Detailed information for compound 777320

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.862 | Formula: C23H20ClNO5
  • H donors: 2 H acceptors: 3 LogP: 3.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(cc(c1O)Cl)C1C(=C(C)N=C2C1=C(O)c1c2cccc1)C(=O)OC
  • InChi: 1S/C23H20ClNO5/c1-4-30-16-10-12(9-15(24)22(16)27)18-17(23(28)29-3)11(2)25-20-13-7-5-6-8-14(13)21(26)19(18)20/h5-10,18,26-27H,4H2,1-3H3
  • InChiKey: CFFRITTZODTDTH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0425 0.1206
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0069 0.0092
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0425 0.0521
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.3262 0.4338
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0239 0.027
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.044 0.0589
Plasmodium vivax CDK-related protein kinase 6, putative 0.0468 1 1
Trypanosoma cruzi ISWI complex protein 0.0017 0.0067 0.024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2124 0.6504
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0441 0.0404
Trypanosoma cruzi hexose transporter 0.0034 0.045 0.3422
Leishmania major hypothetical protein, conserved 0.0017 0.0067 0.024
Leishmania major protein kinase, putative 0.0034 0.044 0.3343
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.159 0.5104
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.2124 0.3201
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.3262 1
Onchocerca volvulus 0.0018 0.0102 0.2052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.044 0.3343
Schistosoma mansoni lamin 0.003 0.035 0.0972
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0239 0.1293
Brugia malayi PHD-finger family protein 0.0031 0.0386 0.0468
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Toxoplasma gondii hypothetical protein 0.003 0.0349 0.0477
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Loa Loa (eye worm) sugar transporter 0.0015 0.0038 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0786 0.1147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0799 0.2554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Trypanosoma cruzi hexose transporter, putative 0.0034 0.045 0.3422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Leishmania major cathepsin L-like protease 0.0018 0.0102 0.0531
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0425 0.6404
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0069 0.0196
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.045 0.3422
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.011 0.0228
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0567 0.1803
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0567 0.1716
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Toxoplasma gondii protein kinase, putative 0.0311 0.6556 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0038 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Echinococcus multilocularis protein patched 0.0041 0.061 0.185
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.1241 1
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0108 0.0584
Echinococcus granulosus voltage gated potassium channel 0.002 0.0143 0.0437
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0546 0.4221
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.035 0.0468
Onchocerca volvulus 0.0018 0.0102 0.2052
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0069 0.0101
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0239 0.0709
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0938 0.3
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.3181 0.4229
Loa Loa (eye worm) cysteine protease 0.0018 0.0102 0.0137
Trichomonas vaginalis sugar transporter, putative 0.0034 0.045 0.0574
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0102 0.0204
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0425 0.1347
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0938 0.5448
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0441 0.0617
Leishmania major cathepsin L-like protease 0.007 0.1241 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0801 0.2372
Schistosoma mansoni zinc finger protein 0.0017 0.0067 0.0096
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1395
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0172 0.0187
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0394 0.1247
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0243 0.0757
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.1241 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0441 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.045 0.0574
Plasmodium vivax vivapain-2 0.0018 0.0102 0.0064
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0938 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0455 0.0582
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.045 0.3422
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2124 0.6831
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0243 0.0721
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0093
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0047 0.0011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.072 0.0964
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2124 0.6831
Echinococcus multilocularis expressed conserved protein 0.0091 0.1695 0.5185
Echinococcus granulosus General substrate transporter 0.0095 0.1783 0.5729
Loa Loa (eye worm) hypothetical protein 0.0034 0.044 0.0589
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0157 0.1322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0239 0.032
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Brugia malayi Cathepsin L-like precursor 0.0018 0.0102 0.0086
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.061 0.1943
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1328
Brugia malayi Probable ClpP-like protease 0.0086 0.159 0.2087
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0441 0.0617
Echinococcus granulosus GPCR family 2 0.005 0.0799 0.2554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0425 0.1206
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0102 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0643 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0038 0.0093
Schistosoma mansoni hypothetical protein 0.0017 0.0067 0.0096
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0157 0.1322
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0069 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0801 0.1073
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.159 1
