Detailed information for compound 829801

Basic information

Technical information
  • TDR Targets ID: 829801
  • Name: 2-(5-methoxy-4,7-dimethyl-2-oxochromen-3-yl)- N-[(4-methylphenyl)methyl]acetamide
  • MW: 365.422 | Formula: C22H23NO4
  • H donors: 1 H acceptors: 2 LogP: 3.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C)cc2c1c(C)c(c(=O)o2)CC(=O)NCc1ccc(cc1)C
  • InChi: 1S/C22H23NO4/c1-13-5-7-16(8-6-13)12-23-20(24)11-17-15(3)21-18(26-4)9-14(2)10-19(21)27-22(17)25/h5-10H,11-12H2,1-4H3,(H,23,24)
  • InChiKey: XLIPUWIYGVHIIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(5-methoxy-4,7-dimethyl-2-oxo-chromen-3-yl)-N-[(4-methylphenyl)methyl]acetamide
  • 2-(5-methoxy-4,7-dimethyl-2-oxo-3-chromenyl)-N-[(4-methylphenyl)methyl]acetamide
  • 2-(2-keto-5-methoxy-4,7-dimethyl-chromen-3-yl)-N-(4-methylbenzyl)acetamide
  • 2-(5-methoxy-4,7-dimethyl-2-oxo-chromen-3-yl)-N-[(4-methylphenyl)methyl]ethanamide
  • ST5327988
  • ZINC04743191

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0109 0.0294
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0015 0.005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.006 0.006
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0019 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.071 0.1482
Echinococcus multilocularis stromal cell derived factor 2 0.0075 0.0339 0.0339
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0198 0.1101 0.2961
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.006 0.023
Toxoplasma gondii thioredoxin reductase 0.0038 0.0109 0.0366
Schistosoma mansoni hypothetical protein 0.0108 0.0544 0.1134
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Loa Loa (eye worm) hypothetical protein 0.0071 0.0311 0.1193
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0064 0.0216
Echinococcus granulosus geminin 0.0171 0.0939 0.1958
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0329 0.1263
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0415 0.1115
Entamoeba histolytica hypothetical protein 0.0024 0.0019 0.0072
Mycobacterium ulcerans hydrolase 0.0198 0.1101 0.2961
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0311 0.1193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.006 0.0125
Brugia malayi Matrixin family protein 0.0392 0.2313 0.8878
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.02 0.0669
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0475 0.1278
Brugia malayi RNA binding protein 0.0061 0.0252 0.0967
Loa Loa (eye worm) matrixin family protein 0.036 0.2111 0.8102
Brugia malayi steroid hormone receptor 0.003 0.006 0.023
Brugia malayi metalloprotease 0.0024 0.0021 0.0081
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0064 0.0064
Trypanosoma brucei cytosolic malate dehydrogenase 0.0049 0.0178 0.0684
Brugia malayi ADAM-TS Spacer 1 family protein 0.0178 0.098 0.3761
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.022 0.0459
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.006 0.006
Leishmania major prostaglandin f synthase, putative 0.0439 0.2605 1
Brugia malayi nuclear hormone receptor 0.003 0.006 0.023
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Trichomonas vaginalis aldo/keto reductase, putative 0.0439 0.2605 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0311 0.1193
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0098 0.0263
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0087 0.0291
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0329 0.1103
Schistosoma mansoni hypothetical protein 0.0033 0.0078 0.0162
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0064 0.0247
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0019 0.0063
Brugia malayi glutathione reductase 0.0038 0.0109 0.0419
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.006 0.006
Entamoeba histolytica alcohol dehydrogenase, putative 0.0127 0.0663 0.2544
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.006 0.0125
Onchocerca volvulus 0.0439 0.2605 1
Schistosoma mansoni malate dehydrogenase 0.0049 0.0178 0.0372
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0081
Leishmania major hypothetical protein, conserved 0.0074 0.0329 0.1263
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0329 0.1103
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0397 0.0828
Brugia malayi beta-lactamase 0.0036 0.0098 0.0375
Trypanosoma cruzi aldo/keto reductase, putative 0.0127 0.0663 0.2544
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0078 0.0298
Entamoeba histolytica alcohol dehydrogenase, putative 0.0127 0.0663 0.2544
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0173 0.0665
Loa Loa (eye worm) oxidoreductase 0.0439 0.2605 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0087 0.0087
Brugia malayi Matrixin family protein 0.0162 0.0881 0.3381
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0329 0.1103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0113 0.0236
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0112 0.0112
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.006 0.023
Trypanosoma cruzi aldo-keto reductase 0.0439 0.2605 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0127 0.0663 0.1383
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0472 0.0986
