TDR Targets

Basic information

Technical information

TDR Targets ID: 867658
Name: N-(4-chlorophenyl)-2-(2-fluorophenyl)quinazol in-4-amine
MW: 349.789 | Formula: C20H13ClFN3
H donors: 1 H acceptors: 2 LogP: 5.81 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Nc1nc(nc2c1cccc2)c1ccccc1F
InChi: 1S/C20H13ClFN3/c21-13-9-11-14(12-10-13)23-20-16-6-2-4-8-18(16)24-19(25-20)15-5-1-3-7-17(15)22/h1-12H,(H,23,24,25)
InChiKey: HBRCUKLHJXARBR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-chlorophenyl)-2-(2-fluorophenyl)-4-quinazolinamine
(4-chlorophenyl)-[2-(2-fluorophenyl)quinazolin-4-yl]amine
STOCK3S-68661
ZINC02232125
Oprea1_266088

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.003
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.003
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.0002	0.1039
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0023	0.0023
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, CMGC DYRK	0.002	0	0.5
Mycobacterium ulcerans	lipase LipD	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0023	1
Giardia lamblia	Kinase, STE Dicty2	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, Wee	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Brugia malayi	hypothetical protein	0.0075	0.0058	0.0058
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CDK	0.002	0	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0023	0.003
Giardia lamblia	Kinase, NEK-like	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-like	0.002	0	0.5
Giardia lamblia	Kinase, NEK-GL-like	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.003
Giardia lamblia	Kinase, CMGC CLK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CAMK unique	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Onchocerca volvulus		0.0041	0.0023	0.0074
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0023	0.003
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0265	0.0258	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0023	0.0074
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0022	0.0002	0.0407
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, CMGC GSK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, STE STE20	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, ULK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Brugia malayi	beta-lactamase family protein	0.0041	0.0023	0.0023
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.7241	0.7612	1
Plasmodium falciparum	importin beta, putative	0.0027	0.0008	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Long-flagella protein, kinase, CMGC RCK	0.002	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.7241	0.7612	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0075	0.0058	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CAMK CAMK1	0.002	0	0.5
Echinococcus multilocularis	importin subunit beta 1	0.0027	0.0008	0.0026
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC RCK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0143	0.0188
Giardia lamblia	Kinase, NEK-like	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Brugia malayi	beta-lactamase family protein	0.0041	0.0023	0.0023
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0023	0.0074
Giardia lamblia	Kinase, CMGC CDK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CDK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.002	0	0.5
Schistosoma mansoni	hypothetical protein	0.0292	0.0287	0.0377
Schistosoma mansoni	peptidase	0.0023	0.0004	0.0005
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Echinococcus granulosus	importin subunit beta 1	0.0027	0.0008	0.0026
Brugia malayi	RNA, U transporter 1	0.0078	0.0061	0.0061
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, STE Dicty2	0.002	0	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Schistosoma mansoni	importin beta-1	0.0027	0.0008	0.001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0022	0.0002	0.1039
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, CMGC GSK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CDKL	0.002	0	0.5
Trichomonas vaginalis	esterase, putative	0.0041	0.0023	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0023	1
Giardia lamblia	Kinase, CAMKK	0.002	0	0.5
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0705	0.0722	0.2373
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.0143	0.047
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, AGC AKT	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Echinococcus multilocularis	snurportin 1	0.0292	0.0287	0.0943
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Schistosoma mansoni	deleted in oral cancer 1/cdk2-associated protein-like	0.2905	0.3042	0.3996
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.2905	0.3042	0.3996
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Onchocerca volvulus		0.0041	0.0023	0.0074
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.002	0	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.0058	0.019
Onchocerca volvulus		0.0041	0.0023	0.0074
Giardia lamblia	Kinase, CMGC RCK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Echinococcus granulosus	Cyclin dependent kinase 2 associated protein	0.2905	0.3042	1
Giardia lamblia	Kinase, CAMK CAMKL	0.002	0	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0023	1
