TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.354 | Formula: C19H16N4O5
H donors: 2 H acceptors: 5 LogP: 2.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1O)/C=N/NC(=O)c1cc(C)nc2c1cccc2)[N+](=O)[O-]
InChi: 1S/C19H16N4O5/c1-11-7-15(14-5-3-4-6-16(14)21-11)19(25)22-20-10-12-8-13(23(26)27)9-17(28-2)18(12)24/h3-10,24H,1-2H3,(H,22,25)/b20-10+
InChiKey: NALIIICREMKATF-KEBDBYFISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tyrosyl-DNA phosphodiesterase 1	Starlite/ChEMBL	No references
Homo sapiens	runt-related transcription factor 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	core-binding factor, beta subunit		No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania infantum	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus multilocularis	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus granulosus	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_129037	All targets in OG5_129037
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Trypanosoma congolense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium parvum	tyrosyl-DNA phodphodiesterase 1 (tdp1)	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133916	All targets in OG5_133916
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania braziliensis	tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210	Get druggable targets OG5_129037	All targets in OG5_129037
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133916	All targets in OG5_133916
Schistosoma japonicum	ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	hypothetical protein	Get druggable targets OG5_133916	All targets in OG5_133916
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Trypanosoma brucei gambiense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus		Get druggable targets OG5_133916	All targets in OG5_133916
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania major	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania mexicana	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PHD-finger family protein	0.003	0.0086	0.0214
Echinococcus multilocularis	enteropeptidase	0.0071	0.0403	0.0635
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0047	0.022	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0047	0.022	0.0547
Onchocerca volvulus		0.0182	0.1274	0.3046
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0282	0.0702
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.6347	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.0086	0.4065
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0033	0.0052
Onchocerca volvulus		0.0052	0.0259	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0033	0.0083
Schistosoma mansoni	hypothetical protein	0.0041	0.0172	0.0271
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0012	0.0019
Schistosoma mansoni	hypothetical protein	0.0071	0.0403	0.0635
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.0473	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.01	0.481
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.019	0.0299
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0046	0.0114
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0282	0.0444
Onchocerca volvulus		0.0071	0.0403	0.0842
Toxoplasma gondii	microneme protein MIC17A	0.0037	0.0144	0.014
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0144	0.014
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.0473	0.0745
Onchocerca volvulus		0.0037	0.0144	0.0185
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0012	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0517	0.1286
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.01	0.0097
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.0079	0.3234
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0172	0.0429
Brugia malayi	Trypsin-like protease protein 5	0.0071	0.0403	0.1003
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.0473	0.0745
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0033	0.0083
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0282	0.0702
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0018	0.0044
Echinococcus granulosus	transmembrane protease serine 3	0.0071	0.0403	0.0635
Mycobacterium ulcerans	polyketide synthase	0.0032	0.01	0.2368
Brugia malayi	Trypsin family protein	0.0071	0.0403	0.1003
Schistosoma mansoni	hypothetical protein	0.0071	0.0403	0.0635
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0047	0.022	0.0217
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0037	0.0144	0.014
Brugia malayi	Trypsin family protein	0.0071	0.0403	0.1003
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0535	0.4021	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0047	0.022	0.0347
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0144	0.0357
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.019	0.0299
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0033	0.0052
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.0086	0.0214
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.01	0.481
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.6347	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0012	0.003
Loa Loa (eye worm)	hypothetical protein	0.0047	0.022	0.0547
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0071	0.0403	0.0635
Echinococcus granulosus	dna polymerase eta	0.0023	0.0033	0.0052
Onchocerca volvulus		0.0535	0.4021	1
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.0012	0.0019
Echinococcus multilocularis	zinc finger protein	0.0024	0.0036	0.0056
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0282	0.0444
Brugia malayi	Protein kinase domain containing protein	0.0065	0.0355	0.0882
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0071	0.0403	0.0635
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.0047	0.1016
