Detailed information for compound 713163

Basic information

Technical information
  • TDR Targets ID: 713163
  • Name: 1-[4-[4-(2,6-dimethylmorpholin-4-yl)butoxy]-3 -methoxyphenyl]ethanone
  • MW: 335.438 | Formula: C19H29NO4
  • H donors: 0 H acceptors: 1 LogP: 2.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OCCCCN1CC(C)OC(C1)C)C(=O)C
  • InChi: 1S/C19H29NO4/c1-14-12-20(13-15(2)24-14)9-5-6-10-23-18-8-7-17(16(3)21)11-19(18)22-4/h7-8,11,14-15H,5-6,9-10,12-13H2,1-4H3
  • InChiKey: HVDNOTGXSYFVOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-[4-(2,6-dimethylmorpholin-4-yl)butoxy]-3-methoxy-phenyl]ethanone
  • 1-[4-[4-(2,6-dimethyl-4-morpholinyl)butoxy]-3-methoxyphenyl]ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0024
Brugia malayi Protein kinase domain containing protein 0.0268 0.124 0.1229
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.005
Plasmodium falciparum thioredoxin reductase 0.0037 0.0129 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0052 0.0636
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0014 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.012 0.0107
Brugia malayi STAT protein, DNA binding domain containing protein 0.0172 0.0779 0.0766
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0014 0.1067
Trypanosoma cruzi ISWI complex protein 0.0015 0.0024 0.008
Echinococcus granulosus microtubule associated protein 2 0.1412 0.6737 0.6733
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0014 0.1067
Onchocerca volvulus 0.0026 0.0078 0.0548
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0105 0.8116
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0355 0.5644
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.04 0.6386
Schistosoma mansoni tyrosine kinase 0.012 0.0528 0.0515
Mycobacterium tuberculosis Probable reductase 0.0084 0.0355 0.5644
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0063 0.0817
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0122 0.0538 0.0526
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0063 0.0817
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0032 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.04 0.6386
Echinococcus granulosus geminin 0.0164 0.0743 0.073
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0355 0.5644
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0618 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.1315 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0032 0.0019
Brugia malayi PHD-finger family protein 0.0024 0.0069 0.0056
Brugia malayi glutathione reductase 0.0037 0.0129 0.0116
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0062 0.478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0231 0.0218
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0013 0.0000013647
Loa Loa (eye worm) TK/INSR protein kinase 0.0268 0.124 0.1232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0014 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0063 0.0817
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.0046
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0052 0.8463
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0052 0.0295
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0014 0.2232
Trypanosoma brucei ISWI complex protein 0.0015 0.0024 0.1859
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0013 0.0000013647
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0062 0.0368
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0108 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0065
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0032 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.6737 0.6733
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.209 1 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.209 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0355 0.5269
Echinococcus granulosus zinc finger protein 0.0019 0.0044 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0078 0.0068
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0014 0.1067
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.012 0.0107
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0633 0.2993 0.299
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0063 0.0817
Loa Loa (eye worm) hypothetical protein 0.2087 0.9985 1
Echinococcus multilocularis epidermal growth factor receptor 0.0122 0.0538 0.0526
Schistosoma mansoni hypothetical protein 0.0164 0.0743 0.073
Loa Loa (eye worm) glutathione reductase 0.0037 0.0129 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0031 0.0281
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0062 1
Schistosoma mansoni tyrosine kinase 0.0268 0.124 0.1229
Schistosoma mansoni protein kinase 0.209 1 1
Loa Loa (eye worm) STAT protein 0.0172 0.0779 0.077
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1315 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0618 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0063 0.4898
Echinococcus multilocularis zinc finger protein 0.0019 0.0044 0.0031
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.002 0.0007
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0014 0.1067
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0058 0.0044
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.034 0.0327
Entamoeba histolytica hypothetical protein 0.0023 0.0062 0.0075
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0035 0.1864
Echinococcus granulosus lamin 0.0026 0.0078 0.0065
Loa Loa (eye worm) hypothetical protein 0.004 0.0143 0.0132
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0013 0.0013 0.0000013647
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0131 0.0118
Trypanosoma brucei trypanothione reductase 0.0037 0.0129 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0131 0.0118
Leishmania major hypothetical protein, conserved 0.0015 0.0024 0.1859
Leishmania major trypanothione reductase 0.0037 0.0129 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0052 0.0174
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.012 0.0107
Trichomonas vaginalis rotamase, putative 0.0032 0.0105 0.0699
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0063 0.4898
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0132 0.0121
Loa Loa (eye worm) TK/EGFR protein kinase 0.0122 0.0538 0.0529
Schistosoma mansoni tyrosine kinase 0.0268 0.124 0.1229
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0231 0.0218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.0046
Brugia malayi Protein kinase domain containing protein 0.0148 0.0665 0.0652
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0141
Brugia malayi hypothetical protein 0.0035 0.012 0.0107
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0129 0.1906
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0063 0.0087
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.1315 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0052 0.4045
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0035 0.1864
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.6737 0.6733
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0024
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0058 0.0044
Schistosoma mansoni tyrosine kinase 0.0122 0.0538 0.0526
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0035 0.0024
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0013 0.0013 0.0002
Echinococcus multilocularis insulin receptor 0.0268 0.124 0.1229
Brugia malayi intermediate filament protein 0.0026 0.0078 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.1067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.012 0.0107
Schistosoma mansoni tyrosine kinase 0.0122 0.0538 0.0526
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.034 0.0327
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.002 0.0009
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0062 0.0792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0078 0.0065
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0052 0.0039
Brugia malayi Thioredoxin reductase 0.0037 0.0129 0.0116
Echinococcus multilocularis geminin 0.0164 0.0743 0.073
