Detailed information for compound 806741

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.684 | Formula: C30H36N2O2S
  • H donors: 0 H acceptors: 1 LogP: 6.24 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccsc1C(=O)N1CCCC(C1)COc1ccc(cc1)CN1CCC(CC1)c1ccccc1
  • InChi: 1S/C30H36N2O2S/c1-23-15-19-35-29(23)30(33)32-16-5-6-25(21-32)22-34-28-11-9-24(10-12-28)20-31-17-13-27(14-18-31)26-7-3-2-4-8-26/h2-4,7-12,15,19,25,27H,5-6,13-14,16-18,20-22H2,1H3
  • InChiKey: LQQYPBZJZURPEG-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0058 0.0106 0.103
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0004 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.0945 0.0945
Schistosoma mansoni malate dehydrogenase 0.008 0.0159 0.0159
Echinococcus multilocularis malate dehydrogenase 0.008 0.0159 0.0159
Giardia lamblia Malate dehydrogenase 0.019 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0119
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0106 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0046 0.0564
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0094 0.0192 0.0192
Echinococcus granulosus expressed protein 0.0422 0.0978 0.0978
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0094 0.0192 0.0192
Onchocerca volvulus 0.003 0.004 0.0749
Echinococcus multilocularis mitogen activated protein kinase 3 0.0101 0.0209 0.0209
Echinococcus multilocularis muscleblind protein 1 0.0445 0.1033 0.1033
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0063 0.0934
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0019 0.0019
Echinococcus multilocularis cytosolic malate dehydrogenase 0.019 0.0423 0.0423
Leishmania major hypothetical protein, conserved 0.0025 0.0027 0.0403
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0012 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0021 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0464 0.4492
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0025 0.0026 0.039
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0403
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0019 0.0019
Brugia malayi RNase H family protein 0.0023 0.0022 0.021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0144 0.0144
Leishmania major malate dehydrogenase, putative 0.008 0.0159 0.2359
Trichomonas vaginalis ribonuclease H1, putative 0.0023 0.0022 0.0407
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0019 0.0187
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0063 0.0181
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0012 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0012 0.0119
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0079 0.0966
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1467 0.3483 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0004 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0362
Onchocerca volvulus 0.0029 0.0036 0.0676
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.1467 0.3483 1
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0079 0.0225
Schistosoma mansoni hypothetical protein 0.0085 0.0171 0.0171
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0012 0.0012
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0019 0.0019
Plasmodium vivax malate dehydrogenase, putative 0.008 0.0159 0.0457
Echinococcus granulosus ribonuclease H1 0.0023 0.0022 0.0022
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1467 0.3483 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0019 0.0012 0.0182
Leishmania major mitochondrial malate dehydrogenase 0.008 0.0159 0.2359
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0488
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.019 0.0423 0.0423
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0013 0.019
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0019 0.0019
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0094 0.0192 0.0192
Schistosoma mansoni phosphoglucomutase 0.0023 0.0022 0.0022
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0013 0.019
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.0674 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0012 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0004 0.0004
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0012 0.0035
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0008 0.0008
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0019 0.0187
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.008 0.0159 0.2359
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0063 0.0934
Brugia malayi jmjC domain containing protein 0.019 0.0423 0.4092
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0019 0.0187
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0027 0.0078
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0063 0.0119
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.019 0.0423 0.5205
Echinococcus granulosus lactate dehydrogenase protein 0.008 0.0159 0.0159
Echinococcus multilocularis geminin 0.0335 0.0771 0.0771
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0019 0.0187
Trypanosoma cruzi malate dehydrogenase, putative 0.008 0.0159 0.2359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.008 0.008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0012 0.0035
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Schistosoma mansoni L-lactate dehydrogenase 0.008 0.0159 0.0159
Echinococcus granulosus mitogen activated protein kinase 0.0101 0.0209 0.0209
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0079 0.0225
Schistosoma mansoni malate dehydrogenase 0.008 0.0159 0.0159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0063 0.0934
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0021 0.0021
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0019 0.0019
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.019 0.0423 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0106 0.0306