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0033	0.0052
Onchocerca volvulus		0.0037	0.0144	0.0185
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0473	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Onchocerca volvulus		0.0065	0.0355	0.072
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.0202	1
Brugia malayi	hypothetical protein	0.0071	0.0403	0.1003
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0064	0.01
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0253	0.0629
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0033	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0245	0.061
Onchocerca volvulus		0.0037	0.0144	0.0185
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Onchocerca volvulus		0.0037	0.0144	0.0185
Onchocerca volvulus		0.0071	0.0403	0.0842
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.0473	0.1176
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.007	0.0175
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0403	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.0047	0.1481
Echinococcus granulosus	geminin	0.0205	0.1447	0.2279
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Schistosoma mansoni	lozenge	0.0067	0.0375	0.059
Toxoplasma gondii	hypothetical protein	0.0037	0.0144	0.014
Onchocerca volvulus		0.0037	0.0144	0.0185
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0057	0.0296	0.0735
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0144	0.014
Brugia malayi	Trypsin family protein	0.0071	0.0403	0.1003
Echinococcus multilocularis	tissue type plasminogen activator	0.0065	0.0355	0.0559
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0413	0.0651
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0086	0.2001
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0071	0.0403	0.0635
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.0079	0.3234
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.01	0.4429
Toxoplasma gondii	hypothetical protein	0.0037	0.0144	0.014
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0172	0.0429
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0144	0.0357
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.0473	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0413	0.0651
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.0018	0.0015
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0086	0.2001
Toxoplasma gondii	microneme protein, putative	0.0037	0.0144	0.014
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0447	0.0705
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.004	0.0847
Echinococcus multilocularis	geminin	0.0205	0.1447	0.2279
Loa Loa (eye worm)	trypsin family protein	0.0071	0.0403	0.1003
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.01	0.2368
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0321	0.0798
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0021	0.0012	0.0019
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0033	0.0673
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0282	0.0444
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0033	0.0083
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0086	0.2001
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Schistosoma mansoni	zinc finger protein	0.0024	0.0036	0.0056
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Onchocerca volvulus		0.0071	0.0403	0.0842
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0033	0.0052
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0033	0.0733
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0033	0.0052
Toxoplasma gondii	subtilisin SUB12	0.0037	0.0144	0.014
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0235	0.0584
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0086	0.3628
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Onchocerca volvulus		0.0037	0.0144	0.0185
Brugia malayi	Kringle domain containing protein	0.0065	0.0355	0.0882
Brugia malayi	hypothetical protein	0.0535	0.4021	1
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0071	0.0403	0.0635
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.004	0.172
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Brugia malayi	Trypsin family protein	0.0071	0.0403	0.1003
Loa Loa (eye worm)	hypothetical protein	0.006	0.0321	0.0798
Echinococcus multilocularis	transmembrane protease serine 3	0.0071	0.0403	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1274	0.3168
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.0086	0.4065
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0033	0.0052
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.0473	0.1176
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0144	0.014
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0033	0.0733
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0321	0.0798
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0047	0.022	0.0347
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0033	0.0083
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.01	0.4429
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0065	0.0355	1
Schistosoma mansoni	hypothetical protein	0.0065	0.0355	0.0559
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0282	0.0444
Toxoplasma gondii	aspartyl protease ASP1	0.0047	0.022	0.0217
Onchocerca volvulus		0.0037	0.0144	0.0185
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.0043	0.1281
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Mycobacterium ulcerans	polyketide synthase	0.003	0.0086	0.2001
Echinococcus granulosus	enteropeptidase	0.0071	0.0403	0.0635
Echinococcus granulosus	zinc finger protein	0.0024	0.0036	0.0056
Plasmodium falciparum	cysteine repeat modular protein 1	0.0065	0.0355	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0282	0.0444