Schistosoma mansoni thyroid hormone receptor 0.003 0.006 0.0125
Brugia malayi beta-lactamase family protein 0.0036 0.0098 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0098 0.0263
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.006 0.0125
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.05 0.2984 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0098 0.0263
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0127 0.0663 0.2544
Mycobacterium leprae Possible oxidoreductase 0.0127 0.0663 0.2221
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0182 0.0488
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0024 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0058
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.012 0.062 0.1666
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0475 0.1278
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.0056 0.022 0.0845
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0019 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0015 0.0058
Schistosoma mansoni cpg binding protein 0.0059 0.0236 0.0493
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0127 0.0663 0.2544
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.006 0.0125
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0098 0.0375
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.006 0.023
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0075 0.0339 0.0706
Loa Loa (eye worm) oxidoreductase 0.0439 0.2605 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.0051 0.0189 0.0724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.006 0.023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0173 0.0665
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.4143 0.4143
Mycobacterium tuberculosis Probable oxidoreductase 0.0439 0.2605 0.7006
Schistosoma mansoni hypothetical protein 0.0171 0.0939 0.1958
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0015 0.005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.02 0.061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.0064
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0604 0.126
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0019 0.0063
Mycobacterium leprae Conserved hypothetical protein 0.0312 0.1813 0.6076
Echinococcus granulosus peregrin 0.0029 0.0055 0.0114
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0064 0.0216
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2605 1
Onchocerca volvulus 0.0127 0.0663 0.2544
Onchocerca volvulus Bile acid receptor homolog 0.003 0.006 0.023
Leishmania major hypothetical protein, conserved 0.0036 0.0098 0.0375
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0198 0.1101 0.4226
Loa Loa (eye worm) oxidoreductase 0.0439 0.2605 1
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0024 0.0021 0.0044
Brugia malayi Thioredoxin reductase 0.0038 0.0109 0.0419
Echinococcus granulosus adam 0.0051 0.0189 0.0394
Schistosoma mansoni ryanodine receptor related 0.0075 0.0339 0.0706
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0049 0.0178 0.0684
Schistosoma mansoni thyroid hormone receptor 0.003 0.006 0.0125
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0076 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.006 0.0125
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0087 0.0291
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0375
Onchocerca volvulus 0.0439 0.2605 1
Entamoeba histolytica aldose reductase, putative 0.0439 0.2605 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0415 0.1115
Schistosoma mansoni hypothetical protein 0.079 0.4793 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0439 0.2605 1
Onchocerca volvulus 0.0023 0.0015 0.0058
Echinococcus granulosus tar DNA binding protein 0.0061 0.0252 0.0526
Brugia malayi ADAMTS-like protease 0.0055 0.0211 0.081
Brugia malayi MIR domain containing protein 0.0075 0.0339 0.13
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0252 0.0967
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0311 0.0836
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0049 0.0178 0.0684
Mycobacterium ulcerans lipase LipD 0.0036 0.0098 0.0263
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.059 0.3543 0.3543
Echinococcus granulosus aldo keto reductase 0.0439 0.2605 0.5436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.006 0.023
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0024 0.0021 0.0021
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0064 0.0247
Brugia malayi Matrixin family protein 0.0162 0.0881 0.3381
Plasmodium falciparum thioredoxin reductase 0.0038 0.0109 0.0366
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0098 0.0375
Brugia malayi Augmenter of liver regeneration 0.0035 0.0087 0.0334
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0087 0.0334
Onchocerca volvulus 0.0439 0.2605 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0415 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0087 0.0334
Trichomonas vaginalis mannosyltransferase 1, putative 0.0041 0.0127 0.0487
Onchocerca volvulus Papilin homolog 0.0056 0.0221 0.0848
Mycobacterium ulcerans malate dehydrogenase 0.0049 0.0178 0.0479
Loa Loa (eye worm) hypothetical protein 0.0075 0.0339 0.13
