TDR Targets

Basic information

Technical information

TDR Targets ID: 869927
Name: 6-chloro-N-(3,4-dimethylphenyl)-2-ethyl-2,3-d ihydro-1,4-benzoxazine-4-carboxamide
MW: 344.835 | Formula: C19H21ClN2O2
H donors: 1 H acceptors: 1 LogP: 4.73 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Oc2ccc(cc2N(C1)C(=O)Nc1ccc(c(c1)C)C)Cl
InChi: 1S/C19H21ClN2O2/c1-4-16-11-22(17-10-14(20)6-8-18(17)24-16)19(23)21-15-7-5-12(2)13(3)9-15/h5-10,16H,4,11H2,1-3H3,(H,21,23)
InChiKey: GQYBDUMCFFWHRZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.0055	0.0316	0.0671
Onchocerca volvulus	Fxna peptidase homolog	0.0055	0.0316	0.0318
Brugia malayi	Peptidase family M28 containing protein	0.0055	0.0316	0.047
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0316	0.047
Brugia malayi	MH2 domain containing protein	0.0118	0.109	0.1623
Schistosoma mansoni	hypothetical protein	0.0189	0.1971	0.2895
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0078	0.008
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0066	0.1595
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0047	0.0225	0.0231
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0036	0.0083	0.0423
Brugia malayi	beta-NAC-like protein	0.0034	0.0066	0.0098
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0066	0.0068
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0099	0.0855	0.1225
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0538	0.6268	0.9333
Schistosoma mansoni	hypothetical protein	0.0189	0.1971	0.2895
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0066	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0316	0.0316
Loa Loa (eye worm)	glutaminase	0.0574	0.6713	0.6713
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0075	0.0562	0.1596
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0066	0.0098
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0137	0.3304
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0063	0.0414	1
Leishmania major	hypothetical protein, conserved	0.004	0.0137	0.4335
Loa Loa (eye worm)	hypothetical protein	0.004	0.0137	0.0137
Brugia malayi	Bromodomain containing protein	0.008	0.0633	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0766	0.908	0.908
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0066	0.0098
Schistosoma mansoni	zinc finger protein	0.0041	0.0149	0.0166
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0099	0.0855	0.0877
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0099	0.0855	0.1225
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0055	0.0316	1
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0066	0.2093
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0066	0.2093
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0075	0.0572	0.0586
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0066	0.2093
Loa Loa (eye worm)	hypothetical protein	0.004	0.0137	0.0137
Onchocerca volvulus	Fxna peptidase homolog	0.0055	0.0316	0.0318
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0055	0.0316	0.0416
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0055	0.0316	0.1603
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.2803	1
Leishmania major	glutaminyl cyclase, putative	0.0055	0.0316	1
Brugia malayi	beta-lactamase family protein	0.004	0.0137	0.0204
Onchocerca volvulus		0.0055	0.0316	0.0318
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0137	0.0204
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0137	0.0137
Loa Loa (eye worm)	bromodomain containing protein	0.0037	0.0099	0.0099
Toxoplasma gondii	peptidase, M28 family protein	0.0055	0.0316	0.7622
Echinococcus granulosus	histone lysine methyltransferase setb	0.0099	0.0855	0.4341
Schistosoma mansoni	hypothetical protein	0.0043	0.0176	0.0207
Leishmania major	hypothetical protein, conserved	0.0055	0.0316	1
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0075	0.0562	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0635	0.0635
Trypanosoma cruzi	ISWI complex protein	0.0032	0.0038	0.12
Brugia malayi	Pre-SET motif family protein	0.0063	0.0414	0.0617
Schistosoma mansoni	transcription factor btf3	0.0034	0.0066	0.0042
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0437	0.5026	0.5026
Toxoplasma gondii	ABC1 family protein	0.004	0.0137	0.3304
Entamoeba histolytica	hypothetical protein	0.0034	0.0066	0.8431
Loa Loa (eye worm)	glutaminase 2	0.0574	0.6713	0.6713
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0316	0.0316
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0055	0.0316	0.0324
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0137	0.4335
Loa Loa (eye worm)	hypothetical protein	0.009	0.0745	0.0745
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0055	0.0316	0.1603
Trichomonas vaginalis	glutaminase, putative	0.0574	0.6713	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0137	0.0137
Brugia malayi	nicalin	0.0055	0.0316	0.047
Brugia malayi	beta-lactamase	0.004	0.0137	0.0204
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.0055	0.0316	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0855	0.0855
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0137	0.0148
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0066	0.1595
Brugia malayi	leucyl aminopeptidase	0.0055	0.0316	0.047
Brugia malayi	Bromodomain containing protein	0.0158	0.1582	0.2357