Onchocerca volvulus		0.0037	0.0144	0.0185
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0282	0.0444
Toxoplasma gondii	PAN domain-containing protein	0.0037	0.0144	0.014
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.0202	0.4923
Loa Loa (eye worm)	hypothetical protein	0.0535	0.4021	1
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.0202	1
Onchocerca volvulus		0.0071	0.0403	0.0842
Schistosoma mansoni	cathepsin D (A01 family)	0.0139	0.0938	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0144	0.0357
Mycobacterium ulcerans	thioesterase	0.0025	0.0047	0.1016
Loa Loa (eye worm)	fatty acid synthase	0.003	0.0083	0.0206
Echinococcus multilocularis	Protein lozenge	0.0067	0.0375	0.059
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.0473	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Echinococcus granulosus	tissue type plasminogen activator	0.0065	0.0355	0.0559
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0473	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Leishmania major	hypothetical protein, conserved	0.0065	0.0355	0.7315
Echinococcus multilocularis	glycoprotein Antigen 5	0.0071	0.0403	0.0635
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0033	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0355	0.0882
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.0086	0.3628
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0282	0.0444
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Onchocerca volvulus		0.0071	0.0403	0.0842
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0064	0.01
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0211	0.0333
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0213	0.0529
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.6347	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0144	0.0357
Echinococcus granulosus	glycoprotein Antigen 5	0.0071	0.0403	0.0635
Toxoplasma gondii	microneme protein MIC17B	0.0037	0.0144	0.014
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Schistosoma mansoni	cercarial elastase (S01 family)	0.0071	0.0403	0.0635
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0021	0.0012	0.0019
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.004	0.0847
Toxoplasma gondii	microneme protein MIC17C	0.0037	0.0144	0.014
Trypanosoma cruzi	hypothetical protein, conserved	0.0065	0.0355	0.7315
Schistosoma mansoni	hypothetical protein	0.0205	0.1447	0.2279
Echinococcus multilocularis	Mastin	0.0071	0.0403	0.0635
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0033	0.5
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0211	0.0333
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.007	0.2782
Loa Loa (eye worm)	PAN domain-containing protein	0.0037	0.0144	0.0357
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0064	0.01
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0321	0.0798
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.0086	0.3628
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.01	0.4429
Toxoplasma gondii	PAN domain-containing protein	0.0349	0.257	0.2567
Onchocerca volvulus		0.0037	0.0144	0.0185
Toxoplasma gondii	kringle domain-containing protein	0.0065	0.0355	0.0351
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Brugia malayi	PAN domain containing protein	0.0037	0.0144	0.0357
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.01	0.481
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0403	0.1003
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.01	0.2368
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0012	0.0019
Onchocerca volvulus		0.0037	0.0144	0.0185
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.0274	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0047	0.022	0.0347
Schistosoma mansoni	hypothetical protein	0.0205	0.1447	0.2279
Toxoplasma gondii	PAN domain-containing protein	0.0349	0.257	0.2567
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.007	0.0175
Schistosoma mansoni	cathepsin D (A01 family)	0.0139	0.0938	0.1478
Schistosoma mansoni	hypothetical protein	0.0025	0.0046	0.0072
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0037	0.0144	0.014
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0071	0.0403	0.1003
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.0012	0.0019
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0012	0.0019
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0473	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0086	0.2001
Toxoplasma gondii	microneme protein MIC4	0.0037	0.0144	0.014
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.0202	1
Brugia malayi	hypothetical protein	0.0182	0.1274	0.3168
Brugia malayi	Bromodomain containing protein	0.0046	0.0212	0.0527
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Loa Loa (eye worm)	runx1	0.0067	0.0375	0.0931
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0144	0.0357
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0071	0.0403	0.0635
Echinococcus granulosus	Mastin	0.0071	0.0403	0.0635
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0033	0.0052
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.0047	0.2064
Brugia malayi	Bromodomain containing protein	0.0091	0.0557	0.1387
Onchocerca volvulus		0.0071	0.0403	0.0842
Loa Loa (eye worm)	TK/ROR protein kinase	0.0065	0.0355	0.0882
Onchocerca volvulus		0.0037	0.0144	0.0185

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	11.7 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	15.5 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	> 94.103 uM	PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	10.3225 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	31.6228 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1995252
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 905903