Detailed information for compound 771572

Basic information

Technical information
  • TDR Targets ID: 771572
  • Name: N-(2,5-dimethoxyphenyl)sulfonyl-N-(2-oxo-1,3- benzoxathiol-5-yl)pentanamide
  • MW: 451.513 | Formula: C20H21NO7S2
  • H donors: 0 H acceptors: 4 LogP: 4.05 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(=O)N(S(=O)(=O)c1cc(OC)ccc1OC)c1ccc2c(c1)sc(=O)o2
  • InChi: 1S/C20H21NO7S2/c1-4-5-6-19(22)21(13-7-9-15-17(11-13)29-20(23)28-15)30(24,25)18-12-14(26-2)8-10-16(18)27-3/h7-12H,4-6H2,1-3H3
  • InChiKey: FZSMNLNSAXCPIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethoxyphenyl)sulfonyl-N-(2-keto-1,3-benzoxathiol-5-yl)valeramide
  • ZINC01926416

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.0174 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0376 0.0685
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.0894 0.1627
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0124 0.7109
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0017 0.0174 1
Schistosoma mansoni ferritin 0.0009 0.0055 0.0085
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.0174 1
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.0174 0.012
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0186 0.2765 0.2725
Schistosoma mansoni hypothetical protein 0.0017 0.0174 0.0271
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Schistosoma mansoni hypothetical protein 0.0424 0.6424 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Schistosoma mansoni hypothetical protein 0.0017 0.0174 0.0271
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0061 0.0028
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0017 0.0174 0.0317
Mycobacterium ulcerans hydrolase 0.0017 0.0174 0.012
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0364 0.5493 0.855
Loa Loa (eye worm) hypothetical protein 0.0016 0.0171 0.031
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0124 0.5548
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0061 0.0111
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0017 0.0174 0.0317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.00000000074633
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0009 0.0061 0.0095
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Echinococcus multilocularis cpg binding protein 0.0032 0.0402 0.0371
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0077 0.0044
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0017 0.0174 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0124 0.1154
Mycobacterium ulcerans beta lactamase-like protein 0.0017 0.0174 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0009 0.0061 0.0111
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0061 0.0095
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0009 0.0061 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0888 0.1383
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0174 0.1731
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.0174 1
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.0894 0.0864
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0009 0.0061 0.0028
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0061 0.0028
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0061 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Mycobacterium ulcerans hydrolase 0.0017 0.0174 0.012
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0174 0.1731
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0009 0.0061 0.0028
Schistosoma mansoni ferritin light chain 0.0009 0.0055 0.0085
Echinococcus multilocularis hypothetical protein 0.0009 0.0061 0.0028
Loa Loa (eye worm) hypothetical protein 0.0125 0.1841 0.3352
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0009 0.0061 0.0003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Onchocerca volvulus 0.0017 0.0174 0.175
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0174 0.1731
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.0174 1
Schistosoma mansoni hypothetical protein 0.0064 0.0894 0.1391
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0061 0.0095
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0712 0.1202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.00000000074633
Schistosoma mansoni hypothetical protein 0.0016 0.0171 0.0265
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0009 0.0061 0.0095
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0077 0.0033
Echinococcus multilocularis ETHE1 protein 0.0017 0.0174 0.0141
Echinococcus multilocularis tumor protein p63 0.0351 0.5293 0.5278
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Mycobacterium tuberculosis Beta lactamase like protein 0.0017 0.0174 0.012
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0174 0.1731
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0017 0.0174 0.175
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0174 0.012
Mycobacterium leprae conserved hypothetical protein 0.0017 0.0174 0.0441
Brugia malayi ethe1-prov protein 0.0017 0.0174 0.0211
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.0174 0.0271
Echinococcus multilocularis ferritin 0.0009 0.0055 0.0021
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0077 0.1442
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.00000000074633
Brugia malayi hypothetical protein 0.0009 0.0061 0.0003
Schistosoma mansoni ferritin 0.0009 0.0055 0.0085
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0061 0.0028
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Schistosoma mansoni cpg binding protein 0.0032 0.0402 0.0626
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0061 0.0095
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Onchocerca volvulus 0.0051 0.0706 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0175 0.2226
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0061 0.0028
Echinococcus granulosus dnaJ subfamily B 0.0424 0.6424 0.6413
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0009 0.0061 0.0095
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0706 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.1731
Echinococcus granulosus tumor protein p63 0.0351 0.5293 0.5278
Brugia malayi hypothetical protein 0.0009 0.0061 0.0003
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.0894 0.0864
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0174 0.1731
Schistosoma mansoni hypothetical protein 0.0016 0.0171 0.0265
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.0174 0.0141
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.0174 1