Onchocerca volvulus 0.0081 0.034 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0078 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.0046
Schistosoma mansoni lamin 0.0026 0.0078 0.0065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0052 0.0039
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0108 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0031 0.0281
Trichomonas vaginalis rotamase, putative 0.0032 0.0108 0.0727
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0129 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0618 1
Brugia malayi Bromodomain containing protein 0.0073 0.0302 0.0289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0052 0.0174
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.034 0.0327
Trypanosoma cruzi ISWI complex protein 0.0015 0.0024 0.008
Schistosoma mansoni bromodomain containing protein 0.0061 0.0248 0.0235
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0011
Echinococcus multilocularis expressed protein 0.0032 0.0108 0.0095
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0062 0.4157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0052 0.3334
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0078 0.0068
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0105 0.8116
Onchocerca volvulus 0.0026 0.0078 0.0548
Schistosoma mansoni intermediate filament proteins 0.0026 0.0078 0.0065
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0062 0.478
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0063 0.0027
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0355 0.5644
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0032 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0031 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Echinococcus granulosus epidermal growth factor receptor 0.0122 0.0538 0.0526
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0355 0.5644
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0014 0.1067
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0062 0.478
Schistosoma mansoni protein kinase 0.209 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Schistosoma mansoni tyrosine kinase 0.0122 0.0538 0.0526
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0068
Echinococcus multilocularis lamin dm0 0.0026 0.0078 0.0065
Schistosoma mansoni ap endonuclease 0.0021 0.0052 0.0039
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0633 0.2993 1
Schistosoma mansoni zinc finger protein 0.0015 0.0024 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.1315 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0032 0.0019
Echinococcus granulosus epidermal growth factor receptor 0.0122 0.0538 0.0526
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0062 0.478
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0063 0.0087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0052 0.0039
Brugia malayi Bromodomain containing protein 0.0037 0.0131 0.0118
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0032 0.0019
Schistosoma mansoni ap endonuclease 0.0021 0.0052 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0052 0.3334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0035 0.0355
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.005
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0105 0.035
Schistosoma mansoni rotamase 0.0032 0.0108 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0024
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0052 0.4045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.012 0.0107
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0355 0.5644
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.04 0.6075
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0063 0.0817
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0129 0.0118
Plasmodium vivax glutathione reductase, putative 0.0037 0.0129 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0014 0.2232
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.054
Toxoplasma gondii exonuclease III APE 0.0021 0.0052 0.4045
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0013 0.0013 0.0000013647
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0058 0.0044
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0063 0.0817
Schistosoma mansoni tyrosine kinase 0.012 0.0528 0.0515
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0268 0.124 0.1229
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0105 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.1315 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0129 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0268 0.124 0.1229
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0129 0.0431
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0063 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0052 0.0295
Loa Loa (eye worm) hypothetical protein 0.0629 0.2978 0.2975
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.04 0.6386
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0014 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0108 0.0727
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0052 0.0041
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0616 0.2915 0.2906
Echinococcus granulosus lamin dm0 0.0026 0.0078 0.0065
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0063 0.0027
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0063 0.0817
Loa Loa (eye worm) hypothetical protein 0.0146 0.0655 0.0645
Echinococcus granulosus expressed protein 0.0032 0.0108 0.0095
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0052 0.0636
Schistosoma mansoni lamin 0.0026 0.0078 0.0065
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0633 0.2993 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0014 0.1067
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.1067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0052
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0105 0.8116
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.054
Schistosoma mansoni hypothetical protein 0.0164 0.0743 0.073
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0062 0.4157
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0063 0.0817
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.034 0.0327
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0052 0.0295
Echinococcus multilocularis lamin 0.0026 0.0078 0.0065
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0062 1
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0031 0.0281
Schistosoma mansoni hypothetical protein 0.0035 0.012 0.0107
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0062 0.0792
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0063 0.4898
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0035 0.4483
Plasmodium falciparum glutathione reductase 0.0037 0.0129 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0035 0.0355
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0052 0.0295
Echinococcus multilocularis epidermal growth factor receptor 0.0122 0.0538 0.0526
Schistosoma mansoni zinc finger protein 0.0019 0.0044 0.0031
Schistosoma mansoni tyrosine kinase 0.012 0.0528 0.0515
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0014 0.1067
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0062 0.0792
Loa Loa (eye worm) hypothetical protein 0.0081 0.034 0.033
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0105 0.035
Brugia malayi Furin-like cysteine rich region family protein 0.0122 0.0538 0.0526
Entamoeba histolytica hypothetical protein 0.0035 0.012 0.054
Echinococcus granulosus insulin receptor 0.0268 0.124 0.1229
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0063 0.0817
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0049 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0063 0.0817
Echinococcus multilocularis musashi 0.0026 0.0078 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0032 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0069 0.0282 0.0272
Echinococcus multilocularis 0.0035 0.0121 0.0108

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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