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0055 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0375
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0109 0.0366
Schistosoma mansoni nuclear hormone receptor 0.003 0.006 0.0125
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0049 0.0178 0.0684
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0049 0.0178 0.0684
Loa Loa (eye worm) hypothetical protein 0.0198 0.1101 0.4226
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0019 0.0051
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0618 0.3718 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0098 0.0327
Onchocerca volvulus 0.0036 0.0098 0.0375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.071 0.071
Loa Loa (eye worm) RNA binding protein 0.0061 0.0252 0.0967
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.006 0.0125
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0019 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0415 0.1115
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0353 0.2067 0.4313
Plasmodium falciparum phd finger protein, putative 0.0029 0.0055 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.006 0.023
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0024 0.0021 0.0044
Echinococcus multilocularis geminin 0.0171 0.0939 0.0939
Mycobacterium tuberculosis Probable reductase 0.0087 0.0415 0.1115
Leishmania major hypothetical protein, conserved 0.0035 0.0087 0.0334
Loa Loa (eye worm) hypothetical protein 0.0071 0.0311 0.1193
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0019 0.0063
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.05 0.2984 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0439 0.2605 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0173 0.0665
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.006 0.023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0055 0.0216 0.0831
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0019 0.0063
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0049 0.0178 0.0684
Onchocerca volvulus 0.0071 0.0311 0.1193
Brugia malayi NADH-dependent xylose reductase 0.0127 0.0663 0.2544
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0053 0.02 0.0766
Mycobacterium leprae Conserved membrane protein 0.0041 0.0127 0.0425
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0311 0.1042
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.071 0.1482
Trypanosoma brucei prostaglandin f synthase 0.0439 0.2605 1
Echinococcus granulosus aldo keto reductase 0.0439 0.2605 0.5436
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0098 0.0375
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0098 0.0263
Schistosoma mansoni hypothetical protein 0.0171 0.0939 0.1958
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0252 0.0967
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0329 0.1263
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0439 0.2605 1
Trypanosoma brucei trypanothione reductase 0.0038 0.0109 0.0419
Loa Loa (eye worm) beta-lactamase 0.0036 0.0098 0.0375
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.006 0.0125
Brugia malayi Matrixin family protein 0.0162 0.0881 0.3381
Loa Loa (eye worm) hypothetical protein 0.0053 0.02 0.0766
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2605 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0098 0.0204
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0311 0.0836
Loa Loa (eye worm) hypothetical protein 0.0162 0.0881 0.3381
Loa Loa (eye worm) metalloprotease 0.0024 0.0021 0.0081
Onchocerca volvulus 0.0162 0.0881 0.3381
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0098 0.0204
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0311 0.1193
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0049 0.0178 0.0479
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0349 0.0728
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0311 0.0836
Trichomonas vaginalis mannosyltransferase 1, putative 0.0206 0.1152 0.4421
Brugia malayi Hemopexin family protein 0.023 0.1303 0.5001
Loa Loa (eye worm) MIR domain-containing protein 0.0075 0.0339 0.13
Onchocerca volvulus 0.0439 0.2605 1
Toxoplasma gondii aldose reductase, putative 0.0439 0.2605 0.873
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0055 0.0114
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0439 0.2605 1
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0109 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Schistosoma mansoni pol-related 0.0439 0.2605 0.5436
Onchocerca volvulus 0.0439 0.2605 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.025 0.096
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Mycobacterium ulcerans hypothetical protein 0.0071 0.0311 0.0836
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0439 0.2605 0.873
Echinococcus multilocularis adam 0.0051 0.0189 0.0189
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0087 0.0181
Brugia malayi jmjC domain containing protein 0.0039 0.0113 0.0433
Loa Loa (eye worm) glutathione reductase 0.0038 0.0109 0.0419
Schistosoma mansoni hypothetical protein 0.0056 0.022 0.0459
Loa Loa (eye worm) hypothetical protein 0.0056 0.0221 0.0848
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0074 0.0334 0.0334
