Detailed information for compound 757941

Basic information

Technical information
  • TDR Targets ID: 757941
  • Name: 2-[(4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen -7-yl)oxy]acetonitrile
  • MW: 241.242 | Formula: C14H11NO3
  • H donors: 0 H acceptors: 2 LogP: 2.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCOc1ccc2c(c1)oc(=O)c1c2CCC1
  • InChi: 1S/C14H11NO3/c15-6-7-17-9-4-5-11-10-2-1-3-12(10)14(16)18-13(11)8-9/h4-5,8H,1-3,7H2
  • InChiKey: CTCDJYZLTPXDCR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-keto-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]acetonitrile
  • 2-[(4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]ethanenitrile
  • ChemDiv2_001063
  • Oprea1_384115
  • ZINC01778820
  • (4-Oxo-1,2,3,4-tetrahydro-cyclopenta[c]chromen-7-yloxy)-acetonitrile
  • BAS 03755601
  • ST5018367

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus leucine aminopeptidase protein 0.0123 0.1169 0.1161
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 0.2404
Brugia malayi mbt repeat family protein 0.0051 0.0353 0.1235
Mycobacterium ulcerans hypothetical protein 0.011 0.1021 0.1482
Brugia malayi beta-lactamase 0.0039 0.0221 0.0764
Schistosoma mansoni pyruvate kinase 0.0035 0.0183 0.0121
Echinococcus multilocularis pyruvate kinase 0.0028 0.01 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0229 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0379 0.2166
Schistosoma mansoni tar DNA-binding protein 0.0068 0.055 0.0491
Brugia malayi follicle stimulating hormone receptor 0.0271 0.282 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0783
Entamoeba histolytica protein kinase, putative 0.0095 0.0847 0.9503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0405 0.3328
Brugia malayi TAR-binding protein 0.0068 0.055 0.1935
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0504 0.1788
Leishmania major pyruvate kinase 0.0035 0.0183 0.0826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0618 0.5109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0379 0.0487
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0183 0.147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0138 0.1089
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0183 0.0184
Giardia lamblia DINP protein human, muc B family 0.0105 0.0966 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0619 0.381
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.0832 0.9327
Brugia malayi polk-prov protein 0.0059 0.0444 0.1558
Leishmania major pyruvate kinase 0.0035 0.0183 0.0826
Trypanosoma brucei DNA damage repair protein, putative 0.003 0.0129 0.0453
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0229 0.1062
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0026
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0163 0.1615 0.2404
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.0847 0.5367
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0183 0.0826
Onchocerca volvulus 0.0039 0.0221 0.0538
Loa Loa (eye worm) hypothetical protein 0.0058 0.0432 0.1531
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0386 0.1369
Trypanosoma cruzi DNA damage repair protein, putative 0.003 0.0129 0.0453
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0183 0.0184
Mycobacterium tuberculosis Conserved protein 0.0039 0.0221 0.0242
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0062 0.0054
Trypanosoma cruzi DNA damage repair protein, putative 0.003 0.0129 0.0453
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.0379 0.3829
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0229 0.1062
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.1021 0.1482
Onchocerca volvulus 0.0053 0.0379 0.2793
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0229 0.0255
Schistosoma mansoni terminal deoxycytidyl transferase 0.0098 0.0888 0.0831
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0221 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0618 0.5109
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.287
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0163 0.1615 0.1608
Echinococcus multilocularis pyruvate kinase 0.0035 0.0183 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0624 0.3846
Schistosoma mansoni tar DNA-binding protein 0.0068 0.055 0.0491
Schistosoma mansoni tar DNA-binding protein 0.0068 0.055 0.0491
Trypanosoma brucei DNA polymerase IV, putative 0.0126 0.1203 0.7808
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.1308 0.1253
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.2877
Echinococcus granulosus peptidase Clp S14 family 0.0107 0.0985 0.0978
Brugia malayi beta-lactamase family protein 0.0039 0.0221 0.0764
Loa Loa (eye worm) beta-lactamase 0.0039 0.0221 0.0783
Brugia malayi Protein kinase domain containing protein 0.0095 0.0847 0.2988
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0221 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0679 0.5619
Mycobacterium ulcerans hypothetical protein 0.011 0.1021 0.1482
Echinococcus multilocularis microtubule associated protein 2 0.0806 0.8823 0.8822
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0062 0.0054
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0229 0.1062
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0062 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0386 0.0377
Schistosoma mansoni microtubule-associated protein tau 0.0806 0.8823 0.8816
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.0832 0.0824
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0221 0.0212
Onchocerca volvulus 0.0098 0.0884 1
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0129 0.0453
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.2019 0.2012
Mycobacterium ulcerans beta-lactamase 0.0039 0.0221 0.0242
Entamoeba histolytica hypothetical protein 0.0095 0.0847 0.9503
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.055 0.1952
Loa Loa (eye worm) hypothetical protein 0.0155 0.1524 0.5404
Echinococcus multilocularis peptidase Clp (S14 family) 0.0107 0.0985 0.0978
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 0.2404
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.2877
Echinococcus multilocularis dna polymerase eta 0.0155 0.1524 0.1516
Giardia lamblia Pyruvate kinase 0.0035 0.0183 0.0651
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.0847 0.5367
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0417 0.2272
Echinococcus multilocularis geminin 0.0377 0.4018 0.4013
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0432 0.0423
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.1615 1
Mycobacterium ulcerans hypothetical protein 0.0039 0.0221 0.0242