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0079 0.1855
Brugia malayi Bromodomain containing protein 0.0038 0.0059 0.0566
Leishmania major malate dehydrogenase, putative 0.008 0.0159 0.2359
Echinococcus granulosus muscleblind protein 0.0445 0.1033 0.1033
Toxoplasma gondii hypothetical protein 0.0048 0.0081 0.0234
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0063 0.1182
Schistosoma mansoni jumonji domain containing protein 0.0151 0.0329 0.0329
Entamoeba histolytica malate dehydrogenase, putative 0.008 0.0159 0.3758
Echinococcus multilocularis L lactate dehydrogenase B chain 0.008 0.0159 0.0159
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0019 0.0019
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0012 0.0012
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.019 0.0423 0.7946
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0012 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0046 0.0564
Echinococcus granulosus dnaJ subfamily B 0.0408 0.0945 0.0945
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0046 0.0564
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0353 0.0813 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0067 0.099
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0053 0.0053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.004 0.004
Mycobacterium ulcerans hypothetical protein 0.0046 0.0079 0.0225
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0079 0.0225
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0021 0.0021
Trypanosoma brucei glycosomal malate dehydrogenase 0.008 0.0159 0.2359
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0136 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0074 0.0144 0.1395
Brugia malayi CXXC zinc finger family protein 0.0029 0.0036 0.0348
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0302 0.4478
Trypanosoma brucei mitochondrial malate dehydrogenase 0.008 0.0159 0.2359
Echinococcus multilocularis ribonuclease H1 0.0023 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.004 0.0064 0.0622
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0004 0.0038
Entamoeba histolytica hypothetical protein 0.0022 0.0019 0.0456
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0063 0.0119
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0119
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.008 0.0159 0.2359
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0067 0.099
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0021 0.0208
Onchocerca volvulus Alhambra homolog 0.0058 0.0106 0.1998
Echinococcus granulosus mitogen activated protein kinase 3 0.0101 0.0209 0.0209
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0004 0.0059
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0113 0.0113
Loa Loa (eye worm) apoptosis regulator protein 0.0094 0.0192 0.1855
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0063 0.0181
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0078
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0026 0.039
Echinococcus granulosus phd:f box containing protein 0.0019 0.0012 0.0012
Trypanosoma brucei RNA helicase, putative 0.0085 0.0171 0.2536
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0101 0.0209 0.3107
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Onchocerca volvulus 0.0236 0.0533 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0079 0.0225
Schistosoma mansoni hypothetical protein 0.0094 0.0192 0.0192
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0032 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0182 0.0182
Echinococcus multilocularis expressed protein 0.0422 0.0978 0.0978
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0302 0.4478
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0056
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.005 0.0145
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0053 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0182 0.0182
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0022 0.0407
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.0674 1
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.1068 0.1068
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Mycobacterium ulcerans hypothetical protein 0.0155 0.034 0.0975
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0019
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.019 0.0423 0.6276
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0063 0.0934
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0025 0.0025
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0004 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0182 0.0182
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Schistosoma mansoni cpg binding protein 0.0029 0.0036 0.0036
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0101 0.0209 0.2028
Echinococcus granulosus malate dehydrogenase 0.008 0.0159 0.0159
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0063 0.0774
Plasmodium falciparum malate dehydrogenase 0.008 0.0159 0.0457
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0013 0.0037
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0302 0.4478
Schistosoma mansoni malate dehydrogenase 0.019 0.0423 0.0423
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0254 0.2463
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0036 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.004 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0079 0.0225
Plasmodium vivax SET domain protein, putative 0.003 0.004 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0182 0.0182
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0025 0.0025
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0019 0.0362
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0187
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0019 0.0187
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0106 0.0303
