Detailed information for compound 877645

Basic information

Technical information
  • TDR Targets ID: 877645
  • Name: 3-(3-iodophenyl)-1-(1-phenylethyl)urea
  • MW: 366.197 | Formula: C15H15IN2O
  • H donors: 2 H acceptors: 1 LogP: 3.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(c1ccccc1)C)Nc1cccc(c1)I
  • InChi: 1S/C15H15IN2O/c1-11(12-6-3-2-4-7-12)17-15(19)18-14-9-5-8-13(16)10-14/h2-11H,1H3,(H2,17,18,19)
  • InChiKey: NYLFUIJBUYBDPK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_365095

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0034 0.0034 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0058 0.0853
Loa Loa (eye worm) MBCTL1 0.0063 0.0088 0.0088
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0049 0.0873
Entamoeba histolytica hypothetical protein 0.0027 0.0022 0.1042
Chlamydia trachomatis pyruvate kinase 0.0039 0.0043 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0049 0.0873
Brugia malayi Heterochromatin protein 1 0.0081 0.0121 0.012
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0022 0.4319
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0043
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0121 0.2163
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0002 0.0002
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0043 0.2089
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0174 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0038 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0058 0.284
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0025 0.1221
Brugia malayi RNA binding protein 0.0147 0.0243 0.0243
Onchocerca volvulus 0.0026 0.002 0.0403
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0005 0.0245
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0204 1
Echinococcus granulosus chromobox protein 1 0.0081 0.0121 0.0121
Echinococcus granulosus intermediate filament protein 0.0026 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0058 0.266
Schistosoma mansoni hypothetical protein 0.0096 0.0149 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0058 0.0058
Brugia malayi intermediate filament protein 0.0026 0.002 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0147 0.0243 0.0241
Echinococcus multilocularis lamin dm0 0.0026 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.5419 1 1
Onchocerca volvulus 0.0057 0.0077 0.1586
Brugia malayi chromobox protein homolog 3 0.0045 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0196 0.0335 0.0333
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0121 0.012
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0036 0.8241
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0034 0.1175
Echinococcus multilocularis pyruvate kinase 0.002 0.0008 0.0008
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0043 0.1169
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0043 0.0886
Schistosoma mansoni jumonji domain containing protein 0.0156 0.026 0.0258
Echinococcus granulosus dnaJ subfamily B 0.0809 0.1469 0.1469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.0179 0.0177
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0033 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0055 0.0985
Plasmodium vivax SET domain protein, putative 0.0036 0.0038 0.8613
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0174 0.8505
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0058 0.0853
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0043 0.2243
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0034 0.1733
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0047 0.0058 0.0058
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0025 0.0023
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0055 0.114
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0002 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0096 0.0149 0.0147
Brugia malayi Pre-SET motif family protein 0.0242 0.042 0.0419
Brugia malayi mbt repeat family protein 0.0055 0.0074 0.0073
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0025 0.1221
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0005 0.0005
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0204 1
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0058 0.0058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0058 0.0057
Plasmodium falciparum pyruvate kinase 0.0039 0.0043 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0009 0.015
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0049 0.0873
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0058 0.284
Plasmodium falciparum phd finger protein, putative 0.0034 0.0034 0.7606
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0043 1
Schistosoma mansoni cpg binding protein 0.006 0.0083 0.0081
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0174 0.0172
Loa Loa (eye worm) phosphofructokinase 0.0126 0.0204 0.0204
Leishmania major pyruvate kinase 0.0039 0.0043 0.2089
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0204 0.3664
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0101 0.01
Schistosoma mansoni alpha-glucosidase 0.0162 0.0272 0.027
Brugia malayi isocitrate dehydrogenase 0.0018 0.0005 0.0005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.002 0.0019
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0049 0.2382
Brugia malayi CHD4 protein 0.0016 0.0002 0.0002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0096 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0072 0.1281
Brugia malayi jmjC domain containing protein 0.0029 0.0025 0.0025
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0074 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0005
Onchocerca volvulus 0.0055 0.0074 0.1525
Schistosoma mansoni alpha glucosidase 0.0042 0.0049 0.0047
Schistosoma mansoni lamin 0.0026 0.002 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0034 0.0612
Brugia malayi jmjC domain containing protein 0.0179 0.0302 0.0302
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0005 0.0245
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.042 0.0419
Trypanosoma brucei polo-like protein kinase 0.0109 0.0174 0.8505
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0022 0.018
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0025 0.0025
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0025 0.0025
Echinococcus multilocularis chromobox protein 1 0.0081 0.0121 0.0121
Schistosoma mansoni survival motor neuron protein 0.0047 0.0058 0.0056
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0037
Schistosoma mansoni alpha-glucosidase 0.0162 0.0272 0.027
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0062 0.1099
Loa Loa (eye worm) hypothetical protein 0.0096 0.0149 0.0149
Onchocerca volvulus 0.0049 0.0062 0.1286
Schistosoma mansoni hypothetical protein 0.0047 0.0058 0.0056
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.002 0.0019
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0074 0.1525
Brugia malayi phosphofructokinase 0.0126 0.0204 0.0204
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0022 0.1042
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Echinococcus granulosus lysine specific demethylase 5A 0.0112 0.0179 0.0179
