Detailed information for compound 906754

Basic information

Technical information
  • TDR Targets ID: 906754
  • Name: ethyl (2E)-5-(2-fluorophenyl)-2-[(4-methoxyph enyl)methylidene]-7-methyl-3-oxo-5H-[1,3]thia zolo[3,2-a]pyrimidine-6-carboxylate
  • MW: 452.498 | Formula: C24H21FN2O4S
  • H donors: 0 H acceptors: 2 LogP: 4.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(C)N=c2n(C1c1ccccc1F)c(=O)c(=Cc1ccc(cc1)OC)s2
  • InChi: 1S/C24H21FN2O4S/c1-4-31-23(29)20-14(2)26-24-27(21(20)17-7-5-6-8-18(17)25)22(28)19(32-24)13-15-9-11-16(30-3)12-10-15/h5-13,21H,4H2,1-3H3/b19-13+
  • InChiKey: OLPHNQLFUPGOPG-CPNJWEJPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl (2E)-5-(2-fluorophenyl)-2-[(4-methoxyphenyl)methylene]-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
  • (2E)-5-(2-fluorophenyl)-2-[(4-methoxyphenyl)methylene]-7-methyl-3-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester
  • (2E)-5-(2-fluorophenyl)-3-keto-2-(4-methoxybenzylidene)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester
  • BAS 00664452
  • STOCK1S-29711

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0006
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0019 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0059 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0006
Echinococcus granulosus expressed conserved protein 0.0093 0.0158 0.0158
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0059 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0599 0.1113 0.5809
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0019 0.0019
Echinococcus granulosus GPCR family 2 0.0064 0.0104 0.0104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0019 0.0019
Schistosoma mansoni nuclear receptor 0.0019 0.0019 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0098 0.0085
Schistosoma mansoni thyroid hormone receptor 0.004 0.0059 0.0046
Plasmodium falciparum serine repeat antigen 2 0.0314 0.0575 0.2975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Toxoplasma gondii cathepsin CPC1 0.0314 0.0575 0.1616
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0059 0.0059
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0314 0.0575 0.2975
Brugia malayi CXXC zinc finger family protein 0.0029 0.0037 0.0027
Onchocerca volvulus 0.1017 0.1902 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0006
Schistosoma mansoni cathepsin B (C01 family) 0.0314 0.0575 0.0563
Brugia malayi nuclear receptor NHR-88 0.004 0.0059 0.0049
Schistosoma mansoni inositol transporter 0.0038 0.0055 0.0042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.0575 0.0563
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0047
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0314 0.0575 0.2975
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.0364 0.0354
Brugia malayi cathepsin F-like cysteine proteinase 0.0314 0.0575 0.0565
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0019
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.0863 0.0863
Schistosoma mansoni lamin 0.0027 0.0034 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0059 0.0059
Echinococcus multilocularis high affinity choline transporter 1 0.0347 0.0637 0.0637
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.0575 0.0563
Schistosoma mansoni nuclear hormone receptor 0.004 0.0059 0.0046
Schistosoma mansoni hypothetical protein 0.0138 0.0244 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0019 0.0006
Echinococcus multilocularis cathepsin L 0.0599 0.1113 0.1113
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0314 0.0575 0.0575
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Onchocerca volvulus 0.0038 0.0055 0.0193
Echinococcus multilocularis solute carrier family 5 0.0038 0.0055 0.0055
Echinococcus multilocularis geminin 0.0179 0.032 0.032
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0189
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0104 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.1087 0.2034 0.2024
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.0575 0.1601
Loa Loa (eye worm) hypothetical protein 0.0314 0.0575 0.0575
Brugia malayi Papain family cysteine protease containing protein 0.0314 0.0575 0.0565
Loa Loa (eye worm) hypothetical protein 0.0732 0.1364 0.1364
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0059 0.0049
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3228 0.6073 0.6073
Brugia malayi Cathepsin L-like precursor 0.1017 0.1902 0.1893
Echinococcus granulosus cathepsin l cysteine peptidase 0.1017 0.1902 0.1902
Entamoeba histolytica cysteine proteinase, putative 0.1017 0.1902 1
Brugia malayi tailless protein 0.0019 0.0019 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0013 0.0013
Echinococcus multilocularis GPCR, family 2 0.0064 0.0104 0.0104
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0063 0.0063
Brugia malayi ecdysteroid receptor 0.004 0.0059 0.0049
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0063 0.0063
Brugia malayi hypothetical protein 0.0019 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0019 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0059 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0059 0.0049
Plasmodium vivax vivapain-1 0.0599 0.1113 0.5823
Plasmodium falciparum serine repeat antigen 1 0.0314 0.0575 0.2975
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0599 0.1113 0.1101
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.0753 0.0753
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0314 0.0575 0.0575
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0013 0.0013
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0019 0.0019
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0008 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0098 0.0098
