Detailed information for compound 839809

Basic information

Technical information
  • TDR Targets ID: 839809
  • Name: 6-(3-ethylphenyl)pyrrolo[3,4-b]pyrazine-5,7-d ione
  • MW: 253.256 | Formula: C14H11N3O2
  • H donors: 0 H acceptors: 4 LogP: 1.78 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1)N1C(=O)c2c(C1=O)nccn2
  • InChi: 1S/C14H11N3O2/c1-2-9-4-3-5-10(8-9)17-13(18)11-12(14(17)19)16-7-6-15-11/h3-8H,2H2,1H3
  • InChiKey: QCROYOXKTIZIKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(3-ethylphenyl)pyrrolo[3,4-b]pyrazine-5,7-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Trypsin family protein 0.0812 0.2349 0.2525
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Echinococcus granulosus notch 0.021 0.0348 0.0374
Onchocerca volvulus 0.021 0.0348 0.0127
Mycobacterium ulcerans hypothetical protein 0.0812 0.2349 0.5
Plasmodium vivax cysteine repeat modular protein 1, putative 0.2905 0.93 1
Schistosoma mansoni hypothetical protein 0.0812 0.2349 0.2167
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Echinococcus multilocularis neural cadherin 0.021 0.0348 0.0374
Brugia malayi Fibulin-1 precursor 0.0538 0.1439 0.1547
Brugia malayi CUB domain containing protein 0.0175 0.0232 0.025
Brugia malayi Protein kinase domain containing protein 0.2905 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0263 0.0524 0.0563
Loa Loa (eye worm) Notch2 0.021 0.0348 0.0374
Brugia malayi astacin protease protein 30 0.0175 0.0232 0.025
Onchocerca volvulus 0.0263 0.0524 0.0321
Mycobacterium tuberculosis Putative ferredoxin reductase 0.024 0.0448 0.8342
Brugia malayi Trypsin family protein 0.2678 0.8545 0.9188
Echinococcus multilocularis fat cadherin tumor suppressor 0.021 0.0348 0.0374
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Loa Loa (eye worm) trypsin family protein 0.0812 0.2349 0.2525
Schistosoma mansoni hypothetical protein 0.0812 0.2349 0.2167
Toxoplasma gondii hypothetical protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.2678 0.8545 0.9188
Loa Loa (eye worm) PAN domain-containing protein 0.0446 0.1132 0.1217
Echinococcus multilocularis Mastin 0.0812 0.2349 0.2525
Onchocerca volvulus Slit protein homolog 0.021 0.0348 0.0127
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.2678 0.8545 0.851
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Onchocerca volvulus 0.0446 0.1132 0.0992
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Brugia malayi Kelch motif family protein 0.0175 0.0232 0.025
Onchocerca volvulus 0.0263 0.0524 0.0321
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Echinococcus granulosus neurogenic locus protein delta 0.021 0.0348 0.0374
Brugia malayi Trypsin-like protease protein 5 0.0812 0.2349 0.2525
Echinococcus granulosus laminin 0.0538 0.1439 0.1547
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.024 0.0448 0.8342
Echinococcus multilocularis fibrillin 1 0.0538 0.1439 0.1547
Echinococcus granulosus neurogenic locus notch protein 4 0.021 0.0348 0.0374
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Mycobacterium tuberculosis Probable reductase 0.024 0.0448 0.8342
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Schistosoma mansoni cell polarity protein 0.021 0.0348 0.0118
Onchocerca volvulus 0.021 0.0348 0.0127
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0812 0.2349 0.2167
Echinococcus granulosus protein jagged 2 0.021 0.0348 0.0374
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Giardia lamblia High cysteine protein 0.021 0.0348 0.5
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0812 0.2349 0.2525
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0812 0.2349 0.2167
Loa Loa (eye worm) CUB domain-containing protein 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.2905 0.93 1
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Toxoplasma gondii microneme protein MIC17C 0.0446 0.1132 0.1217
Echinococcus granulosus Tolloid protein 1 0.0714 0.2021 0.2173
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0538 0.1439 0.1547
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.0976 0.2894 0.3112
Loa Loa (eye worm) TK/ROR protein kinase 0.2905 0.93 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0175 0.0232 0.025
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0812 0.2349 0.2525
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0175 0.0232 0.025
Onchocerca volvulus 0.0246 0.0466 0.0258
Loa Loa (eye worm) hypothetical protein 0.0812 0.2349 0.2525
Echinococcus granulosus basement membrane specific heparan sulfate 0.0263 0.0524 0.0563
Brugia malayi Calcium binding EGF domain containing protein 0.0538 0.1439 0.1547
Echinococcus granulosus glycoprotein Antigen 5 0.0812 0.2349 0.2525
Echinococcus multilocularis cubilin 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.0812 0.2349 0.2525
Mycobacterium tuberculosis Probable oxidoreductase 0.0267 0.0537 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.024 0.0448 0.8342
