Detailed information for compound 719141

Basic information

Technical information
  • TDR Targets ID: 719141
  • Name: 1,7,7-trimethyl-2-oxo-N-(2,2,2-trifluoroethyl )-3-oxabicyclo[2.2.1]heptane-4-carboxamide
  • MW: 279.256 | Formula: C12H16F3NO3
  • H donors: 1 H acceptors: 2 LogP: 2.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C12CCC(C2(C)C)(C(=O)O1)C)NCC(F)(F)F
  • InChi: 1S/C12H16F3NO3/c1-9(2)10(3)4-5-11(9,19-8(10)18)7(17)16-6-12(13,14)15/h4-6H2,1-3H3,(H,16,17)
  • InChiKey: PMZGZVHALWRQHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-keto-1,7,7-trimethyl-N-(2,2,2-trifluoroethyl)-3-oxabicyclo[2.2.1]heptane-4-carboxamide
  • STOCK4S-01879

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0597 0.1273
Brugia malayi Pre-SET motif family protein 0.0032 0.0474 0.1012
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Loa Loa (eye worm) RNA binding protein 0.0067 0.1156 0.2469
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0201 0.1827
Brugia malayi Sugar transporter family protein 0.0018 0.0201 0.043
Onchocerca volvulus 0.0032 0.0474 0.0606
Toxoplasma gondii sugar transporter ST2 0.0018 0.0201 0.0305
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1156 0.2469
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0201 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trypanosoma cruzi hexose transporter, putative 0.0021 0.027 0.386
Giardia lamblia Hexose transporter 0.0018 0.0201 0.346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1646 0.3515
Schistosoma mansoni glucose transport protein 0.0125 0.2253 0.7489
Entamoeba histolytica hypothetical protein 0.0028 0.0399 0.6679
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1156 0.3841
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trypanosoma brucei glucose transporter 2A 0.0039 0.0606 0.8651
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1156 0.2469
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0284 0.0943
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0582 0.1241
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0582 0.1934
Schistosoma mansoni zinc finger protein 0.0015 0.0149 0.0497
Brugia malayi Sugar transporter family protein 0.0018 0.0201 0.043
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.0597 0.0597
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Loa Loa (eye worm) hypothetical protein 0.0048 0.079 0.1687
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1156 0.2469
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0399 0.0603
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1102 0.2355
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.043
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1646 0.5469
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0399 0.0399
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0399 0.6849
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.043
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.043
Brugia malayi major facilitator superfamily protein 0.0018 0.0201 0.043
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0125 0.2253 0.4814
Loa Loa (eye worm) sugar transporter 0.0018 0.0201 0.043
Schistosoma mansoni glucose transporter 0.0018 0.0201 0.0669
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.0597 0.1275
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0182 0.0605
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Toxoplasma gondii sugar transporter ST3 0.0018 0.0201 0.0305
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Mycobacterium ulcerans sugar transporter 0.0018 0.0201 0.1827
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1102 0.3663
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0193 0.0413
Loa Loa (eye worm) hypothetical protein 0.0038 0.0597 0.1275
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0201 0.1827
Loa Loa (eye worm) hypothetical protein 0.0037 0.0577 0.1233
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1646 0.3515
Toxoplasma gondii sugar transporter ST1 0.0018 0.0201 0.0305
Brugia malayi Bromodomain containing protein 0.0037 0.0576 0.1231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.079 0.2625
Schistosoma mansoni hypothetical protein 0.0164 0.3009 1
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0701 0.0701
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0669
Leishmania major glucose transporter, lmgt2 0.0039 0.0606 0.55
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.043
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0399 0.085
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.0597 0.0597
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.0597 0.0597
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0399 0.0852
Plasmodium vivax SET domain protein, putative 0.0032 0.0474 0.0474
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trypanosoma cruzi hexose transporter 0.0039 0.0606 0.8651
Brugia malayi Cam kinase protein 1 0.0038 0.0597 0.1275
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0201 0.0201
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Entamoeba histolytica protein kinase, putative 0.0038 0.0597 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0051 0.0848 0.2818
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0201 0.043
Echinococcus granulosus zinc finger protein 0.0019 0.0229 0.0489
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0597 0.1984
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.0597 0.0597
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0201 0.1827
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.1293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1102 1
Schistosoma mansoni bromodomain containing protein 0.0061 0.104 0.3455
Plasmodium falciparum mitogen-activated protein kinase 2 0.0201 0.3724 0.3724
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1156 0.3841
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.1293
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0201 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0582 0.1934
Echinococcus granulosus geminin 0.0164 0.3009 0.6428
