Detailed information for compound 715189

Basic information

Technical information
  • TDR Targets ID: 715189
  • Name: N-[4-bromo-3-(trifluoromethyl)phenyl]benzenes ulfonamide
  • MW: 380.18 | Formula: C13H9BrF3NO2S
  • H donors: 1 H acceptors: 2 LogP: 4.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1C(F)(F)F)NS(=O)(=O)c1ccccc1
  • InChi: 1S/C13H9BrF3NO2S/c14-12-7-6-9(8-11(12)13(15,16)17)18-21(19,20)10-4-2-1-3-5-10/h1-8,18H
  • InChiKey: YYTIJAMJFDUHOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC02853654

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.2028 0.4804
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0386 0.0385
Schistosoma mansoni alpha glucosidase 0.0036 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0038
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.005
Echinococcus granulosus GPCR family 2 0.0031 0.0047 0.0047
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0111 0.005
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0111 0.1265 0.2995
Onchocerca volvulus 0.0095 0.1014 0.5288
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0286 0.0285
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.0173
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0095 0.1014 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1042 0.1041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Schistosoma mansoni transcription factor btf3 0.0035 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0111 0.1265 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.109 0.2581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Onchocerca volvulus 0.0095 0.1014 0.5288
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0111 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1718 0.4068
Entamoeba histolytica cysteine proteinase 2 0.0053 0.0375 0.297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Echinococcus granulosus cathepsin L cysteine protease 0.0053 0.0375 0.0375
Onchocerca volvulus 0.0095 0.1014 0.5288
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0375 0.0375
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0286 0.0286
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0111 0.005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0578 0.137
Loa Loa (eye worm) hypothetical protein 0.0066 0.0578 0.137
Onchocerca volvulus 0.0095 0.1014 0.5288
Echinococcus multilocularis cathepsin b 0.0304 0.4222 0.4222
Onchocerca volvulus 0.0153 0.1903 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.1685 0.1685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Trypanosoma brucei cysteine peptidase C (CPC) 0.0111 0.1265 0.7361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Trypanosoma cruzi cysteine protease, putative 0.0053 0.0375 0.0889
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Brugia malayi Cathepsin L-like precursor 0.0095 0.1014 0.2401
Echinococcus multilocularis GPCR, family 2 0.0031 0.0047 0.0047
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0375 0.2182
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0111 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0386 0.0914
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0496 0.1175
Schistosoma mansoni microtubule-associated protein tau 0.0681 1 1
Echinococcus multilocularis cysteine protease 0.0095 0.1014 0.1013
Brugia malayi jmjC domain containing protein 0.0096 0.1042 0.2468
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Echinococcus multilocularis microtubule associated protein 2 0.0681 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0111 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0106 0.025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.1014 0.2401
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.1014 0.2401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0578 0.408
Brugia malayi Cathepsin L-like precursor 0.0095 0.1014 0.2401
Echinococcus multilocularis transcription factor btf3 0.0035 0.0106 0.0105
Trypanosoma brucei glucosidase, putative 0.0036 0.0111 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0095 0.1014 0.7836
Plasmodium vivax unspecified product 0.0053 0.0375 0.3703
Plasmodium vivax vivapain-2 0.0095 0.1014 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0095 0.1014 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.422 0.9994
Brugia malayi MH2 domain containing protein 0.0118 0.137 0.3245
Entamoeba histolytica cysteine protease, putative 0.0095 0.1014 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0338 0.0801
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.2028 0.2028
Echinococcus multilocularis peregrin 0.0029 0.0016 0.0015
Plasmodium vivax vivapain-3 0.0053 0.0375 0.3703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0111 0.0264
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0386 0.0385
Echinococcus multilocularis cathepsin L cysteine protease 0.0095 0.1014 0.1013
Brugia malayi cathepsin B-like cysteine proteinase 0.0304 0.4222 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0066 0.0578 0.137
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0106 0.0611
Loa Loa (eye worm) hypothetical protein 0.0304 0.4222 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.1014 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0386 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0111 0.1265 0.7189
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0286 0.0286
Brugia malayi mbt repeat family protein 0.0047 0.0286 0.0678
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0111 0.005
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0047
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0106 0.025
Plasmodium vivax vivapain-2 0.0095 0.1014 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1042 0.1041
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0375 0.297
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.0112
Loa Loa (eye worm) cysteine protease 0.0095 0.1014 0.2401