Giardia lamblia	Aurora kinase	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0075	0.0058	1
Giardia lamblia	Kinase, NAK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Hypothetical protein	0.002	0	0.5
Leishmania major	importin beta-1 subunit, putative	0.0022	0.0002	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0008	0.001
Toxoplasma gondii	ABC1 family protein	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, CMGC CDK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Brugia malayi	beta-lactamase	0.0041	0.0023	0.0023
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Brugia malayi	Muscleblind-like protein	0.0156	0.0143	0.0143
Giardia lamblia	Kinase, PEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CDK	0.002	0	0.5
Giardia lamblia	Kinase, TTK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.003
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.0058	0.019
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, PLK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0025	0.0005	0.2409
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.003
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0023	0.003
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CMGC-GL1	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, VPS15	0.002	0	0.5
Giardia lamblia	Kinase, CK1 Casein kinase	0.002	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0023	1
Echinococcus multilocularis	muscleblind protein	0.0156	0.0143	0.047
Giardia lamblia	Kinase	0.002	0	0.5
Trichomonas vaginalis	importin beta-1, putative	0.0022	0.0002	0.1039
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Schistosoma mansoni	hypothetical protein	0.0075	0.0058	0.0076
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0143	0.0188
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.7241	0.7612	0.7612
Giardia lamblia	Kinase, STE STE20	0.002	0	0.5
Onchocerca volvulus	Diphthamide biosynthesis protein 7 homolog	0.2905	0.3042	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.0058	0.0076
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Echinococcus granulosus	muscleblind protein	0.0156	0.0143	0.047
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Chlamydia trachomatis	serine/threonine-protein kinase	0.002	0	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0023	1
Giardia lamblia	Kinase, AGC PKA	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-like	0.002	0	0.5
Giardia lamblia	Kinase, STE STE20	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Plasmodium vivax	importin-beta 2, putative	0.0027	0.0008	0.3448
Toxoplasma gondii	HEAT repeat-containing protein	0.0027	0.0008	0.3448
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NAK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CMGC-GL1	0.002	0	0.5
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0022	0.0002	0.1039
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0023	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0023	0.0878
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, STE STE20	0.002	0	0.5
Giardia lamblia	Kinase, NEK-like	0.002	0	0.5
Echinococcus granulosus	snurportin 1	0.0292	0.0287	0.0943
Trypanosoma brucei	importin beta-1 subunit, putative	0.0027	0.0008	0.3448
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, Nek-like	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CDK	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, ULK	0.002	0	0.5
Giardia lamblia	Kinase, STE STE20	0.002	0	0.5
Trypanosoma brucei	importin beta-1 subunit, putative	0.0027	0.0008	0.3448
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Leishmania major	hypothetical protein, conserved	0.0041	0.0023	1
Giardia lamblia	Kinase, CAMK CAMKL	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0075	0.0058	1
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, STE STE11	0.002	0	0.5
Giardia lamblia	Kinase, NEK-frag	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0292	0.0287	0.0377
Brugia malayi	Importin beta-1 subunit	0.0027	0.0008	0.0008
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CAMK CAMKL	0.002	0	0.5
Giardia lamblia	Kinase, Nek-like	0.002	0	0.5
Entamoeba histolytica	hypothetical protein	0.0075	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0023	0.003
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0023	1
Giardia lamblia	Kinase, Wnk	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.002	0	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.002	0	0.5
Echinococcus multilocularis	Cyclin dependent kinase 2 associated protein	0.2905	0.3042	1
Giardia lamblia	Kinase, CAMK CAMKL	0.002	0	0.5
Giardia lamblia	Kinase, Uni1	0.002	0	0.5
Giardia lamblia	Kinase, CMGC CK2	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, CDC7	0.002	0	0.5
Giardia lamblia	Kinase	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0023	1
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, AGC MAST	0.002	0	0.5
Giardia lamblia	Kinase, CMGC MAPK	0.002	0	0.5
Giardia lamblia	Kinase, STE STE20	0.002	0	0.5
Giardia lamblia	Kinase, AGC NDR	0.002	0	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0023	1
Giardia lamblia	Kinase, CMGC SRPK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Giardia lamblia	Kinase, NEK	0.002	0	0.5
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0023	0.003
Giardia lamblia	Kinase, AGC PKA	0.002	0	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 867658