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.0597 0.0903
Schistosoma mansoni protein kinase 0.0038 0.0597 0.1984
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0399 0.5689
Plasmodium vivax sugar transporter, putative 0.0018 0.0201 0.0201
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1102 0.1667
Brugia malayi hypothetical protein 0.0018 0.0201 0.043
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0399 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0201 0.043
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0201 0.1827
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1102 0.2355
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0201 0.3724 0.5632
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0606 0.1293
Brugia malayi PHD-finger family protein 0.0024 0.0328 0.07
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0182 0.0389
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0333 0.071
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.4681 1
Plasmodium falciparum protein kinase 7 0.0352 0.6612 0.6612
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1646 0.5469
Brugia malayi RNA binding protein 0.0067 0.1156 0.2469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1646 0.5469
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0182 0.0605
Brugia malayi major facilitator superfamily protein 0.0018 0.0201 0.043
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0119 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1646 0.3515
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0201 0.043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1102 1
Schistosoma mansoni glucose transport protein 0.0125 0.2253 0.7489
Brugia malayi hypothetical protein 0.0251 0.4681 1
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0669
Echinococcus granulosus General substrate transporter 0.0107 0.1918 0.4097
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0399 0.6849
Brugia malayi hypothetical protein 0.0018 0.0201 0.043
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Onchocerca volvulus 0.0051 0.0848 0.144
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1102 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0201 0.0669
Loa Loa (eye worm) hypothetical protein 0.0039 0.0621 0.1327
Leishmania major glucose transporter, lmgt1 0.0039 0.0606 0.55
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0606 0.1293
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1102 0.3663
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Schistosoma mansoni glucose transport protein 0.0125 0.2253 0.7489
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 0.6358
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0701 0.106
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0119 0.2978
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.043
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0119 0.1077
Schistosoma mansoni zinc finger protein 0.0019 0.0229 0.076
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0669
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0451 0.0964
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0606 0.1293
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0474 0.0716
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.016 0.0341
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0201 0.043
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Loa Loa (eye worm) sugar transporter 0.0125 0.2253 0.4814
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0429
Schistosoma mansoni hypothetical protein 0.0125 0.2253 0.7489
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0429
Schistosoma mansoni sugar transporter 0.0018 0.0201 0.0669
Loa Loa (eye worm) hypothetical protein 0.0068 0.1178 0.2515
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0582 1
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0606 0.1293
Loa Loa (eye worm) hypothetical protein 0.0251 0.4681 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1646 0.3515
Leishmania major glucose transporter, lmgt3 0.0039 0.0606 0.55
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.043
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0474 0.1574
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0582 0.1243
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0582 0.1243
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0399 0.3617
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Trypanosoma brucei ISWI complex protein 0.0015 0.0149 0.2133
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.0597 0.0597
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.4681 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.079 0.2625
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1156 0.3841
Leishmania major hypothetical protein, conserved 0.0018 0.0201 0.1827
Loa Loa (eye worm) hypothetical protein 0.0037 0.0582 0.1243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0848 0.1811
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trypanosoma brucei sugar transporter, putative 0.0018 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0474 0.1012
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Schistosoma mansoni hypothetical protein 0.0164 0.3009 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0284 0.0606
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0532 0.1137
Plasmodium vivax CDK-related protein kinase 6, putative 0.0529 1 1
Echinococcus granulosus solute carrier family 22 0.0018 0.0201 0.043
Echinococcus multilocularis solute carrier family 22 0.0018 0.0201 0.043
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0201 0.2874
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0201 0.3724 0.3724
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0318 0.5469
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Echinococcus granulosus tar DNA binding protein 0.0067 0.1156 0.2469
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0201 0.2874
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0201 0.043
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0201 0.043
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0284 0.0606