Loa Loa (eye worm) hypothetical protein 0.0068 0.0607 0.1438
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.0173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0047 0.0047
Giardia lamblia Cathepsin B precursor 0.0111 0.1265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Echinococcus granulosus snurportin 1 0.0304 0.422 0.4219
Brugia malayi RNA, U transporter 1 0.0081 0.0805 0.1906
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0375 0.297
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0047 0.0047
Trypanosoma cruzi cruzipain precursor, putative 0.014 0.1718 0.4068
Loa Loa (eye worm) hypothetical protein 0.0153 0.1903 0.4506
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0121 0.0121
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0304 0.4222 1
Echinococcus granulosus cathepsin l1 0.0095 0.1014 0.1013
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0111 0.0262
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0578 0.5207
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0286 0.0285
Toxoplasma gondii cathepsin B 0.0111 0.1265 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Echinococcus multilocularis cysteine protease 0.0095 0.1014 0.1013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0375 0.297
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0047 0.0112
Loa Loa (eye worm) fibroinase 0.0095 0.1014 0.2401
Onchocerca volvulus 0.0047 0.0286 0.1432
Schistosoma mansoni hypothetical protein 0.0286 0.395 0.395
Leishmania major cathepsin L-like protease 0.0095 0.1014 0.5633
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0111 0.011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.1265 0.1265
Leishmania major cathepsin L-like protease 0.0095 0.1014 0.5633
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0112 0.1282 0.3037
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.1014 0.2401
Schistosoma mansoni hypothetical protein 0.0304 0.422 0.422
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0286 0.0285
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0386 0.0385
Echinococcus multilocularis cathepsin b 0.0304 0.4222 0.4222
Brugia malayi Cathepsin L-like precursor 0.0095 0.1014 0.2401
Echinococcus granulosus cathepsin l cysteine peptidase 0.0095 0.1014 0.1013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0029 0.0016 0.0016
Brugia malayi beta-NAC-like protein 0.0035 0.0106 0.025
Onchocerca volvulus 0.0066 0.0578 0.2982
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.137 0.3245
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0193 0.0192
Plasmodium vivax vivapain-1 0.0053 0.0375 0.3703
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0111 0.0063
Brugia malayi cathepsin L-like precursor 0.0066 0.0578 0.137
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.4222 0.4222
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0047 0.0286 0.0678
Giardia lamblia Cathepsin B precursor 0.0111 0.1265 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0016 0.0119
Schistosoma mansoni hypothetical protein 0.0036 0.0121 0.0121
Leishmania major cathepsin L-like protease 0.0095 0.1014 0.5633
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0286 0.1432
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0286 0.0286
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Echinococcus granulosus cathepsin b 0.0304 0.4222 0.4222
Entamoeba histolytica cysteine proteinase 1, putative 0.0053 0.0375 0.297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0121 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.109 0.2581
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.1014 1
Echinococcus granulosus cathepsin l1 0.0066 0.0578 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Leishmania major cathepsin L-like protease 0.0095 0.1014 0.5633
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2028 0.2028
Onchocerca volvulus 0.0095 0.1014 0.5288
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Schistosoma mansoni alpha-glucosidase 0.0138 0.1685 0.1685
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0095 0.1014 0.7836
Onchocerca volvulus Cathepsin L homolog 0.0095 0.1014 0.5288
Schistosoma mansoni hypothetical protein 0.0031 0.0047 0.0047
Echinococcus multilocularis geminin 0.0338 0.4749 0.4748
Brugia malayi Bromodomain containing protein 0.0029 0.0016 0.0038
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0375 0.0889
Loa Loa (eye worm) DEAH box polypeptide 35 0.0164 0.2077 0.4919
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Brugia malayi hypothetical protein 0.0036 0.0121 0.0288
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.2028 0.2028
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0193 0.0192
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0106 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0375 0.0375
Onchocerca volvulus Cathepsin F homolog 0.0095 0.1014 0.5288
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0607 0.1438
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0016 0.0015
Echinococcus granulosus cathepsin b 0.0304 0.4222 0.4222
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0375 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0375 0.297
Brugia malayi PHD-finger family protein 0.0029 0.0016 0.0038
Loa Loa (eye worm) ctsf protein 0.0095 0.1014 0.2401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0578 0.408
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0111 0.0111
Echinococcus granulosus cysteine protease 0.0053 0.0375 0.0375
Plasmodium falciparum cysteine proteinase falcipain 1 0.0053 0.0375 0.3698
Echinococcus granulosus cathepsin L cysteine proteinase 0.0095 0.1014 0.1013
Brugia malayi jmjC domain containing protein 0.0036 0.0111 0.0262
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.109 0.2581
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.2028 0.4804
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.137 0.3245
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0047 0.0112
