TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.34 | Formula: C24H22BrNO3
H donors: 1 H acceptors: 2 LogP: 4.36 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1=C(C)N=C2C(=C(O)CCC2)C1c1ccccc1Br)OCc1ccccc1
InChi: 1S/C24H22BrNO3/c1-15-21(24(28)29-14-16-8-3-2-4-9-16)22(17-10-5-6-11-18(17)25)23-19(26-15)12-7-13-20(23)27/h2-6,8-11,22,27H,7,12-14H2,1H3
InChiKey: VFZBITSKJITOLC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0015	0.0007	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0213	0.0213
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0041	0.0035
Leishmania major	hypothetical protein, conserved	0.0031	0.0119	0.4576
Entamoeba histolytica	acyl-coA synthetase, putative	0.005	0.0252	0.0454
Schistosoma mansoni	hypothetical protein	0.0159	0.0996	0.1024
Brugia malayi	Eye-specific diacylglycerol kinase	0.0031	0.0119	0.0136
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0077	0.0072
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0252	0.0287
Schistosoma mansoni	microtubule-associated protein tau	0.142	0.9662	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0041	0.0063
Loa Loa (eye worm)	hypothetical protein	0.005	0.0252	0.0287
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.0606	0.069
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0077	0.0072
Echinococcus granulosus	geminin	0.0159	0.0996	0.1024
Onchocerca volvulus		0.005	0.0252	0.0245
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Echinococcus multilocularis	lamin dm0	0.0027	0.0091	0.0087
Entamoeba histolytica	hypothetical protein	0.0034	0.0137	0.0241
Trypanosoma brucei	Sphingosine kinase	0.0031	0.0119	1
Brugia malayi	MH2 domain containing protein	0.0025	0.0077	0.0087
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0041	0.0047
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0038	0.0164	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0007	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0213	0.0213
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0031	0.0119	0.0112
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0213	0.0242
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0185	0.1177	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0164	0.0187
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.015	0.0266
Echinococcus granulosus	Smad4	0.0025	0.0077	0.0072
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0185	0.1177	0.1212
Onchocerca volvulus		0.0027	0.0091	0.0084
Echinococcus multilocularis	Smad4	0.0025	0.0077	0.0072
Onchocerca volvulus		0.0031	0.0119	0.0112
Onchocerca volvulus		0.0185	0.1177	0.1171
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0127	0.0124
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0077	0.0072
Schistosoma mansoni	lamin	0.0027	0.0091	0.0087
Brugia malayi	TAR-binding protein	0.0269	0.1756	0.2001
Echinococcus multilocularis	tumor protein p63	0.0392	0.2597	0.2683
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0185	0.1177	0.1212
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.0164	0.0292
Leishmania major	4-coumarate:coa ligase-like protein	0.005	0.0252	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0077	0.0072
Brugia malayi	hypothetical protein	0.0031	0.0119	0.0136
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0127	0.0124
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0041	0.0047
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.0164	0.0827
Schistosoma mansoni	diacylglycerol kinase theta	0.0031	0.0119	0.0116
Toxoplasma gondii	aminopeptidase N protein	0.0291	0.1906	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0252	0.0454
Entamoeba histolytica	diacylglycerol kinase, putative	0.0031	0.0119	0.0208
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0031	0.0119	0.0116
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0269	0.1756	0.2001
Echinococcus granulosus	histone lysine methyltransferase setb	0.0185	0.1177	0.1212
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0213	0.0213
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0252	0.0454
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0.0119	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.015	0.0266
Leishmania major	diacylglycerol kinase-like protein	0.0031	0.0119	0.4576
Toxoplasma gondii	diacylglycerol kinase accessory domain (presumed) domain-containing protein	0.0031	0.0119	0.059
Brugia malayi	MH2 domain containing protein	0.0025	0.0077	0.0087
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0031	0.0119	1
Trichomonas vaginalis	bmru protein, putative	0.0031	0.0119	0.0112
Loa Loa (eye worm)	MH2 domain-containing protein	0.0366	0.2418	0.2755
Onchocerca volvulus		0.0142	0.0878	0.0871
Schistosoma mansoni	hypothetical protein	0.0032	0.0127	0.0124
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.1291	0.8775	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0127	0.0124
