Detailed information for compound 814486

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.609 | Formula: C23H28N2O5S2
  • H donors: 1 H acceptors: 4 LogP: 3.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c2CCN(Cc2sc1S(=O)(=O)NC1CCCCC1)C(=O)c1cccc(c1)C
  • InChi: 1S/C23H28N2O5S2/c1-15-7-6-8-16(13-15)21(26)25-12-11-18-19(14-25)31-23(20(18)22(27)30-2)32(28,29)24-17-9-4-3-5-10-17/h6-8,13,17,24H,3-5,9-12,14H2,1-2H3
  • InChiKey: IPVKAZXRKDNKEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) SRC-1 0.0044 0.0035 0.0272
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0044 0.0035 0.0195
Schistosoma mansoni tyrosine kinase 0.0101 0.0151 0.0134
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0044 0.0035 0.0195
Loa Loa (eye worm) subtilase 0.0119 0.0185 0.1436
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0119 0.0185 0.1644
Echinococcus granulosus aminopeptidase N 0.0119 0.0186 0.1339
Toxoplasma gondii subtilisin SUB9 0.0119 0.0185 0.0413
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0017 0.0026
Brugia malayi Protein kinase domain containing protein 0.0101 0.0151 0.1168
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0038 0.0022 0.0062
Plasmodium vivax aspartyl proteinase, putative 0.0065 0.0077 0.0146
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.2004
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0134 0.0216 0.1575
Toxoplasma gondii subtilisin SUB12 0.0119 0.0185 0.0413
Trypanosoma brucei N-myristoyl transferase, putative 0.0183 0.0315 0.3009
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0183 0.0315 0.2852
Brugia malayi ribonucleotide reductase 2 0.0134 0.0216 0.1669
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0528 0.1007 0.7797
Plasmodium falciparum plasmepsin III 0.0065 0.0077 0.0146
Loa Loa (eye worm) endoprotease bli-4 0.0669 0.1292 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0101 0.015 0.0277
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.023 0.0409 0.4381
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0528 0.1007 0.3637
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0044 0.0035 0.0195
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0111 0.0171 0.1715
Loa Loa (eye worm) hypothetical protein 0.0106 0.0161 0.1245
Loa Loa (eye worm) hypothetical protein 0.0101 0.015 0.116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0035 0.0195
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0134 0.0216 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0528 0.1007 1
Toxoplasma gondii subtilisin SUB7 0.0119 0.0185 0.0413
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0119 0.0185 0.1436
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0101 0.0151 0.1294
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.023 0.0409 0.4381
Loa Loa (eye worm) TK/INSR protein kinase 0.0101 0.0151 0.1168
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0183 0.0315 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0017 0.0026
Echinococcus granulosus tyrosine protein kinase Src64B 0.0044 0.0035 0.0161
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0119 0.0185 0.17
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0044 0.0035 0.0161
Brugia malayi Peptidase family M1 containing protein 0.0119 0.0186 0.1436
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0017 0.0026
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0528 0.1007 0.9421
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0038 0.0219
Loa Loa (eye worm) peptidase family M1 containing protein 0.0096 0.014 0.1084
Plasmodium vivax subtilisin-like protease 1 0.1372 0.2703 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0119 0.0185 0.0169
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0066 0.0048
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0528 0.1007 0.7797
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.023 0.0409 0.0392
Loa Loa (eye worm) N-myristoyltransferase 2 0.0183 0.0315 0.2439
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.0035 0.0161
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0065 0.0077 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.0288 0.2598
Loa Loa (eye worm) TK protein kinase 0.0038 0.0022 0.0174
Echinococcus granulosus epidermal growth factor receptor 0.0315 0.058 0.4429
Echinococcus multilocularis tyrosine protein kinase Srms 0.0038 0.0022 0.0076
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0147 0.0243 0.228
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0119 0.0185 0.1623
Loa Loa (eye worm) hypothetical protein 0.0065 0.0077 0.0596
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0119 0.0185 0.1339
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Schistosoma mansoni tyrosine kinase 0.0044 0.0035 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Onchocerca volvulus 0.0065 0.0077 0.3552
Plasmodium falciparum plasmepsin VI 0.0101 0.015 0.0419
