Detailed information for compound 770814

Basic information

Technical information
  • TDR Targets ID: 770814
  • Name: 6-tert-butyl-2-[(2-fluorobenzoyl)amino]-4,5,6 ,7-tetrahydro-1-benzothiophene-3-carboxylic a cid
  • MW: 375.457 | Formula: C20H22FNO3S
  • H donors: 2 H acceptors: 3 LogP: 5.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1c(sc2c1CCC(C2)C(C)(C)C)NC(=O)c1ccccc1F
  • InChi: 1S/C20H22FNO3S/c1-20(2,3)11-8-9-13-15(10-11)26-18(16(13)19(24)25)22-17(23)12-6-4-5-7-14(12)21/h4-7,11H,8-10H2,1-3H3,(H,22,23)(H,24,25)
  • InChiKey: GCJUIPVZVSDRKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-tert-butyl-2-[(2-fluorobenzoyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid
  • 6-tert-butyl-2-[[(2-fluorophenyl)-oxomethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid
  • 6-tert-butyl-2-[(2-fluorophenyl)carbonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid
  • Oprea1_073146
  • EU-0011781

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.017 0.0546
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.017 0.0821
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0125 0.1693 0.6075
Onchocerca volvulus 0.0013 0.005 0.0284
Echinococcus granulosus enteropeptidase 0.0013 0.005 0.005
Giardia lamblia Kinase, PLK 0.0093 0.1216 0.5
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.017 0.0611
Onchocerca volvulus 0.0033 0.0333 0.1886
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0333 0.0672
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0183 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.2787 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0937 0.3363
Loa Loa (eye worm) trypsin family protein 0.0013 0.005 0.018
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Onchocerca volvulus 0.0033 0.0333 0.1886
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0596 0.4558
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0112 0.04
Leishmania major phospholipase c-like protein 0.0021 0.0166 0.0784
Brugia malayi Troponin T 0.0062 0.0767 0.275
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.017 0.0546
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0596 0.8806
Toxoplasma gondii microneme protein, putative 0.0033 0.0333 0.0672
Brugia malayi Trypsin family protein 0.0013 0.005 0.018
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0333 0.0672
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0333 0.1194
Schistosoma mansoni phospholipase C beta 0.0017 0.0103 0.0103
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.005 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0333 0.0672
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Brugia malayi Trypsin family protein 0.0013 0.005 0.018
Loa Loa (eye worm) tyrosinase 1 0.009 0.1182 0.4239
Toxoplasma gondii hypothetical protein 0.0033 0.0333 0.0672
Brugia malayi Troponin T 0.0062 0.0767 0.275
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.1182 0.4239
Onchocerca volvulus 0.0051 0.0596 0.3376
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Echinococcus multilocularis Mastin 0.0013 0.005 0.005
Onchocerca volvulus 0.0022 0.017 0.0964
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0937 1
Trypanosoma brucei polo-like protein kinase 0.0093 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0937 0.3363
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0079 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0937 0.3363
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Loa Loa (eye worm) oxidoreductase 0.0022 0.017 0.0611
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0333 0.0672
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.017 0.1353
Onchocerca volvulus 0.0013 0.005 0.0284
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0596 0.1285
Schistosoma mansoni tyrosinase precursor 0.009 0.1182 0.1182
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0079 0.0284
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0937 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0161
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0937 0.3363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0425
Loa Loa (eye worm) hypothetical protein 0.0051 0.0596 0.2138
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Onchocerca volvulus 0.009 0.1182 0.6693
Schistosoma mansoni troponin t invertebrate 0.013 0.1765 0.1765
Schistosoma mansoni troponin I 0.0105 0.1394 0.1394
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0596 0.2138
Loa Loa (eye worm) hypothetical protein 0.0074 0.0937 0.3363
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0731 0.0731
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0937 1
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1216 0.1216
Schistosoma mansoni hypothetical protein 0.0051 0.0596 0.0596
Brugia malayi AMP-binding enzyme family protein 0.0022 0.017 0.0611
Schistosoma mansoni zinc finger protein 0.0015 0.0077 0.0077
Schistosoma mansoni zinc finger protein 0.002 0.014 0.014
Onchocerca volvulus 0.0013 0.005 0.0284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0618 0.6071
Echinococcus multilocularis laminin 0.0013 0.0045 0.0045
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0596 0.8806
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.017 0.1353
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.017 0.0292
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.0119 0.0367
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0663 0.2378
Onchocerca volvulus 0.0033 0.0333 0.1886
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0333 0.0672
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0937 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0045 0.0161
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0333 0.1194
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0079 0.0284
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.017 0.0821
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.005 0.005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.017 0.0611
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0079 0.0284
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0937 1
Schistosoma mansoni troponin I 0.0105 0.1394 0.1394
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.0119 0.0367
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.017 0.1353
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0103 0.0371
Echinococcus granulosus troponin i 0.0105 0.1394 0.1394
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0103 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0937 0.7553
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0381 0.0381
Onchocerca volvulus 0.0033 0.0333 0.1886
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0937 1
Onchocerca volvulus 0.0022 0.017 0.0964
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0611
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Schistosoma mansoni hypothetical protein 0.0105 0.1394 0.1394
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Onchocerca volvulus 0.0074 0.0937 0.5309