Schistosoma mansoni	hypothetical protein	0.0032	0.0127	0.0124
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0007	0.0008
Trypanosoma brucei	unspecified product	0.002	0.0041	0.3024
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0041	0.0047
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.005	0.0252	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.015	0.0266
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0091	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0008
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0213	0.0242
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0252	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0164	0.0187
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0041	0.0034
Brugia malayi	intermediate filament protein	0.0027	0.0091	0.0103
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0185	0.1177	0.1212
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0299	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0008
Leishmania major	hypothetical protein, conserved	0.0031	0.0119	0.4576
Schistosoma mansoni	smad	0.0025	0.0077	0.0072
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0007	0.0008
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0127	0.0145
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0077	0.0087
Loa Loa (eye worm)	hypothetical protein	0.007	0.0384	0.0438
Brugia malayi	AMP-binding enzyme family protein	0.0015	0.0007	0.0008
Mycobacterium ulcerans	hypothetical protein	0.0799	0.5392	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0213	0.0213
Entamoeba histolytica	diacylglycerol kinase, putative	0.0031	0.0119	0.0208
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0041	0.0035
Echinococcus multilocularis	microtubule associated protein 2	0.142	0.9662	1
Schistosoma mansoni	DNA polymerase eta	0.002	0.0041	0.0035
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0127	0.0124
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0041	0.1384
Schistosoma mansoni	hypothetical protein	0.007	0.0384	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0119	0.0136
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.1177	0.1342
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0213	0.0213
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0041	0.0034
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Plasmodium falciparum	diacylglycerol kinase, putative	0.0031	0.0119	0.059
Echinococcus multilocularis	sphingosine kinase 1	0.0799	0.5392	0.5577
Leishmania major	4-coumarate:coa ligase-like protein	0.005	0.0252	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0119	0.0116
Schistosoma mansoni	diacylglycerol kinase theta	0.0031	0.0119	0.0116
Brugia malayi	diacylglycerol kinase	0.0031	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0299	0.0341
Trypanosoma cruzi	Sphingosine kinase	0.0031	0.0119	1
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0041	0.0063
Echinococcus multilocularis	lamin	0.0027	0.0091	0.0087
Entamoeba histolytica	diacylglycerol kinase, putative	0.0031	0.0119	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0164	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0091	0.0103
Echinococcus granulosus	lamin dm0	0.0027	0.0091	0.0087
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0007	0.0008
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0041	0.3024
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0041	0.0063
Leishmania major	4-coumarate:coa ligase-like protein	0.005	0.0252	1
Plasmodium vivax	diacylglycerol kinase, putative	0.0031	0.0119	0.059
Brugia malayi	MH1 domain containing protein	0.0025	0.0077	0.0087
Loa Loa (eye worm)	transcription factor SMAD2	0.0366	0.2418	0.2755
Echinococcus granulosus	Diacylglycerol kinase theta	0.0031	0.0119	0.0116
Echinococcus granulosus	tar DNA binding protein	0.0269	0.1756	0.1811
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0041	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0799	0.5392	0.6144
Schistosoma mansoni	transcription factor LCR-F1	0.0034	0.0137	0.0134
Trichomonas vaginalis	sphingosine kinase, putative	0.0031	0.0119	0.0112
Entamoeba histolytica	hypothetical protein	0.0034	0.0137	0.0241
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Leishmania major	diacylglycerol kinase, putative	0.0031	0.0119	0.4576
Echinococcus granulosus	intermediate filament protein	0.0027	0.0091	0.0087
Echinococcus granulosus	sphingosine kinase 1	0.0799	0.5392	0.5577
Brugia malayi	MH2 domain containing protein	0.0366	0.2418	0.2755
Echinococcus multilocularis	smad	0.0025	0.0077	0.0072
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0077	0.0087
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0213	0.0213
Leishmania major	sphingosine kinase A, B, putative	0.0031	0.0119	0.4576