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0119 0.0185 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Trypanosoma brucei N-myristoyltransferase 0.0183 0.0315 0.3009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Schistosoma mansoni tyrosine kinase 0.017 0.0288 0.0271
Toxoplasma gondii subtilisin SUB11 0.0119 0.0185 0.0413
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.048 0.0911 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0017 0.0021
Echinococcus granulosus insulin receptor 0.0101 0.0151 0.1068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Echinococcus multilocularis Furin 1 0.023 0.0409 0.3744
Trypanosoma cruzi subtilisin peptidase 0.0119 0.0185 0.17
Giardia lamblia CDC72 0.0183 0.0315 0.7018
Plasmodium vivax aspartyl protease, putative 0.0065 0.0077 0.0146
Brugia malayi Subtilase family protein 0.0119 0.0185 0.1436
Loa Loa (eye worm) hypothetical protein 0.0226 0.04 0.3099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Brugia malayi Pepsin A precursor 0.0065 0.0077 0.0596
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.017 0.0288 0.2143
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0101 0.015 0.1483
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0119 0.0185 0.1644
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0038 0.002
Plasmodium vivax subtilisin-like protease 2, putative 0.0119 0.0185 0.0553
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0119 0.0185 0.1688
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Trypanosoma cruzi N-myristoyl transferase, putative 0.0183 0.0315 0.3009
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0101 0.0151 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.023 0.0409 0.4381
Echinococcus multilocularis 0.0097 0.0142 0.1213
Schistosoma mansoni tyrosine kinase 0.0167 0.0282 0.0266
Plasmodium falciparum plasmepsin II 0.0101 0.015 0.0419
Plasmodium vivax subtilisin-like serine protease, putative 0.0119 0.0185 0.0553
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0035 0.0195
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0134 0.0216 0.1909
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.2004
Brugia malayi aspartic protease BmAsp-2, identical 0.0065 0.0077 0.0596
Loa Loa (eye worm) TK/EGFR protein kinase 0.0315 0.058 0.4492
Toxoplasma gondii subtilisin SUB6 0.0119 0.0185 0.0413
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0017 0.0021
Trypanosoma brucei subtilisin peptidase 0.0119 0.0185 0.17
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0528 0.1007 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.0035 0.0195
Echinococcus multilocularis membrane bound transcription factor site 1 0.0119 0.0185 0.1623
Echinococcus multilocularis tyrosine protein kinase Blk 0.0038 0.0022 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0119 0.0185 0.1688
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0444 0.0838 0.9183
Onchocerca volvulus 0.0119 0.0185 0.9996
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0185 0.1881
Schistosoma mansoni site-1 peptidase (S08 family) 0.0119 0.0185 0.0169
Plasmodium falciparum plasmepsin IX 0.0065 0.0077 0.0146
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0038 0.0181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Brugia malayi celfurPC protein 0.0558 0.1068 0.8269
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Echinococcus multilocularis aminopeptidase N 0.0119 0.0186 0.1623
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0017 0.0026
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.0035 0.0161
Giardia lamblia High cysteine membrane protein Group 2 0.0214 0.0376 1
Plasmodium falciparum plasmepsin I 0.0101 0.015 0.0419
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0119 0.0185 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Plasmodium vivax aspartyl protease, putative 0.0065 0.0077 0.0146
Brugia malayi protein-tyrosine kinase 0.0038 0.0022 0.0174
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0111 0.0171 0.1715
Mycobacterium leprae Possible secreted protease 0.0119 0.0185 0.1688
Echinococcus multilocularis adam 0.0059 0.0066 0.0484
Schistosoma mansoni N-myristoyltransferase 0.0183 0.0315 0.0298
Echinococcus multilocularis 0.0558 0.1068 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Plasmodium falciparum subtilisin-like protease 2 0.0119 0.0185 0.0553
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0017 0.0021
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.0666
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.048 0.0911 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0038 0.0022 0.0062
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.2004
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0528 0.1007 0.0991
Brugia malayi proprotein convertase 2 0.0456 0.0862 0.6676
