Detailed information for compound 708565

Basic information

Technical information
  • TDR Targets ID: 708565
  • Name: N-(3-imidazol-1-ylpropyl)-2,5-dimethoxybenzen esulfonamide
  • MW: 325.383 | Formula: C14H19N3O4S
  • H donors: 1 H acceptors: 3 LogP: 0.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)NCCCn1cncc1)OC
  • InChi: 1S/C14H19N3O4S/c1-20-12-4-5-13(21-2)14(10-12)22(18,19)16-6-3-8-17-9-7-15-11-17/h4-5,7,9-11,16H,3,6,8H2,1-2H3
  • InChiKey: VCERYMAXBIWURT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-imidazol-1-ylpropyl)-2,5-dimethoxy-benzenesulfonamide
  • N-[3-(1-imidazolyl)propyl]-2,5-dimethoxybenzenesulfonamide
  • N-(3-Imidazol-1-yl-propyl)-2,5-dimethoxy-benzenesulfonamide
  • BAS 11404086
  • A4127/0175975
  • MLS001208971
  • SMR000524806

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.007 0.007
Echinococcus granulosus neural cadherin 0.0008 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.0677 1 1
Echinococcus granulosus fibropellin Ia 0.0008 0.0046 0.0046
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.007 0.007
Brugia malayi probable protein kinase 0.0168 0.2423 0.7257
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0046 0.0046
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.007 0.0159
Schistosoma mansoni loxhd1 0.0119 0.1688 0.1688
Onchocerca volvulus 0.0012 0.0096 0.0225
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.007 0.0106
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.007 0.007
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.007 0.0209
Schistosoma mansoni sphingoid long chain base kinase 0.03 0.4386 0.4386
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.007 0.0209
Brugia malayi hypothetical protein 0.0119 0.1688 0.5057
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Brugia malayi hypothetical protein 0.0119 0.1688 0.5057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0655 0.8941
Schistosoma mansoni cpg binding protein 0.003 0.0365 0.0365
Brugia malayi nuclear receptor NHR-88 0.001 0.007 0.0209
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0096 0.1055
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5895 0.5895
Brugia malayi Ceramide kinase 0.0012 0.0096 0.0287
Schistosoma mansoni septate junction protein 0.0008 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.007 0.0209
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0096 0.0287
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0049 0.0655 0.0655
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0023 0.027 0.081
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0054 0.0721 0.0721
Brugia malayi valosin containing protein 0.0033 0.0416 0.1246
Echinococcus multilocularis fibropellin Ia 0.0008 0.0046 0.0046
Brugia malayi Blistered cuticle protein 3 0.0026 0.0306 0.0916
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0046 0.0046
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni lipoxygenase 0.0435 0.6393 0.6393
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0054 0.0721 1
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0096 0.0096
Brugia malayi hypothetical protein 0.0012 0.0096 0.0287
Echinococcus granulosus Vam6:Vps39 protein 0.0049 0.0655 0.0655
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0096 0.0096
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0157 0.2265 0.2265
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0046 0.0138
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0219
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0026
Brugia malayi Doublecortin family protein 0.0119 0.1688 0.5057
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.007 0.0209
Echinococcus granulosus protein jagged 2 0.0008 0.0046 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.007 0.007
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0049 0.0655 0.0655
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.007 0.0209
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0096 0.0694
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0023 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.1688 0.1688
Loa Loa (eye worm) steroid hormone receptor 0.001 0.007 0.0159
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.007 0.0159
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Trypanosoma cruzi Valosin-containing protein, putative 0.0054 0.0721 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.007 0.0159
Brugia malayi Cadherin domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni vam6/vps39 related 0.0049 0.0655 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0096 0.1055
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0096 0.0096
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.1688 0.1688
Schistosoma mansoni thyroid hormone receptor 0.001 0.007 0.007
Loa Loa (eye worm) doublecortin family protein 0.0119 0.1688 0.385
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0306 0.1171
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0046 0.0046
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0648 0.9572 0.9572
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0096 0.0096
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0306 0.0698
Brugia malayi hypothetical protein 0.0026 0.0306 0.0916
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0051 0.0677 0.0677
Plasmodium vivax multidomain scavenger receptor, putative 0.0119 0.1688 1
Loa Loa (eye worm) ceramide kinase 0.0012 0.0096 0.0219
Loa Loa (eye worm) vesicle-fusing ATPase 0.0033 0.0416 0.0949
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.0013 0.0121 0.1393
Echinococcus granulosus Polycystic kidney disease protein 0.0119 0.1688 0.1688
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0046 0.0046
Giardia lamblia AAA family ATPase 0.0034 0.0426 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0057 0.0765 0.0765
Echinococcus multilocularis peroxidasin 0.0026 0.0306 0.0306
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0306 0.1171
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0178 0.2568 0.2568
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0052
Mycobacterium ulcerans ATPase 0.0034 0.0426 0.077
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0306 0.1171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0812 0.0812
Loa Loa (eye worm) hypothetical protein 0.03 0.4386 1
Echinococcus granulosus protein jagged 1 0.0008 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.03 0.4386 1
Echinococcus granulosus cpg binding protein 0.003 0.0365 0.0365
Toxoplasma gondii cell division protein CDC48AP 0.0034 0.0426 0.5292
Onchocerca volvulus 0.0026 0.0306 0.1171
Onchocerca volvulus 0.0026 0.0306 0.1171
Echinococcus granulosus protein jagged 2 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0046 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni hypothetical protein 0.0012 0.0096 0.0096