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0386 0.0914
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0286 0.0285
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0304 0.4222 0.4222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Echinococcus granulosus cathepsin L 0.0053 0.0375 0.0375
Plasmodium falciparum cysteine proteinase falcipain 3 0.0095 0.1014 1
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0106 0.083
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0286 0.0678
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.2407 0.2407
Brugia malayi Cathepsin L-like precursor 0.0095 0.1014 0.2401
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0338 0.4749 0.4749
Schistosoma mansoni hypothetical protein 0.0338 0.4749 0.4749
Brugia malayi Importin beta-1 subunit 0.0028 0.0001 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0016 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0375 0.2327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1718 0.4068
Onchocerca volvulus 0.0095 0.1014 0.5288
Leishmania major cathepsin L-like protease 0.014 0.1718 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.2077 0.4919
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0095 0.1014 0.2401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.4222 0.4222
Leishmania major cathepsin L-like protease 0.014 0.1718 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.005
Onchocerca volvulus Cathepsin L homolog 0.0095 0.1014 0.5288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0375 0.2327
Giardia lamblia Cathepsin B precursor 0.0111 0.1265 1
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0375 0.0889
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0738 0.0738
Echinococcus multilocularis cathepsin L cysteine protease 0.0095 0.1014 0.1013
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0016 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0095 0.1014 0.1013
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0111 0.0264
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0047 0.0047
Brugia malayi Cathepsin L-like precursor 0.0066 0.0578 0.137
Schistosoma mansoni hypothetical protein 0.0068 0.0607 0.0607
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0066 0.0578 0.137
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.005
Trypanosoma cruzi cysteine peptidase, putative 0.014 0.1718 0.4068
Echinococcus granulosus transcription factor btf3 0.0035 0.0106 0.0105
Schistosoma mansoni cathepsin F (C01 family) 0.0066 0.0578 0.0578
Onchocerca volvulus 0.0093 0.099 0.5161
Brugia malayi Cathepsin L-like precursor 0.0066 0.0578 0.137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0375 0.2182
Echinococcus multilocularis cathepsin L 0.0053 0.0375 0.0375
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0111 0.0111
Schistosoma mansoni importin beta-1 0.0028 0.0001 0.0001
Loa Loa (eye worm) MBCTL1 0.0054 0.0386 0.0914
Echinococcus multilocularis snurportin 1 0.0304 0.422 0.4219
Toxoplasma gondii cathepsin CPL 0.0095 0.1014 0.8015
Brugia malayi mbt repeat family protein 0.0047 0.0286 0.0678
Schistosoma mansoni cathepsin F (C01 family) 0.0095 0.1014 0.1014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0095 0.1014 0.1013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0121 0.0121
Brugia malayi Probable ATP-dependent helicase DHX35 0.0164 0.2077 0.4919
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0304 0.4222 0.4222
Schistosoma mansoni cathepsin F (C01 family) 0.0095 0.1014 0.1014
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0095 0.1014 0.2401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0047 0.0112
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.2407 0.2407
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Leishmania major cathepsin L-like protease 0.0095 0.1014 0.5633
Entamoeba histolytica hypothetical protein 0.0036 0.0121 0.0173
Leishmania major cysteine peptidase A (CPA) 0.0095 0.1014 0.5633
Brugia malayi Cathepsin L-like precursor 0.0095 0.1014 0.2401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Loa Loa (eye worm) cathepsin B 0.0111 0.1265 0.2995
Entamoeba histolytica cysteine protease, putative 0.0053 0.0375 0.297
Plasmodium vivax importin-beta 2, putative 0.0028 0.0001 0.0008
Brugia malayi hypothetical protein 0.0153 0.1903 0.4506
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0111 0.0063
Echinococcus granulosus geminin 0.0338 0.4749 0.4748
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.0644 0.1525
Onchocerca volvulus 0.0095 0.1014 0.5288
Echinococcus granulosus peregrin 0.0029 0.0016 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.1014 0.7836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.1014 0.7836
Loa Loa (eye worm) hypothetical protein 0.0099 0.109 0.2581
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0375 0.0889
Brugia malayi Cathepsin L-like precursor 0.0095 0.1014 0.2401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.014 0.1718 1
Leishmania major cathepsin L-like protease 0.014 0.1718 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0016 0.0148
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0106 0.1036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0047 0.0047
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0111 0.011
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0053 0.0375 0.0889
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0106 0.025
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0111 0.0876
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0375 0.0889
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0016 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.005
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0375 0.0889
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0111 0.0264

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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