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0013 0.005 0.005
Onchocerca volvulus 0.0022 0.017 0.0964
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.017 0.017
Onchocerca volvulus 0.0018 0.0119 0.0671
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.0119 0.0172
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0333 0.1194
Mycobacterium ulcerans hypothetical protein 0.0074 0.0937 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.005 0.005
Toxoplasma gondii subtilisin SUB12 0.0033 0.0333 0.0672
Toxoplasma gondii propionate-CoA ligase 0.0022 0.017 0.0292
Echinococcus multilocularis zinc finger protein 0.002 0.014 0.014
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1216 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1216 0.1216
Schistosoma mansoni hypothetical protein 0.0033 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.009 0.1182 0.4239
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0119 0.0119
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Onchocerca volvulus 0.009 0.1182 0.6693
Brugia malayi Trypsin-like protease protein 5 0.0013 0.005 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.1182 0.4239
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.005 0.005
Onchocerca volvulus Arrow homolog 0.0013 0.0045 0.0254
Brugia malayi Kringle domain containing protein 0.0051 0.0596 0.2138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0103 0.0103
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0333 0.0672
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0572 0.2051
Loa Loa (eye worm) hypothetical protein 0.0043 0.048 0.172
Brugia malayi Trypsin family protein 0.0013 0.005 0.018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0161
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.013 0.1765 0.1765
Loa Loa (eye worm) hypothetical protein 0.0199 0.2787 1
Echinococcus granulosus Tolloid protein 1 0.0013 0.0045 0.0045
Echinococcus multilocularis GPCR, family 2 0.0015 0.0079 0.0079
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.005 0.005
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.017 0.0821
Toxoplasma gondii PAN domain-containing protein 0.0304 0.4333 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.017 0.0821
Onchocerca volvulus 0.0033 0.0333 0.1886
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Schistosoma mansoni hypothetical protein 0.0021 0.0155 0.0155
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0161
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0011 0.0012 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0022 0.017 0.0611
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0045 0.0161
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1182 0.4239
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0731 0.0731
Onchocerca volvulus Troponin I homolog 0.0105 0.1394 0.7898
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0079 0.0079
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0937 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.017 0.0546
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0371
Loa Loa (eye worm) hypothetical protein 0.0105 0.1394 0.5002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0663 0.6905
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0663 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.017 0.0292
Echinococcus multilocularis troponin i 0.0105 0.1394 0.1394
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Onchocerca volvulus 0.0018 0.0119 0.0671
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0103 0.0103
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Onchocerca volvulus 0.009 0.1182 0.6693
Schistosoma mansoni tyrosinase precursor 0.009 0.1182 0.1182
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0103 0.0371
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0103 0.0103
Brugia malayi Trypsin family protein 0.0013 0.005 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0103
Toxoplasma gondii PAN domain-containing protein 0.0304 0.4333 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.017 0.0821
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0013 0.0045 0.0161
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0062 0.0767 0.4342
Brugia malayi AMP-binding enzyme family protein 0.0022 0.017 0.0611
Loa Loa (eye worm) hypothetical protein 0.0071 0.0893 0.3204
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.0368
Onchocerca volvulus 0.0022 0.017 0.0964
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0161
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.017 0.0821
Brugia malayi Troponin T 0.0062 0.0767 0.275
Brugia malayi Fibulin-1 precursor 0.0013 0.0045 0.0161
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.017 0.017
Brugia malayi Bromodomain containing protein 0.0075 0.0956 0.343
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0013 0.0045 0.0045
Leishmania major hypothetical protein, conserved 0.0051 0.0596 0.4558
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0937 0.7334
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0663 0.6617
Schistosoma mansoni bromodomain containing protein 0.0063 0.0783 0.0783
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.013 0.1765 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1216 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1216 0.6889
Onchocerca volvulus 0.0013 0.005 0.0284
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0937 0.3363
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.017 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Loa Loa (eye worm) hypothetical protein 0.0062 0.0767 0.275
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0166 0.2295 0.2295
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0045 0.0161
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.017 0.0546
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0333 0.1194
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0033 0.0333 0.1886
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.017 0.1353
Brugia malayi Variant SH3 domain containing protein 0.0125 0.1693 0.6075
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0079
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0017 0.0103 0.0234
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0937 0.7334
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.017 0.1353
Schistosoma mansoni hypothetical protein 0.0015 0.0077 0.0077
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1182 0.4239
Schistosoma mansoni hypothetical protein 0.0013 0.005 0.005
Schistosoma mansoni microtubule-associated protein tau 0.0688 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0937 1
Toxoplasma gondii microneme protein MIC4 0.0033 0.0333 0.0672
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.017 0.0546
Loa Loa (eye worm) hypothetical protein 0.0055 0.0663 0.2378
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0527 0.3411
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0596 0.0596