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0247
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.022 0.0845
Mycobacterium ulcerans oxidoreductase 0.0439 0.2605 0.7006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0055 0.0183
Brugia malayi hypothetical protein 0.0047 0.0167 0.064
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.022 0.0459
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.006 0.023
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0087 0.0291
Plasmodium falciparum aldo-keto reductase, putative 0.0127 0.0663 0.2221
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0475 0.1592
Plasmodium vivax aldehyde reductase, putative 0.0127 0.0663 0.2221
Mycobacterium ulcerans hypothetical protein 0.0036 0.0098 0.0263
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0182 0.0488
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0074 0.0334 0.0697
Plasmodium falciparum glutathione reductase 0.0038 0.0109 0.0366
Schistosoma mansoni hypothetical protein 0.0033 0.0076 0.0159
Onchocerca volvulus 0.0025 0.0024 0.0093
Mycobacterium leprae Probable lipase LipE 0.0036 0.0098 0.0327
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0311 0.0836
Schistosoma mansoni malate dehydrogenase 0.0049 0.0178 0.0372
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0098 0.0375
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0098 0.0263
Loa Loa (eye worm) hypothetical protein 0.0071 0.0311 0.1193
Trypanosoma brucei RNA helicase, putative 0.0108 0.0544 0.2087
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0663 0.2544
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.006 0.0125
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0311 0.1042
Onchocerca volvulus 0.023 0.1303 0.5001
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0109 0.0419
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0055 0.0209
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Schistosoma mansoni hypothetical protein 0.0029 0.0055 0.0114
Toxoplasma gondii ABC1 family protein 0.0036 0.0098 0.0327
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Schistosoma mansoni potassium channel beta 0.0127 0.0663 0.1383
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0127 0.0663 0.2221
Loa Loa (eye worm) hypothetical protein 0.0033 0.0078 0.0298
Schistosoma mansoni cpg binding protein 0.0055 0.0216 0.0452
Onchocerca volvulus Alhambra homolog 0.0029 0.0055 0.0209
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0415 0.1389
Brugia malayi beta-lactamase family protein 0.0036 0.0098 0.0375
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0182 0.0488
Loa Loa (eye worm) hypothetical protein 0.0074 0.0329 0.1263
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0015 0.0031
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0098 0.0327
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0439 0.2605 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0039 0.0112 0.043
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0049 0.0178 0.0178
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.02 0.0669
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0112 0.0234
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0113 0.0236
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0127 0.0663 0.2221
Brugia malayi Reprolysin 0.0024 0.0021 0.0081
Echinococcus granulosus FTZ F1 alpha 0.003 0.006 0.0125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.071 0.2726
Onchocerca volvulus 0.0036 0.0098 0.0375
Echinococcus multilocularis cpg binding protein 0.0059 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0031
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2605 1
Onchocerca volvulus 0.0439 0.2605 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0472 0.0472
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0098 0.0263
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0049 0.0178 0.0597
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0015 0.005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.006 0.0125
Echinococcus granulosus dnaJ subfamily B 0.079 0.4793 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.006 0.0125
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0113 0.0236
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0375
Trypanosoma brucei aldo/keto reductase, putative 0.0127 0.0663 0.2544
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0064 0.0064
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0075 0.0339 0.13
Trichomonas vaginalis mannosyltransferase, putative 0.0041 0.0127 0.0487
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0162 0.0881 0.1838
Trichomonas vaginalis mannosyltransferase 1, putative 0.0041 0.0127 0.0487
Loa Loa (eye worm) hypothetical protein 0.0053 0.02 0.0766
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0311 0.0836
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0252 0.0526
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0353 0.2067 0.7935
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0064 0.0135
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0055 0.0055
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0074 0.0334 0.0697
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0252 0.0252
