TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.82 | Formula: C22H15ClN2O
H donors: 0 H acceptors: 1 LogP: 5.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C=CC=Nc1ccc(cc1)c1nc2c(o1)cccc2
InChi: 1S/C22H15ClN2O/c23-18-11-7-16(8-12-18)4-3-15-24-19-13-9-17(10-14-19)22-25-20-5-1-2-6-21(20)26-22/h1-15H/b4-3+,24-15+
InChiKey: NQOHDOHWSPMJNJ-LPFIIVPBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.191	0.1887
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0125	0.0085
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Echinococcus granulosus	5'partial\|Low density lipoprotein receptor class A cysteine rich	0.0131	0.077	0.0734
Echinococcus granulosus	Low density lipoprotein receptor class A cysteine rich	0.0131	0.077	0.0734
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0052	0.0201	0.0168
Brugia malayi	Trypsin family protein	0.0323	0.2169	0.2143
Loa Loa (eye worm)	TK/ROR protein kinase	0.14	1	1
Schistosoma mansoni	egf-like domain protein	0.024	0.1562	0.1549
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Giardia lamblia	GTOR	0.0052	0.0201	0.3606
Schistosoma mansoni	hypothetical protein	0.0323	0.2169	0.2158
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0145	0.0665
Echinococcus multilocularis	Mastin	0.0323	0.2169	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Schistosoma mansoni	hypothetical protein	0.011	0.0617	0.06
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.191	0.1887
Loa Loa (eye worm)	DOMON domain-containing protein	0.0717	0.5035	0.5019
Onchocerca volvulus		0.0287	0.191	0.1855
Loa Loa (eye worm)	DPY-31 protein	0.011	0.0617	0.0586
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0287	0.191	0.1887
Schistosoma mansoni	hypothetical protein	0.011	0.0617	0.06
Brugia malayi	Delta serrate ligand family protein	0.0091	0.0485	0.0453
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Mycobacterium tuberculosis	Probable dehydrogenase	0.0126	0.0734	0.8342
Brugia malayi	CUB domain containing protein	0.011	0.0617	0.0586
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Trypanosoma brucei	trypanothione reductase	0.0055	0.0221	0.3574
Brugia malayi	Pre-SET motif family protein	0.0243	0.1584	0.1556
Brugia malayi	glutathione reductase	0.0055	0.0221	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0617	0.3285
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Schistosoma mansoni	hypothetical protein	0.0131	0.077	0.0753
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.191	0.1887
Plasmodium falciparum	flap endonuclease 1	0.003	0.0041	0.0007
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Onchocerca volvulus		0.0287	0.191	0.1855
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Onchocerca volvulus		0.0091	0.0485	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.011	0.0617	0.0587
Brugia malayi	CUB domain containing protein	0.011	0.0617	0.0586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0047	0.0123
Brugia malayi	Lectin C-type domain containing protein	0.011	0.0617	0.0586
Brugia malayi	Trypsin-like protease protein 5	0.0323	0.2169	0.2143
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Onchocerca volvulus		0.0131	0.077	0.0703
Brugia malayi	Kringle domain containing protein	0.1397	0.9978	0.9978
Schistosoma mansoni	hypothetical protein	0.0323	0.2169	0.2158
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Echinococcus granulosus	tyrosine protein kinase shark	0.0464	0.3195	0.3174
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.191	0.1887
Schistosoma mansoni	notch	0.0091	0.0485	0.0467
Brugia malayi	Low-density lipoprotein receptor-related protein, putative	0.0131	0.077	0.0739
Schistosoma mansoni	notch	0.0091	0.0485	0.0467
Loa Loa (eye worm)	lectin C-type domain-containing protein	0.011	0.0617	0.0586
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.014	0.0836	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Trypanosoma cruzi	target of rapamycin kinase 3	0.0042	0.0123	0.009
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Toxoplasma gondii	subtilisin SUB12	0.0287	0.191	0.1887
Echinococcus granulosus	enteropeptidase	0.0323	0.2169	0.2142
Loa Loa (eye worm)	zinc metalloproteinase toh-2	0.011	0.0617	0.0586
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0349	0.236	0.2334
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Echinococcus multilocularis	CUB	0.011	0.0617	0.058