Schistosoma mansoni glutaminase 0.0317 0.0557 0.0555
Echinococcus multilocularis dnaJ subfamily B 0.0809 0.1469 0.1469
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0074 0.0074
Onchocerca volvulus 0.0109 0.0173 0.3598
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0005
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0008 0.0169
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0058 0.0058
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0012 0.0561
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0036 0.6903
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0049 0.2382
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0025 0.1221
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0062 0.006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0036
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0074 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0049 0.2382
Trichomonas vaginalis glutaminase, putative 0.0317 0.0557 1
Echinococcus granulosus microtubule associated protein 2 0.1598 0.2929 0.2929
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0025 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0034 0.7606
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0049 0.0873
Giardia lamblia Kinase, PLK 0.0109 0.0174 1
Schistosoma mansoni lamin 0.0026 0.002 0.0018
Echinococcus granulosus lamin 0.0026 0.002 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0204 0.3664
Loa Loa (eye worm) hypothetical protein 0.0047 0.0058 0.0058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0058 0.2007
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0002 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0012 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0147 0.0243 0.0241
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0025 0.0025
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.5419 1 1
Schistosoma mansoni hypothetical protein 0.0039 0.0045 0.0043
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0036 0.1558
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0043 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0204 0.3664
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0036
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0034 0.7726
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0074 0.0072
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.0204 0.3531
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0031 0.0546
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0025 0.0025
Schistosoma mansoni chromobox protein 0.0081 0.0121 0.0119
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0096 0.0149 0.0149
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0012 0.1713
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0174 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0034 0.0612
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0006 0.0006
Brugia malayi glutaminase DH11.1 0.0317 0.0557 0.0557
Schistosoma mansoni chromobox protein 0.0081 0.0121 0.0119
Echinococcus granulosus tar DNA binding protein 0.0147 0.0243 0.0243
Schistosoma mansoni pyruvate kinase 0.0039 0.0043 0.0041
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0173 1
Schistosoma mansoni hypothetical protein 0.0096 0.0149 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0276 0.0481 0.8637
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0174 0.8505
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0045 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0005
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.0204 0.0204
Brugia malayi TAR-binding protein 0.0147 0.0243 0.0243
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0058 0.0853
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0025 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0038 0.0038
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.5419 1 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0058 0.0853
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0031 0.0546
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.0321 0.032
Brugia malayi 6-phosphofructokinase 0.0126 0.0204 0.0204
Echinococcus multilocularis pyruvate kinase 0.0039 0.0043 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0021
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0043 0.0886
Brugia malayi Pre-SET motif family protein 0.0036 0.0038 0.0037
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0022 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0321 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0147 0.0243 0.0241
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0049 0.0873
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0034 0.5997
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0022 0.0816
Loa Loa (eye worm) hypothetical protein 0.0045 0.0055 0.0055
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0025 0.0023
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0034 0.1706
Onchocerca volvulus 0.0047 0.0058 0.1193
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0049 0.26
Echinococcus multilocularis musashi 0.0026 0.002 0.002
Brugia malayi jmjC domain containing protein 0.0112 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0036 0.0038 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0012 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Echinococcus multilocularis GPCR, family 2 0.0018 0.0005 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0003
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0204 0.0203
Echinococcus multilocularis lamin 0.0026 0.002 0.002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0005 0.0005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0005 0.0245
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0034 0.0612
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0018
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0022 0.4319
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Onchocerca volvulus 0.0047 0.0058 0.1205
Brugia malayi 6-phosphofructokinase 0.0126 0.0204 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0055 0.0985
Schistosoma mansoni hypothetical protein 0.034 0.0601 0.0599
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0012 0.0561
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.0321 0.032
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0034 0.7726
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0012 0.0561
Brugia malayi RNA recognition motif domain containing protein 0.0147 0.0243 0.0243
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0034 0.7726
Loa Loa (eye worm) jmjC domain-containing protein 0.0112 0.0179 0.0179
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0174 0.0174
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Loa Loa (eye worm) hypothetical protein 0.0096 0.015 0.0149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0012 0.0324
Echinococcus granulosus cpg binding protein 0.006 0.0083 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0038 0.0036
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.0204 0.0204
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0007 0.0119
