
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0928 1
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0611 0.4801
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0164 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.295 0.34
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2132 0.6123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0051
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0552 0.0596
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0824 0.0855
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0164 0.0065
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0552 0.0529
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0164 0.0065
Brugia malayi AKH receptor 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Leishmania major cathepsin L-like protease 0.0034 0.0552 0.1892
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0144 0.0041
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0164 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Onchocerca volvulus 0.0034 0.0552 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0552 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0164 0.0135
Brugia malayi putative neuropeptide receptor 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus granulosus cathepsin l1 0.0023 0.0305 0.0233
Loa Loa (eye worm) hypothetical protein 0.0013 0.0098 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0634 0.2238
Schistosoma mansoni inositol monophosphatase 0.0036 0.0601 0.0654
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni amine GPCR 0.0016 0.0164 0.0135
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0552 0.0596
Brugia malayi Cathepsin L-like precursor 0.0034 0.0552 0.0552
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0144 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1093 0.1239
Loa Loa (eye worm) hypothetical protein 0.0034 0.0552 0.0552
Echinococcus granulosus neuropeptide receptor 0.0016 0.0164 0.0065
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0189 0.1474
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0164 0.0135
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0061 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0601 0.0769
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0061
Schistosoma mansoni neuropeptide receptor 0.0016 0.0164 0.0135
Leishmania major hypothetical protein, conserved 0.0037 0.0611 0.212
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0312 0.3495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0164 0.0135
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0238 0.3089
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni smad1 5 8 and 0.0016 0.0159 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.295 0.3447
Schistosoma mansoni cpg binding protein 0.0028 0.0412 0.0429
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0634 0.0627
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0634 0.0634
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0189 0.053
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0189 0.053
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0157 0.0838
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2392 0.6774
Giardia lamblia DINP protein human, muc B family 0.0038 0.0634 1
Toxoplasma gondii cathepsin CPL 0.0034 0.0552 0.4284
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0611 0.06
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0189 0.053
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0164 0.0135
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0157 0.0164
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0159 0.0159
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0238 0.2134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.295 0.34
Schistosoma mansoni neuropeptide receptor 0.0016 0.0164 0.0135
Leishmania major cathepsin L-like protease 0.0034 0.0552 0.1892
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.0408
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.0408
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0928 0.3342
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.037
Echinococcus multilocularis smad 0.0016 0.0159 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Loa Loa (eye worm) glutaminase 0.028 0.5929 0.5929
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni biogenic amine receptor 0.0016 0.0164 0.0135
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0552 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0517 0.0668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0634 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0164 0.0065
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0611 0.4801
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Brugia malayi GnHR receptor homolog 0.0016 0.0164 0.0164
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0164 0.0135
Schistosoma mansoni opsin-like receptor 0.0016 0.0164 0.0135
Echinococcus granulosus muscleblind protein 0.0147 0.3029 0.3494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) inositol-1 0.0036 0.0601 0.0601
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0164 0.0065
Plasmodium vivax glutathione reductase, putative 0.0047 0.0824 0.8816
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0157 0.0408
Schistosoma mansoni glutaminase 0.028 0.5929 0.6989
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0164 0.0135
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0164 0.0135
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0928 0.3369
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0611 0.2151
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0061 0.0039
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0157 0.0057
Brugia malayi intermediate filament protein 0.0029 0.0438 0.0438
Echinococcus multilocularis muscleblind protein 0.0147 0.3029 0.3494
Leishmania major cathepsin L-like protease 0.013 0.2655 1
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0164 0.0065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0238 0.1822
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2132 0.6123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0189 0.0493
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0238 0.0251
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.3029 0.3029
Schistosoma mansoni hypothetical protein 0.0016 0.0144 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.5017 0.5017
Onchocerca volvulus 0.0029 0.0438 0.7073
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0063 0.0063
Brugia malayi RE15519p 0.0016 0.0164 0.0164
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0164 0.0065
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0634 0.2208
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0238 0.204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.295 0.3447
Mycobacterium ulcerans glutaminase 0.028 0.5929 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0144 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0305 0.0305
Echinococcus granulosus sex peptide receptor 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0011 0.0051 0.0051
Schistosoma mansoni opsin-like receptor 0.0016 0.0164 0.0135
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.2655 1