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0013 0.0045 0.0161
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Echinococcus granulosus GPCR family 2 0.0015 0.0079 0.0079
Onchocerca volvulus 0.0033 0.0333 0.1886
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1182 0.4239
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.005 0.005
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0119 0.0425
Onchocerca volvulus 0.009 0.1182 0.6693
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.1182 0.4239
Brugia malayi PHD-finger family protein 0.0025 0.0218 0.0783
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0618 0.6071
Schistosoma mansoni troponin I 0.0105 0.1394 0.1394
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0663 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0155 0.0557
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1216 0.4363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0663 0.2378
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.005 0.005
Brugia malayi Troponin family protein 0.0105 0.1394 0.5002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0381 0.0381
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0937 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0937 0.7553
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.017 0.1353
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.005 0.005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.017 0.0611
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.017 0.0821
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Echinococcus multilocularis enteropeptidase 0.0013 0.005 0.005
Loa Loa (eye worm) troponin 0.0062 0.0767 0.275
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0333 0.0672
Loa Loa (eye worm) troponin I 0.0105 0.1394 0.5002
Echinococcus multilocularis Tolloid protein 1 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.009 0.1182 0.4239
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.017 0.1195
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0333 0.1194
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.017 0.0821
Onchocerca volvulus 0.0033 0.0333 0.1886
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.017 0.1353
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0013 0.005 0.018
Loa Loa (eye worm) hypothetical protein 0.0033 0.0333 0.1194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0618 0.6071
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0333 0.0672
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.017 0.017
Brugia malayi Protein kinase domain containing protein 0.0051 0.0596 0.2138
Onchocerca volvulus 0.0033 0.0333 0.1886
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.1233
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0079 0.0284
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.017 0.1195
Schistosoma mansoni egf-like domain protein 0.0013 0.0045 0.0045
Onchocerca volvulus 0.0033 0.0333 0.1886
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0103 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1216 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0663 0.2378
Loa Loa (eye worm) hypothetical protein 0.0105 0.1394 0.5002
Brugia malayi hypothetical protein 0.0013 0.005 0.018
Echinococcus granulosus laminin 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.1619
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.005 0.005
Brugia malayi hypothetical protein 0.0062 0.0767 0.275
Brugia malayi PAN domain containing protein 0.0033 0.0333 0.1194
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.017 0.0546
Loa Loa (eye worm) troponin T 0.0062 0.0767 0.275
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0937 1
Brugia malayi Troponin I 0.0105 0.1394 0.5002
Echinococcus granulosus oncosphere protein Tso22e 0.013 0.1765 0.1765
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0937 1
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0333 0.0672
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.017 0.1353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0618 0.6071
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0055 0.0663 0.2378
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0527 0.3411
Echinococcus granulosus zinc finger protein 0.002 0.014 0.014
Schistosoma mansoni troponin I 0.0105 0.1394 0.1394
Toxoplasma gondii hypothetical protein 0.0033 0.0333 0.0672
Brugia malayi AMP-binding enzyme family protein 0.0022 0.017 0.0611
Brugia malayi phospholipase C homolog 0.0011 0.0012 0.0044
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.017 0.1353
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.017 0.0821
Loa Loa (eye worm) hypothetical protein 0.0038 0.0417 0.1494
Echinococcus granulosus Mastin 0.0013 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0013 0.005 0.005
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.017 0.0546
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.1182 0.4239
Echinococcus multilocularis microtubule associated protein 2 0.0688 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.0611
Onchocerca volvulus 0.0033 0.0333 0.1886
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0937 0.7334
Schistosoma mansoni kinase 0.0047 0.0545 0.0545
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0183 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0344 0.1233
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0596 0.0596
Brugia malayi ShTK domain containing protein 0.009 0.1182 0.4239
Echinococcus multilocularis fibrillin 1 0.0013 0.0045 0.0045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.017 0.0546
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1216 0.1216
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0166 0.2295 0.2295
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0937 0.7553
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.018
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.017 0.0546
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0119 0.0425
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0425
Schistosoma mansoni hypothetical protein 0.0015 0.0079 0.0079
Brugia malayi Bromodomain containing protein 0.0038 0.0415 0.1491
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1216 0.4363
Onchocerca volvulus 0.0013 0.005 0.0284
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0572 0.2051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0161
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.017 0.0546
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0017 0.0103 0.0234
Onchocerca volvulus 0.0013 0.005 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.017 0.1353
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.017 0.0611
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0103 0.0371
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0663 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0183 0.0183

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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