Detailed information for compound 880756

Basic information

Technical information
  • TDR Targets ID: 880756
  • Name: N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl ]-4-(2-methylbutan-2-yl)benzenesulfonamide
  • MW: 403.434 | Formula: C19H21F4NO2S
  • H donors: 1 H acceptors: 2 LogP: 5.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(c1ccc(cc1)S(=O)(=O)NCc1cc(ccc1F)C(F)(F)F)(C)C
  • InChi: 1S/C19H21F4NO2S/c1-4-18(2,3)14-5-8-16(9-6-14)27(25,26)24-12-13-11-15(19(21,22)23)7-10-17(13)20/h5-11,24H,4,12H2,1-3H3
  • InChiKey: FAYQRIJJNQWBGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(1,1-dimethylpropyl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]benzenesulfonamide
  • 4-tert-amyl-N-[2-fluoro-5-(trifluoromethyl)benzyl]benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.0442 0.0961
Schistosoma mansoni cpg binding protein 0.0032 0.0301 0.0298
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0616 0.7586
Brugia malayi Pre-SET motif family protein 0.0217 0.2924 0.638
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.016 0.2118 0.2115
Leishmania major heat shock protein, putative 0.0028 0.0246 0.3005
Plasmodium vivax SET domain protein, putative 0.0032 0.0303 0.1225
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Schistosoma mansoni heat shock protein 0.0028 0.0246 0.0243
Onchocerca volvulus 0.0028 0.0251 0.0741
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.2118 0.6274
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0014 0.005 0.0562
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Echinococcus granulosus caspase 8 0.0055 0.0635 0.0634
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.016 0.2118 1
Trypanosoma cruzi metacaspase, putative 0.0055 0.0635 0.7826
Schistosoma mansoni rab6-interacting 0.0021 0.0147 0.0144
Schistosoma mansoni eyes absent homolog 0.0092 0.115 0.1147
Brugia malayi CXXC zinc finger family protein 0.003 0.0277 0.0605
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0811 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Entamoeba histolytica heat shock protein 90, putative 0.0068 0.0811 0.3679
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0616 0.1718
Echinococcus granulosus lamin 0.0028 0.0251 0.025
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0104
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0003 0.0008
Leishmania major DNA topoisomerase ii 0.0014 0.005 0.0562
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0028 0.0246 0.0952
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0139 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Entamoeba histolytica hypothetical protein 0.0037 0.0384 0.1616
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0442 0.5425
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0003 0.0002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0346 0.0899
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0529
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.005 0.0562
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0008
Trypanosoma cruzi metacaspase 5, putative 0.0055 0.0635 0.7826
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0008
Giardia lamblia Grp94/Hsp90 0.0054 0.0616 0.2738
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0087 0.0182
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.0442 0.044
Trypanosoma brucei unspecified product 0.0014 0.0051 0.0575
Trypanosoma brucei unspecified product 0.002 0.0139 0.1667
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0139 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0635 0.1777
Onchocerca volvulus 0.0247 0.3347 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0635 0.1777
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0008
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0251 0.0548
Trichomonas vaginalis rotamase, putative 0.0035 0.0346 0.0899
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0087 0.0086
Echinococcus multilocularis tumor protein p63 0.0352 0.4822 0.4822
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0002
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0014 0.005 0.0108
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0008
Echinococcus multilocularis expressed protein 0.0035 0.0346 0.0344
Schistosoma mansoni hypothetical protein 0.0426 0.5868 0.5867
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0014 0.005 0.0741
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.016 0.2118 0.462
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0014 0.005 0.0741
Echinococcus granulosus dna polymerase kappa 0.002 0.0139 0.0137
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0139 0.1667
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0635 0.2832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0004
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Brugia malayi Probable DNA topoisomerase II 0.0014 0.005 0.0108
Loa Loa (eye worm) heat shock protein 75 0.0028 0.0246 0.0534
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0616 0.1718
Trypanosoma brucei heat shock protein 90, putative 0.0068 0.0811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0303 0.03
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Echinococcus multilocularis lamin 0.0028 0.0251 0.025
Trypanosoma brucei heat shock protein 90, putative 0.0068 0.0811 1
Schistosoma mansoni caspase-3 (C14 family) 0.0207 0.2774 0.2771
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.0442 0.1896
Plasmodium falciparum metacaspase-like protein 0.0055 0.0635 0.2832
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0055 0.0635 0.4132
Schistosoma mansoni lamin 0.0028 0.0251 0.0248