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0131	0.077	0.0734
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0073	0.0054
Loa Loa (eye worm)	notch protein	0.0091	0.0485	0.0453
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0323	0.2169	0.2158
Onchocerca volvulus		0.0717	0.5035	0.501
Echinococcus multilocularis	laminin	0.024	0.1562	0.1531
Brugia malayi	Calcium binding EGF domain containing protein	0.0091	0.0485	0.0453
Echinococcus granulosus	transmembrane protease serine 3	0.0323	0.2169	0.2142
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0131	0.077	0.0753
Echinococcus multilocularis	neurogenic locus notch protein	0.0091	0.0485	0.0447
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Echinococcus granulosus	Mastin	0.0323	0.2169	0.2142
Schistosoma mansoni	hypothetical protein	0.1397	0.9978	1
Brugia malayi	SEA domain containing protein	0.0717	0.5035	0.5019
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0323	0.2169	0.2142
Brugia malayi	enteropeptidase precursor	0.0131	0.077	0.0739
Loa Loa (eye worm)	PAN domain-containing protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	flap endonuclease-1	0.003	0.0041	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0045	0.0111
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0131	0.077	0.0734
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0131	0.077	0.0734
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0201	0.0974
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0201	0.0974
Onchocerca volvulus		0.0323	0.2169	0.2116
Echinococcus multilocularis	fibropellin Ia	0.0091	0.0485	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Echinococcus granulosus	low density lipoprotein receptor protein	0.0131	0.077	0.0734
Onchocerca volvulus		0.0131	0.077	0.0703
Echinococcus multilocularis	Tolloid protein 1	0.0349	0.236	0.2334
Schistosoma mansoni	notch	0.0091	0.0485	0.0467
Onchocerca volvulus		0.011	0.0617	0.055
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0131	0.077	0.0734
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.191	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Brugia malayi	Calcium binding EGF domain containing protein	0.0091	0.0485	0.0453
Entamoeba histolytica	hypothetical protein	0.0042	0.0125	0.5257
Echinococcus granulosus	protein jagged 2	0.0091	0.0485	0.0447
Trypanosoma cruzi	trypanothione reductase, putative	0.0055	0.0221	0.0188
Loa Loa (eye worm)	glutathione reductase	0.0055	0.0221	0.0188
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0287	0.191	0.1887
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.003	0.0041	0.0007
Echinococcus granulosus	Tolloid protein 1	0.0349	0.236	0.2334
Onchocerca volvulus		0.0717	0.5035	0.501
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Brugia malayi	astacin protease protein 30	0.011	0.0617	0.0586
Brugia malayi	CUB domain containing protein	0.011	0.0617	0.0586
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0323	0.2169	0.2158
Onchocerca volvulus		0.0131	0.077	0.0703
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0131	0.077	0.0734
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0323	0.2169	0.2142
Toxoplasma gondii	kringle domain-containing protein	0.1397	0.9978	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Echinococcus multilocularis	neural cadherin	0.0091	0.0485	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Onchocerca volvulus		0.1397	0.9978	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0123	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0126	0.0734	0.8342
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0125	0.0106
Schistosoma mansoni	cell polarity protein	0.0091	0.0485	0.0467
Schistosoma mansoni	hypothetical protein	0.0042	0.0125	0.0106
Onchocerca volvulus		0.011	0.0617	0.055
Onchocerca volvulus		0.0809	0.57	0.5681
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Onchocerca volvulus		0.0131	0.077	0.0703
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Schistosoma mansoni	notch	0.0091	0.0485	0.0467
Onchocerca volvulus		0.0717	0.5035	0.501
Loa Loa (eye worm)	PAN domain-containing protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0323	0.2169	0.2142
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Loa Loa (eye worm)	calcium binding EGF domain-containing protein	0.0131	0.077	0.0739
Echinococcus granulosus	notch	0.0091	0.0485	0.0447