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.0526 0.1761
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0247
Mycobacterium leprae PROBABLE HYDROLASE 0.0198 0.1101 0.3689
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0098 0.0263
Loa Loa (eye worm) hypothetical protein 0.0075 0.0339 0.13
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.006 0.0125
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.02 0.0537
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.006 0.006
Echinococcus granulosus ryanodine receptor 44f 0.0075 0.0339 0.0706
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.4143 0.8644
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.006 0.0125
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0311 0.1193
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.0663 0.2544
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.006 0.023
Echinococcus multilocularis aldehyde reductase 0.0312 0.1813 0.1813
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0329 0.1263
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0127 0.0663 0.2544
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0087 0.0334
Chlamydia trachomatis malate dehydrogenase 0.0049 0.0178 0.0538
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.071 0.2726
Brugia malayi CXXC zinc finger family protein 0.0055 0.0216 0.0831
Loa Loa (eye worm) hypothetical protein 0.0084 0.0397 0.1524
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0311 0.1193
Entamoeba histolytica aldose reductase, putative 0.0439 0.2605 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0055 0.0183
Echinococcus multilocularis aldo keto reductase 0.0439 0.2605 0.2605
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.0663 0.2544
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0098 0.0263
Echinococcus multilocularis aldo keto reductase 0.0439 0.2605 0.2605
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.05 0.2984 1
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0618 0.3718 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Loa Loa (eye worm) hypothetical protein 0.0178 0.098 0.3761
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2605 1
Onchocerca volvulus Matrilysin homolog 0.036 0.2111 0.8102
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0049 0.0178 0.0684
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.006 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Schistosoma mansoni cpg binding protein 0.0059 0.0236 0.0493
Toxoplasma gondii aldo-keto reductase 0.0127 0.0663 0.2221
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0064 0.0247
Brugia malayi hypothetical protein 0.0074 0.0329 0.1263
Trypanosoma brucei aldo-keto reductase, putative 0.0439 0.2605 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0397 0.1524
Schistosoma mansoni apoptosis regulator bax 0.0056 0.022 0.0459
Echinococcus multilocularis dnaJ subfamily B 0.079 0.4793 0.4793
Echinococcus granulosus hypothetical protein 0.0439 0.2605 0.5436
Loa Loa (eye worm) hypothetical protein 0.0049 0.0173 0.0665
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0098 0.0204
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0064 0.0216
Loa Loa (eye worm) oxidoreductase 0.0439 0.2605 1
Brugia malayi Protein kinase domain containing protein 0.0023 0.0015 0.0058
Brugia malayi TAR-binding protein 0.0061 0.0252 0.0967
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0311 0.0836
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0075 0.0339 0.0706
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.05 0.2984 0.8025
Echinococcus granulosus cytosolic malate dehydrogenase 0.0049 0.0178 0.0372
Echinococcus granulosus stromal cell derived factor 2 0.0075 0.0339 0.0706
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0127 0.0663 0.2221
Schistosoma mansoni hypothetical protein 0.0056 0.022 0.0459
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.006 0.023
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0098 0.0375
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0098 0.0263
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0311 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.006 0.023
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.05 0.2984 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0098 0.0263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0311 0.1193
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.05 0.2984 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0353 0.2067 0.2067
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0049 0.0178 0.0178
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0081
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.022 0.0845
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0051 0.0189 0.0394
Loa Loa (eye worm) matrixin family protein 0.0392 0.2313 0.8878
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.006 0.023
Trichomonas vaginalis mannosyltransferase 1, putative 0.0206 0.1152 0.4421
Echinococcus granulosus cpg binding protein 0.0059 0.0236 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.006 0.023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.0075 0.0339 0.13
Echinococcus multilocularis peregrin 0.0029 0.0055 0.0055
