Detailed information for compound 81130

Basic information

Technical information
  • TDR Targets ID: 81130
  • Name: 2-(9-oxoxanthen-2-yl)oxyethyl thiocyanate
  • MW: 297.328 | Formula: C16H11NO3S
  • H donors: 0 H acceptors: 2 LogP: 3.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CSCCOc1ccc2c(c1)c(=O)c1c(o2)cccc1
  • InChi: 1S/C16H11NO3S/c17-10-21-8-7-19-11-5-6-15-13(9-11)16(18)12-3-1-2-4-14(12)20-15/h1-6,9H,7-8H2
  • InChiKey: AFXJBYLSXXLRTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • thiocyanic acid 2-[(9-oxo-2-xanthenyl)oxy]ethyl ester
  • thiocyanic acid 2-(9-ketoxanthen-2-yl)oxyethyl ester
  • 2-(2-thiocyanatoethoxy)xanthen-9-one
  • 2-(2-thiocyanatoethoxy)-9-xanthenone
  • 2-(2-thiocyanatoethoxy)xanthone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0079 0.0224
Echinococcus granulosus axis inhibition protein axin 0.0082 0.0906 0.1007
Brugia malayi nuclear hormone receptor 0.0018 0.0116 0.0116
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1264 0.3464
Brugia malayi nuclear hormone receptor 0.0008 0.0001 0.0001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0074 0.0803 0.279
Echinococcus granulosus bloom syndrome protein 0.0022 0.0166 0.0185
Trichomonas vaginalis glutaminase, putative 0.0281 0.3335 0.9327
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0267 0.064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0116 0.0116
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0116 0.013
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0742 0.8992 0.8992
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0001 0.0001
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0267 0.7084
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0742 0.8992 0.8992
Schistosoma mansoni DNA helicase recq5 0.0009 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.0082 0.0906 0.1007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0116 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0116 0.0116
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.5712 0.6352
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0082 0.0906 0.2448
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0116 0.0116
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0116 0.0116
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2514 0.2514
Onchocerca volvulus 0.0018 0.0116 0.0402
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0116 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0116 0.0116
Schistosoma mansoni rab6-interacting 0.0022 0.0163 0.0163
Mycobacterium ulcerans hypothetical protein 0.0074 0.0803 0.2263
Loa Loa (eye worm) beta-lactamase 0.0074 0.0803 0.0803
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0116 0.013
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0063 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0031 0.0273 0.0273
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0133 0.3425
Loa Loa (eye worm) hypothetical protein 0.0082 0.0906 0.0906
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0906 0.2448
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1264 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.0001 0.0001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3572 1
Brugia malayi beta-lactamase 0.0074 0.0803 0.0803
Echinococcus granulosus regulator of G protein signaling 3 0.0082 0.0906 0.1007
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0273 0.0304
Schistosoma mansoni nuclear receptor 0.0008 0.0001 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.011 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1264 0.3464
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0225 0.025
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0063 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0116 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Schistosoma mansoni axis inhibition protein axin 0.0082 0.0906 0.0906
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1264 0.3464
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0906 0.2448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0803 0.0803
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3572 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0163 0.0182
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0225 0.0521
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1104 0.1853
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0163 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Echinococcus granulosus flap endonuclease 1 0.0027 0.0225 0.025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0273 0.0304
Echinococcus granulosus geminin 0.0348 0.4159 0.4625
Loa Loa (eye worm) hypothetical protein 0.0074 0.0803 0.0803
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0983 0.2018
Brugia malayi regulator of G-protein signaling egl-10 0.0082 0.0906 0.0906
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.00000000063475
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0074 0.0803 0.0803
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0803 0.0893
Plasmodium vivax SET domain protein, putative 0.0031 0.0273 0.2843
Onchocerca volvulus 0.0022 0.0163 0.0565
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1264 0.3464
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0063 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0116 0.0116
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0373 0.4197
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0273 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0803 0.2158
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0166 0.0166
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0267 0.064
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.0001 0.0001
Loa Loa (eye worm) glutaminase 2 0.0281 0.3335 0.3335
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0906 0.2448
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.0001 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1399 0.1399
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0116 0.0116
Schistosoma mansoni lipoxygenase 0.0022 0.0163 0.0163
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.1264 0.1406
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0063 0.0176
Brugia malayi 6-phosphofructokinase 0.0112 0.1264 0.1264
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0166 0.0354
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0803 0.2158
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0803 0.0893
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus beta-adrenergic receptor kinase 0.0084 0.093 0.1034
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0803 0.2158
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0225 0.1505
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1264 0.3464
