Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0145 | 0.0285 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0039 | 0.0015 | 0.0021 |
Echinococcus granulosus | twitchin | 0.0209 | 0.045 | 0.0645 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0145 | 0.0285 | 0.0668 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0039 | 0.0015 | 0.0048 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0145 | 0.0285 | 0.5 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0039 | 0.0015 | 0.0021 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0145 | 0.0285 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0234 | 0.0514 | 0.1686 |
Loa Loa (eye worm) | cytochrome P450 | 0.0145 | 0.0285 | 0.0933 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.2758 | 0.6982 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0145 | 0.0285 | 0.0668 |
Schistosoma mansoni | microtubule-associated protein tau | 0.08 | 0.1963 | 0.1952 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0145 | 0.0285 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1039 | 0.2575 | 0.869 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.1189 | 0.2961 | 0.4241 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.007 | 0.0093 | 0.0133 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0419 | 0.0987 | 0.3236 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0234 | 0.0514 | 0.1469 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0145 | 0.0285 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1189 | 0.2961 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0145 | 0.0285 | 0.5 |
Echinococcus granulosus | defective proboscis extension response | 0.0181 | 0.0377 | 0.0539 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0181 | 0.0377 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0419 | 0.0987 | 0.3117 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0419 | 0.0987 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0145 | 0.0285 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0145 | 0.0285 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0198 | 0.0421 | 0.0603 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0419 | 0.0987 | 0.5 |
Toxoplasma gondii | aurora kinase | 0.0419 | 0.0987 | 1 |
Echinococcus multilocularis | hemicentin 1 | 0.0039 | 0.0015 | 0.0021 |
Echinococcus multilocularis | lachesin | 0.0039 | 0.0015 | 0.0021 |
Echinococcus granulosus | microtubule associated protein 2 | 0.08 | 0.1963 | 0.2812 |
Leishmania major | cytochrome p450-like protein | 0.0145 | 0.0285 | 0.0668 |
Echinococcus granulosus | roundabout 2 | 0.0039 | 0.0015 | 0.0021 |
Mycobacterium leprae | putative cytochrome p450 | 0.0145 | 0.0285 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1189 | 0.2961 | 1 |
Echinococcus granulosus | contactin | 0.0039 | 0.0015 | 0.0021 |
Echinococcus granulosus | neuroglian | 0.0039 | 0.0015 | 0.0021 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0145 | 0.0285 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0181 | 0.0377 | 0.1234 |
Brugia malayi | Cytochrome P450 family protein | 0.0234 | 0.0514 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.0433 | 0.142 |
Trichomonas vaginalis | AGC family protein kinase | 0.0419 | 0.0987 | 0.3117 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0145 | 0.0285 | 0.2144 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0234 | 0.0514 | 0.1686 |
Echinococcus granulosus | hemicentin 1 | 0.0039 | 0.0015 | 0.0021 |
Echinococcus multilocularis | roundabout 2 | 0.0039 | 0.0015 | 0.0021 |
Schistosoma mansoni | cell adhesion molecule | 0.0203 | 0.0433 | 0.0419 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Trypanosoma brucei | polo-like protein kinase | 0.1189 | 0.2961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0145 | 0.0285 | 0.0668 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0419 | 0.0987 | 0.3236 |
Schistosoma mansoni | cytochrome P450 | 0.0145 | 0.0285 | 0.0271 |
Echinococcus granulosus | Immunoglobulin | 0.0181 | 0.0377 | 0.0539 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0145 | 0.0285 | 0.0668 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0143 | 0.047 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0039 | 0.0015 | 0.0048 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0987 | 0.3236 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0419 | 0.0987 | 0.0974 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0145 | 0.0285 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0198 | 0.0421 | 0.0603 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.007 | 0.0093 | 0.0133 |
Trichomonas vaginalis | AGC family protein kinase | 0.0419 | 0.0987 | 0.3117 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0145 | 0.0285 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.007 | 0.0093 | 0.0079 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0039 | 0.0015 | 0.0021 |
Brugia malayi | Cytochrome P450 family protein | 0.0145 | 0.0285 | 0.0933 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0285 | 0.0271 |
Echinococcus granulosus | roundabout 2 | 0.0039 | 0.0015 | 0.0021 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.2758 | 0.6982 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0419 | 0.0987 | 0.1414 |
Schistosoma mansoni | vesicular amine transporter | 0.0181 | 0.0377 | 0.0363 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.1189 | 0.2961 | 0.4241 |