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0415 0.1115
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Schistosoma mansoni coup transcription factor 0.003 0.006 0.0125
Onchocerca volvulus 0.003 0.006 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.006 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0252 0.0526
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0252 0.0967
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Echinococcus granulosus cytosolic malate dehydrogenase 0.0049 0.0178 0.0372
Trichomonas vaginalis mannosyltransferase 1, putative 0.0041 0.0127 0.0487
Brugia malayi PHD-finger family protein 0.0029 0.0055 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.006 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0182 0.0488
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0098 0.0375
Schistosoma mansoni aldo-keto reductase 0.0439 0.2605 0.5436
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0064 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0064 0.0064
Brugia malayi Kringle domain containing protein 0.0023 0.0015 0.0058
Brugia malayi cation channel family protein 0.0075 0.0339 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Trypanosoma cruzi aldo/keto reductase, putative 0.0439 0.2605 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0353 0.2067 0.7935
Loa Loa (eye worm) oxidoreductase 0.0439 0.2605 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0113 0.0433
Echinococcus granulosus aldo keto reductase 0.0439 0.2605 0.5436
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.006 0.023
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0019 0.0063
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0019 0.0051
Mycobacterium ulcerans hypothetical protein 0.0041 0.0127 0.0341
Leishmania major hypothetical protein, conserved 0.0023 0.0015 0.0058
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0126 0.0264
Echinococcus granulosus microtubule associated protein 2 0.0686 0.4143 0.8644
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.006 0.0125
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0064 0.0216
Mycobacterium tuberculosis Conserved protein 0.0036 0.0098 0.0263
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0703 0.4246 0.8859
Echinococcus multilocularis ryanodine receptor 44f 0.0075 0.0339 0.0339
Trichomonas vaginalis mannosyltransferase 1, putative 0.0206 0.1152 0.4421
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0049 0.0178 0.0684
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.132 0.3551
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Giardia lamblia Aldose reductase 0.0439 0.2605 1
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0015 0.0015
Mycobacterium ulcerans beta-lactamase 0.0036 0.0098 0.0263
Loa Loa (eye worm) reprolysin 0.0024 0.0021 0.0081
Brugia malayi isocitrate dehydrogenase 0.0031 0.0064 0.0247
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0098 0.0375
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0353 0.2067 0.4313
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0252 0.0526
Schistosoma mansoni aldo-keto reductase 0.0439 0.2605 0.5436
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0098 0.0098
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Mycobacterium ulcerans hypothetical protein 0.0127 0.0663 0.1783
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0209
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0064 0.0247
Giardia lamblia Aldose reductase 0.0439 0.2605 1
Entamoeba histolytica malate dehydrogenase, putative 0.0049 0.0178 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Schistosoma mansoni hypothetical protein 0.0056 0.022 0.0459
Loa Loa (eye worm) hypothetical protein 0.0439 0.2605 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.02 0.0537
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0098 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.006 0.023
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0055 0.0114
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0019 0.0072
Loa Loa (eye worm) malate dehydrogenase 0.0049 0.0178 0.0684
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.006 0.0125
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0397 0.0828
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.006 0.006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.006 0.0125
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.05 0.2984 1
Echinococcus multilocularis FTZ F1 alpha 0.003 0.006 0.006
Plasmodium vivax glutathione reductase, putative 0.0038 0.0109 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.006 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0057
Loa Loa (eye worm) hypothetical protein 0.0162 0.0881 0.3381
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0439 0.2605 1
Leishmania major aldo-keto reductase-like protein 0.0439 0.2605 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0252 0.0526
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0252 0.0526
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0015 0.0058
Trichomonas vaginalis esterase, putative 0.0036 0.0098 0.0375
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.006 0.0125
