Detailed information for compound 801410

Basic information

Technical information
  • TDR Targets ID: 801410
  • Name: 2-cyclohexyl-N-(4-methoxyphenyl)-3-oxo-1H-iso indole-4-carboxamide
  • MW: 364.438 | Formula: C22H24N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)c1cccc2c1C(=O)N(C2)C1CCCCC1
  • InChi: 1S/C22H24N2O3/c1-27-18-12-10-16(11-13-18)23-21(25)19-9-5-6-15-14-24(22(26)20(15)19)17-7-3-2-4-8-17/h5-6,9-13,17H,2-4,7-8,14H2,1H3,(H,23,25)
  • InChiKey: PDQLECUWHRAQLD-UHFFFAOYSA-N  


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Synonyms

  • 2-cyclohexyl-N-(4-methoxyphenyl)-3-oxo-isoindoline-4-carboxamide
  • 2-cyclohexyl-N-(4-methoxyphenyl)-3-oxo-4-isoindolinecarboxamide
  • 2-cyclohexyl-3-keto-N-(4-methoxyphenyl)isoindoline-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0353 0.0393
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0353 0.0382
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0157 0.1284 0.142
Schistosoma mansoni z-protein (S1r protein) 0.0103 0.0749 0.0739
Entamoeba histolytica hypothetical protein 0.0103 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0321 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0749 0.3517
Echinococcus granulosus alkaline phosphatase 0.0157 0.1284 0.143
Onchocerca volvulus 0.0029 0.0011 0.0013
Brugia malayi beta-lactamase family protein 0.0035 0.007 0.0062
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0157 0.1284 0.142
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.007 0.0321
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0103 0.0749 0.0739
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.007 0.0059
Echinococcus granulosus beta-adrenergic receptor kinase 0.0106 0.0773 0.0862
Echinococcus granulosus regulator of G protein signaling 3 0.0103 0.0749 0.0834
Brugia malayi beta-lactamase 0.0035 0.007 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0773 0.0764
Loa Loa (eye worm) hypothetical protein 0.0041 0.0134 0.0126
Loa Loa (eye worm) hypothetical protein 0.0103 0.0749 0.0741
Brugia malayi PXA domain containing protein 0.0103 0.0749 0.0741
Loa Loa (eye worm) hypothetical protein 0.0103 0.0749 0.0741
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0103 0.0749 0.0739
Echinococcus multilocularis axis inhibition protein axin 0.0103 0.0749 0.0824
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.007 0.1791
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0198 0.022
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0694 0.0684
Echinococcus granulosus axis inhibition protein axin 0.0103 0.0749 0.0834
Brugia malayi A-kinase anchor protein 10, precursor 0.0103 0.0749 0.0741
Mycobacterium leprae Probable lipase LipE 0.0035 0.007 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0132 0.0124
Schistosoma mansoni hypothetical protein 0.004 0.0119 0.0108
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.007 0.0062
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0134 0.0149
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0353 0.1791
Loa Loa (eye worm) RGS-3 protein 0.0103 0.0749 0.0741
Brugia malayi beta-lactamase family protein 0.0035 0.007 0.0062
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1724 0.1718
Mycobacterium tuberculosis Conserved protein 0.0035 0.007 0.0321
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0321 0.0314
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0198 0.019
Onchocerca volvulus 0.0035 0.007 0.031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.007 0.0059
Echinococcus multilocularis regulator of G protein signaling 3 0.0103 0.0749 0.0824
Echinococcus multilocularis beta adrenergic receptor kinase 0.0106 0.0773 0.0851
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0066 0.0379 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0749 0.3517
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0157 0.1284 0.142
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0679 0.0757
Loa Loa (eye worm) hypothetical protein 0.0103 0.0749 0.0741
Echinococcus granulosus axis inhibition protein axin 0.0103 0.0749 0.0834
Echinococcus multilocularis alkaline phosphatase 0.0157 0.1284 0.142
Brugia malayi hypothetical protein 0.0229 0.1997 0.199
Brugia malayi regulator of G-protein signaling egl-10 0.0103 0.0749 0.0741
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0157 0.1284 0.143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.007 0.1791
Schistosoma mansoni serine/threonine protein kinase 0.1035 1 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0103 0.0749 0.0824
Brugia malayi hypothetical protein 0.0103 0.0749 0.0741
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1035 1 1
Schistosoma mansoni hypothetical protein 0.0047 0.0187 0.0177
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0353 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.007 0.0062