Brugia malayi	Nematode astacin protease protein 30	0.011	0.0617	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Brugia malayi	Cadherin domain containing protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0809	0.57	0.5686
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.003	0.0041	0.0007
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Schistosoma mansoni	hypothetical protein	0.011	0.0617	0.06
Toxoplasma gondii	microneme protein MIC17C	0.0287	0.191	0.1887
Onchocerca volvulus		0.0287	0.191	0.1855
Toxoplasma gondii	hypothetical protein	0.0287	0.191	0.1887
Onchocerca volvulus		0.0287	0.191	0.1855
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0073	0.0032
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Echinococcus multilocularis	protein jagged 1	0.0091	0.0485	0.0447
Brugia malayi	hypothetical protein	0.0142	0.0852	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0039	0.0103	0.007
Onchocerca volvulus		0.0287	0.191	0.1855
Onchocerca volvulus	Slit protein homolog	0.0091	0.0485	0.0416
Brugia malayi	basement membrane proteoglycan precursor	0.0131	0.077	0.0739
Onchocerca volvulus		0.0131	0.077	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Schistosoma mansoni	notch	0.0091	0.0485	0.0467
Echinococcus multilocularis	enteropeptidase	0.0323	0.2169	0.2142
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0131	0.077	0.0703
Entamoeba histolytica	hypothetical protein	0.0042	0.0125	0.5257
Echinococcus multilocularis	neurogenic locus protein delta	0.0091	0.0485	0.0447
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.0221	0.0181
Loa Loa (eye worm)	hypothetical protein	0.037	0.2512	0.2487
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0323	0.2169	0.2158
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.011	0.0617	0.0587
Echinococcus multilocularis	notch	0.0091	0.0485	0.0447
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0052	0.0201	0.3252
Mycobacterium tuberculosis	Probable reductase	0.0126	0.0734	0.8342
Echinococcus multilocularis	tissue type plasminogen activator	0.1397	0.9978	1
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0131	0.077	0.0734
Echinococcus granulosus	delta-like protein 1	0.0091	0.0485	0.0447
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.037	0.2512	0.2487
Schistosoma mansoni	hypothetical protein	0.011	0.0617	0.06
Giardia lamblia	High cysteine protein	0.0091	0.0485	1
Brugia malayi	Thioredoxin reductase	0.0055	0.0221	0.0188
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Echinococcus multilocularis	protein jagged 1	0.0091	0.0485	0.0447
Brugia malayi	hypothetical protein	0.011	0.0617	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Toxoplasma gondii	microneme protein MIC17A	0.0287	0.191	0.1887
Onchocerca volvulus		0.0323	0.2169	0.2116
Brugia malayi	Calcium binding EGF domain containing protein	0.024	0.1562	0.1534
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Echinococcus multilocularis	low density lipoprotein receptor protein	0.0131	0.077	0.0734
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Echinococcus multilocularis	neurogenic locus notch protein	0.0091	0.0485	0.0447
Entamoeba histolytica	hypothetical protein	0.0042	0.0125	0.5257
Echinococcus granulosus	tissue type plasminogen activator	0.1397	0.9978	1
Onchocerca volvulus	Arrow homolog	0.037	0.2512	0.2463
Leishmania major	trypanothione reductase	0.0055	0.0221	0.0188
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.0221	0.0188
Toxoplasma gondii	microneme protein MIC17B	0.0287	0.191	0.1887
Plasmodium falciparum	glutathione reductase	0.0055	0.0221	0.0188
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0131	0.077	0.0753
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0123	0.0542
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0034	0.0543
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0091	0.0485	0.0447
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0052	0.0201	0.0168
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0323	0.2169	0.2142
Echinococcus granulosus	protein jagged 1	0.0091	0.0485	0.0447
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Onchocerca volvulus		0.0091	0.0485	0.0416
Plasmodium falciparum	cysteine repeat modular protein 1	0.1397	0.9978	1
Onchocerca volvulus		0.0287	0.191	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0073	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0123	0.0542
