Detailed information for compound 801984

Basic information

Technical information
  • TDR Targets ID: 801984
  • Name: 5-methyl-3-(4-methylphenyl)-1-(4-methylpipera zine-1-carbonyl)pyridazino[4,5-b]indol-4-one
  • MW: 415.488 | Formula: C24H25N5O2
  • H donors: 0 H acceptors: 2 LogP: 2.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(=O)c1nn(c2ccc(cc2)C)c(=O)c2c1c1ccccc1n2C
  • InChi: 1S/C24H25N5O2/c1-16-8-10-17(11-9-16)29-24(31)22-20(18-6-4-5-7-19(18)27(22)3)21(25-29)23(30)28-14-12-26(2)13-15-28/h4-11H,12-15H2,1-3H3
  • InChiKey: BNUOWZBUWGKAOS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-3-(4-methylphenyl)-1-[(4-methyl-1-piperazinyl)-oxomethyl]-4-pyridazino[4,5-b]indolone
  • 5-methyl-3-(4-methylphenyl)-1-(4-methylpiperazin-1-yl)carbonyl-pyridazino[4,5-b]indol-4-one
  • MLS000876935
  • 5-methyl-3-(4-methylphenyl)-1-[(4-methylpiperazin-1-yl)carbonyl]-3,5-dihydro-4H-pyridazino[4,5-b]indol-4-one
  • MLS000045313
  • SMR000026905

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0067 0.0705 0.1604
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0023 0.0143 0.0517
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0579 0.3788
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0143 0.0088
Loa Loa (eye worm) hypothetical protein 0.0157 0.1861 0.2638
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0544 0.0464
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0085 0.0937 0.2203
Entamoeba histolytica hypothetical protein 0.0023 0.0143 0.0153
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.8544 0.8531
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0107 0.123 0.1701
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0043 0.0402 0.2774
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0107 0.123 0.2959
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0192 0.0827
Loa Loa (eye worm) hypothetical protein 0.0173 0.2069 0.2946
Entamoeba histolytica protein kinase rad3, putative 0.0043 0.0402 0.0821
Loa Loa (eye worm) hypothetical protein 0.0147 0.1739 0.2456
Entamoeba histolytica hypothetical protein 0.0023 0.0143 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0192 0.0304
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1391 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0192 0.0827
Echinococcus multilocularis serine protein kinase ATM 0.0043 0.0402 0.0321
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0192 0.0827
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0065 0.0683 0.4581
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0046 0.0447 0.2776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0149 0.057
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0023 0.0143 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Brugia malayi follicle stimulating hormone receptor 0.028 0.3442 0.4983
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0067 0.0705 0.5422
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0067 0.0705 0.1604
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0065 0.0683 0.0889
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.046 0.0444
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.2298 0.2233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0067 0.0705 0.1604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0043 0.0402 0.0321
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0277 0.341 0.8587
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0579 0.0735
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0023 0.0143 0.007
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0504 0.6317 0.6286
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.046 0.0379
Schistosoma mansoni cpg binding protein 0.0037 0.0321 0.0281
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0023 0.0143 0.0153
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.032 0.3957 0.5748
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0912 0.0979
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0254 0.3118 0.4503
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0067 0.0705 0.0735
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0705 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0067 0.0705 0.1749
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.046 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0192 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0579 0.1393
Loa Loa (eye worm) phosphatidylinositol 3 0.0023 0.0143 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0459 0.0557
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0795 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0065 0.0683 0.0889
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0023 0.0143 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0272 0.3345 0.8419
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0067 0.0705 0.5422
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.032 0.3957 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0023 0.0143 0.0167
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0107 0.123 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Entamoeba histolytica hypothetical protein 0.0023 0.0149 0.0169
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0065 0.0683 0.1546
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0065 0.0691 0.2439
Trichomonas vaginalis glucosylceramidase, putative 0.0375 0.4671 0.6808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0065 0.0683 0.1685
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0544 0.0544
Echinococcus granulosus serine protein kinase ATM 0.0043 0.0402 0.0321
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.6822 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0067 0.0705 0.0922
Echinococcus multilocularis muscleblind protein 0.0149 0.1758 0.1688
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0109 0.0038
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0067 0.0705 0.1604
Echinococcus multilocularis 0.0023 0.0143 0.006
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0107 0.123 0.1701
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0023 0.0143 0.0454
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0023 0.0143 0.0454
Giardia lamblia Hypothetical protein 0.0023 0.0143 0.0238
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0143 0.099
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.046 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0067 0.0705 0.0735
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1391 0.1545
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0143 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Brugia malayi FAT domain containing protein 0.0024 0.0154 0.0104
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0143 0.0088
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.1391 0.1318
Entamoeba histolytica hypothetical protein 0.0277 0.341 0.8587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0023 0.0143 0.0088
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0065 0.0683 1
Onchocerca volvulus 0.0023 0.0143 0.0324
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0023 0.0143 0.006
Onchocerca volvulus 0.0023 0.0143 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.6822 1
Echinococcus granulosus cpg binding protein 0.0037 0.0321 0.0239
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1391 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0023 0.0143 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Entamoeba histolytica hypothetical protein 0.0023 0.0143 0.0153