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0093
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0786 0.1043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.045 0.3422
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1395
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.044 0.1253
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0069 0.0041
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.045 0.3422
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0795 0.2351
Trypanosoma brucei ISWI complex protein 0.0017 0.0067 0.024
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0038 0.0006
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.002 0.0143 0.0141
Schistosoma mansoni hypothetical protein 0.004 0.0577 0.1676
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0786 0.1043
Trypanosoma cruzi hexose transporter, putative 0.0034 0.045 0.3422
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0069 0.0101
Echinococcus multilocularis voltage gated potassium channel 0.002 0.0143 0.0416
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0102 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2124 0.2911
Onchocerca volvulus 0.0018 0.0102 0.2052
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0441 0.0617
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0102 0.0064
Echinococcus granulosus Protein patched homolog 1 0.0041 0.061 0.1943
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0102 0.0086
Trichomonas vaginalis glucose transporter, putative 0.0034 0.045 0.0574
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0239 0.0201
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0938 1
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0143 0.0332
Plasmodium falciparum protein kinase 7 0.0311 0.6556 0.6542
Plasmodium falciparum hexose transporter 0.011 0.2124 0.2094
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.1228 0.3937
Entamoeba histolytica protein kinase, putative 0.0034 0.044 0.1963
Loa Loa (eye worm) acetyltransferase 0.0162 0.3262 0.4367
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2124 0.6504
Schistosoma mansoni hypothetical protein 0.004 0.0577 0.1676
Brugia malayi Cathepsin L-like precursor 0.0018 0.0102 0.0086
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0546 0.4221
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0441 0.0404
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.061 0.0816
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0349 0.0312
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0093
Schistosoma mansoni hypothetical protein 0.0108 0.2079 0.6332
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0038 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0102 0.0289
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0353 0.747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0102 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0102 0.0086
Trypanosoma brucei glucose transporter 2A 0.0034 0.045 0.3422
Echinococcus granulosus zinc finger protein 0.0025 0.0257 0.0802
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0102 0.0289
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.044 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Echinococcus granulosus lamin 0.003 0.035 0.1102
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0643 0.3138
Echinococcus granulosus expressed conserved protein 0.0091 0.1695 0.5446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.2079 0.2746
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0441 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0341 0.7206 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0102 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.061 0.0798
Echinococcus multilocularis zinc finger protein 0.0025 0.0257 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Echinococcus granulosus histone acetyltransferase KAT2B 0.0155 0.3106 1
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.1241 1
Leishmania major glucose transporter, lmgt1 0.0034 0.045 0.3422
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0239 0.3318
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0239 0.1667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0102 0.2052
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0786 0.075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0799 0.2432
Toxoplasma gondii cathepsin CPL 0.0018 0.0102 0.0098
Schistosoma mansoni glucose transporter 0.0015 0.0038 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.072 0.2298
Brugia malayi Sugar transporter family protein 0.011 0.2124 0.2807
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0196 0.0263
Schistosoma mansoni glucose transport protein 0.011 0.2124 0.6474
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.159 0.1557
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0546 0.4221
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0441 0.0404
Echinococcus granulosus cathepsin l1 0.0018 0.0102 0.0304
Trichomonas vaginalis sugar transporter, putative 0.0034 0.045 0.0574
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0038 0.0093
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2124 0.6831
Schistosoma mansoni zinc finger protein 0.0025 0.0257 0.0683
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0239 0.1667
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0069 0.0187
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0102 0.0289
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0938 0.2856
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.044 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.159 0.238
Schistosoma mansoni hypothetical protein 0.005 0.0799 0.2366
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0069 0.0187
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0239 0.0628
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0425 0.1282
Schistosoma mansoni hypothetical protein 0.005 0.0799 0.2366
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1857 0.5645
Trichomonas vaginalis glucose transporter, putative 0.0034 0.045 0.0574
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Onchocerca volvulus 0.0018 0.0102 0.2052
Schistosoma mansoni intermediate filament proteins 0.003 0.035 0.0972
Leishmania major glucose transporter, lmgt2 0.0034 0.045 0.3422
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2124 0.6831
Loa Loa (eye worm) hypothetical protein 0.0029 0.0338 0.0452
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0102 0.0289