Brugia malayi Pre-SET motif family protein 0.0029 0.0011 0.0003
Mycobacterium tuberculosis Conserved protein 0.0035 0.007 0.0321
Onchocerca volvulus 0.0229 0.2001 1
Echinococcus granulosus geminin 0.0164 0.1352 0.1507
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0679 0.0746
Schistosoma mansoni hypothetical protein 0.0041 0.0132 0.0122
Entamoeba histolytica hypothetical protein 0.0043 0.0155 0.1986
Brugia malayi regulator of G-protein signaling rgs-7 0.0103 0.0749 0.0741
Echinococcus granulosus intestinal type alkaline phosphatase 0.0157 0.1284 0.143
Echinococcus granulosus expressed protein 0.0103 0.0749 0.0834
Schistosoma mansoni survival motor neuron protein 0.0047 0.0187 0.0177
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1089 0.1203
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0353 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.007 0.0321
Onchocerca volvulus 0.0048 0.0199 0.0959
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0932 0.8975 0.8974
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0932 0.8975 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0198 0.0187
Brugia malayi Pre-SET motif family protein 0.0201 0.1724 0.1718
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0353 1
Onchocerca volvulus 0.0047 0.0187 0.09
Schistosoma mansoni regulator of G protein signaling 0.0103 0.0749 0.0739
Brugia malayi hypothetical protein 0.0043 0.0155 0.0147
Mycobacterium leprae conserved hypothetical protein 0.0035 0.007 1
Entamoeba histolytica hypothetical protein 0.0043 0.0155 0.1986
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.007 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0103 0.0749 0.0834
Leishmania major hypothetical protein, conserved 0.0035 0.007 0.1791
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0321 0.0314
Brugia malayi Regulator of G protein signaling domain containing protein 0.0103 0.0749 0.0741
Loa Loa (eye worm) PXA domain-containing protein 0.0103 0.0749 0.0741
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1089 0.1214
Mycobacterium ulcerans hypothetical protein 0.0035 0.007 0.1791
Loa Loa (eye worm) hypothetical protein 0.0041 0.0132 0.0124
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0134 0.0137
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0157 0.1284 0.143
Schistosoma mansoni hypothetical protein 0.004 0.0119 0.0108
Schistosoma mansoni axis inhibition protein axin 0.0103 0.0749 0.0739
Echinococcus multilocularis regulator of G protein signaling 7 0.0103 0.0749 0.0824
Loa Loa (eye worm) hypothetical protein 0.0103 0.0749 0.0741
Schistosoma mansoni hypothetical protein 0.0082 0.0534 0.0524
Echinococcus granulosus regulator of G protein signaling 3 0.0103 0.0749 0.0834
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0062
Schistosoma mansoni hypothetical protein 0.0164 0.1352 0.1343
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.007 0.5
Toxoplasma gondii ABC1 family protein 0.0035 0.007 0.1727
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0134 0.0126
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0229 0.1997 0.199
Schistosoma mansoni regulator of G protein signaling 0.0103 0.0749 0.0739
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0353 1
Brugia malayi CHE-14 protein 0.0041 0.0134 0.0126
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.007 0.0321
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.007 0.0321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0155 0.0173
Echinococcus multilocularis regulator of G protein signaling 0.0103 0.0749 0.0824
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0103 0.0749 0.0741
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0353 0.0343
Plasmodium vivax hypothetical protein, conserved 0.0035 0.007 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0198 0.0209
Schistosoma mansoni regulator of G protein signaling 0.0103 0.0749 0.0739
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0199 0.0189
Echinococcus multilocularis expressed conserved protein 0.009 0.0621 0.0681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0198 0.0187
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1997 0.2225
Mycobacterium tuberculosis Conserved protein 0.0035 0.007 0.0321
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0103 0.0749 0.3517
Echinococcus granulosus expressed conserved protein 0.009 0.0621 0.0692
Onchocerca volvulus 0.0035 0.007 0.031
Entamoeba histolytica hypothetical protein 0.0043 0.0155 0.1986
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0062
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0011 0.0012
Schistosoma mansoni hypothetical protein 0.0164 0.1352 0.1343
Entamoeba histolytica hypothetical protein 0.0043 0.0155 0.1986
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1997 0.2216