Schistosoma mansoni tar DNA-binding protein 0.0068 0.055 0.0491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.0832 0.2936
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0386 0.0377
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0774 0.0766
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0138 0.0488
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0138 0.0467
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.0832 0.5268
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0138 0.0514
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0062 0.0221
Mycobacterium ulcerans DNA polymerase IV 0.0126 0.1203 0.1765
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0432 0.0423
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0183 0.0649
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0207 0.1242
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0062 0.02
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.011 0.1021 0.1482
Loa Loa (eye worm) hypothetical protein 0.0035 0.0183 0.0649
Trichomonas vaginalis DNA polymerase eta, putative 0.0126 0.1203 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0098 0.0888 0.1276
Schistosoma mansoni DNA polymerase eta 0.0155 0.1524 0.1471
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0163 0.1615 0.1608
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0379 0.3829
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.287
Loa Loa (eye worm) hypothetical protein 0.0094 0.0841 0.2984
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0028 0.0096 0.0321
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0138 0.0129
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.06 0.6516 1
Treponema pallidum licC protein (licC) 0.011 0.1021 0.6165
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0056 0.0417 0.0546
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0087 0.0765 0.471
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0353 0.0345
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0183 0.0826
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0129 0.0453
Leishmania major DNA polymerase kappa, putative 0.003 0.0129 0.0453
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0221 0.0242
Schistosoma mansoni pyruvate kinase 0.0035 0.0183 0.0121
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0183 0.0649
Schistosoma mansoni peptidase Clp (S14 family) 0.0163 0.1615 0.1563
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0221 0.0242
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0221 0.1786
Trypanosoma brucei unspecified product 0.0068 0.0546 0.331
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0138 0.0514
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0062 0.0054
Loa Loa (eye worm) hypothetical protein 0.0053 0.0379 0.1344
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.0832 0.5268
Echinococcus multilocularis dual specificity 0.0095 0.0847 0.0839
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0123 0.1169 0.7571
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0183 0.0184
Schistosoma mansoni hypothetical protein 0.0377 0.4018 0.398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0832 0.6897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0618 0.5109
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.0847 0.9503
Mycobacterium leprae Probable lipase LipE 0.0039 0.0221 0.0242
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0783
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0564 0.3464
Trypanosoma cruzi DNA polymerase eta, putative 0.0087 0.0765 0.4806
Schistosoma mansoni cpg binding protein 0.0068 0.0545 0.0486
Onchocerca volvulus 0.0064 0.0504 0.4577
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0353 0.0293
Echinococcus granulosus cpg binding protein 0.0068 0.0545 0.0537
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0138 0.0129
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0062 0.0054
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0221 0.0242
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0353 0.2428
Onchocerca volvulus 0.0051 0.0353 0.2428
Schistosoma mansoni cpg binding protein 0.0064 0.0504 0.0444
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0379 0.0487
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0183 0.0826
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0444 0.2614
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0062 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0832 0.6897
Trypanosoma brucei DNA polymerase eta, putative 0.0155 0.1524 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0221 0.1086
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0221 0.0242
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0138 0.0514
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0098 0.0888 0.0831
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0098 0.0888 0.3148
Entamoeba histolytica hypothetical protein 0.0025 0.0065 0.0017
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0065 0.0016
Chlamydia trachomatis cytosol aminopeptidase 0.0123 0.1169 0.712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0466 0.3831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0488 0.402
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0221 0.1084
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0281 0.1498
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0221 0.0242
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0129 0.0453
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0221 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0386 0.0326
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0221 0.1007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0063 0.0224
Plasmodium falciparum pyruvate kinase 0.0035 0.0183 0.0764
Echinococcus multilocularis pyruvate kinase 0.0035 0.0183 0.0174
Echinococcus granulosus microtubule associated protein 2 0.0806 0.8823 0.8822
Trypanosoma brucei DNA polymerase kappa, putative 0.0105 0.0966 0.6184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0218
Brugia malayi beta-lactamase family protein 0.0039 0.0221 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0129 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0624 0.3846
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0386 0.0377
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0221 0.1786
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0138 0.0076
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0098 0.0888 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Schistosoma mansoni hypothetical protein 0.0377 0.4018 0.398
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.1615 1