Trypanosoma brucei protein kinase, putative 0.0101 0.0209 0.3107
Entamoeba histolytica malate dehydrogenase, putative 0.019 0.0423 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0159 0.1539
Chlamydia trachomatis malate dehydrogenase 0.019 0.0423 0.1086
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0362
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0187
Brugia malayi PXA domain containing protein 0.0022 0.0019 0.0187
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.008 0.0159 0.0397
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0013 0.0037
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0019 0.0019
Brugia malayi hypothetical protein 0.0022 0.0019 0.0187
Echinococcus granulosus geminin 0.0335 0.0771 0.0771
Schistosoma mansoni zinc finger protein 0.0021 0.0018 0.0018
Trypanosoma cruzi malate dehydrogenase, putative 0.008 0.0159 0.2359
Brugia malayi lactate dehydrogenase. 0.008 0.0159 0.1539
Leishmania major glycosomal malate dehydrogenase 0.008 0.0159 0.2359
Schistosoma mansoni cpg binding protein 0.0032 0.0044 0.0044
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0362
Echinococcus multilocularis zinc finger protein 0.0021 0.0018 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0182 0.0182
Brugia malayi AF-10 protein 0.0019 0.0013 0.0124
Trypanosoma brucei malate dehydrogenase-related 0.008 0.0159 0.2359
Brugia malayi RNase H family protein 0.0023 0.0022 0.021
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0209 0.3933
Schistosoma mansoni hypothetical protein 0.0058 0.0106 0.0106
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0027 0.0078
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1467 0.3483 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0119
Trichomonas vaginalis malate dehydrogenase, putative 0.0149 0.0325 0.61
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0022 0.0321
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0021 0.0021
Plasmodium falciparum lactate dehydrogenase, putative 0.008 0.0159 0.0457
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0019 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0063 0.0063
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0094 0.0192 0.0192
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0063 0.0063
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.006 0.0112 0.1085
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0056
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0046 0.0079 0.076
Echinococcus multilocularis lactate dehydrogenase a 0.008 0.0159 0.0159
Echinococcus multilocularis lactate dehydrogenase a 0.008 0.0159 0.0159
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0019 0.0019
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0012 0.0182
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0012 0.0035
Schistosoma mansoni hypothetical protein 0.0335 0.0771 0.0771
Loa Loa (eye worm) malate dehydrogenase 0.008 0.0159 0.1539
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.1068 0.1068
Trypanosoma brucei ingi protein (ORF1) 0.0025 0.0026 0.039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0067 0.099
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0021 0.0021
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0012 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0089 0.1313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0046 0.0564
Loa Loa (eye worm) hypothetical protein 0.0099 0.0206 0.1991
Giardia lamblia PHD finger protein 15 0.0058 0.0106 0.2111
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0488
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0027 0.0403
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0079 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0106 0.103
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0004 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0079 0.1855
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0019
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0008 0.0008
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0161 0.0161
Echinococcus granulosus lactate dehydrogenase a 0.008 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0335 0.0771 0.0771
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0036 0.0348
Trypanosoma brucei unspecified product 0.0025 0.0026 0.039
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0063 0.1487
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0012 0.0119
Trichomonas vaginalis malate dehydrogenase, putative 0.0039 0.0061 0.1141
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1467 0.3483 1
Trypanosoma brucei cytosolic malate dehydrogenase 0.019 0.0423 0.6276
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0101 0.0209 0.0601
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0079 0.1164
Leishmania major ribonuclease H1, putative 0.0023 0.0022 0.0321
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.008 0.008
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0019 0.0019
Brugia malayi Malate dehydrogenase, cytoplasmic 0.019 0.0423 0.4096
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0019 0.0187
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0004 0.0004
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Echinococcus granulosus zinc finger protein 0.0021 0.0018 0.0018
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0161 0.0161
Echinococcus granulosus peregrin 0.006 0.0112 0.0112
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0182 0.176
Entamoeba histolytica hypothetical protein 0.0022 0.0019 0.0456
Loa Loa (eye worm) hypothetical protein 0.007 0.0136 0.1313
Schistosoma mansoni malate dehydrogenase 0.019 0.0423 0.0423
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0019 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.4185 1 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.008 0.0159 0.1539
Onchocerca volvulus 0.0046 0.0079 0.1474
