TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 474.658 | Formula: C20H30N2O5S3
H donors: 0 H acceptors: 4 LogP: 2.52 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CSCCC(=O)N1CCc2c(C1)sc(c2C(=O)OC)S(=O)(=O)N(CC1CC1)CCC
InChi: 1S/C20H30N2O5S3/c1-4-9-22(12-14-5-6-14)30(25,26)20-18(19(24)27-2)15-7-10-21(13-16(15)29-20)17(23)8-11-28-3/h14H,4-13H2,1-3H3
InChiKey: FALHXMIKAWRYDZ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin s	0.0028	0.001	0.001
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0157	0.2028	0.2028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Schistosoma mansoni	alpha-glucosidase	0.0135	0.1685	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1044	0.2473
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.046	0.3669
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0111	0.0265
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0095	0.1044	0.1044
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.0287	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0057	0.046	0.1091
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.0287	0.0287
Brugia malayi	hypothetical protein	0.0149	0.1901	0.4547
Schistosoma mansoni	hypothetical protein	0.0046	0.0287	0.0287
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0111	0.0242
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0111	0.0064
Schistosoma mansoni	hypothetical protein	0.0046	0.0287	0.0287
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0105	0.0835
Brugia malayi	Bromodomain containing protein	0.0057	0.046	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0287	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0385	0.0913
Echinococcus granulosus	peregrin	0.0057	0.046	0.046
Loa Loa (eye worm)	MBCTL1	0.0052	0.0385	0.0913
Brugia malayi	jmjC domain containing protein	0.0188	0.25	0.5978
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0105	0.0228
Echinococcus granulosus	geminin	0.0331	0.4747	0.4747
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0095	0.1044	0.1044
Brugia malayi	Cathepsin L-like precursor	0.0095	0.1044	0.2496
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0157	0.2028	0.4806
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0095	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1851	0.4386
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1101	0.2609
Echinococcus multilocularis	cathepsin b	0.0295	0.4181	0.4181
Brugia malayi	glutaminase DH11.1	0.0267	0.374	0.8946
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0052	0.0385	0.0385
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0285	0.0285
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0095	0.1044	1
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0285	0.0285
Plasmodium vivax	unspecified product	0.0053	0.039	0.3734
Loa Loa (eye worm)	hypothetical protein	0.0028	0.001	0.0023
Schistosoma mansoni	glutaminase	0.0267	0.374	0.374
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0105	0.0584
Loa Loa (eye worm)	fibroinase	0.0095	0.1044	0.2473
Leishmania major	cathepsin L-like protease	0.0095	0.1044	0.556
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Brugia malayi	latrophilin 2 splice variant baaae	0.01	0.1127	0.2696
Leishmania major	cathepsin L-like protease	0.0095	0.1044	0.556
Onchocerca volvulus		0.0095	0.1044	0.4693
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.012	0.012
Brugia malayi	jmjC domain containing protein	0.0069	0.0649	0.1552
Brugia malayi	Cathepsin L-like precursor	0.0095	0.1044	0.2496
Loa Loa (eye worm)	hypothetical protein	0.0028	0.001	0.0023
Entamoeba histolytica	cysteine proteinase, putative	0.0066	0.0598	0.5251
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.046	0.3669
Schistosoma mansoni	hypothetical protein	0.0046	0.0287	0.0287
Brugia malayi	Cathepsin L-like precursor	0.0066	0.0598	0.143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0066	0.0598	0.1356
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0111	0.0016
Giardia lamblia	Cathepsin B precursor	0.0108	0.1254	1
Onchocerca volvulus	Cathepsin L homolog	0.0095	0.1044	0.4693
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.4181	0.4181
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0598	0.1417
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0598	0.1417
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0285	0.0285
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0028	0.001	0.0023
Schistosoma mansoni	jumonji domain containing protein	0.0149	0.1896	0.1896
Onchocerca volvulus		0.0095	0.1044	0.4693
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0105	0.0228
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.01	0.1127	0.1127
Leishmania major	cysteine peptidase A (CPA)	0.0095	0.1044	0.556
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.01	0.1127	0.2671
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.0287	0.0687