Mycobacterium ulcerans DNA polymerase IV 0.0126 0.1203 0.1765
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.0847 0.5367
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.0832 0.9327
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0783
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0065 0.0016
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0417 0.2272
Loa Loa (eye worm) RNA binding protein 0.0068 0.055 0.1952
Brugia malayi ImpB/MucB/SamB family protein 0.0155 0.1524 0.5394
Echinococcus granulosus dual specificity 0.0095 0.0847 0.0839
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0183 0.147
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0353 0.0293
Loa Loa (eye worm) hypothetical protein 0.0059 0.0444 0.1576
Trypanosoma brucei chrX additional, unordered contigs 0.003 0.0129 0.0453
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0353 0.0345
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0379 0.0487
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.0379 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0619 0.381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0813
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0107 0.0985 0.1427
Echinococcus granulosus pyruvate kinase 0.0035 0.0183 0.0174
Echinococcus granulosus dna polymerase eta 0.0155 0.1524 0.1516
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0105 0.0966 0.1397
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0123 0.1169 0.1712
Toxoplasma gondii leucyl aminopeptidase LAP 0.0123 0.1169 0.7223
Brugia malayi ImpB/MucB/SamB family protein 0.0098 0.0888 0.3134
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0432 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.287
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0444 0.2614
Mycobacterium tuberculosis Conserved hypothetical protein 0.011 0.1021 0.1482
Leishmania major DNA polymerase eta, putative 0.0155 0.1524 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.055 0.1935
Loa Loa (eye worm) hypothetical protein 0.0051 0.0353 0.1253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Trypanosoma cruzi DNA polymerase eta, putative 0.0155 0.1524 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0221 0.0242
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0123 0.1169 0.7571
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.0379 0.0487
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0183 0.1093
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0163 0.1615 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.055 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.2877
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0221 0.0212
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0353 0.0345
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0417 0.2272
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0183 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0412 0.338
Chlamydia trachomatis pyruvate kinase 0.0035 0.0183 0.0764
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0067 0.0503
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0095 0.0847 0.5367
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0813
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0095 0.0847 0.3003
Schistosoma mansoni DNA polymerase IV / kappa 0.003 0.0129 0.0067
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.0379 0.0487
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0123 0.1169 0.7571
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0379 0.1325
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0105 0.0966 0.6184
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0183 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0379 0.0487
Plasmodium vivax DNA repair protein REV1, putative 0.003 0.0129 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Mycobacterium ulcerans leucyl aminopeptidase 0.0123 0.1169 0.1712
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0218
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0432 0.0423
Toxoplasma gondii ABC1 family protein 0.0039 0.0221 0.1328
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0065 0.0357
Loa Loa (eye worm) hypothetical protein 0.0094 0.0841 0.2984
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2559 0.3867
Brugia malayi CXXC zinc finger family protein 0.0064 0.0504 0.177
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0774 0.0766
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.0832 0.5268
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0353 0.1253
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.0832 0.5268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0218
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0138 0.0514
Loa Loa (eye worm) hypothetical protein 0.0088 0.0774 0.2746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0618 0.5109
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.0379 0.3829
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0221 0.1084
Mycobacterium ulcerans hypothetical protein 0.003 0.0129 0.0099
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0221 0.0242
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0062 0.02
Giardia lamblia GTOR 0.0093 0.0832 0.8402
Onchocerca volvulus 0.0088 0.0774 0.843
Schistosoma mansoni cpg binding protein 0.0068 0.0545 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Loa Loa (eye worm) histone methyltransferase 0.002 0.0009 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0379 0.1325
Echinococcus multilocularis dnaJ subfamily B 0.0911 1 1
Leishmania major DNA damage repair protein, putative 0.003 0.0129 0.0453
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0813
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0221 0.0242
Trypanosoma brucei unspecified product 0.0119 0.1125 0.7272
Schistosoma mansoni hypothetical protein 0.0911 1 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0123 0.1169 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0405 0.3328
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0062 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0351 0.2877
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.06 0.6516 1
Onchocerca volvulus 0.0039 0.0221 0.0538
Brugia malayi Probable ClpP-like protease 0.0163 0.1615 0.572
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0098 0.0888 0.088
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0432 0.0372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0386 0.135
Brugia malayi mbt repeat family protein 0.0051 0.0353 0.1235
Echinococcus granulosus pyruvate kinase 0.0035 0.0183 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0107 0.0985 0.1427