Echinococcus granulosus membrane bound transcription factor site 1 0.0119 0.0185 0.1339
Toxoplasma gondii subtilisin SUB8 0.0119 0.0185 0.0413
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0528 0.1007 0.3542
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0134 0.0216 0.1793
Brugia malayi endoprotease bli-4 precursor 0.0669 0.1292 1
Onchocerca volvulus 0.0065 0.0077 0.3552
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0017 0.0017
Echinococcus granulosus tyrosine kinase 0.0038 0.0022 0.0062
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0035 0.0195
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0101 0.015 0.0133
Loa Loa (eye worm) reprolysin 0.0045 0.0038 0.0291
Brugia malayi N-myristoyltransferase 2 0.0183 0.0315 0.2439
Schistosoma mansoni memapsin-2 (A01 family) 0.1343 0.2645 0.2632
Plasmodium falciparum subtilisin-like protease 1 0.1372 0.2703 1
Loa Loa (eye worm) hypothetical protein 0.0669 0.1292 1
Plasmodium falciparum plasmepsin X 0.0065 0.0077 0.0146
Schistosoma mansoni tyrosine kinase 0.0315 0.058 0.0564
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0528 0.1007 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0444 0.0838 0.6451
Toxoplasma gondii subtilisin SUB1 0.1372 0.2703 1
Echinococcus granulosus neuroendocrine convertase 2 0.0456 0.0862 0.6638
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0119 0.0185 0.1436
Loa Loa (eye worm) hypothetical protein 0.0065 0.0077 0.0596
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0134 0.0216 0.2004
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.091 0.1775 0.1761
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0444 0.0838 0.782
Loa Loa (eye worm) proprotein convertase 2 0.023 0.0409 0.3166
Brugia malayi Reprolysin 0.0026 0.0000067011 0.0001
Toxoplasma gondii subtilisin SUB5 0.0119 0.0185 0.0413
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.048 0.0911 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0038 0.0291
Echinococcus granulosus epidermal growth factor receptor 0.017 0.0288 0.2143
Echinococcus granulosus adam 0.0059 0.0066 0.0399
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0134 0.0216 0.0528
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0119 0.0185 0.17
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0017 0.0026
Brugia malayi Guanylate kinase family protein 0.003 0.0007 0.0053
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0101 0.015 0.116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0022 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0185 0.1881
Toxoplasma gondii subtilisin SUB2 0.0119 0.0185 0.0413
Onchocerca volvulus 0.0119 0.0186 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0044 0.0035 0.0161
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0044 0.0035 0.0195
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0038 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Brugia malayi hypothetical protein 0.0059 0.0066 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Toxoplasma gondii aspartyl protease ASP1 0.0101 0.015 0.0277
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Schistosoma mansoni cathepsin D (A01 family) 0.0193 0.0336 0.0319
Trichomonas vaginalis N-myristoyl transferase, putative 0.0183 0.0315 0.333
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0183 0.0315 0.1039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Echinococcus granulosus furin 0.0669 0.1292 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0065 0.0077 0.006
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.0035 0.0161
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0528 0.1007 1
Echinococcus multilocularis epidermal growth factor receptor 0.0315 0.058 0.5369
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Plasmodium falciparum plasmepsin IV 0.0101 0.015 0.0419
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0017 0.0021
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0183 0.0315 0.2353
Schistosoma mansoni furin-1 (S08 family) 0.0344 0.0639 0.0623
Schistosoma mansoni cathepsin D (A01 family) 0.0193 0.0336 0.0319
Schistosoma mansoni tyrosine kinase 0.0044 0.0035 0.0018
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0528 0.1007 0.3637
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0119 0.0185 0.0169
Plasmodium vivax plasmepsin IV, putative 0.0101 0.015 0.0419
Echinococcus granulosus Furin 1 0.023 0.0409 0.3089
Toxoplasma gondii subtilisin SUB10 0.0119 0.0185 0.0413
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0044 0.0035 0.0195
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0183 0.0315 0.1039
Trichomonas vaginalis hypothetical protein 0.0111 0.0171 0.1715
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0134 0.0216 0.1669
Loa Loa (eye worm) TK protein kinase 0.0034 0.0015 0.0112
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.048 0.0911 1