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0316	0.0316
Loa Loa (eye worm)	PHD-finger family protein	0.0043	0.0176	0.0176
Brugia malayi	Pre-SET motif family protein	0.0437	0.5026	0.7486
Mycobacterium ulcerans	hypothetical protein	0.0055	0.0316	0.0272
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0063	0.0414	0.0564
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0078	0.0398
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0055	0.0316	0.0416
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0036	0.0083	0.0068
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0125	0.1186	0.1216
Echinococcus granulosus	geminin	0.0189	0.1971	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0078	0.0061
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.006	0.0386	0.1958
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0036	0.0083	0.0085
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0036	0.0083	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0558	0.6515	0.6515
Loa Loa (eye worm)	hypothetical protein	0.004	0.0137	0.0137
Trypanosoma brucei	glutaminyl cyclase, putative	0.0055	0.0316	1
Echinococcus granulosus	zinc finger protein	0.0041	0.0149	0.0754
Loa Loa (eye worm)	beta-lactamase	0.004	0.0137	0.0137
Echinococcus granulosus	fetal alzheimer antigen falz	0.0047	0.0225	0.1143
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0137	0.0695
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.0055	0.0316	0.1603
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0066	0.0066
Onchocerca volvulus	Fxna peptidase homolog	0.0055	0.0316	0.0318
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0063	0.0414	0.0425
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0137	0.0204
Trichomonas vaginalis	set domain proteins, putative	0.0498	0.577	0.8594
Loa Loa (eye worm)	hypothetical protein	0.004	0.0137	0.0137
Schistosoma mansoni	glutaminase	0.0574	0.6713	1
Schistosoma mansoni	bromodomain containing protein	0.0133	0.1279	0.1859
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0137	0.0204
Leishmania major	hypothetical protein, conserved	0.0032	0.0038	0.12
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0316	0.047
Brugia malayi	beta-lactamase family protein	0.004	0.0137	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0696	0.0696
Onchocerca volvulus		0.0498	0.577	1
Loa Loa (eye worm)	leucyl aminopeptidase	0.0055	0.0316	0.0316
Mycobacterium leprae	Probable lipase LipE	0.004	0.0137	0.5
Brugia malayi	hypothetical protein	0.0035	0.0078	0.0117
Trichomonas vaginalis	esterase, putative	0.004	0.0137	0.0204
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	1
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.0055	0.0316	0.0324
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0066	0.8431
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0075	0.0572	0.2901
Schistosoma mansoni	nicalin (M28 family)	0.0055	0.0316	0.0416
Echinococcus multilocularis	zinc finger protein	0.0041	0.0149	0.0152
Brugia malayi	FXNA	0.0055	0.0316	0.047
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1472	0.1472
Toxoplasma gondii	hypothetical protein	0.0055	0.0316	0.7622
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0055	0.0316	1
Onchocerca volvulus		0.0063	0.0414	0.0493
Echinococcus granulosus	transcription factor btf3	0.0034	0.0066	0.0335
Echinococcus multilocularis	geminin	0.0189	0.1971	0.2021
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0414	0.0564
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0137	0.4335
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.109	0.109
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.109	0.109
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0137	0.4335
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0066	1
Onchocerca volvulus	Glutaminyl cyclase homolog	0.0055	0.0316	0.0318
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0821	0.9753	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0125	0.1186	0.602
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0047	0.0225	0.0281
Trypanosoma brucei	ISWI complex protein	0.0032	0.0038	0.12
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0055	0.0316	0.0324
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0137	0.0204
Mycobacterium ulcerans	glutaminase	0.0574	0.6713	1
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0137	0.5
Brugia malayi	glutaminase DH11.1	0.0574	0.6713	1
Plasmodium vivax	SET domain protein, putative	0.0063	0.0414	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0137	0.014
Brugia malayi	PHD-finger family protein	0.0052	0.0287	0.0427
Entamoeba histolytica	hypothetical protein	0.0035	0.0078	1
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0316	0.047
Loa Loa (eye worm)	hypothetical protein	0.004	0.0137	0.0137
Trypanosoma cruzi	ISWI complex protein	0.0032	0.0038	0.12
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0137	0.0204
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0055	0.0316	0.047
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0137	0.0204
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0137	0.0148
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0066	0.2093
Giardia lamblia	Flap structure-specific endonuclease	0.0029	0	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0078	0.0061

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869927