Detailed information for compound 893877

Basic information

Technical information
  • TDR Targets ID: 893877
  • Name: 1-[1-(2,5-dimethoxyphenyl)-2,5-dioxopyrrolidi n-3-yl]piperidine-4-carboxamide
  • MW: 361.392 | Formula: C18H23N3O5
  • H donors: 1 H acceptors: 3 LogP: 0.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1N1C(=O)CC(C1=O)N1CCC(CC1)C(=O)N)OC
  • InChi: 1S/C18H23N3O5/c1-25-12-3-4-15(26-2)13(9-12)21-16(22)10-14(18(21)24)20-7-5-11(6-8-20)17(19)23/h3-4,9,11,14H,5-8,10H2,1-2H3,(H2,19,23)
  • InChiKey: HCMIALRRFIGPJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[1-(2,5-dimethoxyphenyl)-2,5-dioxo-pyrrolidin-3-yl]piperidine-4-carboxamide
  • 1-[1-(2,5-dimethoxyphenyl)-2,5-dioxo-3-pyrrolidinyl]-4-piperidinecarboxamide
  • 1-[1-(2,5-dimethoxyphenyl)-2,5-diketo-pyrrolidin-3-yl]isonipecotamide
  • STOCK4S-53924
  • BAS 06107553

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major modification methylase-like protein 0.0333 0.2217 0.6289
Chlamydia trachomatis AMP nucleosidase 0.0026 0 0.5
Leishmania major arginine N-methyltransferase, type I 0.003 0.0029 0.0082
Toxoplasma gondii bicoid-interacting protein BIN3 0.003 0.0029 0.013
Schistosoma mansoni cpg binding protein 0.0132 0.0766 0.1169
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0215 0.1362 0.3865
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3525 1
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0215 0.1362 0.208
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0115 0.0648 0.0989
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0043 0.0065
Echinococcus multilocularis hepatoma derived growth factor protein 0.0088 0.045 0.0687
Leishmania major histone-lysine N-methyltransferase, putative 0.0119 0.067 0.1902
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0043 0.0043
Toxoplasma gondii DNA methyltransferase 2, putative 0.0333 0.2217 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.1198 0.1311
Brugia malayi SET domain containing protein 0.0027 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0934 0.655 0.7163
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0032 0.0043 0.0121
Trypanosoma brucei transcription elongation factor s-II, putative 0.0088 0.045 0.1276
Schistosoma mansoni hypothetical protein 0.003 0.0029 0.0044
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0043 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0241 0.1555 0.2374
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0923 0.6471 0.7077
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3525 1
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0073 0.0339 0.0517
Echinococcus granulosus peregrin 0.0118 0.0666 0.1016
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.045 0.1276
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0029 0.0029
Echinococcus multilocularis protein arginine methyltransferase 0.0032 0.0043 0.0065
Echinococcus granulosus protein arginine methyltransferase 0.0032 0.0043 0.0065
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0031 0.0034
Echinococcus granulosus PWWP domain containing protein 2A 0.0088 0.045 0.0687
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.003 0.0029 0.0082
Schistosoma mansoni hepatoma derived growth factor 0.0088 0.045 0.0687
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0032 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.0165 0.1008 0.1102
Echinococcus multilocularis PWWP domain containing protein 2A 0.0088 0.045 0.0687
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0139 0.0814 0.1243
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0089 0.0136
Brugia malayi SET domain containing protein 0.0139 0.0814 0.0891
Echinococcus multilocularis spermidine synthase 0.0515 0.3525 0.5381
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0119 0.067 0.1902
Echinococcus granulosus cpg binding protein 0.0132 0.0766 0.1169
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0138 0.0812 0.2303
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0026 0 0.5
Trypanosoma cruzi arginine N-methyltransferase, type III 0.003 0.0029 0.0082
Echinococcus multilocularis disco interacting protein 2 0.0115 0.0648 0.0989
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0119 0.067 0.1902
Loa Loa (eye worm) hypothetical protein 0.0923 0.6471 0.7077
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0035 0.0066 0.0101
Plasmodium falciparum spermidine synthase 0.0515 0.3525 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1294 0.9145 1
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0333 0.2217 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0007