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0164 0.0065
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0312 0.0428
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0164 0.0164
Schistosoma mansoni ap endonuclease 0.002 0.0238 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.011 0.011
Brugia malayi glutaminase DH11.1 0.028 0.5929 0.5929
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0552 0.566
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0157 0.0164
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0305 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0164 0.0065
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0164 0.0065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0189 0.0164
Echinococcus granulosus neuropeptide receptor 0.0016 0.0164 0.0065
Schistosoma mansoni hypothetical protein 0.0034 0.0539 0.0581
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0164 0.3383 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0634 0.1478
Schistosoma mansoni smad1 5 8 and 0.0016 0.0159 0.0128
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0157 0.0408
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0601 0.0588
Plasmodium falciparum glutathione reductase 0.0047 0.0824 0.8802
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0164 0.0065
Brugia malayi MH2 domain containing protein 0.0016 0.0159 0.0159
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0305 0.0301
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0601 0.2081
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Onchocerca volvulus 0.0028 0.0412 0.6377
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0164 0.0164
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0164 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.0408
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0238 0.0682
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0238 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0157 0.0057
Schistosoma mansoni opsin-like receptor 0.0016 0.0164 0.0135
Schistosoma mansoni amine GPCR 0.0016 0.0164 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1207 0.1952
Schistosoma mansoni amine GPCR 0.0016 0.0164 0.0135
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0438 0.0438
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.295 0.295
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0312 0.0428
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0164 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1207 0.1952
Brugia malayi Muscleblind-like protein 0.0147 0.3029 0.3029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0144 0.0144
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0157 0.037
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0157 0.037
Mycobacterium tuberculosis Probable aminotransferase 0.0164 0.3383 1
Brugia malayi G protein-coupled receptor 0.0016 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0157 0.1108
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0157 0.0164
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0552 0.0552
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2132 0.6123
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0144 0.0144
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0164 0.0164
Brugia malayi Cathepsin L-like precursor 0.0023 0.0305 0.0305
Brugia malayi Cathepsin L-like precursor 0.0034 0.0552 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0634 0.2208
Plasmodium vivax vivapain-2 0.0034 0.0552 0.5711
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0135
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Plasmodium vivax vivapain-1 0.0018 0.0189 0.1574
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0312 0.0311
Echinococcus multilocularis serotonin receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0164 0.0065
Brugia malayi cathepsin L-like precursor 0.0023 0.0305 0.0305
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0824 0.2068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0634 0.0693
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0164 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.0408
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0376 0.1214
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0159 0.0058
Schistosoma mansoni biogenic amine receptor 0.0016 0.0164 0.0135
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0824 0.0824
Brugia malayi MH2 domain containing protein 0.0238 0.5017 0.5017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0164 0.0065
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0552 0.0552
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0164 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0189 0.0493
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1207 0.1952
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0164 0.0065
Loa Loa (eye worm) glutaminase 2 0.028 0.5929 0.5929
Brugia malayi Dopamine receptor 0.0016 0.0164 0.0164
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0164 0.0135
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2392 0.6929
Brugia malayi Cathepsin L-like precursor 0.0011 0.0051 0.0051
Trypanosoma brucei unspecified product 0.0038 0.0634 0.2208
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0164 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0164 0.0135
Schistosoma mansoni smad1 5 8 and 0.0016 0.0159 0.0128
Schistosoma mansoni lamin 0.0029 0.0438 0.0461
Echinococcus multilocularis muscleblind protein 1 0.0147 0.3029 0.3494
Loa Loa (eye worm) hypothetical protein 0.0016 0.0164 0.0164
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0164 0.0164
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0601 0.2081
Brugia malayi hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0144 0.0144
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1207 0.4416
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.2655 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0164 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0552 0.0684
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0157 0.0408
Schistosoma mansoni intermediate filament proteins 0.0029 0.0438 0.0461
Loa Loa (eye worm) hypothetical protein 0.0051 0.0928 0.0928
Brugia malayi Dopamine receptor protein 1 0.0016 0.0164 0.0164
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0164 0.0065
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0552 0.0529
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0164 0.0065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0539 0.0539
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0305 0.0305
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0157 0.037
Mycobacterium tuberculosis Probable reductase 0.0106 0.2132 0.6123
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0601 0.4712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0552 0.0684
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0164 0.0065
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0238 0.0719
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0164 0.0065
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0312 0.0481
Brugia malayi neuropeptide F receptor 0.0016 0.0164 0.0164

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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