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0201 0.1827
Brugia malayi Pre-SET motif family protein 0.0221 0.4104 0.8767
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.0597 0.0597
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0606 0.55
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0028 0.0399 0.0852
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1156 0.2469
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0399 0.0399
Giardia lamblia Sugar-proton symporter 0.0018 0.0201 0.346
Brugia malayi Bromodomain containing protein 0.0073 0.1257 0.2685
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0582 0.1243
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1156 0.3841
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.0597 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0606 0.1293
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0399 0.0852
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 1
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0552 0.1178
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0399 0.1325
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1102 1
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0606 0.8651
Echinococcus multilocularis zinc finger protein 0.0019 0.0229 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0474 0.1574
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trypanosoma brucei glucose transporter, putative 0.0039 0.0606 0.8651
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0701 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0701 0.6358
Brugia malayi hypothetical protein 0.0018 0.0201 0.043
Toxoplasma gondii facilitative glucose transporter GT1 0.0125 0.2253 0.3408
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0399 0.3617
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0701 0.0701
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.079 0.1687
Loa Loa (eye worm) hypothetical protein 0.0037 0.0582 0.1243
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0399 0.3617
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.0597 0.0903
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1646 0.3515
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0201 0.1827
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.0597 0.1275
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0399 0.1325
Toxoplasma gondii protein kinase, putative 0.0352 0.6612 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.079 0.1687
Leishmania major hypothetical protein, conserved 0.0015 0.0149 0.1356
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0532 0.1137
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0973 0.2079
Trypanosoma cruzi ISWI complex protein 0.0015 0.0149 0.2133
Schistosoma mansoni protein kinase 0.0038 0.0597 0.1984
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.0597 0.1275
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Entamoeba histolytica protein kinase, putative 0.0038 0.0597 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0318 0.2888
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.0597 0.8517
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0125 0.2253 0.4814
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0318 0.2888
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.043
Onchocerca volvulus 0.0252 0.4689 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2253 0.4805
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1102 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0606 0.8651
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0399 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0201 0.0429
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.0597 0.1275
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0582 0.1243
Plasmodium vivax hexose transporter 0.0125 0.2253 0.2253
Loa Loa (eye worm) hypothetical protein 0.003 0.0448 0.0956
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.4104 0.8767
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Trypanosoma brucei glucose transporter 1E 0.0039 0.0606 0.8651
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0182 0.0389
Brugia malayi Sugar transporter family protein 0.0125 0.2253 0.4814
Brugia malayi TAR-binding protein 0.0067 0.1156 0.2469
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0429
Leishmania major protein kinase, putative 0.0038 0.0597 0.5415
Echinococcus multilocularis General substrate transporter 0.0107 0.1918 0.4097
Schistosoma mansoni hypothetical protein 0.002 0.0248 0.0826
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0582 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0582 0.9752
Loa Loa (eye worm) hypothetical protein 0.0041 0.0657 0.1403
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0201 0.0429
Plasmodium falciparum hexose transporter 0.0125 0.2253 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.0597 0.1275
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0201 0.0305
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0973 0.2079
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0552 0.1178
Trypanosoma cruzi ISWI complex protein 0.0015 0.0149 0.2133
Trichomonas vaginalis set domain proteins, putative 0.0252 0.4689 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0701 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1646 0.3515
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1156 0.3841
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0248 0.0531
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Echinococcus multilocularis geminin 0.0164 0.3009 0.6428
Schistosoma mansoni protein kinase 0.0038 0.0597 0.1984
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0201 0.0429
Schistosoma mansoni hypothetical protein 0.0015 0.0149 0.0497
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0201 0.0429
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0201 0.043
Schistosoma mansoni survival motor neuron protein 0.0051 0.0848 0.2818

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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