Detailed information for compound 804766

Basic information

Technical information
  • TDR Targets ID: 804766
  • Name: 4-(4-Chloro-phenyl)-4-aza-tricyclo[5.2.2.0*2, 6*]undec-8-ene-3,5-dione
  • MW: 287.741 | Formula: C16H14ClNO2
  • H donors: 0 H acceptors: 2 LogP: 3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C2C3CCC(C2C(=O)N1c1ccc(cc1)Cl)C=C3
  • InChi: 1S/C16H14ClNO2/c17-11-5-7-12(8-6-11)18-15(19)13-9-1-2-10(4-3-9)14(13)16(18)20/h1-2,5-10,13-14H,3-4H2
  • InChiKey: GKNXOIQWUMCVKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AG-205/37007334
  • A1539/0066941
  • BAS 00851864

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0043 0.0535 0.0765
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0286 0.0394
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0259 0.6746 0.6746
Schistosoma mansoni hypothetical protein 0.0041 0.0468 0.0468
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0535 1
Plasmodium falciparum peptidase, putative 0.0027 0.0064 0.1658
Loa Loa (eye worm) hypothetical protein 0.0085 0.1744 0.1744
Trypanosoma brucei prolyl oligopeptidase, putative 0.0103 0.225 0.3315
Trypanosoma brucei prolyl endopeptidase 0.0259 0.6746 1
Schistosoma mansoni importin beta-1 0.0035 0.0286 0.0286
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0286 0.0394
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0064 0.5844
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0535 0.0765
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0067 0.0067
Onchocerca volvulus 0.0043 0.0535 0.0705
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0027 0.0064 0.0065
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0064 0.0065
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.002 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1017 0.1017
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0027 0.0064 0.0065
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0064 0.0065
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0064 0.5844
Toxoplasma gondii ABC1 family protein 0.0043 0.0535 0.0765
Onchocerca volvulus 0.0043 0.0535 0.0705
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0064 0.0854
Leishmania major oligopeptidase b 0.0103 0.225 0.3315
Leishmania major hypothetical protein, conserved 0.0043 0.0535 0.0765
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0027 0.0064 0.0065
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0096 0.0112
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0064 0.0064
Echinococcus granulosus prolyl endopeptidase 0.0259 0.6746 0.6739
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0027 0.0064 0.0065
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0259 0.6746 0.6746
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0064 0.5844
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0874 0.1269
Echinococcus granulosus importin subunit beta 1 0.0035 0.0286 0.0266
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0064 0.0064
Brugia malayi beta-lactamase family protein 0.0043 0.0535 0.0765
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0535 0.0765
Schistosoma mansoni bromodomain containing protein 0.0076 0.1485 0.1485
Toxoplasma gondii hypothetical protein 0.0027 0.0064 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0854
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0064 0.0854
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0874 0.0856
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0535 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0535 0.0516
Brugia malayi PHD-finger family protein 0.003 0.0149 0.0191
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0103 0.225 1
Echinococcus multilocularis prolyl endopeptidase 0.0259 0.6746 0.6739
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0096 0.1461
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0618 0.0618
Brugia malayi beta-lactamase family protein 0.0043 0.0535 0.0765
Entamoeba histolytica hypothetical protein 0.0028 0.0096 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0027 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0035 0.0286 0.0286
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0535 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0874 0.0856
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0535 0.0516
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0064 0.5844
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0064 1
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0064 0.0065
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0064 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0535 0.0535
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0286 0.0266
Loa Loa (eye worm) hypothetical protein 0.006 0.1017 0.1017
Onchocerca volvulus Prolyl endopeptidase homolog 0.0259 0.6746 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0027 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0049 0.07 0.07
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0067 0.0046
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0064 0.0065
Trypanosoma cruzi oligopeptidase b 0.0103 0.225 0.3315
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0064 0.0854
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0535 0.0535
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0535 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0096 0.1461
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0027 0.0064 0.0044
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.136 0.1343
Trichomonas vaginalis esterase, putative 0.0043 0.0535 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0535 0.0535
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0027 0.0064 0.0044
Echinococcus granulosus Dipeptidyl peptidase 9 0.0027 0.0064 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0874 0.0874
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0286 0.0394
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0535 0.0765
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0064 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0064 0.0065
Brugia malayi RNA, U transporter 1 0.0099 0.2137 0.3147
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0535 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0533 0.0513
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0535
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1017 0.1482
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0103 0.225 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0874 0.0856
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0103 0.225 0.2538
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0535
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0103 0.225 0.3315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0874 0.0874
Loa Loa (eye worm) beta-lactamase 0.0043 0.0535 0.0535
Trypanosoma cruzi oligopeptidase b 0.0103 0.225 0.3315
Schistosoma mansoni ran 0.0026 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0874 0.0874
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0535
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0533 0.0513
Onchocerca volvulus 0.0043 0.0535 0.0705
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0064 0.5844
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0067 0.0046
Toxoplasma gondii prolyl endopeptidase 0.0259 0.6746 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0064 0.0064
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0064 0.5844
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0064 0.0044
Brugia malayi Bromodomain containing protein 0.0046 0.0615 0.0884
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0103 0.225 0.3315
Plasmodium falciparum importin beta, putative 0.0035 0.0286 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0064 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0259 0.6746 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0103 0.225 0.3315
Mycobacterium tuberculosis Probable peptidase 0.0103 0.225 0.2538
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0103 0.225 0.3315
Plasmodium vivax importin-beta 2, putative 0.0035 0.0286 0.515
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0064 0.0044
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0535 0.0765
Loa Loa (eye worm) hypothetical protein 0.0052 0.0767 0.0767
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0535 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0468 0.0666
Brugia malayi Bromodomain containing protein 0.0091 0.1893 0.2784
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.136 0.1343
Trypanosoma brucei oligopeptidase b 0.0103 0.225 0.3315
Brugia malayi Importin beta-1 subunit 0.0035 0.0286 0.0394
Echinococcus multilocularis snurportin 1 0.0372 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0874 0.0856
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1017 0.1482
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0874 0.0874
Brugia malayi prolyl oligopeptidase family protein 0.0259 0.6746 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0468 0.0468
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0535
Leishmania major importin beta-1 subunit, putative 0.0028 0.0096 0.0112
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0027 0.0064 0.0065
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0027 0.0064 0.0044
Loa Loa (eye worm) hypothetical protein 0.0259 0.6746 0.6746
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0096 0.1461
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0232 0.5963 0.8034
Schistosoma mansoni hypothetical protein 0.0372 1 1
Trypanosoma cruzi prolyl endopeptidase 0.0259 0.6746 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7291 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0535 0.0535
Schistosoma mansoni ran 0.0026 0.002 0.002
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0027 0.0064 0.0065

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 1.0323 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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