Loa Loa (eye worm)	ctsf protein	0.0095	0.1044	0.2473
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.016	0.2075	0.4919
Schistosoma mansoni	transcription factor btf3	0.0035	0.0105	0.0105
Leishmania major	cathepsin L-like protease	0.0095	0.1044	0.556
Plasmodium vivax	vivapain-2	0.0095	0.1044	1
Brugia malayi	RNA, U transporter 1	0.0079	0.0804	0.1923
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.039	0.2173
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0095	0.1044	0.2473
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0295	0.4181	0.4181
Loa Loa (eye worm)	glutaminase	0.0267	0.374	0.8866
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0053	0.039	0.039
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.039	0.0932
Entamoeba histolytica	hypothetical protein	0.0036	0.012	0.0167
Brugia malayi	PHD-finger family protein	0.0057	0.046	0.1101
Brugia malayi	Cathepsin L-like precursor	0.0095	0.1044	0.2496
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0111	0.0016
Schistosoma mansoni	hypothetical protein	0.0331	0.4747	0.4747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0285	0.0676
Echinococcus multilocularis	geminin	0.0331	0.4747	0.4747
Onchocerca volvulus		0.0095	0.1044	0.4693
Echinococcus granulosus	cathepsin b	0.0295	0.4181	0.4181
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0111	0.0016
Loa Loa (eye worm)	DEAH box polypeptide 35	0.016	0.2075	0.4919
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1901	0.4506
Loa Loa (eye worm)	glutaminase 2	0.0267	0.374	0.8866
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.1044	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.0287	0.0287
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0105	0.1003
Onchocerca volvulus		0.0095	0.1044	0.4693
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0066	0.0598	0.143
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0111	0.0016
Echinococcus granulosus	cathepsin L cysteine protease	0.0053	0.039	0.039
Onchocerca volvulus		0.0095	0.1044	0.4693
Echinococcus multilocularis	peregrin	0.0057	0.046	0.046
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.4181	0.4181
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0146	0.1851	0.4386
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0057	0.046	0.046
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.046	0.4411
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0052	0.0385	0.0385
Trypanosoma cruzi	cysteine peptidase, putative	0.0095	0.1044	0.2478
Loa Loa (eye worm)	MH2 domain-containing protein	0.0232	0.3193	0.7569
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.1793	0.4275
Brugia malayi	Cathepsin L-like precursor	0.0028	0.001	0.0023
Brugia malayi	mbt repeat family protein	0.0046	0.0285	0.0682
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.1044	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0111	0.0262
Loa Loa (eye worm)	jmjC domain-containing protein	0.0069	0.0649	0.1538
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Mycobacterium ulcerans	glutaminase	0.0267	0.374	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.039	0.0784
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0111	0.0882
Schistosoma mansoni	hypothetical protein	0.0036	0.012	0.012
Trypanosoma cruzi	cysteine proteinase, putative	0.0053	0.039	0.0911
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0188	0.25	0.25
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0095	0.1044	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Schistosoma mansoni	hypothetical protein	0.0057	0.046	0.046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0095	0.1044	0.2582
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0105	0.0105
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0295	0.4181	0.4181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.039	0.0784
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Echinococcus granulosus	cathepsin l1	0.0066	0.0598	0.0598
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0285	0.0285
Trypanosoma cruzi	cysteine proteinase, putative	0.0053	0.039	0.0911
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0111	0.0016
Echinococcus multilocularis	jumonji domain containing protein	0.008	0.0811	0.0811
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0146	0.1851	0.4426
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0108	0.1254	0.6995
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0053	0.039	0.039
Loa Loa (eye worm)	jmjC domain-containing protein	0.0118	0.1415	0.3353
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Plasmodium vivax	unspecified product	0.0028	0.001	0.0094
Brugia malayi	Cathepsin L-like precursor	0.0095	0.1044	0.2496
Brugia malayi	MH2 domain containing protein	0.0232	0.3193	0.7638
Schistosoma mansoni	hypothetical protein	0.0331	0.4747	0.4747
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0111	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0108	0.1254	0.3162
