Detailed information for compound 809830

Basic information

Technical information
  • TDR Targets ID: 809830
  • Name: phenylmethyl 2-[(4-bromophenyl)carbamoyl]pyrr olidine-1-carboxylate
  • MW: 403.27 | Formula: C19H19BrN2O3
  • H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)NC(=O)C1CCCN1C(=O)OCc1ccccc1
  • InChi: 1S/C19H19BrN2O3/c20-15-8-10-16(11-9-15)21-18(23)17-7-4-12-22(17)19(24)25-13-14-5-2-1-3-6-14/h1-3,5-6,8-11,17H,4,7,12-13H2,(H,21,23)
  • InChiKey: MLJARNVBZVRIRB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(4-bromophenyl)amino]-oxomethyl]-1-pyrrolidinecarboxylic acid phenylmethyl ester
  • 2-[(4-bromophenyl)carbamoyl]pyrrolidine-1-carboxylic acid benzyl ester
  • BAS 00602659
  • CBMicro_009784
  • BIM-0009868.P001
  • 2-(4-Bromo-phenylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0117 0.1686 0.1686
Echinococcus granulosus cpg binding protein 0.0029 0.0373 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0078 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0078 0.0235
Schistosoma mansoni hypothetical protein 0.0397 0.5899 0.5899
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0054 0.0054
Schistosoma mansoni lipoxygenase 0.0638 0.9515 0.9515
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Onchocerca volvulus 0.0026 0.0314 0.1382
Loa Loa (eye worm) hypothetical protein 0.0005 0.0008 0.0019
Brugia malayi Ceramide kinase 0.0012 0.0104 0.0315
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.2272 0.5174
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0054 0.0239
Onchocerca volvulus 0.0026 0.0314 0.1382
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0078 0.0078
Brugia malayi Blistered cuticle protein 3 0.0026 0.0314 0.0949
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Schistosoma mansoni loxhd1 0.0117 0.1686 0.1686
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0054 0.0054
Brugia malayi nuclear hormone receptor 0.001 0.0078 0.0235
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0104 0.0104
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0079 0.1115 0.639
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0314 0.0949
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0314 0.1382
Schistosoma mansoni cpg binding protein 0.0028 0.035 0.035
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0638 0.9515 0.9515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Schistosoma mansoni rab6-interacting 0.0117 0.1686 0.1686
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0078 0.0235
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.006 0.006
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0104 0.0443
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.005 0.0685 0.0685
Schistosoma mansoni peroxidasin 0.0026 0.0314 0.0314
Plasmodium vivax multidomain scavenger receptor, putative 0.0117 0.1686 1
Schistosoma mansoni slit 0.0008 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0078 0.0078
Brugia malayi hypothetical protein 0.0117 0.1686 0.5093
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0314 0.1382
Brugia malayi map kinase activated protein kinase protein 2 0.0176 0.2574 0.7776
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0078 0.0235
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0034 0.0447 0.135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0078 0.0078
Brugia malayi ecdysteroid receptor 0.001 0.0078 0.0235
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0104 0.0683
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Echinococcus multilocularis protein jagged 1 0.0008 0.0054 0.0054
Onchocerca volvulus Peroxidase homolog 0.0026 0.0314 0.1382
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus granulosus protein jagged 1 0.0008 0.0054 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.2574 0.2574
Mycobacterium ulcerans ATPase 0.005 0.0678 0.1338
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0104 0.0104
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.005 0.0685 0.0685
Brugia malayi diacylglycerol kinase 0.0012 0.0104 0.0315
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0176 0.2574 0.5862
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0078 0.0235
Brugia malayi diacylglycerol kinase 0.0012 0.0104 0.0315
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0078 0.0078
Schistosoma mansoni vam6/vps39 related 0.0049 0.0663 0.0663
Toxoplasma gondii cell division protein CDC48CY 0.0083 0.1179 1
Brugia malayi probable protein kinase 0.0166 0.2429 0.7339
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0314 0.0949
Loa Loa (eye worm) hypothetical protein 0.0117 0.1686 0.3839
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0078 0.0078
Plasmodium vivax cell division cycle ATPase, putative 0.003 0.0383 0.176
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0078 0.0235
Echinococcus granulosus lipoxygenase domain containing protein 0.0117 0.1686 0.1686
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0078 0.0078
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0034 0.0447 0.0447
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0054 0.0054
Echinococcus multilocularis protein jagged 2 0.0008 0.0054 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0078 0.0235
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0054 0.0054
Schistosoma mansoni microtubule-associated protein tau 0.067 1 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0104 0.0458
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0078 0.0235
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0078 0.0343
Echinococcus granulosus fibropellin Ia 0.0008 0.0054 0.0054
Onchocerca volvulus 0.0117 0.1686 0.742
Echinococcus granulosus protein kinase 0.0118 0.1697 0.1697
Brugia malayi CXXC zinc finger family protein 0.0028 0.035 0.1056