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0073	0.0054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0045	0.0111
Trypanosoma cruzi	hypothetical protein, conserved	0.1397	0.9978	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0131	0.077	0.0739
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0126	0.0734	0.8342
Plasmodium falciparum	thioredoxin reductase	0.0055	0.0221	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Leishmania major	hypothetical protein, conserved	0.1397	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0042	0.0123	0.1995
Loa Loa (eye worm)	hypothetical protein	0.037	0.2509	0.2484
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0073	0.0054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Loa Loa (eye worm)	hypothetical protein	0.024	0.1562	0.1534
Brugia malayi	Kelch motif family protein	0.011	0.0617	0.0586
Echinococcus granulosus	slit 2 protein	0.0091	0.0485	0.0447
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0091	0.0485	0.0453
Onchocerca volvulus		0.0287	0.191	0.1855
Plasmodium vivax	flap endonuclease 1, putative	0.003	0.0041	0.0007
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0323	0.2169	0.2158
Onchocerca volvulus		0.0717	0.5035	0.501
Toxoplasma gondii	microneme protein, putative	0.0287	0.191	0.1887
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	trypsin family protein	0.0323	0.2169	0.2143
Echinococcus granulosus	protein jagged 1	0.0091	0.0485	0.0447
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Plasmodium vivax	glutathione reductase, putative	0.0055	0.0221	0.0188
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0563	0.3916	0.3913
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Onchocerca volvulus		0.0131	0.077	0.0703
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0026	0.0002
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0131	0.077	0.0734
Echinococcus multilocularis	protein jagged 2	0.0091	0.0485	0.0447
Toxoplasma gondii	hypothetical protein	0.0287	0.191	0.1887
Schistosoma mansoni	hypothetical protein	0.0717	0.5035	0.5037
Onchocerca volvulus		0.0287	0.191	0.1855
Echinococcus multilocularis	transmembrane protease serine 3	0.0323	0.2169	0.2142
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.003	0.0041	0.0658
Brugia malayi	notch-like transmembrane receptor	0.0091	0.0485	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0201	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Echinococcus granulosus	fibropellin Ia	0.0091	0.0485	0.0447
Brugia malayi	Nematode astacin protease protein 30	0.011	0.0617	0.0586
Onchocerca volvulus	Terribly reduced optic lobes homolog	0.0131	0.077	0.0703
Toxoplasma gondii	calcium binding egf domain-containing protein	0.024	0.1562	0.1537
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0091	0.0485	0.0416
Plasmodium vivax	SET domain protein, putative	0.0035	0.0073	0.004
Loa Loa (eye worm)	hypothetical protein	0.0349	0.236	0.2334
Echinococcus granulosus	neurogenic locus notch protein	0.0091	0.0485	0.0447
Onchocerca volvulus		0.0323	0.2169	0.2116
Brugia malayi	CUB domain containing protein	0.024	0.1567	0.1539
Brugia malayi	Muscle positioning protein 4	0.0809	0.57	0.5686
Echinococcus multilocularis	cubilin	0.011	0.0617	0.058
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Echinococcus multilocularis	slit 2 protein	0.0091	0.0485	0.0447
Loa Loa (eye worm)	hypothetical protein	0.048	0.331	0.3287
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Schistosoma mansoni	tyrosine kinase	0.0464	0.3195	0.3189
Brugia malayi	Zinc metalloproteinase toh-2 precursor	0.011	0.0617	0.0586
Echinococcus multilocularis	neuropilin (nrp) and tolloid (tll)	0.011	0.0617	0.058
Onchocerca volvulus		0.0323	0.2169	0.2116
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0052	0.0201	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0047	0.0123
Loa Loa (eye worm)	PAN domain-containing protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	hypothetical protein	0.024	0.1562	0.1534
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Brugia malayi	Flap endonuclease-1	0.003	0.0041	0.0007
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Echinococcus granulosus	cubilin	0.011	0.0617	0.058
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.024	0.1562	0.1534
Onchocerca volvulus		0.0287	0.191	0.1855
