Detailed information for compound 810077

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.531 | Formula: C25H30N4O3
  • H donors: 1 H acceptors: 2 LogP: 2.68 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)CNCCC1CCC(=O)N1Cc1cnn(c1)c1cccc(c1)OC
  • InChi: 1S/C25H30N4O3/c1-31-23-7-3-5-19(13-23)15-26-12-11-21-9-10-25(30)28(21)17-20-16-27-29(18-20)22-6-4-8-24(14-22)32-2/h3-8,13-14,16,18,21,26H,9-12,15,17H2,1-2H3
  • InChiKey: ONNGJNQRDUEBTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0293 0.1266 0.1266
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0329 0.0329
Brugia malayi Bromodomain containing protein 0.0032 0.0052 0.0196
Brugia malayi jmjC domain containing protein 0.0096 0.035 0.1313
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0124 0.0124
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 0.0929
Brugia malayi TAR-binding protein 0.0062 0.0195 0.0733
Brugia malayi Bromodomain containing protein 0.0076 0.0256 0.0962
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0049 0.0135 0.0507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.08 0.307
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0264
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Schistosoma mansoni hypothetical protein 0.0049 0.0135 0.0134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0329 0.1257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0071 0.007
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0042 0.0155
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0095 0.0353
Toxoplasma gondii ABC1 family protein 0.0035 0.0071 0.0153
Schistosoma mansoni zinc finger protein 0.0021 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0243
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.1816 0.6987
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0049 0.0135 0.0507
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0042 0.004
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0144 0.0544
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0144 0.0832
Loa Loa (eye worm) hypothetical protein 0.004 0.0092 0.0345
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0078 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0195
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.027 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0078 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0329 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0195
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.08 0.307
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Brugia malayi RNase H family protein 0.058 0.2598 0.9745
Onchocerca volvulus 0.0049 0.0135 0.037
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0095 0.0353
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0042 0.0041
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0139 0.0419
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0139 0.4515
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0049 0.0135 0.0134
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0071 0.0729
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0154 0.0582
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0071 0.0264
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0086 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0086 0.0321
Schistosoma mansoni bromodomain containing protein 0.0064 0.0203 0.0203
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0139 0.027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0264
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0078 0.029
Brugia malayi hypothetical protein 0.0032 0.0056 0.0211
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0049 0.0135 0.0364
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0049 0.0135 0.0364
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0139 0.4515
Schistosoma mansoni cpg binding protein 0.0032 0.0056 0.0056
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0049 0.0135 0.0364
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0049 0.0135 0.0254
Schistosoma mansoni ap endonuclease 0.0037 0.0078 0.0078
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0042 0.0148
Trypanosoma brucei ingi protein (ORF1) 0.0629 0.2826 0.2775
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0086 0.0086
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.027 0.0929
Trypanosoma brucei RNA helicase, putative 0.2175 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 0.5
Brugia malayi jmjC domain containing protein 0.0039 0.0086 0.0324
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 0.0759
Echinococcus granulosus geminin 0.0164 0.0668 0.2561
Brugia malayi mbt repeat family protein 0.0047 0.0124 0.0465
Brugia malayi RNase H family protein 0.058 0.2598 0.9745
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.0518
Giardia lamblia Ribonuclease H 0.058 0.2598 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Giardia lamblia Reverse transcriptase/endonuclease 0.0049 0.0135 0.0364
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0049 0.0135 0.0065
Brugia malayi PHD-finger family protein 0.0026 0.0027 0.0103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0078 0.0293
Brugia malayi Bromodomain containing protein 0.0038 0.0081 0.0304
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0078 0.1975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0329 0.0329
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0186 0.0696
Onchocerca volvulus 0.0049 0.0135 0.037
Brugia malayi CXXC zinc finger family protein 0.0029 0.004 0.015
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0124 0.0466
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.027 0.0929
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0186 0.0707
Echinococcus multilocularis cpg binding protein 0.0032 0.0056 0.0206
Brugia malayi hypothetical protein 0.005 0.0139 0.0521
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Loa Loa (eye worm) hypothetical protein 0.0253 0.1081 0.4053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0264
Brugia malayi mbt repeat family protein 0.0047 0.0124 0.0465