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0149 0.05
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.8544 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0192 0.0304
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0065 0.0683 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.013 0.1522 0.3712
Onchocerca volvulus 0.0027 0.0192 0.0434
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0065 0.0683 0.0604
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.2069 0.2946
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0154 0.0104
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0067 0.0705 0.5422
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0032
Plasmodium vivax hypothetical protein 0.0023 0.0143 0.099
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0543 0.6822 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0065 0.0683 0.0889
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0143 0.0088
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.046 0.1039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0459 0.0379
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.123 0.1701
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.1391 0.1318
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0143 0.0153
Loa Loa (eye worm) MBCTL1 0.0054 0.0544 0.0683
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0143 0.0517
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0402 0.0472
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0694 0.467
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0143 0.099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0402 0.0472
Brugia malayi mbt repeat family protein 0.0047 0.046 0.0558
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0067 0.0705 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0109 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0459 0.0379
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0149 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0912 0.0835
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0192 0.0304
Schistosoma mansoni hypothetical protein 0.0023 0.0143 0.007
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0192 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0375 0.4671 0.6808
Entamoeba histolytica hypothetical protein 0.0043 0.0402 0.0821
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.053 0.0662
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0109 0.0066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0459 0.0379
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.032 0.3957 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0504 0.6317 0.6286
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0149 0.05
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0579 0.0499
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.016
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0023 0.0143 0.006
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0067 0.0705 0.5422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0065 0.0683 0.1546
Leishmania major phosphatidylinositol kinase, putative 0.0023 0.0143 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.6822 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Loa Loa (eye worm) phosphatidylinositol 3 0.0023 0.0143 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0092 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0023 0.0143 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Echinococcus multilocularis cpg binding protein 0.0037 0.0321 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Loa Loa (eye worm) phosphatidylinositol 3 0.0023 0.0143 0.0088
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0107 0.123 0.1355
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0579 0.3788
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0149 0.1091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0106 0.0167
Leishmania major phosphatidylinositol 4-kinase, putative 0.0023 0.0143 0.0167
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0065 0.0683 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0067 0.0705 0.1604
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0504 0.6317 0.7368
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0173 0.2069 0.2002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Onchocerca volvulus 0.0083 0.0912 0.2062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0143 0.0088
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0149 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0065 0.0683 0.0708
Schistosoma mansoni hypothetical protein 0.0292 0.36 0.4156
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0184 0.2211 0.3156
Onchocerca volvulus 0.0157 0.1861 0.4207
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0024 0.0154 0.0071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0402 0.0472
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0067 0.0705 0.1749
Brugia malayi hypothetical protein 0.0157 0.1861 0.2638
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0192 0.0827
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0067 0.0705 0.1604
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.1391 1
Onchocerca volvulus Glucosylceramidase homolog 0.0356 0.4425 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0065 0.0683 0.1546
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0705 0.4755
Loa Loa (eye worm) phosphatidylinositol 3 0.0461 0.577 0.8439
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0067 0.0705 0.1749
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0106 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0447 0.0538
Loa Loa (eye worm) hypothetical protein 0.0149 0.1758 0.2484
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0143 0.099
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3442 0.4983
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0192 0.0279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0459 0.0444
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0023 0.0143 0.099
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0791 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0067 0.0705 0.0627
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0149 0.05
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0106 0.0364
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0023 0.0143 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0705 0.0922
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0192 0.016
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0023 0.0143 0.006
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0024 0.0154 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0459 0.0379
Loa Loa (eye worm) hypothetical protein 0.0046 0.0447 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0067 0.0705 0.0627
Schistosoma mansoni fkbp-rapamycin associated protein 0.0043 0.0402 0.0376
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0192 0.016
Brugia malayi mbt repeat family protein 0.0047 0.046 0.0558
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0912 0.0835
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0544 0.0683
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Loa Loa (eye worm) phosphatidylinositol 3 0.0085 0.0937 0.1267
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0579 0.3788