Echinococcus multilocularis caspase 0.0207 0.2774 0.2772
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0002
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.2118 0.6274
Trypanosoma cruzi metacaspase, putative 0.0055 0.0635 0.7826
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0564 0.1231
Plasmodium falciparum endoplasmin, putative 0.0042 0.0441 0.1893
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0139 0.0137
Schistosoma mansoni cpg binding protein 0.003 0.0277 0.0274
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0139 0.0431
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0513 0.6311
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0054 0.0616 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0014 0.005 0.0297
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0147 0.0317
Leishmania major DNA polymerase kappa, putative 0.002 0.0139 0.1667
Brugia malayi hypothetical protein 0.0021 0.0147 0.0321
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0081
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1602 0.1601
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0139 0.1667
Onchocerca volvulus 0.0021 0.0147 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0008
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.005 0.0297
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.016 0.2118 0.2117
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.1029
Echinococcus granulosus heat shock protein 90 0.0054 0.0616 0.0614
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0616 0.1718
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.005 0.5
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0334 0.4095
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.0442 0.5425
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0139 0.1667
Echinococcus multilocularis dna polymerase eta 0.0047 0.0513 0.0512
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0278 0.0276
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0055 0.0635 0.0632
Trypanosoma brucei heat shock protein 84, putative 0.0028 0.0246 0.3005
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0051 0.0575
Echinococcus granulosus dnaJ subfamily B 0.0426 0.5868 0.5867
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0081
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0139 0.1573
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.005 0.0297
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.0442 0.1896
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0139 0.1573
Loa Loa (eye worm) hypothetical protein 0.0032 0.0303 0.0658
Loa Loa (eye worm) hypothetical protein 0.0246 0.3331 0.7268
Schistosoma mansoni polycystin 1-related 0.0021 0.0147 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0635 0.1777
Echinococcus multilocularis endoplasmin 0.0054 0.0616 0.0614
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.005 0.0048
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0003 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0139 0.1667
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0147 0.0145
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0014 0.005 0.0048
Trypanosoma brucei DNA topoisomerase ii 0.0014 0.005 0.0562
Brugia malayi kinase, mitochondrial precursor 0.0014 0.005 0.0108
Echinococcus granulosus caspase 2 0.0055 0.0635 0.0634
Toxoplasma gondii heat shock protein 90, putative 0.0068 0.0811 0.528
Plasmodium vivax heat shock protein 86, putative 0.0068 0.0811 0.3679
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Loa Loa (eye worm) endoplasmin 0.0068 0.0811 0.1766
Onchocerca volvulus 0.0042 0.0442 0.1311
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0147 0.0145
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0054 0.0616 1
Schistosoma mansoni pyruvate dehydrogenase 0.0014 0.005 0.0046
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0139 0.1573
Leishmania major developmentally regulated phosphoprotein-like protein 0.0014 0.005 0.0562
Onchocerca volvulus Cell death protein 3 homolog 0.0055 0.0635 0.189
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0616 0.7586
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0054 0.0616 0.0614
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0028 0.0255 0.0251
Echinococcus multilocularis heat shock protein 90 0.0054 0.0616 0.0614
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0067 0.0143
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.005 0.0562
Giardia lamblia Rab geranylgeranyltransferase 0.016 0.2118 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0087 0.0543
Echinococcus granulosus heat shock protein 90 0.0068 0.0811 0.0809
Brugia malayi heat shock protein 90 0.0068 0.0811 0.1769
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0139 0.0302
Trypanosoma brucei metacaspase MCA3 0.0055 0.0635 0.7826
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0014 0.005 0.0562
Echinococcus multilocularis lamin dm0 0.0028 0.0251 0.025
Plasmodium vivax prenyltransferase alpha subunit, putative 0.016 0.2118 1
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0811 1
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.3331 0.333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Loa Loa (eye worm) hypothetical protein 0.0028 0.0255 0.0553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0004
Schistosoma mansoni caspase-7 (C14 family) 0.0207 0.2774 0.2771
Loa Loa (eye worm) hypothetical protein 0.0055 0.0635 0.1383
Echinococcus multilocularis heat shock protein 90 0.0068 0.0811 0.0809
Echinococcus multilocularis caspase 8 0.0055 0.0635 0.0634
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0346 0.0752
