Detailed information for compound 757463

Basic information

Technical information
  • TDR Targets ID: 757463
  • Name: N-(3-methoxypropyl)-2-[3-[(2-oxo-1-phenylindo l-3-ylidene)methyl]indol-1-yl]acetamide
  • MW: 465.543 | Formula: C29H27N3O3
  • H donors: 1 H acceptors: 2 LogP: 4.37 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)Cn1cc(c2c1cccc2)C=C1c2ccccc2N(C1=O)c1ccccc1
  • InChi: 1S/C29H27N3O3/c1-35-17-9-16-30-28(33)20-31-19-21(23-12-5-7-14-26(23)31)18-25-24-13-6-8-15-27(24)32(29(25)34)22-10-3-2-4-11-22/h2-8,10-15,18-19H,9,16-17,20H2,1H3,(H,30,33)/b25-18+
  • InChiKey: JJOSOBHZYXNWOB-XIEYBQDHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-methoxypropyl)-2-[3-[(E)-(2-oxo-1-phenylindol-3-ylidene)methyl]indol-1-yl]acetamide
  • N-(3-methoxypropyl)-2-[3-[(E)-(2-oxo-1-phenyl-indolin-3-ylidene)methyl]indol-1-yl]acetamide
  • N-(3-methoxypropyl)-2-[3-[(2-oxo-1-phenyl-indolin-3-ylidene)methyl]indol-1-yl]acetamide
  • N-(3-methoxypropyl)-2-[3-[(E)-(2-oxo-1-phenyl-3-indolinylidene)methyl]-1-indolyl]acetamide
  • N-(3-methoxypropyl)-2-[3-[(2-oxo-1-phenyl-3-indolinylidene)methyl]-1-indolyl]acetamide
  • 2-[3-[(2-keto-1-phenyl-indolin-3-ylidene)methyl]indol-1-yl]-N-(3-methoxypropyl)acetamide
  • 2-[3-[(E)-(2-keto-1-phenyl-indolin-3-ylidene)methyl]indol-1-yl]-N-(3-methoxypropyl)acetamide
  • N-(3-methoxypropyl)-2-[3-[(2-oxo-1-phenyl-indol-3-ylidene)methyl]indol-1-yl]ethanamide
  • N-(3-methoxypropyl)-2-[3-[(E)-(2-oxo-1-phenyl-indol-3-ylidene)methyl]indol-1-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1567 0.4685 0.5672
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0729 0.1236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0936 0.2764 0.4774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0778 0.0778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0981 0.29 0.5011
Echinococcus multilocularis serine protein kinase ATM 0.0583 0.1688 0.1684
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0626 0.0698
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0418 0.1184 0.1432
Leishmania major phosphatidylinositol 4-kinase, putative 0.0234 0.0626 0.1332
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0098 0.0212 0.0447
Loa Loa (eye worm) phosphatidylinositol kinase 0.0234 0.0626 0.0698
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0234 0.0626 0.5208
Schistosoma mansoni hypothetical protein 0.0138 0.0333 0.0333
Brugia malayi Cytochrome P450 family protein 0.0079 0.0152 0.0185
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1582 0.473 0.8194
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0062 0.0373
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Leishmania major phosphatidylinositol 3-kinase, putative 0.0418 0.1184 0.2524
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0234 0.0626 0.0621
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0098 0.0212 0.0254
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0234 0.0626 0.0626
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.3312 1 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.0449 0.0501
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0211 0.0253
Brugia malayi CHE-14 protein 0.0043 0.0042 0.005
Schistosoma mansoni fkbp-rapamycin associated protein 0.0583 0.1688 0.1688
Mycobacterium ulcerans beta-lactamase 0.0035 0.0019 0.0805
Toxoplasma gondii thioredoxin reductase 0.0049 0.0062 0.0109
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1923 0.5768 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0511 0.1469 0.1465
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0524 0.1508 0.1824
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1567 0.4685 0.4682
Schistosoma mansoni hypothetical protein 0.0064 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0234 0.0626 0.5208
Loa Loa (eye worm) hypothetical protein 0.0409 0.1158 0.1292
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1567 0.4685 0.5673
Loa Loa (eye worm) hypothetical protein 0.1281 0.3814 0.4256
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1365 0.407 0.8686
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0344 0.0339
Leishmania major hypothetical protein, conserved 0.0035 0.0019 0.0036
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0418 0.1184 0.1321
Loa Loa (eye worm) RNA binding protein 0.0192 0.0497 0.0555
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0583 0.1688 0.2044
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0234 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Entamoeba histolytica hypothetical protein 0.0234 0.0626 0.1052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0019 0.0023
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0418 0.1184 0.2524
Loa Loa (eye worm) hypothetical protein 0.0176 0.0449 0.0501
Plasmodium vivax SET domain protein, putative 0.0091 0.019 0.1468
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0411 0.1163 0.1989
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0234 0.0626 0.0626
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0597 0.9517
Schistosoma mansoni hypothetical protein 0.0348 0.0972 0.0972
Trichomonas vaginalis PIKK family atypical protein kinase 0.1567 0.4685 0.8116
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0098 0.0212 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.274 0.8259 0.8259
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.0528 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0583 0.1688 0.1684
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0037
Loa Loa (eye worm) CYP4Cod1 0.003 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.0031 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3238 0.9776 0.9776
