Detailed information for compound 799106

Basic information

Technical information
  • TDR Targets ID: 799106
  • Name: 6-bromo-4-hydroxy-3-(3-methoxyphenyl)-2-oxo-N -propan-2-yl-1H-quinazoline-4-carboxamide
  • MW: 434.284 | Formula: C19H20BrN3O4
  • H donors: 3 H acceptors: 3 LogP: 2.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N1C(=O)Nc2c(C1(O)C(=O)NC(C)C)cc(cc2)Br
  • InChi: 1S/C19H20BrN3O4/c1-11(2)21-17(24)19(26)15-9-12(20)7-8-16(15)22-18(25)23(19)13-5-4-6-14(10-13)27-3/h4-11,26H,1-3H3,(H,21,24)(H,22,25)
  • InChiKey: TUIXIWUEXGGSMQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-bromo-4-hydroxy-N-isopropyl-3-(3-methoxyphenyl)-2-oxo-1H-quinazoline-4-carboxamide
  • 6-bromo-4-hydroxy-N-isopropyl-2-keto-3-(3-methoxyphenyl)-1H-quinazoline-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.0057
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0028 0.0415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0203 0.1157
Onchocerca volvulus 0.0014 0.0002 0.002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0311 0.0311
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0311 0.0999
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0028 0.0427
Echinococcus granulosus CREB binding protein 0.002 0.0067 0.0238
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0203 0.1157
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0346 0.5573
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0072 0.0601 1
Toxoplasma gondii kringle domain-containing protein 0.0053 0.0401 0.1285
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Onchocerca volvulus 0.0014 0.0004 0.0037
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0791
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Onchocerca volvulus 0.0034 0.0209 0.2018
Toxoplasma gondii subtilisin SUB12 0.0034 0.0209 0.0672
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0074 0.0619 1
Onchocerca volvulus 0.0034 0.0209 0.2018
Loa Loa (eye worm) MH2 domain-containing protein 0.0145 0.1352 0.4801
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0028 0.0147
Echinococcus multilocularis enteropeptidase 0.0014 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0483 0.1714
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0004 0.0014
Schistosoma mansoni survival motor neuron protein 0.0059 0.0462 0.2867
Schistosoma mansoni CREB-binding protein 2 0.0123 0.1127 0.6986
Echinococcus granulosus enteropeptidase 0.0014 0.0004 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0346 0.1227
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0321 0.1839
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Loa Loa (eye worm) hypothetical protein 0.0047 0.0346 0.1227
Toxoplasma gondii hypothetical protein 0.0034 0.0209 0.0672
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0346 0.198
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Brugia malayi Kringle domain containing protein 0.0053 0.0401 0.1423
Echinococcus multilocularis CREB binding protein 0.0084 0.0729 0.0729
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0209 0.0672
Loa Loa (eye worm) CBP-B 0.0085 0.074 0.2626
Loa Loa (eye worm) trypsin family protein 0.0014 0.0004 0.0014
Toxoplasma gondii microneme protein MIC17B 0.0034 0.0209 0.0672
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Toxoplasma gondii microneme protein, putative 0.0034 0.0209 0.0672
Echinococcus multilocularis lysosomal alpha glucosidase 0.0198 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.0057
Brugia malayi Trypsin family protein 0.0014 0.0004 0.0014
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Loa Loa (eye worm) hypothetical protein 0.0053 0.0401 0.1423
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0346 0.198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0791
Onchocerca volvulus 0.0034 0.0209 0.2018
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0076 0.0426
Brugia malayi Glycosyl hydrolases family 31 protein 0.0198 0.1897 0.6734
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0072 0.0601 0.972
Brugia malayi Trypsin family protein 0.0014 0.0004 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0346 0.5573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0201
Onchocerca volvulus 0.0034 0.0209 0.2018
Echinococcus multilocularis CREB binding protein 0.002 0.0067 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0346 0.1227
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Schistosoma mansoni inositol monophosphatase 0.0045 0.0321 0.1991
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0311 0.1783
Echinococcus multilocularis Mastin 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0028 0.0427
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0311 0.1106
Loa Loa (eye worm) variant SH3 domain-containing protein 0.013 0.1199 0.4256
Onchocerca volvulus 0.0114 0.1038 1
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.035
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0209 0.0744
Onchocerca volvulus 0.0034 0.0209 0.2018
Brugia malayi TAZ zinc finger family protein 0.0123 0.1127 0.4001
Leishmania major phospholipase c-like protein 0.0019 0.0054 0.0835
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0321 0.1839
Loa Loa (eye worm) Csnk2b protein 0.0072 0.0601 0.2135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0346 0.198
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Onchocerca volvulus 0.0019 0.0054 0.0516
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0072 0.0601 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0311 0.5017
Brugia malayi MH2 domain containing protein 0.0145 0.1352 0.4801
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Mycobacterium ulcerans aldehyde dehydrogenase 0.0074 0.0619 0.3554
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0072 0.0601 0.1929
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0002 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0346 0.1227
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0321 0.5176
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0182 0.1737 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0346 0.1227
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0004 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0028 0.0147
Echinococcus multilocularis GPCR, family 2 0.0019 0.0057 0.0057
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0076 0.0426
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Toxoplasma gondii PAN domain-containing protein 0.0316 0.3118 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0028 0.0147
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0311 0.1783
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0054 0.019
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Onchocerca volvulus 0.0014 0.0004 0.0037
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0182 0.1737 1
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.035
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0209 0.0672
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0098
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0057 0.0201