Giardia lamblia PHD finger protein 15 0.003 0.0031 1
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0105 0.0569 0.1614
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0028 0.0018 0.0028
Brugia malayi hypothetical protein 0.0088 0.045 0.0492
Loa Loa (eye worm) SET domain-containing protein 0.0139 0.0814 0.0891
Loa Loa (eye worm) PWWP domain-containing protein 0.0088 0.045 0.0492
Loa Loa (eye worm) hypothetical protein 0.0111 0.0613 0.0671
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0215 0.1362 0.149
Plasmodium vivax spermidine synthase, putative 0.0515 0.3525 1
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0333 0.2217 0.6289
Loa Loa (eye worm) SET domain-containing protein 0.0204 0.1286 0.1407
Echinococcus multilocularis cpg binding protein 0.0132 0.0766 0.1169
Echinococcus multilocularis histone h3 methyltransferase 0.0934 0.655 1
Trichomonas vaginalis set domain proteins, putative 0.1413 1 1
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0119 0.067 0.1902
Loa Loa (eye worm) hypothetical protein 0.0061 0.0256 0.028
Entamoeba histolytica hypothetical protein 0.0088 0.045 0.2029
Trypanosoma brucei protein arginine n-methyltransferase 7 0.003 0.0029 0.0082
Brugia malayi PHD-finger family protein 0.003 0.0031 0.0034
Loa Loa (eye worm) CXXC zinc finger family protein 0.013 0.0753 0.0824
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0085 0.0425 0.1206
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0029 0.0029
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0116 0.0177
Plasmodium vivax hypothetical protein, conserved 0.003 0.0031 0.0089
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0215 0.1362 0.3865
Leishmania major methylthioadenosine phosphorylase, putative 0.0138 0.0812 0.2303
Brugia malayi CXXC zinc finger family protein 0.013 0.0753 0.0824
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0119 0.067 0.1902
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.003 0.0029 0.013
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0138 0.0812 0.2303
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0138 0.0812 0.2303
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.003 0.0029 0.0082
Loa Loa (eye worm) hypothetical protein 0.0923 0.6471 0.7077
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0383 0.2577 1
Brugia malayi Protein arginine N-methyltransferase 0.003 0.0029 0.0031
Entamoeba histolytica hypothetical protein 0.0061 0.0256 0.1155
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0043 0.0043
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0149 0.0892 0.1362
Echinococcus multilocularis peregrin 0.0118 0.0666 0.1016
Echinococcus granulosus hepatoma derived growth factor protein 0.0088 0.045 0.0687
Brugia malayi jmjC domain containing protein 0.0098 0.0523 0.0571
Loa Loa (eye worm) Carm1-pending protein 0.0149 0.0892 0.0976
Loa Loa (eye worm) hypothetical protein 0.0088 0.045 0.0492
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0061 0.0256 0.0726
Echinococcus multilocularis protein arginine N methyltransferase 7 0.003 0.0029 0.0044
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0119 0.067 0.1902
Toxoplasma gondii hypothetical protein 0.0254 0.1644 0.7417
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0757 0.3416
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0351 0.0536
Echinococcus granulosus PWWP domain containing protein 2A 0.0088 0.045 0.0687
Onchocerca volvulus 0.0115 0.0648 0.0648
Schistosoma mansoni hypothetical protein 0.0088 0.045 0.0687
Brugia malayi hypothetical protein 0.0165 0.1008 0.1102
Loa Loa (eye worm) protein arginine N-methyltransferase 0.003 0.0029 0.0031
Brugia malayi NNMT/PNMT/TEMT family protein 0.0923 0.6471 0.7077
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0088 0.045 0.1276
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.003 0.0029 0.013
Trypanosoma brucei histone-lysine n-methyltransferase 0.0119 0.067 0.1902
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0333 0.2217 0.6289
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0077 0.0117
Brugia malayi Disco-interacting protein 2 homolog 0.0115 0.0648 0.0709
Onchocerca volvulus 0.0088 0.045 0.045
Onchocerca volvulus 0.0241 0.1555 0.1555
Schistosoma mansoni hypothetical protein 0.0088 0.045 0.0687
Loa Loa (eye worm) hypothetical protein 0.0165 0.1008 0.1102
Mycobacterium ulcerans spermidine synthase 0.0383 0.2577 1
Leishmania major hypothetical protein, conserved 0.0119 0.067 0.1902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0757 0.1156
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.003 0.0029 0.0029
Brugia malayi hypothetical protein 0.0165 0.1008 0.1102