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0089 0.0175
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0344 0.0339
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0062 0.0057
Brugia malayi TAR-binding protein 0.0192 0.0497 0.0602
Entamoeba histolytica hypothetical protein 0.0583 0.1688 0.29
Loa Loa (eye worm) TAR-binding protein 0.0192 0.0497 0.0555
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1567 0.4685 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.002
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0418 0.1184 0.2524
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1389 0.4143 0.5017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0418 0.1184 0.292
Loa Loa (eye worm) phosphatidylinositol 3 0.0524 0.1508 0.1683
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.274 0.8259 0.8258
Loa Loa (eye worm) hypothetical protein 0.0349 0.0974 0.1087
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0107 0.0102
Brugia malayi FAT domain containing protein 0.0409 0.1158 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.1041 0.3084 0.5331
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.0778 0.0773
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0511 0.1469 0.1465
Trichomonas vaginalis PIKK family atypical protein kinase 0.139 0.4146 0.7178
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0992 0.2934 0.626
Plasmodium vivax hypothetical protein 0.0234 0.0626 0.5208
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0255 0.3895
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Toxoplasma gondii target of rapamycin (TOR), putative 0.1345 0.401 1
Toxoplasma gondii FATC domain-containing protein 0.0583 0.1688 0.4181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.0528 0.0639
Brugia malayi hypothetical protein 0.0036 0.0021 0.0026
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0583 0.1688 0.1688
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0234 0.0626 0.0758
Leishmania major phosphatidylinositol 3-kinase, putative 0.0992 0.2934 0.626
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0418 0.1184 0.1432
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.019 0.0185
Loa Loa (eye worm) hypothetical protein 0.0064 0.0107 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0643 0.1872 0.3223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0936 0.2764 0.4774
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1567 0.4685 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0956 0.2824 0.4877
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Trichomonas vaginalis ap endonuclease, putative 0.0098 0.0212 0.0335
Loa Loa (eye worm) hypothetical protein 0.0091 0.019 0.0212
Onchocerca volvulus 0.0234 0.0626 0.2972
Trichomonas vaginalis PIKK family atypical protein kinase 0.139 0.4146 0.7178
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1567 0.4685 0.5672
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0729 0.1236
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0098 0.0212 0.0254
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0729 0.1236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0778 0.0778
Schistosoma mansoni ap endonuclease 0.0098 0.0212 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.139 0.4146 0.7178
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0178 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.1168 0.3471 0.6004
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0019 0.002
Echinococcus multilocularis protein patched 0.0043 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0021
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0759 0.2222 0.3832
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0583 0.1688 0.2042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0021
Trypanosoma brucei trypanothione reductase 0.0049 0.0062 0.0129
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0234 0.0626 0.0755
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.0497 0.0555
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0098 0.0212 0.3175
Loa Loa (eye worm) hypothetical protein 0.0373 0.1048 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0349 0.0974 0.1661
Echinococcus multilocularis tar DNA binding protein 0.0192 0.0497 0.0493
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0109 0.0109
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0234 0.0626 0.0755
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0219 0.0219
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0333 0.0403
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1567 0.4685 0.8115
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0729 0.1236
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0234 0.0626 0.0621
Giardia lamblia GTOR 0.1567 0.4685 1
Loa Loa (eye worm) hypothetical protein 0.0373 0.1048 0.1169
Loa Loa (eye worm) phosphatidylinositol 3 0.1567 0.4685 0.5228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0021 0.0016
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0418 0.1184 0.1434
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0418 0.1184 0.292
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0107 0.0119
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0234 0.0626 0.5023
Loa Loa (eye worm) hypothetical protein 0.0099 0.0214 0.0239
Mycobacterium leprae conserved hypothetical protein 0.0234 0.0626 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0234 0.0626 0.5208
Loa Loa (eye worm) hypothetical protein 0.0583 0.1688 0.1883