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0209 0.0744
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0321 0.1839
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0346 0.5573
Toxoplasma gondii microneme protein MIC17A 0.0034 0.0209 0.0672
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0483 0.1714
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0223 0.1272
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0059 0.0462 0.1642
Schistosoma mansoni alpha-glucosidase 0.017 0.1613 1
Onchocerca volvulus 0.0034 0.0209 0.2018
Brugia malayi Csnk2b protein 0.0072 0.0601 0.2135
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0057 0.0201
Plasmodium falciparum casein kinase II beta chain 0.0072 0.0601 0.3454
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0043 0.0151
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0209 0.0744
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0321 0.5324
Schistosoma mansoni aldehyde dehydrogenase 0.0074 0.0619 0.3835
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0791
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0311 0.1783
Plasmodium falciparum casein kinase II beta chain 0.0072 0.0601 0.3454
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0321 0.1839
Loa Loa (eye worm) hypothetical protein 0.0287 0.2816 1
Trypanosoma brucei glucosidase, putative 0.0044 0.0311 0.5161
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0346 0.198
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0321 0.103
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Loa Loa (eye worm) transcription factor SMAD2 0.0145 0.1352 0.4801
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0054 0.0859
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0346 0.5733
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0002 0.0007
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0054 0.019
Brugia malayi hypothetical protein 0.0287 0.2816 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0002 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0057 0.0201
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Toxoplasma gondii ck2 beta subunit 0.0072 0.0601 0.1929
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0346 0.198
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0198 0.1897 0.6734
Onchocerca volvulus 0.0019 0.0054 0.0516
Loa Loa (eye worm) hypothetical protein 0.0041 0.0285 0.1013
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0311 0.1783
Echinococcus granulosus CREB binding protein 0.0076 0.0641 0.2276
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0028 0.0147
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Onchocerca volvulus 0.0014 0.0004 0.0037
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.0201
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0311 0.5161
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0209 0.0744
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0028 0.0147
Onchocerca volvulus 0.0014 0.0004 0.0037
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0004 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0028 0.0147
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0076 0.1234
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0273 0.156
Echinococcus granulosus Mastin 0.0014 0.0004 0.0014
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.0401 0.2298
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0076 0.1234
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0028 0.0427
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0182 0.1737 1
Loa Loa (eye worm) inositol-1 0.0045 0.0321 0.114
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0321 0.5324
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0043 0.0656
Toxoplasma gondii PAN domain-containing protein 0.0316 0.3118 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0311 0.5161
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0054 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0791
Plasmodium vivax casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0311 0.1106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.0201
Echinococcus multilocularis lysosomal alpha glucosidase 0.0198 0.1897 0.1897
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0043 0.0656
Schistosoma mansoni hypothetical protein 0.0041 0.0285 0.177
Schistosoma mansoni hypothetical protein 0.0053 0.0401 0.2485
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.035
Onchocerca volvulus 0.0014 0.0004 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Onchocerca volvulus 0.0034 0.0209 0.2018
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0024
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0072 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0072 0.0601 0.5795
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0311 0.1783
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0151
Toxoplasma gondii microneme protein MIC4 0.0034 0.0209 0.0672
Onchocerca volvulus 0.0014 0.0002 0.002
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0004 0.0014
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0028 0.0427
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Loa Loa (eye worm) hypothetical protein 0.0034 0.0209 0.0744
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0002 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0346 0.198
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0034 0.0209 0.0672
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0182 0.1737 0.5571
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0209 0.0744
Echinococcus granulosus GPCR family 2 0.0019 0.0057 0.0201
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0004 0.0014
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0054 0.0172
Onchocerca volvulus 0.0059 0.0462 0.4456
Echinococcus granulosus CREB binding protein 0.0123 0.1127 0.4001
Toxoplasma gondii PAN/Apple domain-containing protein 0.0034 0.0209 0.0672
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0007
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0223 0.1272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0346 0.198
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0311 0.5161
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0346 0.198
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0043 0.0151
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0182 0.1737 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0209 0.0672
Echinococcus granulosus lysosomal alpha glucosidase 0.0198 0.1897 0.6734
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Brugia malayi Trypsin family protein 0.0014 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0004 0.0004
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0209 0.0672
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0182 0.1737 1
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0401 0.6653
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0223 0.1272
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0007
Echinococcus granulosus casein kinase ii subunit beta 0.0072 0.0601 0.2135