Leishmania major hypothetical protein, conserved 0.2905 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0812 0.2349 0.2525
Onchocerca volvulus 0.0446 0.1132 0.0992
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Brugia malayi Calcium binding EGF domain containing protein 0.0263 0.0524 0.0563
Onchocerca volvulus 0.0446 0.1132 0.0992
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0812 0.2349 0.2167
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0263 0.0524 0.0298
Loa Loa (eye worm) PAN domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Loa Loa (eye worm) PAN domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.1443 0.4445 0.478
Echinococcus multilocularis neurogenic locus protein delta 0.021 0.0348 0.0374
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Echinococcus multilocularis neurogenic locus protein delta 0.021 0.0348 0.0374
Toxoplasma gondii PAN domain-containing protein 0.0446 0.1132 0.1217
Toxoplasma gondii microneme protein MIC17A 0.0446 0.1132 0.1217
Onchocerca volvulus 0.021 0.0348 0.0127
Schistosoma mansoni notch 0.021 0.0348 0.0118
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0263 0.0524 0.0298
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0466 1
Brugia malayi CUB domain containing protein 0.0175 0.0232 0.025
Echinococcus granulosus protein jagged 1 0.021 0.0348 0.0374
Echinococcus granulosus low density lipoprotein receptor ldl 0.0263 0.0524 0.0563
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.021 0.0348 0.0118
Echinococcus granulosus cubilin 0.0175 0.0232 0.025
Schistosoma mansoni hypothetical protein 0.0263 0.0524 0.0298
Toxoplasma gondii hypothetical protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Schistosoma mansoni hypothetical protein 0.2905 0.93 0.9283
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.024 0.0448 0.8342
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.0714 0.2021 0.2173
Brugia malayi Cadherin domain containing protein 0.021 0.0348 0.0374
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Onchocerca volvulus 0.0446 0.1132 0.0992
Schistosoma mansoni notch 0.021 0.0348 0.0118
Onchocerca volvulus 0.1443 0.4445 0.4646
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Echinococcus multilocularis low density lipoprotein receptor protein 0.0263 0.0524 0.0563
Schistosoma mansoni notch 0.021 0.0348 0.0118
Onchocerca volvulus 0.0263 0.0524 0.0321
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Echinococcus multilocularis slit 2 protein 0.021 0.0348 0.0374
Echinococcus granulosus enteropeptidase 0.0812 0.2349 0.2525
Echinococcus multilocularis glycoprotein Antigen 5 0.0812 0.2349 0.2525
Toxoplasma gondii microneme protein MIC4 0.0446 0.1132 0.1217
Schistosoma mansoni notch 0.021 0.0348 0.0118
Onchocerca volvulus 0.0812 0.2349 0.2334
Schistosoma mansoni septate junction protein 0.021 0.0348 0.0118
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.021 0.0348 0.0374
Echinococcus multilocularis CUB 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Echinococcus multilocularis laminin 0.0538 0.1439 0.1547
Brugia malayi Calcium binding EGF domain containing protein 0.0385 0.093 0.1
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.1653 0.5142 0.553
Brugia malayi Trypsin family protein 0.0812 0.2349 0.2525
Onchocerca volvulus 0.0263 0.0524 0.0321
Brugia malayi GCC2 and GCC3 family protein 0.021 0.0348 0.0374
Echinococcus granulosus low density lipoprotein receptor ldl 0.0263 0.0524 0.0563
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Toxoplasma gondii calcium binding egf domain-containing protein 0.0538 0.1439 0.1547
Schistosoma mansoni egf-like domain protein 0.0538 0.1439 0.1235
Loa Loa (eye worm) hypothetical protein 0.2678 0.8545 0.9188
Trypanosoma cruzi hypothetical protein, conserved 0.2905 0.93 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0714 0.2021 0.2173
Onchocerca volvulus 0.0812 0.2349 0.2334
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Onchocerca volvulus 0.0446 0.1132 0.0992
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0263 0.0524 0.0563
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Echinococcus granulosus neural cadherin 0.021 0.0348 0.0374
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0812 0.2349 0.2525
Echinococcus multilocularis protein jagged 2 0.021 0.0348 0.0374
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0263 0.0524 0.0563
Echinococcus granulosus neurogenic locus notch protein 0.021 0.0348 0.0374
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0175 0.0232 0.025
Brugia malayi Muscle positioning protein 4 0.1653 0.5142 0.553
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Echinococcus multilocularis enteropeptidase 0.0812 0.2349 0.2525
Onchocerca volvulus 0.0446 0.1132 0.0992
Brugia malayi hypothetical protein 0.0175 0.0232 0.025