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0317
Schistosoma mansoni heat shock protein 0.0068 0.0811 0.0807
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Echinococcus granulosus caspase 3 0.0152 0.1993 0.1992
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.005 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0147 0.0145
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0014 0.005 0.0562
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.1029
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0441 0.1188
Trypanosoma brucei metacaspase MCA2 0.0055 0.0635 0.7826
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0255 0.0556
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0317 0.3885
Schistosoma mansoni hypothetical protein 0.0028 0.0255 0.0251
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.1531 0.4495
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0028 0.0246 0.1586
Trypanosoma brucei Heat shock protein 83, putative 0.0068 0.0811 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0002
Onchocerca volvulus 0.005 0.0564 0.1677
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0014 0.005 0.0741
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0635 0.1777
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0303 0.0301
Toxoplasma gondii heat shock protein HSP90 0.0068 0.0811 0.528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0147 0.0317
Brugia malayi Pre-SET motif family protein 0.0032 0.0303 0.0661
Schistosoma mansoni hypothetical protein 0.0021 0.0147 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0004
Schistosoma mansoni caspase-7 (C14 family) 0.0055 0.0635 0.0632
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0513 0.6311
Plasmodium vivax heat shock protein 90, putative 0.0028 0.0246 0.0952
Echinococcus granulosus endoplasmin 0.0054 0.0616 0.0614
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.0442 0.1189
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0334 0.1377
Trichomonas vaginalis rotamase, putative 0.0034 0.0334 0.0864
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0087 0.0543
Plasmodium vivax heat shock protein, putative 0.0028 0.0246 0.0952
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0046 0.0045
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0147 0.0471
Leishmania major metacaspase, putative 0.0055 0.0635 0.7826
Trypanosoma brucei Metacaspase-4 0.0055 0.0635 0.7826
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0147 0.0145
Echinococcus granulosus intermediate filament protein 0.0028 0.0251 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0004
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.0442 0.044
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0014 0.005 0.0048
Treponema pallidum heat shock protein 90 0.0054 0.0616 1
Echinococcus granulosus lamin dm0 0.0028 0.0251 0.025
Echinococcus multilocularis dna polymerase kappa 0.002 0.0139 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0303 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0442 0.5425
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0671 0.4366
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0003 0.0004
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.005 0.0562
Schistosoma mansoni DNA topoisomerase II 0.0014 0.005 0.0046
Onchocerca volvulus 0.0052 0.0582 0.173
Echinococcus multilocularis heat shock protein 0.0068 0.0811 0.0809
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0303 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0303 0.0301
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0054 0.0616 0.7586
Schistosoma mansoni hypothetical protein 0.005 0.0564 0.0561
Brugia malayi steroid hormone receptor 0.0011 0.0003 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Echinococcus granulosus dna polymerase eta 0.0047 0.0513 0.0512
Loa Loa (eye worm) hypothetical protein 0.0055 0.0635 0.1383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0003 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0334 0.4095
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0051 0.0575
Schistosoma mansoni lipoxygenase 0.0124 0.1602 0.16
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0635 0.1777
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0002
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0303 0.0301
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0054 0.0616 1
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Brugia malayi hypothetical protein 0.0021 0.0147 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0317 0.2051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0303 0.1956
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0384 0.038
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0419 0.5144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trichomonas vaginalis endoplasmin, putative 0.0042 0.0441 0.1188
Echinococcus granulosus cpg binding protein 0.0032 0.0301 0.03
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0087 0.0664
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0207 0.2774 0.2772
Brugia malayi Endoplasmin precursor 0.0068 0.0811 0.1769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0582 0.0579
Trypanosoma cruzi heat shock protein 90, putative 0.0068 0.0811 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Schistosoma mansoni DNA polymerase eta 0.0047 0.0513 0.051
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.0442 0.0964
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Loa Loa (eye worm) tumor suppressor 0.0335 0.4583 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2924 0.6379