Schistosoma mansoni	tyrosine kinase	0.0454	0.3118	0.3111
Trichomonas vaginalis	flap endonuclease-1, putative	0.003	0.0041	0.0085
Brugia malayi	GCC2 and GCC3 family protein	0.0091	0.0485	0.0453
Schistosoma mansoni	neuropilin (nrp) and tolloid (tll)-like	0.011	0.0617	0.06
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0323	0.2169	0.2158
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0073	0.0054
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0052	0.0201	0.0182
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.003	0.0041	0.0007
Brugia malayi	Suppressor of lurcher protein 1 precursor	0.011	0.0617	0.0586
Trichomonas vaginalis	set domain proteins, putative	0.0276	0.1828	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0126	0.0734	0.8342
Brugia malayi	zinc metalloproteinase toh-2 precursor	0.011	0.0617	0.0586
Echinococcus multilocularis	neurogenic locus protein delta	0.0091	0.0485	0.0447
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0323	0.2169	0.2158
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0131	0.077	0.0734
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0131	0.077	0.0753
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0067	0.0233
Loa Loa (eye worm)	hypothetical protein	0.024	0.1567	0.1539
Toxoplasma gondii	thioredoxin reductase	0.0055	0.0221	0.0188
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0131	0.077	0.0734
Brugia malayi	Trypsin family protein	0.0323	0.2169	0.2143
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0042	0.0123	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0026	0.0002
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0243	0.1584	0.1556
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0052	0.0201	0.3252
Onchocerca volvulus		0.0287	0.191	0.1855
Schistosoma mansoni	neuropilin (nrp) and tolloid (tll)-like	0.011	0.0617	0.06
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.037	0.2512	0.2487
Echinococcus granulosus	neurogenic locus notch protein	0.0091	0.0485	0.0447
Echinococcus multilocularis	glycoprotein Antigen 5	0.0323	0.2169	0.2142
Loa Loa (eye worm)	hypothetical protein	0.1397	0.9978	0.9978
Schistosoma mansoni	hypothetical protein	0.011	0.0617	0.06
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0323	0.2169	0.2143
Schistosoma mansoni	slit	0.0091	0.0485	0.0467
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0126	0.0734	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Toxoplasma gondii	microneme protein MIC4	0.0287	0.191	0.1887
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0349	0.236	0.235
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0717	0.5035	0.5019
Onchocerca volvulus		0.0323	0.2169	0.2116
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	CUB domain-containing protein	0.011	0.0617	0.0586
Brugia malayi	Trypsin family protein	0.0323	0.2169	0.2143
Brugia malayi	hypothetical protein	0.0323	0.2169	0.2143
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Schistosoma mansoni	notch	0.0091	0.0485	0.0467
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0052	0.0201	0.0168
Loa Loa (eye worm)	phosphatidylinositol 3	0.0052	0.0201	0.0168
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Schistosoma mansoni	hypothetical protein	0.0131	0.077	0.0753
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Schistosoma mansoni	cercarial elastase (S01 family)	0.0323	0.2169	0.2158
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0091	0.0485	0.0467
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.011	0.0617	1
Brugia malayi	Cadherin domain containing protein	0.0091	0.0485	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0026	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0073	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0323	0.2169	0.2143
Echinococcus granulosus	laminin	0.024	0.1562	0.1531
Loa Loa (eye worm)	CUB domain-containing protein	0.011	0.0617	0.0586
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0131	0.077	0.0734
Schistosoma mansoni	laminin gamma-3 chain	0.0091	0.0485	0.0467
Toxoplasma gondii	calcium binding egf domain-containing protein	0.024	0.1562	0.1537
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Schistosoma mansoni	hypothetical protein	0.0091	0.0485	0.0467
Loa Loa (eye worm)	hypothetical protein	0.011	0.0617	0.0586
Entamoeba histolytica	hypothetical protein	0.0042	0.0125	0.5257