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0055 0.0055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.0521 0.0509
Entamoeba histolytica cysteine protease, putative 0.1017 0.1902 1
Leishmania major cathepsin L-like protease 0.1087 0.2034 0.5813
Onchocerca volvulus 0.1017 0.1902 1
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0059 0.0059
Echinococcus multilocularis cathepsin L cysteine protease 0.1017 0.1902 0.1902
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.531 1 1
Schistosoma mansoni thyroid hormone receptor 0.004 0.0059 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0732 0.1364 0.3874
Onchocerca volvulus 0.0027 0.0034 0.0079
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0019 0.0006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1017 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Brugia malayi Papain family cysteine protease containing protein 0.0314 0.0575 0.0565
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1017 0.1902 1
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.017 0.017
Echinococcus granulosus lamin dm0 0.0027 0.0034 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0466 0.0863 0.0863
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0599 0.1113 0.3151
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0098 0.0098
Echinococcus multilocularis cysteine protease 0.1017 0.1902 0.1902
Onchocerca volvulus 0.0027 0.0034 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0189
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0285 0.0521 0.0511
Loa Loa (eye worm) hypothetical protein 0.0314 0.0575 0.0575
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0104 0.0093
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0059 0.0059
Brugia malayi conserved hypotetical protein 0.0019 0.0019 0.0009
Brugia malayi hypothetical protein 0.0019 0.0019 0.0009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0098 0.1675
Plasmodium falciparum serine repeat antigen 7 0.0314 0.0575 0.2975
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0063 0.0126
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.0364 0.0354
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0019 0.0019
Schistosoma mansoni intermediate filament proteins 0.0027 0.0034 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0034
Schistosoma mansoni sodium/solute symporter 0.0038 0.0055 0.0042
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0283 0.0517 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0037 0.0037
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0059 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0055
Onchocerca volvulus Cathepsin L homolog 0.1017 0.1902 1
Brugia malayi CHE-14 protein 0.0042 0.0063 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Entamoeba histolytica cysteine proteinase, putative 0.0599 0.1113 0.5809
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0019 0.0006
Echinococcus granulosus dnaJ subfamily B 0.0408 0.0753 0.0753
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus granulosus expressed protein 0.0372 0.0685 0.0685
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Giardia lamblia Cathepsin B precursor 0.1859 0.349 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0019 0.0019
Echinococcus granulosus geminin 0.0179 0.032 0.032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Entamoeba histolytica cysteine protease, putative 0.0314 0.0575 0.2952
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0098 0.0243
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0006
Brugia malayi hypothetical protein 0.0019 0.0019 0.0009
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0314 0.0575 0.2975
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.017
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0029 0.0037 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0599 0.1113 0.5809
Loa Loa (eye worm) hypothetical protein 0.0314 0.0575 0.0575
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.531 1 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.0521 0.0521
Brugia malayi cathepsin L-like precursor 0.0732 0.1364 0.1355
Schistosoma mansoni hypothetical protein 0.0064 0.0104 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Plasmodium vivax unspecified product 0.0599 0.1113 0.5823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Onchocerca volvulus 0.004 0.0059 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0314 0.0575 0.1601
Loa Loa (eye worm) hypothetical protein 0.0064 0.0104 0.0104
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0019 0.0019
Trypanosoma cruzi cysteine proteinase, putative 0.0599 0.1113 0.1101
Echinococcus multilocularis expressed conserved protein 0.0093 0.0158 0.0158
Onchocerca volvulus 0.0462 0.0854 0.4435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0314 0.0575 0.1601
Echinococcus granulosus cathepsin b 0.531 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0059 0.0059
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0019 0.0009
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0019 0.0019
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0283 0.0517 0.5
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.017 0.0798
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Brugia malayi Papain family cysteine protease containing protein 0.0599 0.1113 0.1103
Entamoeba histolytica cysteine protease, putative 0.0314 0.0575 0.2952
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0059 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0055 0.0055
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1017 0.1902 0.1902
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0047
Onchocerca volvulus Cathepsin L homolog 0.0314 0.0575 0.2953