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0087 0.0334
Brugia malayi Bromodomain containing protein 0.0029 0.0055 0.0209
Trichomonas vaginalis aldo/keto reductase, putative 0.0439 0.2605 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0311 0.1193
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0126 0.0126
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0093 0.0093
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0087 0.0291
Trichomonas vaginalis mannosyltransferase 1, putative 0.0041 0.0127 0.0487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.071 0.1482
Onchocerca volvulus 0.0084 0.0397 0.1524
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0064 0.0247
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0475 0.1278
Brugia malayi Matrixin family protein 0.0162 0.0881 0.3381
Entamoeba histolytica MIR domain protein 0.0075 0.0339 0.13
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0024 0.0021 0.0044
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Onchocerca volvulus 0.0055 0.0216 0.0831
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Leishmania major cytosolic malate dehydrogenase 0.0049 0.0178 0.0684
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0311 0.1193
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.059 0.3543 0.7392
Trichomonas vaginalis malate dehydrogenase, putative 0.0049 0.0178 0.0684
Plasmodium falciparum aldehyde reductase, putative 0.0127 0.0663 0.2221
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0098 0.0375
Echinococcus multilocularis aldo keto reductase 0.0439 0.2605 0.2605
Onchocerca volvulus Matrilysin homolog 0.0162 0.0881 0.3381
Brugia malayi angiogenesis inhibito 0.0055 0.0211 0.081
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0311 0.1193
Schistosoma mansoni hypothetical protein 0.023 0.1303 0.2718
Brugia malayi hypothetical protein 0.0051 0.0189 0.0724
Brugia malayi jmjC domain containing protein 0.0097 0.0472 0.1814
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0049 0.0178 0.0684
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2605 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Trichomonas vaginalis mannosyltransferase 1, putative 0.0075 0.0339 0.13
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0329 0.1103
Mycobacterium tuberculosis Conserved protein 0.0127 0.0663 0.1783
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.022 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.071 0.1482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.006 0.023
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0127 0.0663 0.2544
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0311 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0015 0.0057
Onchocerca volvulus Matrix metalloproteinase homolog 0.036 0.2111 0.8102
Loa Loa (eye worm) angiogenesis inhibito 0.0028 0.0043 0.0166
Echinococcus multilocularis voltage gated potassium channel subunit 0.0127 0.0663 0.0663
Echinococcus multilocularis aldo keto reductase 0.0439 0.2605 0.2605
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0017 0.0035
Loa Loa (eye worm) hypothetical protein 0.0053 0.02 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.1152 0.4421
Loa Loa (eye worm) hypothetical protein 0.0051 0.0186 0.0713
Echinococcus granulosus aldehyde reductase 0.0312 0.1813 0.3783
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0087 0.0334
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0311 0.0836
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0703 0.4246 0.4246
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2605 0.2605
Mycobacterium tuberculosis Conserved protein 0.0036 0.0098 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0098 0.0375
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0036 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Leishmania major trypanothione reductase 0.0038 0.0109 0.0419
Onchocerca volvulus 0.0075 0.0339 0.13
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.05 0.2984 1
Loa Loa (eye worm) matrix metalloproteinase 0.0162 0.0881 0.3381
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.023
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.006 0.023
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2605 0.5436
Loa Loa (eye worm) hypothetical protein 0.0162 0.0881 0.3381
Entamoeba histolytica aldose reductase, putative 0.0439 0.2605 1
Brugia malayi Steroid receptor seven-up type 2 0.003 0.006 0.023
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0127 0.0663 0.1383
Brugia malayi ecdysteroid receptor 0.003 0.006 0.023
Onchocerca volvulus 0.0036 0.0098 0.0375
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.0663 0.2544
Loa Loa (eye worm) steroid hormone receptor 0.003 0.006 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0127 0.0487
Brugia malayi nuclear receptor NHR-88 0.003 0.006 0.023
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0098 0.0375
Giardia lamblia Malate dehydrogenase 0.0049 0.0178 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.006 0.023
Loa Loa (eye worm) hypothetical protein 0.0053 0.02 0.0766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.071 0.1482

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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