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0116 0.0402
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0163 0.0163
Brugia malayi ecdysteroid receptor 0.0018 0.0116 0.0116
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0082 0.0906 0.2448
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0063 0.0152
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0008 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0116 0.013
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0063 0.0176
Plasmodium vivax glutathione reductase, putative 0.0039 0.0373 0.4197
Entamoeba histolytica hypothetical protein 0.0082 0.0906 0.2448
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0116 0.013
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0267 0.3253
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0116 0.013
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1399 0.1399
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.093 0.093
Echinococcus multilocularis beta adrenergic receptor kinase 0.0084 0.093 0.1034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0116 0.0116
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0082 0.0906 0.0906
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.3572 1
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.093 0.093
Loa Loa (eye worm) hypothetical protein 0.0082 0.0906 0.0906
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0267 0.0582
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0983 0.1637
Schistosoma mansoni z-protein (S1r protein) 0.0082 0.0906 0.0906
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2876 0.8028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0983 0.1637
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0983 0.1637
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0116 0.0116
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0082 0.0906 0.1007
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0166 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1264 0.1264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.5682 1
Mycobacterium ulcerans glutaminase 0.0281 0.3335 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0116 0.0116
Brugia malayi Doublecortin family protein 0.0022 0.0163 0.0163
Brugia malayi conserved hypotetical protein 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0803 0.1318
Brugia malayi beta-lactamase family protein 0.0074 0.0803 0.0803
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0373 0.0553
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0116 0.0116
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0163 0.0182
Brugia malayi Flap endonuclease-1 0.0027 0.0225 0.0225
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.0001 0.0001
Brugia malayi regulator of G-protein signaling rgs-7 0.0082 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0803 0.0803
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0084 0.093 0.093
Loa Loa (eye worm) DR-78 0.0008 0.0001 0.0001
Plasmodium falciparum flap endonuclease 1 0.0027 0.0225 0.5939
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.0001 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0116 0.0116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Brugia malayi hypothetical protein 0.0082 0.0906 0.0906
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0163 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0116 0.0116
Brugia malayi PXA domain containing protein 0.0082 0.0906 0.0906
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0267 0.276
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0259 0.0288
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0063 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0116 0.013
Mycobacterium tuberculosis Conserved protein 0.0074 0.0803 0.1318
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0116 0.013
Trichomonas vaginalis esterase, putative 0.0074 0.0803 0.2158
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0803 0.1318
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0357 0.4268 0.4268
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0116 0.0402
Brugia malayi hypothetical protein 0.0082 0.0906 0.0906
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0008 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0273 0.0304
Brugia malayi nuclear receptor NHR-88 0.0018 0.0116 0.0116
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0225 0.2727
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.038 0.0422
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0803 0.1318
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0116 0.0116
Schistosoma mansoni loxhd1 0.0022 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0906 0.2448
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0166 0.0354
Brugia malayi hypothetical protein 0.0009 0.0013 0.0013
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0742 0.8992 0.8992
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0983 0.1637
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0001 0.0001
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.0001 0.0001
Schistosoma mansoni glutaminase 0.0281 0.3335 0.3335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0803 0.2263
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0803 0.0803
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.0001 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0267 0.064
Brugia malayi nuclear receptor RXR 0.0009 0.0013 0.0013
Mycobacterium tuberculosis Conserved protein 0.0074 0.0803 0.1318
Brugia malayi beta-lactamase family protein 0.0074 0.0803 0.0803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0116 0.0402
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0074 0.0803 0.0803
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0008 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Plasmodium falciparum glutathione reductase 0.0039 0.0373 1
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0906 0.0906
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0116 0.013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0803 0.0803
Brugia malayi nuclear receptor NHR-67 0.0008 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0116 0.013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0013 0.0013
Echinococcus multilocularis regulator of G protein signaling 7 0.0082 0.0906 0.1007
Brugia malayi hypothetical protein 0.0008 0.0001 0.0001
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.1264 0.1406
Loa Loa (eye worm) hypothetical protein 0.0074 0.0803 0.0803
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1264 0.1264
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0082 0.0906 0.0906
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0803 0.6229