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0026 0.039
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0106 0.0106
Echinococcus multilocularis lactate dehydrogenase protein 0.008 0.0159 0.0159
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0019 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0079 0.076
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0079 0.0225
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0063 0.1028
Plasmodium vivax lactate dehydrogenase 0.008 0.0159 0.0457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0187
Brugia malayi MAP kinase sur-1 0.0101 0.0209 0.2028
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0063 0.1182
Schistosoma mansoni hypothetical protein 0.0408 0.0945 0.0945
Plasmodium vivax lactate/malate dehydrogenase, putative 0.008 0.0159 0.0457
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0063 0.0609
Schistosoma mansoni apoptosis regulator bax 0.0094 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0488
Entamoeba histolytica hypothetical protein 0.0022 0.0019 0.0456
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.008 0.0159 0.2359
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.034 0.4179
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0101 0.0209 0.3107
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0209 0.3933
Brugia malayi Muscleblind-like protein 0.0445 0.1033 1
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.1467 0.3483 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0008 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0209 0.3933
Toxoplasma gondii lactate dehydrogenase LDH2 0.008 0.0159 0.0457
Plasmodium falciparum phd finger protein, putative 0.0058 0.0106 0.0306
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0012 0.0012
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0017 0.0049
Toxoplasma gondii ribonuclease HI protein 0.0023 0.0022 0.0062
Brugia malayi Pre-SET motif family protein 0.0207 0.0464 0.4492
Brugia malayi hypothetical protein 0.0016 0.0006 0.0058
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0094 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0445 0.1033 1
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0019 0.0019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0019 0.0019
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0021 0.0021
Trichomonas vaginalis malate dehydrogenase, putative 0.008 0.0159 0.2986
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0079 0.076
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.004 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0021 0.0021
Echinococcus granulosus lysine specific demethylase 5A 0.0074 0.0144 0.0144
Echinococcus granulosus cpg binding protein 0.0032 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0182 0.0182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0074 0.0144 0.0144
Schistosoma mansoni bromodomain containing protein 0.0064 0.0122 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0017 0.0049
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0004 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0079 0.076
Schistosoma mansoni hypothetical protein 0.0094 0.0192 0.0192
Brugia malayi Bromodomain containing protein 0.0076 0.015 0.145
Brugia malayi PHD-finger family protein 0.0022 0.0021 0.0206
Trypanosoma brucei ISWI complex protein 0.0015 0.0004 0.0056
Plasmodium falciparum L-lactate dehydrogenase 0.008 0.0159 0.0457
Echinococcus multilocularis lactate dehydrogenase a 0.008 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0704
Toxoplasma gondii lactate dehydrogenase LDH1 0.008 0.0159 0.0457
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0445 0.1033 1
Echinococcus multilocularis cytosolic malate dehydrogenase 0.019 0.0423 0.0423
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0004 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.008 0.008
Toxoplasma gondii exonuclease III APE 0.004 0.0063 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0116 0.0116
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0119
Schistosoma mansoni ap endonuclease 0.004 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0079 0.076
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.0779
Brugia malayi RNase H family protein 0.0023 0.0022 0.021
Leishmania major malate dehydrogenase 0.008 0.0159 0.2359
Brugia malayi hypothetical protein 0.0025 0.0027 0.0263
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0209 0.3107
Leishmania major cytosolic malate dehydrogenase 0.019 0.0423 0.6276
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0067 0.099
Echinococcus granulosus lactate dehydrogenase a 0.008 0.0159 0.0159
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0004 0.0004
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.019 0.0423 0.7946
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0027 0.0403
Echinococcus granulosus neuropeptide s receptor 0.0459 0.1068 0.1068
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0009 0.0091
Echinococcus granulosus L lactate dehydrogenase B chain 0.008 0.0159 0.0159
Schistosoma mansoni ap endonuclease 0.004 0.0063 0.0063
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Echinococcus multilocularis mitogen activated protein kinase 0.0101 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0094 0.0192 0.1855
Echinococcus multilocularis muscleblind protein 0.0445 0.1033 0.1033
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0094 0.0192 0.1855
Brugia malayi PXA domain containing protein 0.0022 0.0019 0.0187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0063 0.0181
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0004 0.0011
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.019 0.0423 0.6276
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Echinococcus multilocularis peregrin 0.006 0.0112 0.0112
Brugia malayi Pre-SET motif family protein 0.003 0.004 0.0386