Loa Loa (eye worm) Notch2 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.007 0.007
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0057 0.0765 0.0765
Schistosoma mansoni protein kinase 0.0051 0.0677 0.0677
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0096 0.0225
Brugia malayi Protein kinase domain containing protein 0.0051 0.0677 0.2029
Schistosoma mansoni thyroid hormone receptor 0.001 0.007 0.007
Onchocerca volvulus 0.0119 0.1688 0.74
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.007 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.007 0.0209
Schistosoma mansoni rab6-interacting 0.0119 0.1688 0.1688
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni peroxidasin 0.0026 0.0306 0.0306
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Mycobacterium ulcerans hypothetical protein 0.03 0.4386 1
Echinococcus multilocularis protein jagged 2 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0167 0.24 0.5473
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.007 0.0159
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.007 0.0209
Onchocerca volvulus Peroxidase homolog 0.0026 0.0306 0.1171
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0096 0.0096
Brugia malayi follicle stimulating hormone receptor 0.023 0.3339 1
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0096 0.0096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0416 0.0949
Brugia malayi hypothetical protein 0.0049 0.0655 0.1962
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0052 0.0052
Brugia malayi Peroxidasin 0.0026 0.0306 0.0916
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.007 0.007
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0306 0.1171
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Echinococcus granulosus sphingosine kinase 1 0.03 0.4386 0.4386
Echinococcus multilocularis notch 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Echinococcus multilocularis sphingosine kinase 1 0.03 0.4386 0.4386
Echinococcus multilocularis ceramide kinase 0.0012 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Brugia malayi steroid hormone receptor 0.001 0.007 0.0209
Onchocerca volvulus 0.0049 0.0655 0.2744
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Schistosoma mansoni cpg binding protein 0.003 0.0365 0.0365
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0096 0.1055
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.015
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0052 0.0118
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0054 0.0721 0.3926
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.007 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0717 0.9333
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0023 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0178 0.2568 0.5854
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Echinococcus granulosus FTZ F1 alpha 0.001 0.007 0.007
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0157 0.2265 0.5165
Schistosoma mansoni polycystin 1-related 0.0119 0.1688 0.1688
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.3339 0.7612
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Schistosoma mansoni coup transcription factor 0.001 0.007 0.007
Schistosoma mansoni rap gtpase-activating protein 0.0049 0.0655 0.0655
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0096 0.0287
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0677 0.0677
Brugia malayi Protein kinase domain containing protein 0.0157 0.2265 0.6785
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.007 0.007
Toxoplasma gondii cell division protein CDC48CY 0.0057 0.0765 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.007 0.007
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0026 0.0026
Schistosoma mansoni peroxidasin 0.0026 0.0306 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.2568 0.2568
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0341 0.0778
Loa Loa (eye worm) notch protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0219
Echinococcus multilocularis RUN 0.0119 0.1688 0.1688
Echinococcus granulosus protein kinase 0.0119 0.169 0.169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Brugia malayi Steroid receptor seven-up type 2 0.001 0.007 0.0209
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0178 0.2568 0.2568
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0046 0.0046
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Mycobacterium tuberculosis Putative conserved ATPase 0.0034 0.0426 0.077
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Temporarily assigned gene name protein 59 0.0049 0.0655 0.1962
Onchocerca volvulus Peroxidase homolog 0.0026 0.0306 0.1171
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Loa Loa (eye worm) hypothetical protein 0.0049 0.0655 0.1493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.007 0.0159
Echinococcus multilocularis protein jagged 1 0.0008 0.0046 0.0046
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0655 0.8941
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0096 0.1055
Schistosoma mansoni nuclear hormone receptor 0.001 0.007 0.007
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) VCP protein 0.0023 0.027 0.0617
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0057 0.0765 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0341 0.1023
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0034 0.0426 0.5291
Trichomonas vaginalis bmru protein, putative 0.0012 0.0096 0.1055
Onchocerca volvulus 0.0026 0.0306 0.1171
Entamoeba histolytica cdc48-like protein, putative 0.0054 0.0721 0.1457
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Onchocerca volvulus 0.0028 0.0341 0.1331
Echinococcus multilocularis neural cadherin 0.0008 0.0046 0.0046
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0167 0.24 0.24
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.007 0.007
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0096 0.1055
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni protein kinase 0.0119 0.169 0.169
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.007 0.0106
Schistosoma mansoni rab6-interacting 0.0119 0.1688 0.1688
Echinococcus granulosus delta-like protein 1 0.0008 0.0046 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.007 0.007
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0049 0.0655 0.0655
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0051 0.0677 0.0677
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0054 0.0721 0.1457
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0119 0.1688 0.385
Brugia malayi vesicle-fusing ATPase 0.0033 0.0416 0.1246
Brugia malayi nuclear hormone receptor 0.001 0.007 0.0209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0096 0.0694
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0054 0.0721 0.3926