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0497 0.0497
Treponema pallidum exodeoxyribonuclease (exoA) 0.0098 0.0212 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0477 0.0797
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0633 0.184 0.2053
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0234 0.0626 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.1169 0.3473 0.6008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1923 0.5768 0.6985
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0042 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0019 0.0021
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0234 0.0626 0.0755
Loa Loa (eye worm) beta-lactamase 0.0035 0.0019 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.1168 0.3471 0.6004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.0778 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.1688 0.2903
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0729 0.1236
Entamoeba histolytica hypothetical protein 0.0234 0.0626 0.1052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0759 0.2222 0.3832
Trichomonas vaginalis PIKK family atypical protein kinase 0.1169 0.3473 0.6008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0294 0.4527
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0098 0.0212 0.0332
Plasmodium vivax glutathione reductase, putative 0.0049 0.0062 0.0373
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.274 0.8259 0.8258
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0626 0.0698
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0062 0.0057
Echinococcus multilocularis GPCR, family 2 0.0064 0.0107 0.0102
Leishmania major phosphatidylinositol kinase related protein, putative 0.0234 0.0626 0.1332
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0234 0.0626 0.1056
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0062 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.1567 0.4685 0.8116
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1567 0.4685 1
Schistosoma mansoni hypothetical protein 0.0234 0.0626 0.0626
Onchocerca volvulus 0.0035 0.0019 0.009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0759 0.2222 0.383
Brugia malayi N-terminal motif family protein 0.0176 0.0449 0.0544
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0234 0.0626 0.0621
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0234 0.0626 0.1332
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0575 0.1664 0.3247
Brugia malayi RNA binding protein 0.0192 0.0497 0.0602
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0588 0.1702 0.363
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0729 0.1236
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1567 0.4685 0.4685
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0234 0.0626 0.1521
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0234 0.0626 0.1332
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0098 0.0212 0.0207
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1923 0.5768 0.6984
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0107 0.0129
Loa Loa (eye worm) hypothetical protein 0.0642 0.1866 0.2082
Trypanosoma cruzi target of rapamycin kinase 3 0.1391 0.4148 0.5021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0956 0.2824 0.4879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.1688 0.2903
Loa Loa (eye worm) hypothetical protein 0.0643 0.1872 0.2089
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0234 0.0626 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.139 0.4146 0.7178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0234 0.0626 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1391 0.4148 0.8853
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.0778 0.0773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0234 0.0626 0.0758
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0418 0.1184 0.2027
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0042 0.0046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0583 0.1688 0.2044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0107 0.0102
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0214 0.0259
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0409 0.1158 0.1153
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0759 0.2222 0.383
Mycobacterium ulcerans lipase LipD 0.0035 0.0019 0.0805
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0759 0.2222 0.2222
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.14 0.4177 0.7231
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1169 0.3473 0.6008
Echinococcus multilocularis protein dispatched 1 0.0049 0.006 0.0055
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0448 0.2129
Echinococcus granulosus expressed conserved protein 0.0093 0.0196 0.0191
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0234 0.0626 0.1052
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0583 0.1688 0.36
Trichomonas vaginalis conserved hypothetical protein 0.0349 0.0974 0.1661
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0497 0.0497
Plasmodium vivax hypothetical protein, conserved 0.0234 0.0626 0.5208
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0449 0.2133
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.0497 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.2934 0.507
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1281 0.3814 0.4618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0234 0.0626 0.1056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0021
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1365 0.407 0.8686