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0287	0.191	0.1883
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Echinococcus granulosus	neuropilin nrp and tolloid tll	0.011	0.0617	0.058
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0052	0.0201	0.0161
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Brugia malayi	Trypsin family protein	0.0323	0.2169	0.2143
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0064	0.0023
Onchocerca volvulus		0.011	0.0617	0.055
Echinococcus granulosus	neurogenic locus notch protein 4	0.0091	0.0485	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0026	0.0002
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0131	0.077	0.0734
Onchocerca volvulus		0.011	0.0617	0.055
Loa Loa (eye worm)	hypothetical protein	0.0201	0.1282	0.1253
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0091	0.0485	0.0447
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0073	0.0032
Echinococcus granulosus	CUB	0.011	0.0617	0.058
Onchocerca volvulus		0.0287	0.191	0.1855
Brugia malayi	Calcium binding EGF domain containing protein	0.0201	0.1282	0.1253
Onchocerca volvulus	Putative cubilin	0.0201	0.1282	0.1221
Echinococcus multilocularis	cubilin	0.011	0.0617	0.058
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0052	0.0201	0.0161
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0073	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0433	0.2966	0.2959
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.0221	0.0188
Echinococcus granulosus	neural cadherin	0.0091	0.0485	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Echinococcus granulosus	cubilin	0.011	0.0617	0.058
Brugia malayi	CUB domain containing protein	0.011	0.0617	0.0586
Brugia malayi	hypothetical protein	0.0042	0.0125	0.0092
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.1397	0.9978	1
Echinococcus granulosus	glycoprotein Antigen 5	0.0323	0.2169	0.2142
Echinococcus granulosus	protein jagged 2	0.0091	0.0485	0.0447
Brugia malayi	Pre-SET motif family protein	0.0035	0.0073	0.004
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0131	0.077	0.0739
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.011	0.0617	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0125	0.0085
Toxoplasma gondii	EGF family domain-containing protein	0.0091	0.0485	0.0454
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0945	0.6693	0.6694
Onchocerca volvulus		0.0091	0.0485	0.0416
Brugia malayi	PAN domain containing protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	Notch2	0.0091	0.0485	0.0453
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0052	0.0201	0.0168
Onchocerca volvulus		0.0091	0.0485	0.0416
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0052	0.0201	0.0168
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.0836	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0052	0.0201	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0047	0.0123
Onchocerca volvulus		0.0323	0.2169	0.2116
Loa Loa (eye worm)	PAN domain-containing protein	0.0287	0.191	0.1883
Mycobacterium ulcerans	hypothetical protein	0.0323	0.2169	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Onchocerca volvulus		0.0276	0.1828	0.1771
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0103	0.0432
Echinococcus multilocularis	fibrillin 1	0.024	0.1562	0.1531
Brugia malayi	EGF-like domain containing protein	0.0091	0.0485	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0123	0.0542
Loa Loa (eye worm)	PAN domain-containing protein	0.0287	0.191	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0131	0.077	0.0739
Toxoplasma gondii	PAN domain-containing protein	0.0287	0.191	0.1887
Onchocerca volvulus	Neurogenic locus notch homolog	0.0091	0.0485	0.0416
Echinococcus multilocularis	tyrosine protein kinase shark	0.0464	0.3195	0.3174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0123	0.0542
Echinococcus granulosus	neurogenic locus protein delta	0.0091	0.0485	0.0447
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.014	0.0836	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.014	0.0836	1
Schistosoma mansoni	septate junction protein	0.0091	0.0485	0.0467
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0075	0.0278
Brugia malayi	Fibulin-1 precursor	0.024	0.1562	0.1534
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.0221	0.0181

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 838358