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0051 0.0677 0.0677
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus multilocularis protein jagged 1 0.0008 0.0046 0.0046
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0057 0.0765 0.0765
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.1688 0.1688
Trypanosoma brucei Valosin-containing protein 0.0054 0.0721 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0049 0.0655 0.0655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.007 0.0159
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.007 0.007
Echinococcus multilocularis microtubule associated protein 2 0.0677 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0096 0.0096
Echinococcus granulosus notch 0.0008 0.0046 0.0046
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.007 0.0209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.007 0.007
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.007 0.007
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0096 0.0694
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0655 0.8941
Loa Loa (eye worm) hypothetical protein 0.0049 0.0655 0.1493
Schistosoma mansoni cell polarity protein 0.0008 0.0046 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.001 0.007 0.0106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Brugia malayi Cadherin domain containing protein 0.0008 0.0046 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0677 0.0677
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0096 0.0096
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0119 0.169 0.3853
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0157 0.2265 1
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0157 0.2265 0.2265
Echinococcus multilocularis cpg binding protein 0.003 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus RUN 0.0119 0.1688 0.1688
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0096 0.1055
Trichomonas vaginalis bmru protein, putative 0.0012 0.0096 0.1055
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0096 0.0219
Plasmodium falciparum LCCL domain-containing protein 0.0119 0.1688 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.007 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.0157 0.2265 0.2265
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.007 0.007
Onchocerca volvulus 0.001 0.007 0.0106
Echinococcus multilocularis slit 2 protein 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.007 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.007 0.0209
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0057 0.0765 0.3237
Echinococcus multilocularis Polycystic kidney disease protein 0.0119 0.1688 0.1688
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Loa Loa (eye worm) hypothetical protein 0.0049 0.0655 0.1493
Echinococcus multilocularis FTZ F1 alpha 0.001 0.007 0.007
Onchocerca volvulus 0.0119 0.1688 0.74
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0306 0.0698
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0096 0.1055
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0306 0.0916
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0157 0.2265 0.5165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0096 0.0219
Brugia malayi diacylglycerol kinase 0.0012 0.0096 0.0287
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0159
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0049 0.0655 0.0655
Brugia malayi Muscle positioning protein 4 0.0008 0.0046 0.0138
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.0013 0.0121 0.1393
Schistosoma mansoni hypothetical protein 0.0401 0.5895 0.5895
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.007 0.0209
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0648 0.9572 0.9572
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0026 0.0026
Brugia malayi Delta serrate ligand family protein 0.0008 0.0046 0.0138
Brugia malayi EGF-like domain containing protein 0.0008 0.0046 0.0138
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.007 0.007
Schistosoma mansoni notch 0.0008 0.0046 0.0046
Echinococcus granulosus protein jagged 1 0.0008 0.0046 0.0046
Brugia malayi diacylglycerol kinase 0.0012 0.0096 0.0287
Loa Loa (eye worm) hypothetical protein 0.0119 0.1688 0.385
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0698
Echinococcus granulosus slit 2 protein 0.0008 0.0046 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5895 0.5895
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0046 0.0138
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0051 0.0677 0.0677
Schistosoma mansoni lipoxygenase 0.0648 0.9572 0.9572
Entamoeba histolytica hypothetical protein, conserved 0.03 0.4386 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.007 0.007
Brugia malayi map kinase activated protein kinase protein 2 0.0178 0.2568 0.7691
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0026 0.0026
Schistosoma mansoni sphingosine kinase A B 0.03 0.4386 0.4386
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0119 0.1688 0.1688
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus ceramide kinase 0.0012 0.0096 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.007 0.0209
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0157 0.2265 0.6785
Schistosoma mansoni protein kinase 0.0168 0.2423 0.2423
Brugia malayi notch-like transmembrane receptor 0.0008 0.0046 0.0138
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0096 0.0096
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0046 0.0046
Echinococcus granulosus peroxidasin 0.0026 0.0306 0.0306
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0096 0.0219
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0046 0.0138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0105
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0051 0.0677 0.0677
Schistosoma mansoni hypothetical protein 0.0008 0.0046 0.0046
Brugia malayi ecdysteroid receptor 0.001 0.007 0.0209
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0051 0.0677 0.0677
Plasmodium vivax cell division cycle ATPase, putative 0.002 0.0227 0.0824
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0096 0.0096
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0051 0.0677 0.1544
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.1688 0.1688
Schistosoma mansoni slit 0.0008 0.0046 0.0046
Schistosoma mansoni cpg binding protein 0.0028 0.0341 0.0341
Echinococcus multilocularis 0.0119 0.169 0.169
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.007 0.007
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0046 0.0046
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0096 0.1055

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1853 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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