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.019 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.2934 0.507
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0729 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Onchocerca volvulus 0.0234 0.0626 0.2972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.2934 0.507
Loa Loa (eye worm) phosphatidylinositol 3 0.2971 0.8962 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0042 0.0037
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0098 0.0212 0.133
Brugia malayi beta-lactamase family protein 0.0035 0.0019 0.0023
Schistosoma mansoni hypothetical protein 0.0036 0.0021 0.0021
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0759 0.2222 0.4741
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0255 0.3895
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.0778 0.0778
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0626 0.0698
Loa Loa (eye worm) hypothetical protein 0.0138 0.0333 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.019 0.019
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.14 0.4177 0.7231
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0019 0.0036
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0042 0.0037
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0214 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.1214 0.3609 0.6244
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0583 0.1688 0.2042
Giardia lamblia Phosphatidylinositol 4-kinase 0.0234 0.0626 0.0926
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0255 0.3895
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0759 0.2222 0.2689
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.1169 0.3473 0.6008
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0643 0.1872 0.4643
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0255 0.3895
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0255 0.3895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1158 0.3439 0.5949
Onchocerca volvulus 0.0035 0.0019 0.009
Brugia malayi Pre-SET motif family protein 0.0091 0.019 0.023
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0019 0.0014
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0418 0.1184 0.2024
Brugia malayi exodeoxyribonuclease III family protein 0.0098 0.0212 0.0256
Leishmania major trypanothione reductase 0.0049 0.0062 0.0129
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0042 0.0037
Echinococcus multilocularis 0.0234 0.0626 0.0621
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0234 0.0626 0.1521
Loa Loa (eye worm) glutathione reductase 0.0049 0.0062 0.007
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0418 0.1184 1
Trichomonas vaginalis conserved hypothetical protein 0.0409 0.1158 0.1981
Mycobacterium ulcerans hypothetical protein 0.0035 0.0019 0.0805
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1923 0.5768 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1345 0.401 0.6942
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0418 0.1184 0.118
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.274 0.8259 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0418 0.1184 0.2027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0348 0.0972 0.0972
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.019 0.019
Entamoeba histolytica protein kinase rad3, putative 0.0583 0.1688 0.29
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0409 0.1158 0.1153
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0002 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1391 0.4148 0.8853
Trichomonas vaginalis set domain proteins, putative 0.072 0.2106 0.363
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1567 0.4685 0.4682
Trichomonas vaginalis PIKK family atypical protein kinase 0.1168 0.3471 0.6004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0098 0.0212 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0019 0.0805
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1567 0.4685 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.082 0.2411 0.5144
Echinococcus multilocularis Zinc finger, PHD finger 0.0418 0.1184 0.118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0042 0.0046
Giardia lamblia Hypothetical protein 0.0234 0.0626 0.0926
Schistosoma mansoni hypothetical protein 0.0064 0.0107 0.0107
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0107 0.0102
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0234 0.0626 0.0755
Brugia malayi Pre-SET motif family protein 0.0633 0.184 0.2228
Brugia malayi Thioredoxin reductase 0.0049 0.0062 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0234 0.0626 0.1056
Loa Loa (eye worm) hypothetical protein 0.0234 0.0626 0.0698
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0021
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0214 0.0209
Onchocerca volvulus 0.0035 0.0019 0.009
Onchocerca volvulus 0.0091 0.019 0.0902
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0418 0.1184 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0294 0.4527
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0234 0.0626 0.1521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.019 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0992 0.2934 0.507
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0234 0.0626 0.5023
Leishmania major hypothetical protein, unknown function 0.0234 0.0626 0.1332
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0729 0.0883
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0098 0.0212 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.1214 0.3609 0.6244