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0175 0.0232 0.025
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0812 0.2349 0.2525
Loa Loa (eye worm) hypothetical protein 0.0812 0.2349 0.2525
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Echinococcus multilocularis transmembrane protease serine 3 0.0812 0.2349 0.2525
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Echinococcus multilocularis tissue type plasminogen activator 0.2905 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Onchocerca volvulus 0.0446 0.1132 0.0992
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Onchocerca volvulus Arrow homolog 0.0801 0.2312 0.2293
Loa Loa (eye worm) DOMON domain-containing protein 0.1443 0.4445 0.478
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Brugia malayi hypothetical protein 0.0812 0.2349 0.2525
Toxoplasma gondii PAN domain-containing protein 0.0446 0.1132 0.1217
Schistosoma mansoni laminin gamma-3 chain 0.021 0.0348 0.0118
Echinococcus multilocularis fibropellin Ia 0.021 0.0348 0.0374
Toxoplasma gondii PAN domain-containing protein 0.0446 0.1132 0.1217
Onchocerca volvulus 0.0446 0.1132 0.0992
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Schistosoma mansoni slit 0.021 0.0348 0.0118
Loa Loa (eye worm) hypothetical protein 0.0801 0.2312 0.2486
Echinococcus granulosus transmembrane protease serine 3 0.0812 0.2349 0.2525
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0801 0.2312 0.2486
Echinococcus multilocularis protein jagged 1 0.021 0.0348 0.0374
Echinococcus granulosus neurogenic locus notch protein 0.021 0.0348 0.0374
Loa Loa (eye worm) notch protein 0.021 0.0348 0.0374
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0714 0.2021 0.1831
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0263 0.0524 0.0563
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Loa Loa (eye worm) hypothetical protein 0.0175 0.0232 0.025
Schistosoma mansoni notch 0.021 0.0348 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0267 0.0537 1
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0263 0.0524 0.0563
Echinococcus multilocularis protein jagged 1 0.021 0.0348 0.0374
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0175 0.0232 0.025
Echinococcus multilocularis neurogenic locus notch protein 4 0.021 0.0348 0.0374
Loa Loa (eye worm) PAN domain-containing protein 0.0446 0.1132 0.1217
Toxoplasma gondii PAN domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Brugia malayi Calcium binding EGF domain containing protein 0.021 0.0348 0.0374
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0175 0.0232 1
Echinococcus multilocularis notch 0.021 0.0348 0.0374
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0263 0.0524 0.0298
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0263 0.0524 0.0563
Brugia malayi Delta serrate ligand family protein 0.021 0.0348 0.0374
Echinococcus granulosus CUB 0.0175 0.0232 0.025
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0801 0.2312 0.2486
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0987 0.293 0.2762
Toxoplasma gondii EGF family domain-containing protein 0.021 0.0348 0.0374
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0263 0.0524 0.0563
Onchocerca volvulus 0.0812 0.2349 0.2334
Echinococcus granulosus cubilin 0.0175 0.0232 0.025
Plasmodium falciparum cysteine repeat modular protein 1 0.2905 0.93 1
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Brugia malayi Cadherin domain containing protein 0.021 0.0348 0.0374
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Onchocerca volvulus 0.0263 0.0524 0.0321
Brugia malayi Nematode astacin protease protein 30 0.0175 0.0232 0.025
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0175 0.0232 0.025
Brugia malayi enteropeptidase precursor 0.0263 0.0524 0.0563
Schistosoma mansoni notch 0.021 0.0348 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Echinococcus granulosus tissue type plasminogen activator 0.2905 0.93 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0074 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Toxoplasma gondii PAN domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.0538 0.1439 0.1547
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0812 0.2349 0.2525
Echinococcus granulosus fibropellin Ia 0.021 0.0348 0.0374
Echinococcus granulosus basement membrane specific heparan sulfate 0.0263 0.0524 0.0563
Toxoplasma gondii calcium binding egf domain-containing protein 0.0538 0.1439 0.1547
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0175 0.0232 0.025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0267 0.0537 1
Onchocerca volvulus Putative cubilin 0.0385 0.093 0.0769
Echinococcus granulosus protein jagged 2 0.021 0.0348 0.0374
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0263 0.0524 0.0321
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Schistosoma mansoni hypothetical protein 0.1443 0.4445 0.4313