Brugia malayi Probable ClpP-like protease 0.0078 0.027 0.1011
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.058 0.2598 1
Schistosoma mansoni hypothetical protein 0.0029 0.0042 0.0041
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Schistosoma mansoni phosphoglucomutase 0.058 0.2598 0.2598
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0259 0.0258
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0595 0.2666 0.2666
Loa Loa (eye worm) beta-lactamase 0.0035 0.0071 0.0264
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1265 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.1265 0.4786
Schistosoma mansoni cpg binding protein 0.0029 0.004 0.004
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0124 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0195
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 0.3987
Echinococcus granulosus biogenic amine 5HT receptor 0.0253 0.1081 0.4153
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0264
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0195 0.0733
Brugia malayi Zinc knuckle family protein 0.0049 0.0135 0.0505
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.057 1
Schistosoma mansoni ap endonuclease 0.0037 0.0078 0.0078
Onchocerca volvulus Alhambra homolog 0.0029 0.0042 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0071 0.007
Brugia malayi hypothetical protein 0.0049 0.0135 0.0505
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0154 0.0582
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0124 0.0466
Trichomonas vaginalis reverse transcriptases, putative 0.0049 0.0135 0.0254
Echinococcus multilocularis ribonuclease H1 0.058 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0139 0.052
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.035 0.1337
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Echinococcus granulosus peregrin 0.0032 0.0052 0.019
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.001 0.0028
Echinococcus granulosus tar DNA binding protein 0.0062 0.0195 0.0741
Loa Loa (eye worm) hypothetical protein 0.0595 0.2666 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0139 0.0521
Loa Loa (eye worm) hypothetical protein 0.0038 0.0081 0.0304
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0595 0.2666 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0049 0.0135 0.0507
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0078 0.0294
Schistosoma mansoni protein kinase 0.0049 0.0135 0.0134
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Schistosoma mansoni hypothetical protein 0.0164 0.0668 0.0667
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0078 0.0008
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.035 0.1337
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.007 0.0259
Brugia malayi hypothetical protein 0.0049 0.0135 0.0505
Schistosoma mansoni phosphoglucomutase 0.058 0.2598 0.2598
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0078 0.029
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0154 0.0578
Brugia malayi PHD-finger family protein 0.0029 0.0042 0.0156
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0078 0.0144
Loa Loa (eye worm) hypothetical protein 0.0595 0.2666 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0049 0.0135 0.0507
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0139 0.027
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.057 0.5632
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Onchocerca volvulus 0.0047 0.0124 0.0328
Loa Loa (eye worm) RNA binding protein 0.0062 0.0195 0.0732
Loa Loa (eye worm) hypothetical protein 0.0522 0.2329 0.8736
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0042 0.0431
Trypanosoma brucei ingi protein (ORF1) 0.0629 0.2826 0.2775
Brugia malayi RNA binding protein 0.0062 0.0195 0.0733
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 1
Echinococcus multilocularis geminin 0.0164 0.0668 0.2561
Loa Loa (eye worm) hypothetical protein 0.0047 0.0124 0.0464
Onchocerca volvulus Ribonuclease H1 homolog 0.058 0.2598 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0078 0.0031
Brugia malayi hypothetical protein 0.0049 0.0135 0.0505
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0078 0.0088
Brugia malayi beta-lactamase 0.0035 0.0071 0.0265
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.001 0.0028
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0329 0.1235
Echinococcus multilocularis serotonin receptor 0.0253 0.1081 0.4153
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0049 0.0135 0.0065
Loa Loa (eye worm) hypothetical protein 0.0078 0.027 0.101
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0329 0.1234
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0078 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0135 0.0254
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0195 0.0732
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0124 0.0464
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0139 0.052
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0144 0.2099
Leishmania major ribonuclease H1, putative 0.058 0.2598 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0124 0.0466
Plasmodium falciparum phd finger protein, putative 0.0029 0.0042 0.0431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0078 0.0031
Schistosoma mansoni hypothetical protein 0.0412 0.1816 0.1816
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0078 0.0031
Echinococcus granulosus dnaJ subfamily B 0.0412 0.1816 0.6987
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0329 0.1257
Brugia malayi beta-lactamase family protein 0.0035 0.0071 0.0265
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.027 0.4425
Toxoplasma gondii exonuclease III APE 0.0037 0.0078 0.0183
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0155
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Schistosoma mansoni hypothetical protein 0.0164 0.0668 0.0667
Loa Loa (eye worm) hypothetical protein 0.0053 0.0154 0.0577
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0086 0.0323
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0957 1