Echinococcus multilocularis sphingosine kinase 1 0.0297 0.4391 0.4391
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.035 0.0796
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Brugia malayi hypothetical protein 0.0005 0.0008 0.0025
Brugia malayi hypothetical protein 0.0049 0.0663 0.2002
Brugia malayi hypothetical protein 0.0012 0.0104 0.0315
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0078 0.0078
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0054 0.0164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0078 0.0078
Schistosoma mansoni rap gtpase-activating protein 0.0049 0.0663 0.0663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0078 0.0177
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0104 0.0104
Brugia malayi hypothetical protein 0.0005 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Loa Loa (eye worm) hypothetical protein 0.0005 0.0008 0.0019
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0297 0.4391 1
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0083 0.1179 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0156 0.2272 0.2272
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0104 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0078 0.0235
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0104 0.0315
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0156 0.2272 0.6863
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0054 0.0164
Trichomonas vaginalis bmru protein, putative 0.0012 0.0104 0.0683
Onchocerca volvulus 0.0026 0.0314 0.1382
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Schistosoma mansoni protein kinase 0.0166 0.2429 0.2429
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Echinococcus multilocularis ceramide kinase 0.0012 0.0104 0.0104
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.005 0.0685 0.0685
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.2272 0.2272
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0156 0.2272 0.2272
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0104 0.0237
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0078 0.0177
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0054 0.0054
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0083 0.1179 0.1179
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.005 0.0685 0.0685
Schistosoma mansoni hypothetical protein 0.0012 0.0104 0.0104
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0104 0.0683
Brugia malayi Temporarily assigned gene name protein 59 0.0049 0.0663 0.2002
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.002 0.0226 0.1736
Entamoeba histolytica cdc48-like protein, putative 0.0079 0.1115 0.2358
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Schistosoma mansoni sphingosine kinase A B 0.0297 0.4391 0.4391
Schistosoma mansoni notch 0.0008 0.0054 0.0054
Onchocerca volvulus Putative cubilin 0.0008 0.0054 0.0239
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Loa Loa (eye worm) doublecortin family protein 0.0117 0.1686 0.3839
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0685 0.0685
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0054 0.0054
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0104 0.0104
Brugia malayi hypothetical protein 0.0117 0.1686 0.5093
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0104 0.0683
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0104 0.0683
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0176 0.2574 0.2574
Echinococcus multilocularis lipoxygenase domain containing protein 0.0117 0.1686 0.1686
Onchocerca volvulus 0.0008 0.0054 0.0239
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0078 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0819 0.0819
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0078 0.0177
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0034 0.0447 0.0447
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0078 0.0078
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0035 0.0035
Schistosoma mansoni cpg binding protein 0.0029 0.0373 0.0373
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.005 0.0685 0.0685
Brugia malayi Protein kinase domain containing protein 0.0156 0.2272 0.6863
Loa Loa (eye worm) hypothetical protein 0.0049 0.0663 0.1509
Onchocerca volvulus 0.0008 0.0054 0.0239
Loa Loa (eye worm) notch protein 0.0008 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Echinococcus granulosus FTZ F1 alpha 0.001 0.0078 0.0078
Schistosoma mansoni peroxidasin 0.0026 0.0314 0.0314
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0078 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0078 0.0078
Echinococcus multilocularis protein jagged 1 0.0008 0.0054 0.0054
Loa Loa (eye worm) Notch2 0.0008 0.0054 0.0124
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0005 0.0008 0.0019
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0049 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.005 0.0678 0.5542
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0079 0.1115 0.2358
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0054 0.0164
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0078 0.0078
Brugia malayi notch-like transmembrane receptor 0.0008 0.0054 0.0164
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0035 0.0035
Trypanosoma cruzi Valosin-containing protein, putative 0.0079 0.1115 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.006 0.006
Echinococcus multilocularis fibropellin Ia 0.0008 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Schistosoma mansoni notch 0.0008 0.0054 0.0054
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0314 0.0715
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0008 0.0008
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0083 0.1179 0.519
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Echinococcus multilocularis 0.0118 0.1697 0.1697