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.005 0.0138
Schistosoma mansoni endoplasmin 0.0068 0.0811 0.0807
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.1267
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0046 0.0045
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.0442 0.1896
Trypanosoma brucei metacaspase 5, putative 0.0055 0.0635 0.7826
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0513 0.112
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0147 0.0145
Brugia malayi Hsp90 protein 0.0028 0.0246 0.0538
Leishmania major DNA polymerase eta, putative 0.0047 0.0513 0.6311
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1602 0.1601
Schistosoma mansoni hypothetical protein 0.0037 0.0384 0.038
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0246 0.0952
Leishmania major DNA polymerase eta, putative 0.0033 0.0317 0.3885
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0087 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0087 0.1029
Trypanosoma cruzi metacaspase, putative 0.0055 0.0635 0.7826
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0008
Echinococcus multilocularis caspase 3 0.0152 0.1993 0.1992
Echinococcus granulosus caspase 0.0207 0.2774 0.2772
Echinococcus multilocularis caspase 2 0.0055 0.0635 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Leishmania major hypothetical protein, conserved 0.0014 0.005 0.0562
Echinococcus multilocularis microtubule associated protein 2 0.0719 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0616 0.2738
Entamoeba histolytica hypothetical protein 0.0037 0.0384 0.1616
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.005 0.0048
Schistosoma mansoni lipoxygenase 0.0087 0.1077 0.1074
Leishmania major mitochondrial DNA topoisomerase II 0.0014 0.005 0.0562
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0442 0.5425
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0442 0.044
Brugia malayi Cell death protein 3 precursor 0.0055 0.0635 0.1386
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0014 0.005 0.0138
Plasmodium falciparum heat shock protein 90 0.0068 0.0811 0.3679
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0002
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.005 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0087 0.0182
Loa Loa (eye worm) hypothetical protein 0.0092 0.115 0.2508
Entamoeba histolytica hypothetical protein 0.0037 0.0384 0.1616
Schistosoma mansoni cpg binding protein 0.0032 0.0301 0.0298
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0028 0.0246 0.0245
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.016 0.2118 1
Trypanosoma cruzi metacaspase 5, putative 0.0055 0.0635 0.7826
Echinococcus granulosus hypothetical protein 0.0028 0.0255 0.0253
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0003 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0725 0.0722
Onchocerca volvulus 0.0032 0.0303 0.0896
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0334 0.2162
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0003 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0087 0.0086
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0087 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0303 0.03
Onchocerca volvulus 0.0021 0.0147 0.0429
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.0442 0.1896
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0004
Brugia malayi hypothetical protein 0.0037 0.0384 0.0838
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0003 0.0002
Giardia lamblia DINP protein human, muc B family 0.002 0.0139 0.0431
Echinococcus multilocularis RUN 0.0021 0.0147 0.0145
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0442 0.5425
Echinococcus multilocularis cpg binding protein 0.0032 0.0301 0.03
Loa Loa (eye worm) hypothetical protein 0.0028 0.0251 0.0545
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0246 0.0952
Plasmodium vivax metacaspase 1, putative 0.0055 0.0635 0.2832
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0442 0.5425
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0384 0.0382
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0139 0.0137
Brugia malayi tumor suppressor. 0.0335 0.4583 1
Toxoplasma gondii hypothetical protein 0.0119 0.1531 1
Echinococcus multilocularis protein quaking 0.0028 0.0255 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0251 0.0545
Schistosoma mansoni loxhd1 0.0021 0.0147 0.0144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.016 0.2118 0.6274
Brugia malayi hypothetical protein 0.0028 0.0255 0.0556
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0003 0.0002
Brugia malayi ecdysteroid receptor 0.0011 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0097
Loa Loa (eye worm) heat shock protein 90 0.0068 0.0811 0.1766
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0028 0.0246 0.0727
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Echinococcus granulosus expressed protein 0.0035 0.0346 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0051 0.0575
Brugia malayi Doublecortin family protein 0.0021 0.0147 0.0321
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0442 0.5425
Entamoeba histolytica hypothetical protein 0.0037 0.0384 0.1616
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0147 0.0145
Trypanosoma brucei developmentally regulated phosphoprotein 0.0014 0.005 0.0562
Schistosoma mansoni rotamase 0.0035 0.0346 0.0343
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.016 0.2118 0.4622
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0087 0.019
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0028 0.0246 0.0245
Plasmodium vivax endoplasmin, putative 0.0068 0.0811 0.3679