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0025 0.0025
Echinococcus granulosus L aminoadipate semialdehyde 0.0096 0.015 0.015
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0034 0.0612
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0019
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.0321 0.0321
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0012 0.0011
Plasmodium falciparum pyruvate kinase 2 0.002 0.0008 0.0753
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0012 0.0218
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0049 0.2382
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.5419 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0005 0.0245
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0025 0.1188
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0034 0.0612
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0025 0.0025
Schistosoma mansoni microtubule-associated protein tau 0.1598 0.2929 0.2927
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0049 0.0873
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0096 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0009 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0033 0.138
Echinococcus multilocularis chromobox protein 1 0.0081 0.0121 0.0121
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.0809 0.1469 0.1467
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0348
Echinococcus granulosus peregrin 0.0034 0.0034 0.0034
Echinococcus granulosus pyruvate kinase 0.002 0.0008 0.0008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0179 0.0302 0.0302
Plasmodium vivax JmjC domain containing protein 0.0029 0.0025 0.5293
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0034 0.1733
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0022 0.0509
Giardia lamblia PHD finger protein 15 0.0034 0.0034 0.1556
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0026 0.0026
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0062 0.1272
Loa Loa (eye worm) hypothetical protein 0.0058 0.0078 0.0078
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0031 0.0031
Brugia malayi jmjC domain containing protein 0.0029 0.0025 0.0025
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0043 0.2089
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0058 0.284
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0228 0.0394 0.0394
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0121 0.2163
Brugia malayi mbt repeat family protein 0.0055 0.0074 0.0073
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0204 0.0204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0006 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0058 0.284
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0174 0.8505
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0174 0.8505
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0038 0.0038
Brugia malayi hypothetical protein 0.0228 0.0394 0.0394
Onchocerca volvulus 0.0276 0.0481 1
Onchocerca volvulus 0.0035 0.0037 0.0764
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0022 0.018
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0043 0.0043
Brugia malayi jmjC domain containing protein 0.0029 0.0025 0.0025
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0204 0.0204
Echinococcus granulosus chromobox protein 1 0.0081 0.0121 0.0121
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0088 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.002 0.0348
Echinococcus multilocularis pyruvate kinase 0.002 0.0008 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.0204 1
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0006 0.0006
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0222 0.0382 0.0382
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0038 0.1932
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0038 0.0038
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0204 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0222 0.0382 0.0382
Giardia lamblia Pyruvate kinase 0.0039 0.0043 0.2099
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0043 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0078 0.0078
Loa Loa (eye worm) glutaminase 0.0317 0.0557 0.0557
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0058 0.2007
Schistosoma mansoni pyruvate kinase 0.0039 0.0043 0.0041
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0077 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0058 0.284
Echinococcus multilocularis pyruvate kinase 0.002 0.0008 0.0008
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0005 0.0005
Echinococcus granulosus lamin dm0 0.0026 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0063 0.0088 0.0088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0112 0.0179 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0045 0.0044
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0049 0.0873
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0088 0.0088
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.0204 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0025 0.5293
Schistosoma mansoni hypothetical protein 0.0034 0.0034 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0058 0.0853
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0058 0.0058
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0043 0.2089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0005 0.0005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0012 0.0011
Echinococcus granulosus GPCR family 2 0.0018 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0348
Loa Loa (eye worm) RNA binding protein 0.0147 0.0243 0.0243
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0043 0.189
Echinococcus multilocularis cpg binding protein 0.006 0.0083 0.0083
Loa Loa (eye worm) TAR-binding protein 0.0147 0.0243 0.0243
Echinococcus granulosus phd:f box containing protein 0.0029 0.0025 0.0025
Echinococcus multilocularis pyruvate kinase 0.0039 0.0043 0.0043
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0147 0.0243 0.0243
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0034 0.167
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0005 0.0003
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0196 0.0335 0.0333
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0034 0.7726
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0043 0.0765
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0096 0.015 0.0149
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0147 0.0243 0.0241
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0034 0.5997
Loa Loa (eye worm) hypothetical protein 0.0118 0.0191 0.019
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0088 0.0086
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0043 0.0886
Schistosoma mansoni ap endonuclease 0.0022 0.0012 0.001
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0074 0.0073
Brugia malayi hypothetical protein 0.0118 0.0191 0.019
Echinococcus multilocularis tar DNA binding protein 0.0147 0.0243 0.0243
Onchocerca volvulus Huntingtin homolog 0.0118 0.0191 0.3954
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0036