Loa Loa (eye worm) hypothetical protein 0.0051 0.0226 0.0218
Loa Loa (eye worm) hypothetical protein 0.0103 0.0749 0.0741
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0773 0.0764
Echinococcus multilocularis protein patched 0.0041 0.0134 0.0137
Echinococcus granulosus regulator of G protein signaling 7 0.0103 0.0749 0.0834
Schistosoma mansoni lipoxygenase 0.0066 0.0379 0.0369
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2001 1
Brugia malayi hypothetical protein 0.0103 0.0749 0.0741
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0321 0.0314
Schistosoma mansoni alkaline phosphatase 0.0157 0.1284 0.1274
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0353 1
Mycobacterium ulcerans lipase LipD 0.0035 0.007 0.1791
Mycobacterium ulcerans beta-lactamase 0.0035 0.007 0.1791
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0749 0.3517
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0679 0.0672
Brugia malayi PXA domain containing protein 0.0103 0.0749 0.0741
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0103 0.0749 0.0739
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0103 0.0749 0.0834
Schistosoma mansoni regulator of G protein signaling 0.0103 0.0749 0.0739
Schistosoma mansoni hypothetical protein 0.004 0.0119 0.0108
Echinococcus multilocularis Regulator of G protein signaling 20 0.0103 0.0749 0.0824
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0198 0.0209
Echinococcus multilocularis tumor protein p63 0.0327 0.2972 0.3303
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0155 0.0161
Onchocerca volvulus 0.0148 0.119 0.5934
Loa Loa (eye worm) hypothetical protein 0.0148 0.119 0.1183
Onchocerca volvulus 0.0035 0.007 0.031
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0932 0.8975 0.8974
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0198 0.0187
Entamoeba histolytica hypothetical protein 0.0103 0.0749 1
Schistosoma mansoni hypothetical protein 0.0043 0.0155 0.0145
Echinococcus multilocularis regulator of G protein signaling 3 0.0103 0.0749 0.0824
Echinococcus multilocularis protein dispatched 1 0.0047 0.0192 0.0202
Echinococcus multilocularis geminin 0.0164 0.1352 0.1497
Brugia malayi hypothetical protein 0.0148 0.119 0.1183
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0353 0.0343
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.007 0.0321
Echinococcus granulosus tumor protein p63 0.0327 0.2972 0.3311
Schistosoma mansoni hypothetical protein 0.004 0.0119 0.0108
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.007 0.0066
Schistosoma mansoni axis inhibition protein axin 0.0103 0.0749 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0134 0.0332
Echinococcus multilocularis axis inhibition protein axin 0.0103 0.0749 0.0824
Schistosoma mansoni patched 1 0.0041 0.0134 0.0123
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0932 0.8975 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0103 0.0749 0.0741
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.7595 0.846
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0198 0.019
Echinococcus multilocularis expressed protein 0.0103 0.0749 0.0824
Loa Loa (eye worm) beta-lactamase 0.0035 0.007 0.0062
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0134 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0749 0.3517
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0749 0.3517
Echinococcus multilocularis regulator of G protein signaling 7 0.0103 0.0749 0.0824
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.007 0.0078
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1935 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0106 0.0773 0.0766
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.007 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0198 0.022
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.007 0.0321
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0066 0.0379 0.0411
Loa Loa (eye worm) hypothetical protein 0.0103 0.0749 0.0741
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0187 0.0179
Loa Loa (eye worm) hypothetical protein 0.0096 0.0679 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0749 0.3517
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0932 0.8975 0.8974
Entamoeba histolytica hypothetical protein 0.0103 0.0749 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0679 0.9062
Echinococcus granulosus Regulator of G protein signaling 20 0.0103 0.0749 0.0834
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0003
Schistosoma mansoni regulator of G protein signaling 0.0103 0.0749 0.0739
Schistosoma mansoni alkaline phosphatase 0.0157 0.1284 0.1274
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0155 0.0145
Loa Loa (eye worm) hypothetical protein 0.0035 0.007 0.0062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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