Leishmania major arginine N-methyltransferase-like protein 0.0032 0.0043 0.0121
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0149 0.0892 0.4025
Loa Loa (eye worm) hypothetical protein 0.003 0.0031 0.0034
Schistosoma mansoni methylthioadenosine phosphorylase 0.0138 0.0812 0.124
Schistosoma mansoni enhancer of zeste ezh 0.0204 0.1286 0.1964
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0192 0.1198 0.183
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0934 0.655 0.7163
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.0355
Trypanosoma brucei spermidine synthase 0.0515 0.3525 1
Brugia malayi Pre-SET motif family protein 0.0165 0.1008 0.1102
Echinococcus multilocularis PWWP domain containing protein 2A 0.0088 0.045 0.0687
Brugia malayi hypothetical protein 0.0061 0.0256 0.028
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0215 0.1362 0.3865
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0138 0.0812 0.315
Schistosoma mansoni hepatoma derived growth factor 0.0088 0.045 0.0687
Echinococcus multilocularis geminin 0.0174 0.107 0.1634
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0043 0.0065
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0032 0.0043 0.0193
Schistosoma mansoni methylthioadenosine phosphorylase 0.0138 0.0812 0.124
Echinococcus granulosus geminin 0.0174 0.107 0.1634
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0043 0.0065
Mycobacterium leprae probable uridine phosphorylase 0.0026 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.045 0.1276
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.01 0.0536 0.0819
Schistosoma mansoni hypothetical protein 0.0053 0.0201 0.0306
Schistosoma mansoni methyl-cpg binding protein mbd 0.0026 0.0006 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0192 0.1198 0.183
Schistosoma mansoni methyl-cpg binding protein mbd 0.0026 0.0006 0.0009
Brugia malayi hypothetical protein 0.0088 0.045 0.0492
Brugia malayi SET domain containing protein 0.0204 0.1286 0.1407
Schistosoma mansoni cpg binding protein 0.013 0.0753 0.115
Loa Loa (eye worm) hypothetical protein 0.0051 0.0186 0.0203
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0061 0.0256 0.0726
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0377 0.0576
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0333 0.2217 0.3384
Plasmodium vivax SET domain protein, putative 0.0131 0.0757 0.2149
Brugia malayi Bromodomain containing protein 0.0028 0.0018 0.002
Schistosoma mansoni protein arginine n-methyltransferase 0.0149 0.0892 0.1362
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.4955 0.7565
Onchocerca volvulus 0.0165 0.1008 0.1008
Echinococcus granulosus histone h3 methyltransferase 0.0934 0.655 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.1008 0.1102
Onchocerca volvulus 0.013 0.0753 0.0753
Loa Loa (eye worm) spermidine synthase 0.0515 0.3525 0.3855
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0105 0.0569 0.1614
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0523 0.0798
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0138 0.0812 0.124
Leishmania major hypothetical protein, conserved 0.0088 0.045 0.1276
Toxoplasma gondii hypothetical protein 0.0119 0.067 0.3024
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0254 0.1644 0.4664
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0215 0.1362 0.149
Leishmania major spermidine synthase 0.0515 0.3525 1
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0215 0.1362 0.3865
Echinococcus granulosus disco interacting protein 2 0.0115 0.0648 0.0989
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0192 0.1198 0.183
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0215 0.1362 0.3865
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3525 1
Toxoplasma gondii hypothetical protein 0.0088 0.045 0.2029
Trypanosoma cruzi spermidine synthase, putative 0.0515 0.3525 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0021 0.0032
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0088 0.045 0.1276
Onchocerca volvulus Alhambra homolog 0.003 0.0031 0.0031
Leishmania major S-adenosylmethionine decarboxylase 0.0215 0.1362 0.3865
Schistosoma mansoni cpg binding protein 0.0132 0.0766 0.1169
Schistosoma mansoni hypothetical protein 0.0174 0.107 0.1634
Trypanosoma cruzi arginine N-methyltransferase, type I 0.003 0.0029 0.0082
Echinococcus granulosus protein arginine N methyltransferase 7 0.003 0.0029 0.0044
Echinococcus granulosus methyl CpG binding domain protein 2 0.0026 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0066 0.0072
Onchocerca volvulus 0.012 0.0679 0.0679