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0246 0.0597
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0067 0.0147
Giardia lamblia Heat shock protein HSP 90-alpha 0.0068 0.0811 0.3679
Trypanosoma cruzi heat shock protein, putative 0.0028 0.0246 0.3005
Schistosoma mansoni intermediate filament proteins 0.0028 0.0251 0.0248
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.5868 0.5867
Toxoplasma gondii hypothetical protein 0.0042 0.0442 0.2865
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0139 0.1667
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.016 0.2118 0.2117
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0139 0.1667
Toxoplasma gondii heat shock protein 75, putative 0.0028 0.0246 0.1586
Trypanosoma brucei metacaspase 0.0055 0.0635 0.7826
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0055 0.0635 0.4132
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0635 0.1777
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0139 0.027
Loa Loa (eye worm) hypothetical protein 0.0092 0.115 0.2508
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0104
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0139 0.1667
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3347 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.005 0.0297
Loa Loa (eye worm) hypothetical protein 0.016 0.2118 0.462
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0002
Schistosoma mansoni endoplasmin 0.0068 0.0811 0.0807
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0384 0.0382
Brugia malayi isocitrate dehydrogenase 0.0016 0.0087 0.019
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0442 0.044
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.005 0.0104
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.005 0.0562
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0004
Trypanosoma brucei unspecified product 0.0014 0.0051 0.0575
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0008
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.005 0.0138
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0139 0.0135
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0002
Schistosoma mansoni heat shock protein 0.0068 0.0811 0.0807
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0251 0.0545
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Onchocerca volvulus 0.0028 0.0251 0.0741
Onchocerca volvulus 0.003 0.0277 0.0819
Schistosoma mansoni microtubule-associated protein tau 0.0719 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0087 0.0187
Entamoeba histolytica heat shock protein 90, putative 0.0068 0.0811 0.3679
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0442 0.5425
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0104
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0442 0.5425
Trypanosoma brucei heat shock protein, putative 0.0068 0.0811 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0014 0.005 0.0048
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0334 0.4095
Leishmania major heat shock protein 83-1 0.0068 0.0811 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.005 0.0562
Echinococcus granulosus RUN 0.0021 0.0147 0.0145
Echinococcus granulosus tumor protein p63 0.0352 0.4822 0.4822
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0139 0.1667
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0334 0.4095
Brugia malayi hypothetical protein 0.0246 0.3331 0.7269
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0346 0.0755
Loa Loa (eye worm) hypothetical protein 0.0047 0.0513 0.1116
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0139 0.1667
Schistosoma mansoni lamin 0.0028 0.0251 0.0248
Schistosoma mansoni survival motor neuron protein 0.005 0.0564 0.0561
Echinococcus multilocularis musashi 0.0028 0.0251 0.025
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.005 0.0562
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0811 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0003 0.0008
Trypanosoma cruzi Heat shock protein 83, putative 0.0068 0.0811 1
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.0442 0.5425
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0087 0.1029
Echinococcus granulosus protein quaking 0.0028 0.0255 0.0253
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0207 0.2774 0.2772
Plasmodium falciparum metacaspase 1 0.0055 0.0635 0.2832
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0055 0.0635 0.4132
Brugia malayi hypothetical protein 0.0092 0.115 0.251
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0277 0.0601
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0811 0.2308
Trypanosoma cruzi metacaspase, putative 0.0055 0.0635 0.7826
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0147 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0008
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.3331 0.333
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0767 0.0763
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0014 0.005 0.0108
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0055 0.0635 0.1386
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0635 0.1777
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0087 0.1029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0002
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0139 0.0299
Echinococcus granulosus heat shock protein 0.0068 0.0811 0.0809
Brugia malayi intermediate filament protein 0.0028 0.0251 0.0548
Mycobacterium ulcerans heat shock protein 90 0.0054 0.0616 1
Schistosoma mansoni rab6-interacting 0.0021 0.0147 0.0144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.