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0126 0.1203 1
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.1125 0.7272
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0624 0.3846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0386 0.0377
Onchocerca volvulus 0.0039 0.0221 0.0538
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0847 0.0789
Loa Loa (eye worm) MBCTL1 0.0058 0.0432 0.1531
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0138 0.0514
Trypanosoma brucei DNA polymerase IV, putative 0.0126 0.1203 0.7808
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.0832 0.0775
Schistosoma mansoni hypothetical protein 0.0307 0.323 0.3188
Leishmania major DNA polymerase eta, putative 0.0087 0.0765 0.4806
Loa Loa (eye worm) hypothetical protein 0.0053 0.0379 0.1344
Mycobacterium tuberculosis Conserved protein 0.0039 0.0221 0.0242
Echinococcus multilocularis tar DNA binding protein 0.0068 0.055 0.0542
Loa Loa (eye worm) hypothetical protein 0.0098 0.0884 0.3136
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0138 0.0514
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0221 0.1786
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.0379 0.0487
Echinococcus multilocularis leucine aminopeptidase protein 0.0123 0.1169 0.1161
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0379 0.2166
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0123 0.1169 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0412 0.338
Mycobacterium ulcerans lipase LipD 0.0039 0.0221 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0138 0.1089
Trichomonas vaginalis esterase, putative 0.0039 0.0221 0.1786
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.0832 0.5268
Entamoeba histolytica deoxycytidyl transferase, putative 0.0098 0.0888 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0129 0.0755
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0353 0.0293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Loa Loa (eye worm) TAR-binding protein 0.0068 0.055 0.1952
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0221 0.1084
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.2019 0.2012
Toxoplasma gondii hypothetical protein 0.0056 0.0417 0.2547
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.1146 0.7078
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.011 0.1021 0.6302
Echinococcus granulosus geminin 0.0377 0.4018 0.4013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0221 0.0159
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0107 0.0985 0.1427
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0183 0.0764
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0412 0.338
Brugia malayi cytosol aminopeptidase 0.0025 0.0062 0.02
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0774 0.273
Loa Loa (eye worm) hypothetical protein 0.0163 0.1615 0.5729
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0884 0.0827
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0123 0.1169 0.7571
Plasmodium falciparum DNA repair protein REV1, putative 0.003 0.0129 0.0412
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0221 0.1786
Echinococcus multilocularis tumor protein p63 0.0669 0.7285 0.7282
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0183 0.0826
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0783
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0221 0.0764
Echinococcus multilocularis dna polymerase kappa 0.0126 0.1203 0.1196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.0379 0.0487
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0065 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0068 0.055 0.0491
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.282 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0432 0.1513
Mycobacterium tuberculosis Conserved protein 0.0039 0.0221 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.0832 0.0824
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0183 0.0629
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0379 0.0487
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0353 0.0345
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0619 0.381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0138 0.1089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0386 0.0326
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0123 0.1169 0.712
Plasmodium falciparum M17 leucyl aminopeptidase 0.0123 0.1169 0.712
Trypanosoma brucei DNA damage repair protein, putative 0.003 0.0129 0.0453
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0221 0.0242
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0813
Leishmania major hypothetical protein, conserved 0.0039 0.0221 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0618 0.5109
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.06 0.6516 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.0832 0.5268
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0063 0.0224
Leishmania major DNA polymerase kappa, putative 0.0105 0.0966 0.6184
Loa Loa (eye worm) hypothetical protein 0.0039 0.0229 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0138 0.1089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0564 0.4657
Mycobacterium ulcerans hypothetical protein 0.0053 0.0379 0.0487
Brugia malayi RNA binding protein 0.0068 0.055 0.1935
Trypanosoma brucei unspecified product 0.0068 0.0546 0.331
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.06 0.6516 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.0379 0.2166
Loa Loa (eye worm) hypothetical protein 0.0053 0.0379 0.1344
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0205 0.0218
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0163 0.1615 0.2404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0386 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0832 0.6897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0138 0.1089
Echinococcus granulosus dna polymerase kappa 0.0126 0.1203 0.1196
Entamoeba histolytica protein kinase, putative 0.0095 0.0847 0.9503
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0221 0.0242
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0783
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.0379 0.0487
Brugia malayi AMP-binding enzyme family protein 0.0053 0.0379 0.1325
Echinococcus multilocularis cpg binding protein 0.0068 0.0545 0.0537
Echinococcus granulosus tumor protein p63 0.0669 0.7285 0.7282
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0774 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0126 0.1203 0.7808
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.0832 0.2951

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.