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0063 0.0063
Brugia malayi nuclear receptor RXR 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0116 0.013
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0063 0.007
Plasmodium falciparum glutathione reductase 0.0013 0.0063 0.1482
Loa Loa (eye worm) hypothetical protein 0.0022 0.0163 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0267 0.064
Echinococcus multilocularis regulator of G protein signaling 3 0.0082 0.0906 0.1007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0063 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0803 0.2158
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0225 0.0521
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0063 0.1482
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0116 0.0116
Loa Loa (eye worm) glutathione reductase 0.0039 0.0373 0.0373
Schistosoma mansoni flap endonuclease-1 0.0024 0.0194 0.0194
Echinococcus granulosus regulator of G protein signaling 3 0.0082 0.0906 0.1007
Brugia malayi hypothetical protein 0.0022 0.0163 0.0163
Brugia malayi Regulator of G protein signaling domain containing protein 0.0082 0.0906 0.0906
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.3572 1
Schistosoma mansoni rab6-interacting 0.0022 0.0163 0.0163
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0082 0.0906 0.0906
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0013 0.0013
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0063 0.0176
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1264 0.3464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0273 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0825 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0267 0.064
Loa Loa (eye worm) hypothetical protein 0.0074 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.1264 0.5184
Echinococcus multilocularis axis inhibition protein axin 0.0082 0.0906 0.1007
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0008 0.0009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0803 0.2263
Brugia malayi hypothetical protein 0.0009 0.0013 0.0013
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0373 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0906 0.2448
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0983 0.1637
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0116 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0116 0.0116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0082 0.0906 0.1007
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0906 0.0906
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0267 0.7084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0116 0.013
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1693 0.2901
Echinococcus granulosus neuropeptide s receptor 0.0475 0.5712 0.6352
Schistosoma mansoni hypothetical protein 0.0022 0.0163 0.0163
Onchocerca volvulus 0.0022 0.0163 0.0565
Brugia malayi tailless protein 0.0008 0.0001 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0116 0.013
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0225 0.2196
Leishmania major trypanothione reductase 0.0039 0.0373 0.2716
Loa Loa (eye worm) hypothetical protein 0.0022 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0906 0.2448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0116 0.0116
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0373 0.2716
Loa Loa (eye worm) hypothetical protein 0.0082 0.0906 0.0906
Schistosoma mansoni nuclear receptor 0.0008 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.0018 0.0116 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0074 0.0803 0.0803
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0906 0.0906
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0116 0.0116
Onchocerca volvulus 0.0031 0.0273 0.0947
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0267 0.276
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0116 0.0116
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0225 0.1505
Brugia malayi Pre-SET motif family protein 0.0031 0.0273 0.0273
Toxoplasma gondii ABC1 family protein 0.0074 0.0803 1
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0225 0.0608
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0803 0.2263
Loa Loa (eye worm) phosphofructokinase 0.0112 0.1264 0.1264
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0063 0.0176
Brugia malayi ecdysone receptor 0.0008 0.0001 0.0001
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.1264 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1693 0.4982
Echinococcus multilocularis expressed protein 0.0082 0.0906 0.1007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1104 0.3379
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0225 0.1505
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0803 0.6229
Loa Loa (eye worm) hypothetical protein 0.0082 0.0906 0.0906
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.0001 0.0001
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0267 0.3253
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0008 0.0009
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0225 0.0225
Onchocerca volvulus 0.0074 0.0803 0.279
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0803 0.1318
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0077 0.0862
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0063 0.068
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0063 0.1482
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0063 0.0176
Echinococcus multilocularis regulator of G protein signaling 7 0.0082 0.0906 0.1007
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0214 0.2514 0.2514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0082 0.0906 0.1007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0116 0.0116
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0013 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0803 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0906 0.0906
Onchocerca volvulus 0.0074 0.0803 0.279
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0116 0.0116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0803 0.1318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0116 0.0116
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0267 0.3253
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1693 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0273 0.333
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Mycobacterium tuberculosis Probable reductase 0.0089 0.0983 0.1637
Plasmodium falciparum thioredoxin reductase 0.0013 0.0063 0.1482
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0803 0.1318
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0019 0.0019
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0074 0.0803 0.1318