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0025 0.0025
Echinococcus multilocularis malate dehydrogenase 0.008 0.0159 0.0159
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.019 0.0423 0.1215
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0022 0.0321
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0019 0.0019
Echinococcus granulosus malate dehydrogenase 0.008 0.0159 0.0159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0182 0.176
Brugia malayi jmjC domain containing protein 0.0019 0.0012 0.0119
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0101 0.0209 0.3107
Loa Loa (eye worm) malate dehydrogenase 0.019 0.0423 0.4096
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0113 0.0113
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0004 0.0059
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0012 0.0012
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0106 0.0306
Brugia malayi hypothetical protein 0.0022 0.0019 0.0187
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.019 0.0423 0.7946
Schistosoma mansoni microtubule-associated protein tau 0.4185 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0041 0.0396
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0063 0.0609
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0488
Echinococcus granulosus cytosolic malate dehydrogenase 0.019 0.0423 0.0423
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0012 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0206
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0079 0.1164
Brugia malayi jmjC domain containing protein 0.0074 0.0144 0.1395
Toxoplasma gondii malate dehydrogenase MDH 0.008 0.0159 0.0457
Schistosoma mansoni cpg binding protein 0.0032 0.0044 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0079 0.076
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.1068 0.1068
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1467 0.3483 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0019 0.0187
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0021 0.0208
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0101 0.0209 0.3107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0079 0.0225
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0016 0.0159
Schistosoma mansoni hypothetical protein 0.002 0.0016 0.0016
Mycobacterium ulcerans malate dehydrogenase 0.019 0.0423 0.1215
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0079 0.0966
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.1845 0.1845
Plasmodium vivax JmjC domain containing protein 0.0019 0.0012 0.0035
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.0674 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.019 0.0423 0.0423
Schistosoma mansoni phosphoglucomutase 0.0023 0.0022 0.0022
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0012 0.0012
Schistosoma mansoni phosphoglucomutase 0.0023 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0209 0.0209
Schistosoma mansoni L-lactate dehydrogenase 0.008 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0094 0.0192 0.0192
Giardia lamblia Kinase, CMGC MAPK 0.0101 0.0209 0.4678
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0182 0.0182
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.019 0.0423 0.7946
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0004 0.0049
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0004 0.0059
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0019 0.0019
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0004 0.0011
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0021 0.0208
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0362
Leishmania major hypothetical protein, conserved 0.0015 0.0004 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0362
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0019 0.0187
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0209 0.3107
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0106 0.0306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0079 0.1855
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0187
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0027 0.0078
Brugia malayi PHD-finger family protein 0.0058 0.0106 0.103
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0079 0.1164
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0019 0.0019
Echinococcus multilocularis cpg binding protein 0.0032 0.0044 0.0044
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0101 0.0209 0.3107
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0012 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0209 0.3933
Brugia malayi isocitrate dehydrogenase 0.0015 0.0004 0.0038
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0004 0.0004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.005 0.0145
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0187
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0106 0.0106
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.1467 0.3483 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.0674 1
Trypanosoma brucei ribonuclease H1 0.0023 0.0022 0.0321
Echinococcus granulosus cytosolic malate dehydrogenase 0.019 0.0423 0.0423
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.005 0.0145
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.005 0.062
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0568
Loa Loa (eye worm) hypothetical protein 0.0035 0.005 0.0488
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0533 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0019 0.0362
Trichomonas vaginalis malate dehydrogenase, putative 0.019 0.0423 0.7946
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0079 0.0225
Brugia malayi PHD-finger family protein 0.0026 0.0031 0.0296
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0019 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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