Echinococcus multilocularis	cysteine protease	0.0095	0.1044	0.1044
Brugia malayi	cathepsin F-like cysteine proteinase	0.0028	0.001	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0028	0.001	0.0023
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Onchocerca volvulus	Cathepsin F homolog	0.0095	0.1044	0.4693
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0052	0.0385	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Schistosoma mansoni	hypothetical protein	0.028	0.3949	0.3949
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Trypanosoma brucei	glucosidase, putative	0.0035	0.0111	0.0617
Onchocerca volvulus	Cathepsin L homolog	0.0095	0.1044	0.4693
Schistosoma mansoni	hypothetical protein	0.0297	0.4219	0.4219
Trypanosoma cruzi	cysteine protease, putative	0.0053	0.039	0.0911
Echinococcus granulosus	lysine specific demethylase 5A	0.0069	0.0649	0.0649
Leishmania major	cathepsin L-like protease	0.0142	0.1793	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Leishmania major	cathepsin L-like protease	0.0095	0.1044	0.556
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.012	0.012
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0095	0.1044	1
Schistosoma mansoni	alpha glucosidase	0.0035	0.0111	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0111	0.0242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	0.4219	1
Entamoeba histolytica	cysteine protease, putative	0.0095	0.1044	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0066	0.0598	0.0598
Echinococcus granulosus	snurportin 1	0.0297	0.4219	0.4219
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.0649	0.0649
Plasmodium vivax	vivapain-3	0.0053	0.039	0.3734
Echinococcus granulosus	PHD finger protein rhinoceros	0.0057	0.046	0.046
Leishmania major	cathepsin L-like protease	0.0142	0.1793	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0053	0.039	0.3035
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0105	0.0248
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0052	0.0385	0.0385
Toxoplasma gondii	cathepsin CPL	0.0095	0.1044	0.8319
Onchocerca volvulus		0.0095	0.1044	0.4693
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0295	0.4181	1
Brugia malayi	Cathepsin L-like precursor	0.0095	0.1044	0.2496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Echinococcus multilocularis	snurportin 1	0.0297	0.4219	0.4219
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0285	0.0285
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0182	0.2407	0.2407
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0111	0.0016
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0182	0.2407	0.2407
Echinococcus granulosus	cysteine protease	0.0053	0.039	0.039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Toxoplasma gondii	cathepsin B	0.0108	0.1254	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.0649	0.0649
Echinococcus granulosus	cathepsin l1	0.0095	0.1044	0.1044
Leishmania major	cathepsin L-like protease	0.0142	0.1793	1
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0285	0.0285
Echinococcus multilocularis	cathepsin L	0.0053	0.039	0.039
Onchocerca volvulus		0.0149	0.1901	1
Brugia malayi	cathepsin L-like precursor	0.0066	0.0598	0.143
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0146	0.1851	0.4426
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.0287	0.0287
Echinococcus granulosus	cathepsin b	0.0295	0.4181	0.4181
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0108	0.1254	0.6809
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Brugia malayi	hypothetical protein	0.0036	0.012	0.0288
Echinococcus granulosus	jumonji domain containing protein	0.008	0.0811	0.0811
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0095	0.1044	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4181	0.991
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0111	0.0016
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.039	0.3035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.039	0.3035
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Brugia malayi	Cathepsin L-like precursor	0.0066	0.0598	0.143
Brugia malayi	Papain family cysteine protease containing protein	0.0095	0.1044	0.2496
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0028	0.001	0.0023
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0114	0.1347	0.3207
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.039	0.3035
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0111	0.0035
Echinococcus multilocularis	cathepsin L cysteine protease	0.0095	0.1044	0.1044
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0095	0.1044	0.2473
Entamoeba histolytica	hypothetical protein	0.0036	0.012	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Brugia malayi	cathepsin B-like cysteine proteinase	0.0295	0.4181	1
Brugia malayi	Cathepsin L-like precursor	0.0095	0.1044	0.2496