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0078 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0078 0.0177
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0079 0.1115 0.1115
Loa Loa (eye worm) hypothetical protein 0.0049 0.0663 0.1509
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0078 0.0235
Loa Loa (eye worm) vesicle-fusing ATPase 0.0049 0.0663 0.1509
Onchocerca volvulus 0.0008 0.0054 0.0239
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0049 0.0663 0.1509
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0054 0.0054
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0079 0.1115 0.639
Echinococcus multilocularis lipoxygenase domain containing protein 0.0117 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.0049 0.0663 0.1509
Loa Loa (eye worm) hypothetical protein 0.0165 0.2407 0.5482
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus granulosus protein jagged 2 0.0008 0.0054 0.0054
Onchocerca volvulus 0.0012 0.0104 0.0458
Echinococcus granulosus peroxidasin 0.0026 0.0314 0.0314
Schistosoma mansoni protein kinase 0.005 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0176 0.2574 0.2574
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0314 0.0715
Schistosoma mansoni lipoxygenase 0.0428 0.6356 0.6356
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Plasmodium falciparum LCCL domain-containing protein 0.0117 0.1686 1
Entamoeba histolytica hypothetical protein, conserved 0.0297 0.4391 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0104 0.0443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0078 0.0177
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0054 0.0054
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0314 0.1382
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0049 0.0663 0.0663
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0054 0.0054
Brugia malayi Peroxidasin 0.0026 0.0314 0.0949
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0078 0.0177
Schistosoma mansoni protein kinase 0.0118 0.1697 0.1697
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0237
Echinococcus multilocularis Polycystic kidney disease protein 0.0117 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Schistosoma mansoni hypothetical protein 0.0049 0.0663 0.0663
Onchocerca volvulus 0.0049 0.0663 0.2917
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Toxoplasma gondii cell division protein CDC48AP 0.005 0.0678 0.5542
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0118 0.1697 0.3865
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0035 0.0035
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0314 0.0949
Brugia malayi vesicle-fusing ATPase 0.0049 0.0663 0.2002
Brugia malayi Delta serrate ligand family protein 0.0008 0.0054 0.0164
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Schistosoma mansoni septate junction protein 0.0008 0.0054 0.0054
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0663 0.5527
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0104 0.0443
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0078 0.0078
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0049 0.0663 0.0663
Onchocerca volvulus 0.0028 0.035 0.1538
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0237
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0078 0.0078
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.005 0.0685 0.1561
Schistosoma mansoni rab6-interacting 0.0117 0.1686 0.1686
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0663 0.5527
Echinococcus granulosus protein jagged 2 0.0008 0.0054 0.0054
Mycobacterium ulcerans hypothetical protein 0.0297 0.4391 1
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.2272 0.5174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0237
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0078 0.0078
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0638 0.9515 0.9515
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Trypanosoma brucei Valosin-containing protein 0.0079 0.1115 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0078 0.0177
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0104 0.0683
Loa Loa (eye worm) hypothetical protein 0.0117 0.1686 0.3839
Mycobacterium tuberculosis Putative conserved ATPase 0.005 0.0678 0.1338
Brugia malayi Muscle positioning protein 4 0.0008 0.0054 0.0164
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0104 0.0104
Loa Loa (eye worm) histone methyltransferase 0.0009 0.006 0.0137
Giardia lamblia AAA family ATPase 0.005 0.0678 1
Echinococcus multilocularis slit 2 protein 0.0008 0.0054 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0008 0.0025
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0054 0.0164
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0078 0.0078
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0078 0.0078
Schistosoma mansoni coup transcription factor 0.001 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0078 0.0078
Schistosoma mansoni cpg binding protein 0.0029 0.0373 0.0373
Brugia malayi Cadherin domain containing protein 0.0008 0.0054 0.0164
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0078 0.0235
Schistosoma mansoni notch 0.0008 0.0054 0.0054
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0083 0.1179 0.1179
Echinococcus granulosus RUN 0.0117 0.1686 0.1686
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0078 0.0343
Schistosoma mansoni polycystin 1-related 0.0117 0.1686 0.1686
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0724 0.5957
Schistosoma mansoni thyroid hormone receptor 0.001 0.0078 0.0078
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0079 0.1115 1
Brugia malayi valosin containing protein 0.0049 0.0663 0.2002
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0104 0.0104