Echinococcus granulosus | mitogen activated protein kinase | 0.007 | 0.0093 | 0.0133 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.1189 | 0.2961 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0145 | 0.0285 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0145 | 0.0285 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0419 | 0.0987 | 0.1414 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0477 | 0.1565 |
Echinococcus granulosus | roundabout 2 | 0.022 | 0.0477 | 0.0684 |
Trypanosoma brucei | aurora B kinase | 0.0419 | 0.0987 | 0.3117 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0145 | 0.0285 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0056 | 0.0057 | 0.0042 |
Trypanosoma brucei | cytochrome P450, putative | 0.0234 | 0.0514 | 0.1469 |
Echinococcus granulosus | lachesin | 0.0039 | 0.0015 | 0.0021 |
Echinococcus granulosus | peroxidasin | 0.0039 | 0.0015 | 0.0021 |
Brugia malayi | Prion-like- | 0.0039 | 0.0015 | 0.0048 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.1189 | 0.2961 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0234 | 0.0514 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0145 | 0.0285 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0419 | 0.0987 | 0.1414 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0987 | 0.3236 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0181 | 0.0377 | 0.0539 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0203 | 0.0433 | 0.062 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0145 | 0.0285 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0145 | 0.0285 | 0.0668 |
Leishmania major | protein kinase, putative | 0.0419 | 0.0987 | 0.3117 |
Trichomonas vaginalis | AGC family protein kinase | 0.0419 | 0.0987 | 0.3117 |
Brugia malayi | MAP kinase sur-1 | 0.007 | 0.0093 | 0.0305 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0145 | 0.0285 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1189 | 0.2961 | 0.2951 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.08 | 0.1963 | 0.2812 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Schistosoma mansoni | protein kinase | 0.0419 | 0.0987 | 0.0974 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0234 | 0.0514 | 0.1469 |
Echinococcus multilocularis | Immunoglobulin | 0.0181 | 0.0377 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0987 | 0.3236 |
Echinococcus multilocularis | peroxidasin | 0.0039 | 0.0015 | 0.0021 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0039 | 0.0015 | 0.0021 |
Leishmania major | cytochrome p450-like protein | 0.0234 | 0.0514 | 0.1469 |
Echinococcus multilocularis | roundabout 2 | 0.022 | 0.0477 | 0.0684 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0039 | 0.0015 | 0.0021 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0145 | 0.0285 | 0.0408 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0039 | 0.0015 | 0.0021 |
Echinococcus multilocularis | 0.0145 | 0.0285 | 0.0408 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.007 | 0.0093 | 0.0305 |
Giardia lamblia | Kinase, PLK | 0.1189 | 0.2961 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.1189 | 0.2961 | 0.9707 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0145 | 0.0285 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.0419 | 0.0987 | 0.1414 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0181 | 0.0377 | 0.1234 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.1189 | 0.2961 | 1 |
Brugia malayi | cytochrome P450 | 0.0145 | 0.0285 | 0.0933 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0039 | 0.0015 | 0.0021 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.1189 | 0.2961 | 0.9707 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1224 | 0.305 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0051 | 0.0044 | 0.0144 |
Brugia malayi | Peroxidasin | 0.0039 | 0.0015 | 0.0048 |
Trichomonas vaginalis | AGC family protein kinase | 0.0419 | 0.0987 | 0.3117 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.007 | 0.0093 | 0.0133 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0145 | 0.0285 | 0.5 |
Echinococcus multilocularis | hemicentin 1 | 0.0039 | 0.0015 | 0.0021 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1224 | 0.305 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0145 | 0.0285 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0234 | 0.0514 | 0.1686 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0039 | 0.0015 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.0477 | 0.1565 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0535 | 0.1285 | 0.4214 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0015 | 0.0048 |
Echinococcus multilocularis | roundabout 2 | 0.0039 | 0.0015 | 0.0021 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0181 | 0.0377 | 0.0363 |
Echinococcus multilocularis | neuroglian | 0.0039 | 0.0015 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0234 | 0.0514 | 0.1686 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0145 | 0.0285 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0039 | 0.0015 | 0.0048 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.0015 | 0.0048 |
Onchocerca volvulus | 0.1005 | 0.2489 | 0.8397 | |
Giardia lamblia | Aurora kinase | 0.0419 | 0.0987 | 0.3117 |
Brugia malayi | serine/threonine kinase 12 | 0.0419 | 0.0987 | 0.3236 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0377 | 0.1234 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1189 | 0.2961 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0145 | 0.0285 | 0.0668 |
Echinococcus multilocularis | Immunoglobulin | 0.0181 | 0.0377 | 0.0539 |
Brugia malayi | Cytochrome P450 family protein | 0.0535 | 0.1285 | 0.4214 |
Schistosoma mansoni | nephrin | 0.0198 | 0.0421 | 0.0407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.