Brugia malayi Zinc knuckle family protein 0.0049 0.0135 0.0505
Brugia malayi RNase H family protein 0.058 0.2598 0.9745
Echinococcus granulosus RNA directed DNA polymerase 0.0049 0.0135 0.0507
Brugia malayi reverse transcriptase 0.0049 0.0135 0.0505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0264
Brugia malayi hypothetical protein 0.0049 0.0135 0.0505
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0629 0.2826 0.2775
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0139 0.4515
Onchocerca volvulus 0.0035 0.0071 0.0119
Trypanosoma brucei hypothetical protein, conserved 0.0629 0.2826 0.2775
Schistosoma mansoni phosphoglucomutase 0.058 0.2598 0.2598
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0195 0.0732
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0195 0.0741
Echinococcus granulosus ribonuclease H1 0.058 0.2598 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0065 0.0244
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.1265 0.4807
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0154 0.0582
Schistosoma mansoni hypothetical protein 0.0049 0.0135 0.0134
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0017 0.0052
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0124 0.0124
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0144 0.0832
Trypanosoma cruzi ribonuclease H1, putative 0.058 0.2598 1
Toxoplasma gondii ribonuclease HI protein 0.058 0.2598 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0124 0.0466
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0078 0.1975
Echinococcus multilocularis peregrin 0.0032 0.0052 0.019
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0049 0.0135 0.0254
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.004 0.0149
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.007 0.0258
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.027 0.0269
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0186 0.0707
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0071 0.1647
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.057 1
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0049 0.0135 0.0065
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0049 0.0135 0.0507
Loa Loa (eye worm) hypothetical protein 0.007 0.0229 0.0859
Schistosoma mansoni hypothetical protein 0.0034 0.0065 0.0065
Schistosoma mansoni biogenic amine (5HT) receptor 0.0253 0.1081 0.108
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0144 0.0544
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.027 0.1027
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0049 0.0135 0.037
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0154 0.0582
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.027 0.1027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0078 0.0183
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0139 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0139 0.0521
Trichomonas vaginalis ribonuclease H1, putative 0.058 0.2598 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0154 0.0154
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Trichomonas vaginalis reverse transcriptases, putative 0.0049 0.0135 0.0254
Brugia malayi reverse transcriptase 0.0049 0.0135 0.0505
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0042 0.0148
Mycobacterium leprae Probable lipase LipE 0.0035 0.0071 0.0729
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0135 0.0134
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0049 0.0135 0.0364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0329 0.1257
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0124 0.0124
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Loa Loa (eye worm) hypothetical protein 0.0253 0.1081 0.4053
Loa Loa (eye worm) MBCTL1 0.0053 0.0154 0.0577
Trypanosoma cruzi ribonuclease H1, putative 0.058 0.2598 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.027 0.3987
Loa Loa (eye worm) hypothetical protein 0.005 0.0139 0.052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0071 0.026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.007 0.0259
Trypanosoma brucei ribonuclease H1 0.058 0.2598 0.2545
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0071 0.0265
Brugia malayi Pao retrotransposon peptidase family protein 0.0049 0.0135 0.0505
Loa Loa (eye worm) hypothetical protein 0.0044 0.0109 0.0406
Treponema pallidum ribonuclease H (rnhA) 0.058 0.2598 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0017 0.0016
Trypanosoma brucei unspecified product 0.0629 0.2826 0.2775
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0195 0.0195
Brugia malayi reverse transcriptase 0.0049 0.0135 0.0505
Onchocerca volvulus 0.0035 0.0071 0.0119
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.1265 1
Brugia malayi beta-lactamase family protein 0.0035 0.0071 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0264
Mycobacterium tuberculosis Possible maturase 0.0049 0.0135 0.0723
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0071 0.026
Echinococcus granulosus KRAB A domain containing protein 0.0049 0.0135 0.0507
Leishmania major hypothetical protein, conserved 0.005 0.0139 0.027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.1265 0.4726
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0049 0.0135 0.0507
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0329 0.1257
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0171 0.0544
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.019 0.019
Schistosoma mansoni hypothetical protein 0.0023 0.001 0.001
Echinococcus granulosus cpg binding protein 0.0032 0.0056 0.0206
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0049 0.0135 0.0507
Onchocerca volvulus 0.0035 0.0071 0.0119
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0042 0.004
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0017 0.0052
Echinococcus multilocularis serotonin receptor 0.0253 0.1081 0.4153
Schistosoma mansoni cpg binding protein 0.0032 0.0056 0.0056

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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