Schistosoma mansoni hypothetical protein 0.0023 0.0196 0.0496
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0786 0.1147
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0239 0.1293
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0786 0.251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.011 0.0228
Leishmania major cathepsin L-like protease 0.0018 0.0102 0.0531
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0086 0.159 0.2128
Brugia malayi intermediate filament protein 0.003 0.035 0.0419
Onchocerca volvulus 0.003 0.035 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0239 0.057
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Echinococcus multilocularis lamin dm0 0.003 0.035 0.105
Loa Loa (eye worm) hypothetical protein 0.0049 0.0769 0.1029
Echinococcus granulosus potassium voltage gated channel subfamily H 0.002 0.0143 0.0437
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0441 0.0404
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0239 0.1667
Loa Loa (eye worm) hypothetical protein 0.0017 0.0069 0.0092
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0239 0.028
Echinococcus multilocularis solute carrier family 22 0.0015 0.0038 0.0093
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0425 0.0569
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.011 0.0228
Brugia malayi Latrophilin receptor protein 2 0.005 0.0799 0.1024
Brugia malayi Bromodomain containing protein 0.0086 0.1598 0.2099
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.044 0.0561
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 0.1557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Schistosoma mansoni glucose transport protein 0.011 0.2124 0.6474
Loa Loa (eye worm) hypothetical protein 0.0097 0.1824 0.2442
Brugia malayi Bromodomain containing protein 0.0046 0.071 0.0904
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.061 0.185
Schistosoma mansoni protein kinase 0.0034 0.044 0.1253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0039 0.0546 0.4221
Echinococcus multilocularis cysteine protease 0.0018 0.0102 0.0289
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0455 0.0582
Echinococcus granulosus intermediate filament protein 0.003 0.035 0.1102
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0012
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0441 0.0404
Leishmania major cathepsin L-like protease 0.0018 0.0102 0.0531
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.021 0.0282
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0795 0.2351
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0069 0.0196
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.091 0.7252
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.045 0.0574
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0069 0.0101
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0799 0.107
Loa Loa (eye worm) hypothetical protein 0.0042 0.0626 0.0837
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0801 0.2372
Leishmania major glucose transporter, lmgt3 0.0034 0.045 0.3422
Echinococcus multilocularis lamin 0.003 0.035 0.105
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0038 0.0098
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.011 0.0228
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.072 0.2188
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.011 0.0328
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.072 0.0917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0801 0.2438
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.0098
Onchocerca volvulus 0.0018 0.0102 0.2052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Onchocerca volvulus 0.0018 0.0102 0.2052
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0069 0.0196
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0289 0.0386
Echinococcus multilocularis GPCR, family 2 0.005 0.0799 0.2432
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0069 0.0187
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0102 0.0089
Trypanosoma cruzi hexose transporter, putative 0.0034 0.045 0.3422
Trichomonas vaginalis sugar transporter, putative 0.0034 0.045 0.0574
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1824 0.5862
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.035 0.0419
Leishmania major cathepsin L-like protease 0.0018 0.0102 0.0531
Loa Loa (eye worm) ctsf protein 0.0018 0.0102 0.0137
Schistosoma mansoni hypothetical protein 0.004 0.0577 0.1676
Schistosoma mansoni lamin 0.003 0.035 0.0972
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.159 0.4815
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0069 0.0196
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.002 0.0143 0.0416
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0069 0.0043
Loa Loa (eye worm) hypothetical protein 0.0158 0.3181 0.4259
Leishmania major cathepsin L-like protease 0.007 0.1241 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0425 0.0521
Plasmodium vivax proline--tRNA ligase, putative 0.0039 0.0546 0.051
Schistosoma mansoni patched 1 0.0041 0.061 0.1778
Brugia malayi CHE-14 protein 0.0041 0.061 0.0769
Trypanosoma brucei glucose transporter 1E 0.0034 0.045 0.3422
Schistosoma mansoni protein kinase 0.0034 0.044 0.1253
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.044 0.1395
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0047 0.0062
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0143 0.0332
Schistosoma mansoni hypothetical protein 0.005 0.0799 0.2366
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0239 0.0308
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0643 0.0607
Loa Loa (eye worm) sugar transporter 0.011 0.2124 0.2844
Plasmodium vivax vivapain-2 0.0018 0.0102 0.0064
Brugia malayi Cathepsin L-like precursor 0.0018 0.0102 0.0086
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0349 0.0312
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1328
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.3262 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0799 0.107
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.159 0.238
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0102 0.0089
Echinococcus multilocularis musashi 0.003 0.035 0.105
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0069 0.0043
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0006
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.159 0.486
Loa Loa (eye worm) fibroinase 0.0018 0.0102 0.0137
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1824 1