Echinococcus granulosus notch 0.0008 0.0054 0.0054
Echinococcus granulosus protein jagged 1 0.0008 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0078 0.0235
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0078 0.0078
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Brugia malayi follicle stimulating hormone receptor 0.0225 0.331 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0008 0.0019
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0314 0.1382
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0156 0.2272 1
Echinococcus multilocularis RUN 0.0117 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Onchocerca volvulus 0.0008 0.0054 0.0239
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Mycobacterium tuberculosis Conserved protein 0.0297 0.4391 1
Brugia malayi hypothetical protein 0.0026 0.0314 0.0949
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.002 0.0226 0.1736
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Echinococcus granulosus Polycystic kidney disease protein 0.0117 0.1686 0.1686
Brugia malayi Protein kinase domain containing protein 0.005 0.0685 0.207
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0008 0.0025
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0165 0.2407 0.2407
Echinococcus granulosus delta-like protein 1 0.0008 0.0054 0.0054
Loa Loa (eye worm) ceramide kinase 0.0012 0.0104 0.0237
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.331 0.7539
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0078 0.0078
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0104 0.0683
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.005 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0078 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0078 0.0235
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.5899 0.5899
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0078 0.0343
Echinococcus granulosus neural cadherin 0.0008 0.0054 0.0054
Schistosoma mansoni notch 0.0008 0.0054 0.0054
Brugia malayi EGF-like domain containing protein 0.0008 0.0054 0.0164
Onchocerca volvulus Slit protein homolog 0.0008 0.0054 0.0239
Schistosoma mansoni cell polarity protein 0.0008 0.0054 0.0054
Schistosoma mansoni thyroid hormone receptor 0.001 0.0078 0.0078
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0104 0.0104
Loa Loa (eye worm) VCP protein 0.0034 0.0447 0.1018
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus multilocularis peroxidasin 0.0026 0.0314 0.0314
Echinococcus multilocularis cpg binding protein 0.0029 0.0373 0.0373
Echinococcus multilocularis neural cadherin 0.0008 0.0054 0.0054
Schistosoma mansoni sphingoid long chain base kinase 0.0297 0.4391 0.4391
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0054 0.0054
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0083 0.1179 0.1179
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0104 0.0683
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0104 0.0683
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0685 0.0685
Trichomonas vaginalis bmru protein, putative 0.0012 0.0104 0.0683
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0008 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0397 0.5899 0.5899
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0314 0.0949
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0058 0.0177
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0049 0.0663 0.5527
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0008 0.0008
Schistosoma mansoni notch 0.0008 0.0054 0.0054
Echinococcus granulosus slit 2 protein 0.0008 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0005 0.0008 0.0019
Brugia malayi nuclear receptor RXR 0.0005 0.0008 0.0025
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0104 0.0104
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0049 0.0663 0.0663
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0054 0.0054
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0104 0.0237
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0177
Onchocerca volvulus 0.0008 0.0054 0.0239
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0314 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0078 0.0235
Schistosoma mansoni notch 0.0008 0.0054 0.0054
Echinococcus granulosus Vam6:Vps39 protein 0.0049 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus granulosus sphingosine kinase 1 0.0297 0.4391 0.4391
Brugia malayi Doublecortin family protein 0.0117 0.1686 0.5093
Brugia malayi steroid hormone receptor 0.001 0.0078 0.0235
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0054 0.0239
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0314 0.0949
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0124
Echinococcus multilocularis notch 0.0008 0.0054 0.0054
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0054 0.0164
Onchocerca volvulus 0.001 0.0078 0.0343
Brugia malayi Cadherin domain containing protein 0.0008 0.0054 0.0164
Onchocerca volvulus Peroxidase homolog 0.0026 0.0314 0.1382
Echinococcus granulosus ceramide kinase 0.0012 0.0104 0.0104
Echinococcus granulosus lipoxygenase domain containing protein 0.0117 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0715
Onchocerca volvulus 0.0117 0.1686 0.742
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0078 0.0078
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0008 0.0008
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0314 0.0715
Echinococcus multilocularis microtubule associated protein 2 0.067 1 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0078 0.0235
Schistosoma mansoni nuclear hormone receptor 0.001 0.0078 0.0078
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0314 0.0715

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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