Mycobacterium ulcerans hypothetical protein 0.0014 0.0004 0.001
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0004 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0321 0.0321
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0273 0.156
Plasmodium falciparum enoyl-acyl carrier reductase 0.0182 0.1737 1
Onchocerca volvulus 0.0014 0.0004 0.0037
Schistosoma mansoni hypothetical protein 0.0059 0.0462 0.2867
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0321 0.5324
Echinococcus multilocularis casein kinase ii subunit beta 0.0072 0.0601 0.0601
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0074 0.0619 0.0619
Schistosoma mansoni alpha glucosidase 0.0044 0.0311 0.193
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0004 0.0004
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0002 0.0007
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0043 0.0233
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0223 0.1272
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0007
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0401 0.1423
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0028 0.0147
Echinococcus granulosus survival motor neuron protein 1 0.0287 0.2816 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Loa Loa (eye worm) casein kinase II 0.0021 0.0076 0.027
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Onchocerca volvulus 0.0034 0.0209 0.2018
Schistosoma mansoni casein kinase II beta subunit 0.0072 0.0601 0.3728
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0004 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0483 0.1714
Brugia malayi casein kinase II, putaitve 0.0021 0.0076 0.027
Plasmodium vivax casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.0601 1
Echinococcus multilocularis CREB binding protein 0.002 0.0067 0.0067
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.0601 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0346 0.198
Toxoplasma gondii hypothetical protein 0.0034 0.0209 0.0672
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0311 0.1106
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.019
Schistosoma mansoni hypothetical protein 0.0014 0.0004 0.0024
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0004
Giardia lamblia Casein kinase II beta chain 0.0072 0.0601 1
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.0401 0.1423
Mycobacterium ulcerans aldehyde dehydrogenase 0.0074 0.0619 0.3554
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0002 0.0013
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.0401 0.0401
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0311 0.1783
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0002 0.0007
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0028 0.0098
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0346 0.5733
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Schistosoma mansoni inositol monophosphatase 0.0045 0.0321 0.1991
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0074 0.0619 0.2196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0791
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0203 0.1157
Toxoplasma gondii aldehyde dehydrogenase 0.0074 0.0619 0.1984
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Mycobacterium ulcerans hypothetical protein 0.0047 0.0346 0.198
Leishmania major hypothetical protein, conserved 0.0053 0.0401 0.6467
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Loa Loa (eye worm) hypothetical protein 0.006 0.0483 0.1714
Mycobacterium ulcerans aldehyde dehydrogenase 0.0074 0.0619 0.3554
Loa Loa (eye worm) hypothetical protein 0.0047 0.0346 0.1227
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0002 0.0002
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0123 0.1127 0.6986
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0182 0.1737 1
Onchocerca volvulus 0.0034 0.0209 0.2018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0346 0.198
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0346 0.198
Echinococcus granulosus CREB binding protein 0.002 0.0067 0.0238
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0054 0.019
Onchocerca volvulus 0.0034 0.0209 0.2018
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0076 0.0426
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0014
Brugia malayi hypothetical protein 0.0014 0.0004 0.0014
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0311 0.1783
Loa Loa (eye worm) hypothetical protein 0.0058 0.0454 0.1613
Schistosoma mansoni alpha-glucosidase 0.017 0.1613 1
Brugia malayi Trypsin family protein 0.0014 0.0004 0.0014
Toxoplasma gondii microneme protein MIC17C 0.0034 0.0209 0.0672
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.0601 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0074 0.0619 0.3554
Brugia malayi Variant SH3 domain containing protein 0.013 0.1199 0.4256
Onchocerca volvulus 0.0053 0.0401 0.3862
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0311 0.5161
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0346 0.5733
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0285 0.1013
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0004 0.0024
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0321 0.114
Echinococcus multilocularis survival motor neuron protein 1 0.0287 0.2816 0.2816
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0072 0.0601 0.5795
Brugia malayi Inositol-1 0.0045 0.0321 0.114
Trichomonas vaginalis hypothetical protein 0.0182 0.1737 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0203 0.1157
Onchocerca volvulus 0.0034 0.0209 0.2018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0002 0.0007
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0311 0.1783
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0311 0.1783
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0002 0.0007
Loa Loa (eye worm) oxidoreductase 0.0014 0.0002 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0321 0.5324
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0028 0.0147
Onchocerca volvulus 0.0014 0.0002 0.002
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0043 0.0151
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0043 0.0233
Echinococcus multilocularis CREB binding protein 0.002 0.0067 0.0067
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.0401 0.2298
Brugia malayi Protein kinase domain containing protein 0.0053 0.0401 0.1423
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Schistosoma mansoni phospholipase C beta 0.0018 0.0043 0.0264
Onchocerca volvulus 0.0047 0.0346 0.3331
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0004 0.0024
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0028 0.0266
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0601 0.3454
Schistosoma mansoni aldehyde dehydrogenase 0.0074 0.0619 0.3835
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0054 0.0054
Brugia malayi PAN domain containing protein 0.0034 0.0209 0.0744
Onchocerca volvulus 0.0014 0.0002 0.002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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