Schistosoma mansoni axis inhibition protein axin 0.0082 0.0906 0.0906
Toxoplasma gondii thioredoxin reductase 0.0039 0.0373 0.4592
Brugia malayi nuclear receptor NHR-88 0.0008 0.0001 0.0001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0082 0.0906 0.0906
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.5712 0.6352
Echinococcus multilocularis geminin 0.0348 0.4159 0.4625
Echinococcus granulosus Regulator of G protein signaling 20 0.0082 0.0906 0.1007
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0267 1
Schistosoma mansoni hypothetical protein 0.0348 0.4159 0.4159
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0803 0.6229
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0267 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0116 0.0116
Mycobacterium ulcerans beta-lactamase 0.0074 0.0803 0.2263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0116 0.013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0013 0.0013
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0267 1
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0906 0.0906
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0116 0.0116
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0742 0.8992 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0116 0.0116
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0825 1 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.1264 0.2139
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0063 0.0176
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0803 0.1318
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Plasmodium falciparum thioredoxin reductase 0.0039 0.0373 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1104 0.1853
Echinococcus granulosus RUN 0.0022 0.0163 0.0182
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1104 0.1853
Schistosoma mansoni polycystin 1-related 0.0022 0.0163 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0116 0.013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0063 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0116 0.0116
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1264 0.3464
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Schistosoma mansoni coup transcription factor 0.0018 0.0116 0.0116
Leishmania major hypothetical protein, conserved 0.0074 0.0803 0.6229
Loa Loa (eye worm) RGS-3 protein 0.0082 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0082 0.0906 0.2448
Loa Loa (eye worm) PXA domain-containing protein 0.0082 0.0906 0.0906
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0163 0.0182
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1264 0.1264
Schistosoma mansoni regulator of G protein signaling 0.0082 0.0906 0.0906
Echinococcus multilocularis regulator of G protein signaling 0.0082 0.0906 0.1007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0348 0.4159 0.4159
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0001 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1264 0.1264
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.1264 0.3673
Brugia malayi Thioredoxin reductase 0.0039 0.0373 0.0373
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0063 0.068
Loa Loa (eye worm) RecQ helicase 0.0022 0.0166 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3572 1
Echinococcus multilocularis axis inhibition protein axin 0.0082 0.0906 0.1007
Brugia malayi A-kinase anchor protein 10, precursor 0.0082 0.0906 0.0906
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0063 0.0176
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1264 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0163 0.0182
Brugia malayi hypothetical protein 0.0022 0.0163 0.0163
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0742 0.8992 1
Trypanosoma brucei trypanothione reductase 0.0039 0.0373 0.2716
Brugia malayi glutaminase DH11.1 0.0281 0.3335 0.3335
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0116 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0116 0.013
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0163 0.1361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0063 0.0061
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0267 0.064
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0163 0.4244
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Onchocerca volvulus 0.0243 0.2876 1
Brugia malayi phosphofructokinase 0.0112 0.1264 0.1264
Echinococcus multilocularis RUN 0.0022 0.0163 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Echinococcus granulosus axis inhibition protein axin 0.0082 0.0906 0.1007
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0267 0.064
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0013 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0116 0.013
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.038 0.0422
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0267 0.064
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0116 0.0116
Schistosoma mansoni zinc finger protein 0.0008 0.0001 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0001 0.0001
Schistosoma mansoni DNA helicase recq1 0.0009 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0116 0.0116
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.1264 0.3424
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0082 0.0906 0.0906
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Brugia malayi glutathione reductase 0.0039 0.0373 0.0373
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0063 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0063 0.0176
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0123 0.1399 0.1399
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0116 0.0116
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.0008
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.5712 0.6352
Loa Loa (eye worm) glutaminase 0.0281 0.3335 0.3335
Brugia malayi 6-phosphofructokinase 0.0112 0.1264 0.1264
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0273 0.0273
Echinococcus granulosus expressed protein 0.0082 0.0906 0.1007
Echinococcus multilocularis regulator of G protein signaling 3 0.0082 0.0906 0.1007
Echinococcus granulosus regulator of G protein signaling 7 0.0082 0.0906 0.1007
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0803 0.2158
Brugia malayi PXA domain containing protein 0.0082 0.0906 0.0906

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 54 uM 50% inhibitory concentration against the growth of Trypanosoma cruzi (Epimastigotes) ChEMBL. 10794699
IC50 (functional) = 54 uM 50% inhibitory concentration against the growth of Trypanosoma cruzi (Epimastigotes) ChEMBL. 10794699

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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