Echinococcus granulosus ETHE1 protein 0.0017 0.0174 0.0141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0174 0.0317
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Echinococcus multilocularis thymidine phosphorylase 0.0658 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Schistosoma mansoni ferritin light chain 0.0009 0.0055 0.0085
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0017 0.0174 0.2216
Echinococcus multilocularis GPCR, family 2 0.0016 0.0171 0.0138
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.0174 0.012
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0061 0.0028
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Brugia malayi Protein-tyrosine phosphatase 1 0.0009 0.0061 0.0003
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.0174 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0171 0.0138
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0174 0.012
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0017 0.0174 1
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0186 0.2765 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0077 0.0044
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.1731
Mycobacterium ulcerans hypothetical protein 0.0017 0.0174 0.012
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0009 0.0061 0.0095
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.0174 1
Echinococcus multilocularis 0.0009 0.0061 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0364 0.5493 1
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0174 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0009 0.0061 0.0095
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0174 0.0211
Echinococcus granulosus bloom syndrome protein 0.0025 0.0301 0.0269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0023 0.00000000074633
Onchocerca volvulus 0.0017 0.0174 0.175
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.0174 1
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0221 0.0344
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.0174 0.0141
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Schistosoma mansoni apoferritin-2 0.0009 0.0055 0.0085
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0364 0.5493 0.5478
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0009 0.0061 0.3506
Chlamydia trachomatis ribonuclease Z 0.0017 0.0174 0.5
Brugia malayi hypothetical protein 0.0009 0.0061 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0706 0.1099
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0301 0.3196
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Trypanosoma cruzi glyoxalase II 0.0017 0.0174 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0712 0.1202
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0009 0.0061 0.0111
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.00000000074633
Loa Loa (eye worm) protein tyrosine phosphatase 0.0009 0.0061 0.0111
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0017 0.0174 0.0271
Schistosoma mansoni hypothetical protein 0.0017 0.0174 0.0271
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0009 0.0061 0.0028
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0174 0.1731
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0785 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0077 0.0044
Schistosoma mansoni ferritin 0.0009 0.0055 0.0085
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.0174 1
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0061 0.0095
Brugia malayi hypothetical protein 0.0017 0.0174 0.0211
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0364 0.5493 0.5478
Loa Loa (eye worm) hypothetical protein 0.0052 0.0712 0.1297
Echinococcus granulosus expressed protein 0.0009 0.0055 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Schistosoma mansoni hypothetical protein 0.0016 0.0171 0.0265
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0061 0.0003
Trypanosoma cruzi glyoxalase II 0.0017 0.0174 1
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.0894 1
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0174 0.1731
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0077 0.0033
Brugia malayi CXXC zinc finger family protein 0.003 0.0376 0.0584
Brugia malayi hypothetical protein 0.0009 0.0061 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0124 0.7109
Mycobacterium ulcerans hypothetical protein 0.0017 0.0174 0.012
Mycobacterium leprae POSSIBLE HYDROLASE 0.0017 0.0174 0.0441
Schistosoma mansoni pcd6 interacting protein-related 0.0009 0.0061 0.0095
Leishmania major metallo-beta-lactamase family protein-like protein 0.0017 0.0174 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0061 0.0028
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0061 0.0028
Schistosoma mansoni DNA helicase recq1 0.001 0.0077 0.012
Trypanosoma cruzi glyoxalase II 0.0017 0.0174 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0077 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0017 0.0174 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0009 0.0061 0.3506
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0178 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.0174 0.0211
Echinococcus granulosus zinc phosphodiesterase 0.0017 0.0174 0.0141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0033 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0174 0.0317
Brugia malayi DnaJ domain containing protein 0.0064 0.0894 0.1536
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0174 0.012
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0017 0.0174 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0009 0.0061 0.0028
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0009 0.0061 0.0095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0712 0.1297
Schistosoma mansoni apoferritin-2 0.0009 0.0055 0.0085
Leishmania major hypothetical protein, conserved 0.0017 0.0174 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0171 0.0138
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0017 0.0174 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0017 0.0174 0.0141
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0301 0.0269
Echinococcus multilocularis expressed protein 0.0009 0.0055 0.0021
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.0174 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0009 0.0061 0.3506
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0301 0.3196
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0009 0.0061 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Leishmania major metallo-beta-lactamase family-like protein 0.0017 0.0174 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0186 0.2765 0.2725