Leishmania major subtilisin-like serine peptidase 0.0119 0.0185 0.17
Brugia malayi hypothetical protein 0.0065 0.0077 0.0596
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0043 0.0053
Brugia malayi neuroendocrine convertase 1 precursor 0.0456 0.0862 0.6676
Echinococcus granulosus tyrosine protein kinase Fyn 0.0044 0.0035 0.0161
Trichomonas vaginalis N-myristoyl transferase, putative 0.012 0.0189 0.1919
Plasmodium vivax plasmepsin V, putative 0.0065 0.0077 0.0146
Loa Loa (eye worm) aspartyl protease 6 0.0065 0.0077 0.0596
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0111 0.0171 0.1715
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0528 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0185 0.1436
Echinococcus granulosus tyrosine protein kinase Lyn 0.0044 0.0035 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0185 0.1881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Schistosoma mansoni hypothetical protein 0.0111 0.0171 0.0154
Brugia malayi Eukaryotic aspartyl protease family protein 0.0065 0.0077 0.0596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Leishmania major N-myristoyl transferase, putative 0.0183 0.0315 0.3009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0444 0.0838 0.9183
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.2004
Toxoplasma gondii subtilisin SUB4 0.0119 0.0185 0.0413
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.2004
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0119 0.0185 0.1881
Schistosoma mansoni tyrosine kinase 0.0167 0.0282 0.0266
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0017 0.0134
Brugia malayi SRC-1 0.0044 0.0035 0.0272
Brugia malayi Furin-like cysteine rich region family protein 0.0315 0.058 0.4492
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0045 0.0038 0.0233
Plasmodium falciparum plasmepsin VII 0.0065 0.0077 0.0146
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0017 0.0026
Trypanosoma cruzi N-myristoyl transferase, putative 0.0183 0.0315 0.3009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.023 0.0409 0.4381
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0119 0.0185 0.1881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0045 0.0038 0.021
Plasmodium falciparum plasmepsin VIII, putative 0.0065 0.0077 0.0146
Echinococcus multilocularis neuroendocrine convertase 2 0.0456 0.0862 0.8046
Loa Loa (eye worm) hypothetical protein 0.0084 0.0115 0.0893
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0119 0.0185 0.1644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.023 0.0409 0.4381
Brugia malayi aspartic protease BmAsp-1, identical 0.0065 0.0077 0.0596
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0669 0.1292 0.1277
Echinococcus multilocularis insulin receptor 0.0101 0.0151 0.1294
Plasmodium vivax aspartyl proteinase, putative 0.0101 0.015 0.0419
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0528 0.1007 0.7772
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0134 0.0216 0.1991
Brugia malayi hypothetical protein 0.0065 0.0077 0.0596
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0134 0.0216 0.0666
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.048 0.0911 1
Schistosoma mansoni tyrosine kinase 0.017 0.0288 0.0271
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.023 0.0409 0.4381
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0134 0.0216 0.0199
Schistosoma mansoni tyrosine kinase 0.0101 0.0151 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0119 0.0185 0.1644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0119 0.0185 0.1881
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0119 0.0185 0.1881
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0017 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0171 0.1715
Plasmodium falciparum subtilisin-like protease 3 0.0119 0.0185 0.0553
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0173 0.0294 0.289
Brugia malayi hypothetical protein 0.0035 0.0017 0.0134
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0017 0.0134
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0119 0.0185 0.17
Plasmodium falciparum plasmepsin V 0.0065 0.0077 0.0146
Mycobacterium ulcerans transcriptional regulator NrdR 0.0048 0.0043 0.0284
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0101 0.015 0.106
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0185 0.1881
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0134 0.0216 0.2004
Plasmodium vivax aspartyl protease, putative 0.0065 0.0077 0.0146
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0134 0.0216 0.2004
Schistosoma mansoni tyrosine kinase 0.0167 0.0282 0.0266
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0017 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0185 0.1881
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0101 0.015 0.1284

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.