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0212 0.2571 1
Giardia lamblia GTOR 0.0067 0.0705 0.2499
Loa Loa (eye worm) hypothetical protein 0.0149 0.1758 0.2484
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0192 0.0827
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0023 0.0143 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0459 0.0557
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0107 0.123 0.1701
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0023 0.0143 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0065 0.0683 0.4581
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.6822 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0579 0.0585
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0107 0.123 0.2959
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0065 0.0683 0.1546
Brugia malayi CXXC zinc finger family protein 0.0035 0.0296 0.0315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0192 0.0827
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0067 0.0705 0.0627
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0173 0.2069 0.2002
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Schistosoma mansoni hypothetical protein 0.0024 0.0154 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0106 0.0167
Echinococcus granulosus microtubule associated protein 2 0.0677 0.8544 0.8531
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0192 0.0827
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0192 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.6822 1
Brugia malayi Muscleblind-like protein 0.0149 0.1758 0.2484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0296 0.0315
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1758 0.1688
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0023 0.0143 0.0088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0192 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0143 0.0454
Leishmania major hypothetical protein, conserved 0.0295 0.3638 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0046 0.0447 0.3166
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0065 0.0683 0.5225
Schistosoma mansoni cpg binding protein 0.0037 0.0321 0.0281
Leishmania major phosphatidylinositol 3-kinase, putative 0.0065 0.0683 0.1685
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0067 0.0705 0.1749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0459 0.0444
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0149 0.05
Loa Loa (eye worm) hypothetical protein 0.0024 0.0154 0.0104
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.0402 0.0821
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0149 0.123
Schistosoma mansoni cpg binding protein 0.0035 0.0296 0.0251
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0065 0.0683 0.0708
Mycobacterium ulcerans hypothetical protein 0.0027 0.0192 0.0827
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0065 0.0683 0.0889
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0023 0.0143 0.0153
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0067 0.0705 0.1749
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0092 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1391 0.1545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0143 0.0088
Toxoplasma gondii FATC domain-containing protein 0.0043 0.0402 0.2433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0092 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0544 0.0464
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.3118 0.4503
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0023 0.0143 0.0517
Loa Loa (eye worm) hypothetical protein 0.0054 0.0544 0.0683
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0402 0.0472
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.2298 0.2233
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0579 0.0499
Leishmania major hypothetical protein, unknown function 0.0023 0.0143 0.0167
Echinococcus granulosus muscleblind protein 0.0149 0.1758 0.1688
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0149 0.1091
Loa Loa (eye worm) hypothetical protein 0.0083 0.0912 0.1229
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0023 0.0143 0.0153
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0067 0.0705 0.5422
Giardia lamblia Phosphatidylinositol 4-kinase 0.0023 0.0143 0.0238
Loa Loa (eye worm) phosphatidylinositol kinase 0.0023 0.0143 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0912 0.1229
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.032 0.3957 0.5748
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0043 0.0402 0.0821
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0067 0.0705 0.0922
Onchocerca volvulus 0.0035 0.0296 0.0669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0107 0.123 0.2959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.032 0.3957 0.5748
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0297 0.3665 0.9245
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.046 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0447 0.0538
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0459 0.0444
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0543 0.6822 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0092 0.006
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0023 0.0143 0.099
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0032
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0043 0.0402 0.0821
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0544 0.0464
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0065 0.0683 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.1391 0.3678
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0149 0.0184
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1391 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0023 0.0143 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.046 0.0379
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.6822 1
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.1391 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0043 0.0402 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0043 0.0402 0.0376
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.046 0.0444
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.046 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0705 0.0922
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0192 0.0827
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0149 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0192 0.0827
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.4425 0.6442
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0065 0.0683 0.0889
Onchocerca volvulus 0.0047 0.046 0.1039
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0023 0.0143 0.0153
Echinococcus multilocularis Zinc finger, PHD finger 0.0065 0.0683 0.0604
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0149 0.05
Trypanosoma cruzi target of rapamycin kinase 3 0.0067 0.0705 0.1604
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0544 0.0464
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.032 0.3957 0.5748
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.032 0.3957 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0192 0.016
Loa Loa (eye worm) hypothetical protein 0.0047 0.046 0.0558

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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