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0303 0.1365
Echinococcus granulosus microtubule associated protein 2 0.0713 0.4955 0.7565
Brugia malayi jmjC domain containing protein 0.0038 0.0089 0.0097
Schistosoma mansoni hypothetical protein 0.0174 0.107 0.1634
Treponema pallidum uridine phosphorylase (udp) 0.0026 0 0.5
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0061 0.0256 0.0726
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0523 0.0798
Brugia malayi PWWP domain containing protein 0.0088 0.045 0.0492
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0261 0.0286
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0031 0.0048
Leishmania major hypothetical protein, conserved 0.0119 0.067 0.1902
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0028 0.0018 0.0028
Schistosoma mansoni phd finger protein 0.0088 0.045 0.0687
Loa Loa (eye worm) hypothetical protein 0.0115 0.0648 0.0709
Echinococcus granulosus DNA methyltransferase 2, putative 0.0333 0.2217 0.3384
Schistosoma mansoni hypothetical protein 0.003 0.0031 0.0048
Schistosoma mansoni SET domain protein 0.0102 0.0548 0.0837
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0088 0.045 0.1276
Brugia malayi SET domain containing protein 0.0123 0.07 0.0765
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0333 0.2217 0.3384
Brugia malayi Pre-SET motif family protein 0.1294 0.9145 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0153 0.0922 0.1407
Echinococcus granulosus methyltransferase protein 5 0.003 0.0029 0.0044
Brugia malayi Bromodomain containing protein 0.003 0.0031 0.0034
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0031 0.0142
Echinococcus granulosus spermidine synthase 0.0515 0.3525 0.5381
Brugia malayi MTAP 0.0138 0.0812 0.0888
Schistosoma mansoni histone J3 methyltransferase 0.0934 0.655 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0089 0.0097
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0333 0.2217 0.6289
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0139 0.0814 0.1243
Plasmodium falciparum phd finger protein, putative 0.003 0.0031 0.0089
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0031 0.0048
Echinococcus granulosus SET and MYND domain containing protein 3 0.0073 0.0339 0.0517
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0031 0.0142
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0061 0.0256 0.1155
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0089 0.0136
Treponema pallidum pfs protein (pfs) 0.0026 0 0.5
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0204 0.1286 0.1964
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0138 0.0812 0.0888
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0031 0.0048
Echinococcus granulosus methylthioadenosine phosphorylase 0.0138 0.0812 0.124
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0333 0.2217 1
Schistosoma mansoni hypothetical protein 0.0088 0.045 0.0687
Brugia malayi Spermidine synthase 0.0515 0.3525 0.3855
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0757 0.1156
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.01 0.0536 0.0819
Echinococcus granulosus protein arginine N methyltransferase 8 0.0032 0.0043 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0192 0.1198 0.183
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0089 0.0136
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0033 0.0036
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0116 0.0177
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0215 0.1362 0.208
Onchocerca volvulus 0.0088 0.045 0.045
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0026 0.0006 0.0009
Trypanosoma cruzi arginine N-methyltransferase, type I 0.003 0.0029 0.0082
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0113 0.0627 0.2434
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0032 0.0043 0.0121
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0085 0.0425 0.1206
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0026 0 0.5
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0204 0.1286 0.1964
Brugia malayi Carm1-pending protein 0.0149 0.0892 0.0976
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.4955 0.7565
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0035 0.0066 0.0101
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0149 0.0892 0.1362
Schistosoma mansoni suppressor of variegation 4-20-related 0.0139 0.0814 0.1243
Loa Loa (eye worm) hypothetical protein 0.0114 0.0636 0.0696
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0119 0.067 0.1902

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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