Loa Loa (eye worm)	hypothetical protein	0.005	0.0252	0.0287
Mycobacterium ulcerans	hypothetical protein	0.005	0.0252	0.0454
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0178	0.1131	0.1164
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0127	0.0145
Echinococcus granulosus	GPCR family 2	0.0032	0.0127	0.0124
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0031	0.0119	1
Schistosoma mansoni	sphingosine kinase A B	0.0799	0.5392	0.5577
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0185	0.1177	0.1212
Loa Loa (eye worm)	TAR-binding protein	0.0269	0.1756	0.2001
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0031	0.0119	1
Echinococcus multilocularis	geminin	0.0159	0.0996	0.1024
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0041	0.0063
Trichomonas vaginalis	diacylglycerol kinase, epsilon, putative	0.0031	0.0119	0.0112
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Entamoeba histolytica	hypothetical protein	0.0034	0.0137	0.0241
Schistosoma mansoni	Smad4	0.0025	0.0077	0.0072
Schistosoma mansoni	hypothetical protein	0.0159	0.0996	0.1024
Loa Loa (eye worm)	ceramide kinase	0.0031	0.0119	0.0136
Brugia malayi	RNA recognition motif domain containing protein	0.0269	0.1756	0.2001
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0384	0.0438
Echinococcus granulosus	tumor protein p63	0.0392	0.2597	0.2683
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0127	0.0145
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0127	0.0145
Loa Loa (eye worm)	RNA binding protein	0.0269	0.1756	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0878	0.1
Schistosoma mansoni	lamin	0.0027	0.0091	0.0087
Brugia malayi	Smad1	0.0025	0.0077	0.0087
Trichomonas vaginalis	set domain proteins, putative	0.147	1	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0091	0.0103
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0005	0.0005
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0041	0.0035
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0034	0.0137	0.0134
Toxoplasma gondii	aminopeptidase n, putative	0.0291	0.1906	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0031	0.0119	0.0112
Onchocerca volvulus		0.0027	0.0091	0.0084
Mycobacterium ulcerans	diacylglycerol kinase	0.0031	0.0119	0.0208
Giardia lamblia	DINP protein human, muc B family	0.002	0.0041	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.015	0.0266
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0077	0.0072
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0119	0.0112
Entamoeba histolytica	diacylglycerol kinase, putative	0.0031	0.0119	0.0208
Leishmania major	DNA polymerase kappa, putative	0.002	0.0041	0.1384
Toxoplasma gondii	aminopeptidase N, putative	0.0291	0.1906	1
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0031	0.0119	0.0116
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.005	0.0252	0.0454
Brugia malayi	Diacylglycerol kinase protein 2	0.0031	0.0119	0.0136
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0252	0.0454
Schistosoma mansoni	hypothetical protein	0.0032	0.0127	0.0124
Brugia malayi	Pre-SET motif family protein	0.0185	0.1177	0.1342
Loa Loa (eye worm)	hypothetical protein	0.005	0.0252	0.0287
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0041	0.0047
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0031	0.0119	0.0116
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.0606	0.069
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0041	0.3024
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0031	0.0119	0.0112
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0127	0.0124
Brugia malayi	Pre-SET motif family protein	0.1291	0.8775	1
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0031	0.0119	0.0136
Onchocerca volvulus	Ceramide kinase 1 homolog	0.0031	0.0119	0.0112
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.005	0.0252	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0119	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0034	0.0137	0.0134
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0291	0.1906	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0185	0.1177	0.1212
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0031	0.0119	0.0112
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0041	0.3024
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Echinococcus granulosus	microtubule associated protein 2	0.142	0.9662	1
Schistosoma mansoni	sphingoid long chain base kinase	0.0799	0.5392	0.5577
Echinococcus granulosus	dna polymerase kappa	0.002	0.0041	0.0035
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Brugia malayi	hypothetical protein	0.0142	0.0878	0.1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0127	0.0124
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0041	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0606	0.069
Echinococcus granulosus	lamin	0.0027	0.0091	0.0087