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0462 0.0741
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0009 0.0061 0.0028
Trichomonas vaginalis A-type flavoprotein 0.0017 0.0174 0.1731
Schistosoma mansoni cpg binding protein 0.003 0.0376 0.0586
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0009 0.0061 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0171 0.0138
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0017 0.0174 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.1731
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0017 0.0174 1
Trypanosoma brucei glyoxalase II 0.0017 0.0174 1
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0017 0.0174 0.0317
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.0174 0.0271
Mycobacterium leprae conserved hypothetical protein 0.0017 0.0174 0.0441
Mycobacterium ulcerans glyoxalase II, GloB 0.0017 0.0174 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.1731
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Echinococcus granulosus ferritin 0.0009 0.0055 0.0021
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Echinococcus granulosus protein tyrosine phosphatase n9 0.0009 0.0061 0.0028
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0009 0.0061 0.0028
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Mycobacterium tuberculosis Conserved protein 0.0017 0.0174 0.012
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0255 1
Brugia malayi Protein-tyrosine phosphatase 0.0009 0.0061 0.0003
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0017 0.0174 0.0211
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.0174 1
Schistosoma mansoni DNA helicase recq5 0.001 0.0077 0.012
Trichomonas vaginalis pten, drome, putative 0.0009 0.0061 0.0434
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0174 0.0317
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0009 0.0061 0.0111
Echinococcus multilocularis zinc phosphodiesterase 0.0017 0.0174 0.0141
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.0174 0.1731
Loa Loa (eye worm) hypothetical protein 0.0035 0.0462 0.084
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0009 0.0061 0.0111
Schistosoma mansoni hypothetical protein 0.0016 0.0171 0.0265
Echinococcus granulosus cpg binding protein 0.0032 0.0402 0.0371
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0061 0.0028
Onchocerca volvulus Putative hydrolase PNKD 0.0017 0.0174 0.175
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Loa Loa (eye worm) RecQ helicase 0.0025 0.0301 0.0549
Mycobacterium ulcerans hydrolase 0.0017 0.0174 0.012
Echinococcus granulosus GPCR family 2 0.0016 0.0171 0.0138
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0009 0.0061 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0023 0.00000000074633
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0171 0.031
Schistosoma mansoni ferritin 0.0009 0.0055 0.0085
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.0174 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0077 0.0141
Schistosoma mansoni cpg binding protein 0.0032 0.0402 0.0626
Onchocerca volvulus 0.003 0.0376 0.4889
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.0174 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0124 0.5548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.00000000074633
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0077 0.0984
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0009 0.0061 0.3506
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0171 0.0138
Mycobacterium ulcerans hypothetical protein 0.0017 0.0174 0.012
Schistosoma mansoni protein tyrosine phosphatase 0.0009 0.0061 0.0095
Mycobacterium leprae Beta-lactamase-like protein 0.0017 0.0174 0.0441
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.0174 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.0174 0.0141
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0017 0.0174 1
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0658 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0171 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0023 0.00000000074633
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.6424 0.6413
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0077 0.0141
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0009 0.0061 0.0095
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Schistosoma mansoni hypothetical protein 0.0035 0.0462 0.0719
Mycobacterium ulcerans thymidine phosphorylase 0.0658 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0009 0.0061 0.0028
Treponema pallidum ribonuclease Z 0.0017 0.0174 1
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0009 0.0061 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.1731
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0017 0.0174 0.012
Plasmodium falciparum cytosolic glyoxalase II 0.0017 0.0174 0.5435
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Brugia malayi hypothetical protein 0.0009 0.0061 0.0003
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0301 0.0446
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Trichomonas vaginalis ferritin, putative 0.0009 0.0055 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.1731
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0009 0.0061 0.3506
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0009 0.0061 0.0003
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0017 0.0174 0.2216
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0364 0.5493 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0009 0.0061 0.0028
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0055 0.3134
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0077 0.0984
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0017 0.0174 1
Mycobacterium ulcerans hypothetical protein 0.0017 0.0174 0.012
Mycobacterium tuberculosis Conserved protein 0.0017 0.0174 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0174 0.0317
Loa Loa (eye worm) hypothetical protein 0.0009 0.0061 0.0111
Mycobacterium tuberculosis Conserved protein 0.0017 0.0174 0.012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0009 0.0061 0.3506
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0171 0.0205
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0009 0.0061 0.0111
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0009 0.0061 0.0028
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0009 0.0061 0.0028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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