Leishmania major	cathepsin L-like protease	0.0095	0.1044	0.556
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0057	0.046	0.046
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Loa Loa (eye worm)	cathepsin B	0.0108	0.1254	0.2973
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Entamoeba histolytica	cysteine proteinase 2	0.0053	0.039	0.3035
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0105	0.1003
Trichomonas vaginalis	glutaminase, putative	0.0267	0.374	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0069	0.0649	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0598	0.1417
Plasmodium vivax	vivapain-1	0.0053	0.039	0.3734
Schistosoma mansoni	microtubule-associated protein tau	0.0667	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0111	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.039	0.0932
Echinococcus multilocularis	microtubule associated protein 2	0.0667	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0108	0.1254	0.2984
Giardia lamblia	Cathepsin B precursor	0.0108	0.1254	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0285	0.0676
Entamoeba histolytica	hypothetical protein	0.0036	0.012	0.0167
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0052	0.0385	0.0921
Schistosoma mansoni	cathepsin F (C01 family)	0.0095	0.1044	0.1044
Onchocerca volvulus		0.0091	0.0989	0.4355
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Schistosoma mansoni	cathepsin F (C01 family)	0.0095	0.1044	0.1044
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.012	0.012
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0285	0.0285
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.039	0.2173
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.039	0.0911
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Trypanosoma cruzi	major cysteine proteinase, putative	0.0072	0.0694	0.1639
Plasmodium vivax	vivapain-2	0.0095	0.1044	1
Echinococcus multilocularis	cysteine protease	0.0095	0.1044	0.1044
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.1793	0.4275
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1
Echinococcus multilocularis	cathepsin b	0.0295	0.4181	0.4181
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0188	0.25	0.25
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0053	0.039	0.039
Onchocerca volvulus		0.0066	0.0598	0.1934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0095	0.1044	0.2582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Entamoeba histolytica	hypothetical protein	0.0036	0.012	0.0167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.0287	0.0681
Loa Loa (eye worm)	PHD-finger family protein	0.0057	0.046	0.1091
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0157	0.2028	0.2028
Echinococcus multilocularis	cathepsin L cysteine protease	0.0095	0.1044	0.1044
Brugia malayi	beta-NAC-like protein	0.0035	0.0105	0.025
Trypanosoma cruzi	cruzipain precursor, putative	0.0142	0.1793	0.4275
Echinococcus granulosus	histone acetyltransferase MYST2	0.0052	0.0385	0.0385
Schistosoma mansoni	hypothetical protein	0.0046	0.0287	0.0287
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0053	0.039	0.3734
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0066	0.0598	0.1356
Loa Loa (eye worm)	transcription factor SMAD2	0.0232	0.3193	0.7569
Echinococcus granulosus	GPCR family 2	0.0046	0.0287	0.0287
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0111	0.0016
Echinococcus granulosus	transcription factor btf3	0.0035	0.0105	0.0105
Loa Loa (eye worm)	cysteine protease	0.0095	0.1044	0.2473
Onchocerca volvulus		0.0095	0.1044	0.4693
Echinococcus granulosus	cathepsin L	0.0053	0.039	0.039
Entamoeba histolytica	cysteine protease, putative	0.0053	0.039	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0053	0.039	0.0911
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0108	0.1254	0.1254
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Schistosoma mansoni	alpha-glucosidase	0.0135	0.1685	0.1685
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0157	0.2028	0.485
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.039	0.3035
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.1793	0.4275
Brugia malayi	mbt repeat family protein	0.0046	0.0285	0.0682
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0095	0.1044	0.2582
Giardia lamblia	Cathepsin B precursor	0.0108	0.1254	1
Onchocerca volvulus	Alhambra homolog	0.0057	0.046	0.1083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.1044	0.2582
Echinococcus granulosus	lysosomal alpha glucosidase	0.0157	0.2028	0.2028
Echinococcus multilocularis	GPCR, family 2	0.0046	0.0287	0.0287
Plasmodium falciparum	phd finger protein, putative	0.0057	0.046	0.4411
Brugia malayi	Probable ATP-dependent helicase DHX35	0.016	0.2075	0.4963
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.1793	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 814974