Loa Loa (eye worm) hypothetical protein 0.0353 0.747 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0178 0.362 0.3595
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0013
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1824 0.2403
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0441 0.0404
Onchocerca volvulus 0.0018 0.0102 0.2052
Brugia malayi Cam kinase protein 1 0.0034 0.044 0.0541
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.011 0.0312
Schistosoma mansoni glucose transport protein 0.011 0.2124 0.6474
Onchocerca volvulus 0.003 0.035 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1328
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.011 0.0312
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.2079 0.2783
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0178 0.362 0.5495
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.2737 0.8809
Brugia malayi Cathepsin L-like precursor 0.0018 0.0102 0.0086
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0349 0.1339
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0102 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0801 0.1027
Plasmodium falciparum proline--tRNA ligase 0.0039 0.0546 0.051
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0425 0.054
Loa Loa (eye worm) hypothetical protein 0.0033 0.0425 0.0569
Schistosoma mansoni hypothetical protein 0.004 0.0577 0.1676
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0441 0.0404
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0069 0.0196
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.1241 1
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0239 0.0201
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0102 0.2052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0069 0.0092
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Leishmania major cathepsin L-like protease 0.007 0.1241 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.3181 0.4229
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0069 0.0101
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0039 0.0546 0.0779
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0069 0.0187
Loa Loa (eye worm) intermediate filament protein 0.003 0.035 0.0468
Loa Loa (eye worm) hypothetical protein 0.0051 0.0815 0.1091
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.0098
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Echinococcus multilocularis protein dispatched 1 0.0047 0.0739 0.2246
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0425 0.1876
Loa Loa (eye worm) hypothetical protein 0.0078 0.1409 0.1885
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1328
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0069 0.0187
Echinococcus granulosus solute carrier family 22 0.0015 0.0038 0.0098
Loa Loa (eye worm) hypothetical protein 0.0042 0.0613 0.082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.3181 0.4259
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0038 0.0098
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0394 0.1187
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0102 0.0064
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0239 0.0745
Entamoeba histolytica protein kinase, putative 0.0034 0.044 0.1963
Echinococcus multilocularis cysteine protease 0.0018 0.0102 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0102 0.0531
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0799 0.2432
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0799 0.1024
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0039 0.0546 0.4221
Echinococcus multilocularis General substrate transporter 0.0095 0.1783 0.5455
Schistosoma mansoni hypothetical protein 0.005 0.0799 0.2366
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0102 0.0137
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.011 0.0328
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0239 0.0628
Loa Loa (eye worm) hypothetical protein 0.002 0.0143 0.0192
Plasmodium vivax hexose transporter 0.011 0.2124 0.2094
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0102 0.2052
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.2737 0.8387
Echinococcus granulosus lamin dm0 0.003 0.035 0.1102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0801 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Plasmodium falciparum mitogen-activated protein kinase 2 0.0178 0.362 0.3595
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1824 0.5582
Entamoeba histolytica hypothetical protein 0.0025 0.0239 0.0793
Trypanosoma brucei glucose transporter, putative 0.0034 0.045 0.3422
Loa Loa (eye worm) hypothetical protein 0.003 0.035 0.0468
Trypanosoma cruzi ISWI complex protein 0.0017 0.0067 0.024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0147
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.159 1
Schistosoma mansoni hypothetical protein 0.011 0.2124 0.6474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0801 0.2372
Schistosoma mansoni sugar transporter 0.0015 0.0038 0.0006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.1228 0.3748
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0801 0.2561
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0799 0.2554
Loa Loa (eye worm) hypothetical protein 0.0051 0.0815 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0801 0.2561
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0069 0.0196
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.1107 0.8886
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0102 0.0304
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1241 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0102 0.0086
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0069 0.0101
Schistosoma mansoni bromodomain containing protein 0.0073 0.1314 0.3962
Leishmania major cathepsin L-like protease 0.0018 0.0102 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.2124 0.6504
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0425 0.1872
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.044 0.1395
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.061 0.0816
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0051
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0102 0.0304
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0243 0.064
Schistosoma mansoni protein kinase 0.0034 0.044 0.1253
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2124 0.6504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0102 0.0089

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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