Onchocerca volvulus 0.0446 0.1132 0.0992
Onchocerca volvulus 0.2905 0.93 1
Brugia malayi Lectin C-type domain containing protein 0.0175 0.0232 0.025
Brugia malayi CUB domain containing protein 0.0175 0.0232 0.025
Onchocerca volvulus 0.0446 0.1132 0.0992
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Brugia malayi Nematode astacin protease protein 30 0.0175 0.0232 0.025
Brugia malayi Pre-SET motif family protein 0.0216 0.0367 0.0395
Brugia malayi Kringle domain containing protein 0.2905 0.93 1
Mycobacterium tuberculosis Probable dehydrogenase 0.024 0.0448 0.8342
Toxoplasma gondii kringle domain-containing protein 0.2905 0.93 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0812 0.2349 0.2167
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Toxoplasma gondii PAN/Apple domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) CUB domain-containing protein 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.0385 0.093 0.1
Echinococcus granulosus slit 2 protein 0.021 0.0348 0.0374
Onchocerca volvulus Neurogenic locus notch homolog 0.021 0.0348 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0074 0.008
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Onchocerca volvulus 0.1865 0.5847 0.6192
Loa Loa (eye worm) hypothetical protein 0.0538 0.1439 0.1547
Echinococcus granulosus Mastin 0.0812 0.2349 0.2525
Onchocerca volvulus 0.1653 0.5142 0.5415
Loa Loa (eye worm) hypothetical protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) PAN domain-containing protein 0.0446 0.1132 0.1217
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Brugia malayi basement membrane proteoglycan precursor 0.0263 0.0524 0.0563
Schistosoma mansoni hypothetical protein 0.0263 0.0524 0.0298
Onchocerca volvulus 0.0263 0.0524 0.0321
Toxoplasma gondii microneme protein MIC17B 0.0446 0.1132 0.1217
Onchocerca volvulus 0.1443 0.4445 0.4646
Echinococcus multilocularis tumor protein p63 0.035 0.0814 0.0875
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0263 0.0524 0.0321
Brugia malayi MH2 domain containing protein 0.0127 0.0074 0.008
Brugia malayi notch-like transmembrane receptor 0.021 0.0348 0.0374
Echinococcus multilocularis cubilin 0.0175 0.0232 0.025
Loa Loa (eye worm) DPY-31 protein 0.0175 0.0232 0.025
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Brugia malayi CUB domain containing protein 0.0175 0.0232 0.025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0812 0.2349 0.2167
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Schistosoma mansoni hypothetical protein 0.021 0.0348 0.0118
Brugia malayi Trypsin family protein 0.0812 0.2349 0.2525
Onchocerca volvulus 0.021 0.0348 0.0127
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Echinococcus granulosus tumor protein p63 0.035 0.0814 0.0875
Onchocerca volvulus 0.2678 0.8545 0.9168
Loa Loa (eye worm) hypothetical protein 0.0812 0.2349 0.2525
Echinococcus multilocularis neurogenic locus notch protein 0.021 0.0348 0.0374
Echinococcus granulosus delta-like protein 1 0.021 0.0348 0.0374
Onchocerca volvulus 0.1443 0.4445 0.4646
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Onchocerca volvulus 0.1443 0.4445 0.4646
Echinococcus granulosus protein jagged 1 0.021 0.0348 0.0374
Onchocerca volvulus 0.0812 0.2349 0.2334
Brugia malayi CUB domain containing protein 0.0438 0.1105 0.1189
Onchocerca volvulus 0.0446 0.1132 0.0992
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Onchocerca volvulus Neurogenic locus notch protein homolog 0.021 0.0348 0.0127
Loa Loa (eye worm) hypothetical protein 0.021 0.0348 0.0374
Brugia malayi SEA domain containing protein 0.1443 0.4445 0.478
Toxoplasma gondii microneme protein, putative 0.0446 0.1132 0.1217
Brugia malayi EGF-like domain containing protein 0.021 0.0348 0.0374
Loa Loa (eye worm) hypothetical protein 0.0438 0.1105 0.1189
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Schistosoma mansoni cercarial elastase (S01 family) 0.0812 0.2349 0.2167
Loa Loa (eye worm) hypothetical protein 0.0263 0.0524 0.0563
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0263 0.0524 0.0563
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0175 0.0232 0.025
Onchocerca volvulus 0.0812 0.2349 0.2334
Brugia malayi Calcium binding EGF domain containing protein 0.021 0.0348 0.0374
Echinococcus multilocularis neurogenic locus notch protein 0.021 0.0348 0.0374
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0367 0.0395
Brugia malayi PAN domain containing protein 0.0446 0.1132 0.1217
Toxoplasma gondii subtilisin SUB12 0.0446 0.1132 0.1217
Echinococcus multilocularis Tolloid protein 1 0.0714 0.2021 0.2173
Echinococcus granulosus low density lipoprotein receptor protein 0.0263 0.0524 0.0563
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0267 0.0537 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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