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0031	0.0119	1
Loa Loa (eye worm)	Smad1	0.0025	0.0077	0.0087
Trypanosoma brucei	diacylglycerol kinase, putative	0.0031	0.0119	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0015	0.0007	0.0008
Echinococcus multilocularis	tar DNA binding protein	0.0269	0.1756	0.1811
Echinococcus granulosus	ceramide kinase	0.0031	0.0119	0.0116
Brugia malayi	diacylglycerol kinase	0.0031	0.0119	0.0136
Echinococcus granulosus	smad	0.0025	0.0077	0.0072
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0015	0.0007	0.0008
Echinococcus granulosus	dna polymerase eta	0.002	0.0041	0.0035
Mycobacterium tuberculosis	Diacylglycerol kinase	0.0031	0.0119	0.0208
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0041	0.3024
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0031	0.0119	0.0136
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0252	0.0454
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0213	0.0213
Entamoeba histolytica	hypothetical protein	0.0034	0.0137	0.0241
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0077	0.0072
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0091	0.0103
Plasmodium vivax	SET domain protein, putative	0.0185	0.1177	0.6164
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0291	0.1906	1
Toxoplasma gondii	diacylglycerol kinase, putative	0.0031	0.0119	0.059
Trichomonas vaginalis	bmru protein, putative	0.0031	0.0119	0.0112
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0185	0.1177	0.6164
Plasmodium falciparum	diacylglycerol kinase, putative	0.0031	0.0119	0.059
Entamoeba histolytica	acyl-CoA synthetase, putative	0.005	0.0252	0.0454
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.0606	0.069
Trichomonas vaginalis	sphingosine kinase, putative	0.0031	0.0119	0.0112
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0038	0.0164	0.0292
Schistosoma mansoni	tar DNA-binding protein	0.0269	0.1756	0.1811
Entamoeba histolytica	acyl-CoA synthetase, putative	0.005	0.0252	0.0454
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0034	0.0137	0.0134
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0041	0.3024
Brugia malayi	hypothetical protein	0.0034	0.0137	0.0156
Echinococcus multilocularis	musashi	0.0027	0.0091	0.0087
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.005	0.0252	0.0454
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0091	0.0087
Schistosoma mansoni	tar DNA-binding protein	0.0269	0.1756	0.1811
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0031	0.0119	0.0116
Schistosoma mansoni	tar DNA-binding protein	0.0269	0.1756	0.1811
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.005	0.0252	0.0454
Toxoplasma gondii	diacylglycerol kinase catalytic domain-containing protein	0.0031	0.0119	0.059
Entamoeba histolytica	hypothetical protein, conserved	0.0799	0.5392	1
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0077	0.0072
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.005	0.0252	0.0454
Trypanosoma cruzi	Sphingosine kinase	0.0031	0.0119	1
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.0164	0.0827
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0031	0.0119	0.0116
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0031	0.0119	0.0116
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0252	0.0287
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.005	0.0252	0.0454
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0041	0.0063
Onchocerca volvulus		0.0057	0.0299	0.0292
Mycobacterium tuberculosis	Conserved protein	0.0799	0.5392	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0077	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0087	0.01
Brugia malayi	MH1 domain containing protein	0.0025	0.0077	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0164	0.0187
Echinococcus multilocularis	dna polymerase eta	0.002	0.0041	0.0035
Brugia malayi	Ceramide kinase	0.0031	0.0119	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0164	0.0187
Leishmania major	DNA polymerase eta, putative	0.002	0.0041	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0119	0.0136
Brugia malayi	RNA binding protein	0.0269	0.1756	0.2001
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0031	0.0119	1
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0031	0.0119	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0007	0.0008
Plasmodium vivax	diacylglycerol kinase, putative	0.0031	0.0119	0.059
Schistosoma mansoni	tar DNA-binding protein	0.0269	0.1756	0.1811
Echinococcus multilocularis	ceramide kinase	0.0031	0.0119	0.0116
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0031	0.0119	0.0116
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0041	0.3024
Schistosoma mansoni	tar DNA-binding protein	0.0269	0.1756	0.1811

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 796083