Echinococcus granulosus GPCR family 2 0.0064 0.0107 0.0102
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0062 0.007
Onchocerca volvulus 0.072 0.2106 1
Brugia malayi beta-lactamase family protein 0.0035 0.0019 0.0023
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0294 0.4527
Mycobacterium tuberculosis Probable reductase 0.0113 0.0255 0.3895
Echinococcus multilocularis geminin 0.0348 0.0972 0.0967
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.274 0.8259 1
Echinococcus granulosus tar DNA binding protein 0.0192 0.0497 0.0493
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1281 0.3814 0.3811
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0418 0.1184 0.1184
Loa Loa (eye worm) phosphatidylinositol 3 0.1365 0.407 0.4541
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.0778 0.0942
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0418 0.1184 0.118
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0294 0.4527
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.3312 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0019 0.0014
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0418 0.1184 0.2027
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0418 0.1184 0.2024
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0214 0.0209
Loa Loa (eye worm) hypothetical protein 0.0202 0.0528 0.0589
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1281 0.3814 0.3811
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1923 0.5768 0.6984
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.019 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0019 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0759 0.2222 0.2691
Echinococcus granulosus geminin 0.0348 0.0972 0.0967
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.019 0.0429
Schistosoma mansoni cpg binding protein 0.0031 0.0005 0.0005
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0234 0.0626 0.0621
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0098 0.0212 0.0207
Loa Loa (eye worm) cytochrome P450 family protein 0.0079 0.0152 0.017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0098 0.0212 0.0447
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.019 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.139 0.4146 0.7178
Schistosoma mansoni patched 1 0.0043 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0349 0.0974 0.1177
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1567 0.4685 0.8115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0936 0.2764 0.4774
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0418 0.1184 0.118
Trichomonas vaginalis PIKK family atypical protein kinase 0.1365 0.407 0.7046
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0418 0.1184 0.1184
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1923 0.5768 1
Leishmania major hypothetical protein, conserved 0.0333 0.0925 0.197
Schistosoma mansoni ap endonuclease 0.0098 0.0212 0.0212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0098 0.0212 0.1654
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0079
Schistosoma mansoni hypothetical protein 0.0064 0.0107 0.0107
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0759 0.2222 0.3832
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.0778 0.0868
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1059 0.3138 0.6543
Entamoeba histolytica hypothetical protein 0.1582 0.473 0.8194
Brugia malayi beta-lactamase 0.0035 0.0019 0.0023
Toxoplasma gondii exonuclease III APE 0.0098 0.0212 0.0483
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.0528 0.0589
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0234 0.0626 0.0758
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0021 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0098 0.0212 0.0335
Echinococcus multilocularis expressed conserved protein 0.0093 0.0196 0.0191
Brugia malayi glutathione reductase 0.0049 0.0062 0.0076
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0107 0.0129
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0234 0.0626 0.0621
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.274 0.8259 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1923 0.5768 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0255 0.3895
Schistosoma mansoni hypothetical protein 0.0409 0.1158 0.1158
Echinococcus granulosus serine protein kinase ATM 0.0583 0.1688 0.1684
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0583 0.1688 0.1684
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0107 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.0778 0.0773
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0497 0.0497
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0234 0.0626 0.1056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0062 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.1567 0.4685 0.8116
Brugia malayi Cytochrome P450 family protein 0.003 0.0002 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0019 0.0805
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.0477 0.0797
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0448 0.0747
Schistosoma mansoni hypothetical protein 0.0064 0.0107 0.0107
Brugia malayi Cytochrome P450 family protein 0.003 0.0002 0.0003
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.094 0.2776 0.4793
Leishmania major phosphatidylinositol kinase, putative 0.0234 0.0626 0.1332
Loa Loa (eye worm) phosphatidylinositol 3 0.0234 0.0626 0.0698
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1688 0.5054 0.8758

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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