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0049 0.0873
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0096 0.0149 0.0147
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0022 0.0969
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0348
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0034 0.1706
Leishmania major hypothetical protein, conserved 0.0029 0.0025 0.1221
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0058 0.266
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.0204 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0174 0.0174
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0179 0.0302 0.0302
Trypanosoma brucei glucosidase, putative 0.0042 0.0049 0.2382
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0096 0.0149 0.0149
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0034 0.0034
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0394 0.0394
Loa Loa (eye worm) apoptosis regulator protein 0.0096 0.0149 0.0149
Onchocerca volvulus Huntingtin homolog 0.0118 0.0191 0.3954
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0005 0.0005
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0043 0.0043
Echinococcus multilocularis L aminoadipate semialdehyde 0.0096 0.015 0.015
Onchocerca volvulus 0.0026 0.002 0.0403
Leishmania major pyruvate kinase 0.0039 0.0043 0.2089
Schistosoma mansoni tar DNA-binding protein 0.0147 0.0243 0.0241
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0321 0.0321
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0031 0.0031
Mycobacterium ulcerans glutaminase 0.0317 0.0557 1
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0204 1
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0025 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0204 0.3664
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0012 0.0206
Loa Loa (eye worm) hypothetical protein 0.0118 0.0191 0.019
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0074 0.0072
Echinococcus multilocularis pyruvate kinase 0.003 0.0028 0.0028
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0043 0.0765
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0008 0.0753
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0348
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0043 0.0572
Brugia malayi CXXC zinc finger family protein 0.0057 0.0077 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0058 0.0853
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0012 0.1713
Echinococcus granulosus pyruvate kinase 0.0039 0.0043 0.0043
Brugia malayi Bromodomain containing protein 0.0034 0.0034 0.0034
Echinococcus multilocularis lysine specific demethylase 5A 0.0109 0.0173 0.0173
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0005 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0058 0.0058
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0043 0.2089
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0034 0.1733
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0096 0.015 0.0148
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0034 0.1583
Loa Loa (eye worm) intermediate filament protein 0.0026 0.002 0.0019
Schistosoma mansoni apoptosis regulator bax 0.0096 0.0149 0.0147
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0036 0.045
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0049 0.2382
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0025 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0049 0.0873
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0047 0.0058 0.0058
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0062 0.1099
Echinococcus multilocularis peregrin 0.0034 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0076 0.0112 0.0112
Loa Loa (eye worm) glutaminase 2 0.0317 0.0557 0.0557
Onchocerca volvulus Alhambra homolog 0.0034 0.0034 0.0699
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0049 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0034 0.0612
Schistosoma mansoni ap endonuclease 0.0022 0.0012 0.001
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0058 0.284
Echinococcus multilocularis microtubule associated protein 2 0.1598 0.2929 0.2929
Toxoplasma gondii exonuclease III APE 0.0022 0.0012 0.0384
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0033 0.138
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.0197 0.0195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0033 0.138
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0072 0.1281
Onchocerca volvulus 0.0096 0.015 0.3104
Echinococcus granulosus pyruvate kinase 0.0039 0.0043 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0348
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0043 0.0043
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0058 0.0853
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.002 0.0348
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0049 0.0049
Schistosoma mansoni cpg binding protein 0.0057 0.0077 0.0075
Schistosoma mansoni kinase 0.0056 0.0074 0.0072
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0025 0.0025
Echinococcus granulosus pyruvate kinase 0.002 0.0008 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0012 0.0561
Echinococcus multilocularis geminin 0.0196 0.0335 0.0335
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0025 0.1188
Schistosoma mansoni intermediate filament proteins 0.0026 0.002 0.0018
Echinococcus granulosus geminin 0.0196 0.0335 0.0335
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0073
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0036 0.8241
Schistosoma mansoni pyruvate kinase 0.002 0.0008 0.0006
Schistosoma mansoni cpg binding protein 0.006 0.0083 0.0081
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0021 0.1029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.002 0.0018
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0096 0.0149 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0078 0.0078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0012 0.0561
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0033 0.138
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0058 0.0853
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0174 0.3608
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0034 0.0612
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.0204 1
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0174 0.3116
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0204 0.0203
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0012 0.0012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0088 0.0088
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0022 0.1042
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0034 0.0034
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0022 0.0969
Brugia malayi jmjC domain containing protein 0.0029 0.0025 0.0025
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0074 0.0074
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.002 0.0348
Echinococcus granulosus pyruvate kinase 0.002 0.0008 0.0008

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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