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0314 0.0575 0.2975
Brugia malayi nuclear receptor RXR 0.0021 0.0023 0.0013
Brugia malayi nuclear receptor NHR-67 0.0019 0.0019 0.0009
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0019 0.0019
Plasmodium vivax vivapain-2 0.1017 0.1902 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0059 0.0049
Brugia malayi MH2 domain containing protein 0.012 0.0209 0.0199
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus multilocularis cathepsin b 0.531 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0314 0.0575 0.0565
Echinococcus multilocularis protein patched 0.0042 0.0063 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Entamoeba histolytica cysteine proteinase 1, putative 0.0599 0.1113 0.5809
Leishmania major cathepsin L-like protease 0.1087 0.2034 0.5813
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0019 0.0009
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.017 0.0159
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0059 0.0046
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0599 0.1113 0.1101
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0055 0.0055
Plasmodium falciparum serine repeat antigen 9 0.0314 0.0575 0.2975
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1859 0.349 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0314 0.0575 0.2975
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Brugia malayi cathepsin L-like cysteine proteinase 0.0314 0.0575 0.0565
Plasmodium falciparum cysteine proteinase falcipain 3 0.1017 0.1902 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0059 0.0049
Onchocerca volvulus 0.0314 0.0575 0.2953
Brugia malayi Cathepsin L-like precursor 0.0285 0.0521 0.0511
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0059 0.0049
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0579 0.1075 0.5611
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0059 0.0059
Onchocerca volvulus Cathepsin L homolog 0.1017 0.1902 1
Entamoeba histolytica cysteine protease, putative 0.0314 0.0575 0.2952
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0019 0.0009
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Echinococcus granulosus intermediate filament protein 0.0027 0.0034 0.0034
Echinococcus granulosus cathepsin L cysteine proteinase 0.1017 0.1902 0.1902
Echinococcus granulosus lamin 0.0027 0.0034 0.0034
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0314 0.0575 0.2975
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0314 0.0575 0.2975
Entamoeba histolytica cysteine protease, putative 0.0314 0.0575 0.2952
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0104 0.0104
Brugia malayi nuclear receptor NHR-88 0.0019 0.0019 0.0009
Onchocerca volvulus 0.0029 0.0037 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0314 0.0575 0.0563
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0019 0.0006
Echinococcus granulosus cathepsin b 0.531 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.0575 0.1601
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0019 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.531 1 1
Schistosoma mansoni hypothetical protein 0.0064 0.0104 0.0091
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0314 0.0575 0.2975
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0019 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0314 0.0575 0.1601
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Echinococcus multilocularis lamin dm0 0.0027 0.0034 0.0034
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Loa Loa (eye worm) hypothetical protein 0.0314 0.0575 0.0575
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0104 0.0104
Trypanosoma cruzi major cysteine proteinase, putative 0.0314 0.0575 0.0563
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0019 0.0009
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Loa Loa (eye worm) cathepsin B 0.1859 0.349 0.349
Brugia malayi PXA domain containing protein 0.0019 0.0019 0.0009
Loa Loa (eye worm) hypothetical protein 0.0732 0.1364 0.1364
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.1087 0.2034 0.2024
Schistosoma mansoni hypothetical protein 0.0064 0.0104 0.0091
Echinococcus multilocularis lamin 0.0027 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0314 0.0575 0.2952
Echinococcus multilocularis cpg binding protein 0.003 0.004 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0019 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0732 0.1364 0.1364
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0314 0.0575 0.2975
Brugia malayi ecdysone receptor 0.0019 0.0019 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.0575 0.1601
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0019 0.0019
Brugia malayi fibroinase precursor 0.0314 0.0575 0.0565
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0086 0.0208
Loa Loa (eye worm) hypothetical protein 0.0285 0.0521 0.0521
Brugia malayi hypothetical protein 0.0021 0.0023 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0098 0.0243
Schistosoma mansoni hypothetical protein 0.0408 0.0753 0.0741
Trypanosoma cruzi cruzipain precursor, putative 0.1087 0.2034 0.2024
Plasmodium vivax serine-repeat antigen (SERA) 0.0314 0.0575 0.2975
Onchocerca volvulus 0.1017 0.1902 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Loa Loa (eye worm) cysteine protease 0.1017 0.1902 0.1902
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1017 0.1902 0.5423
Onchocerca volvulus 0.1017 0.1902 1
Trypanosoma cruzi cysteine proteinase, putative 0.0599 0.1113 0.1101
Leishmania major cathepsin L-like protease 0.1017 0.1902 0.5431
Loa Loa (eye worm) hypothetical protein 0.0314 0.0575 0.0575
Entamoeba histolytica cysteine protease, putative 0.0314 0.0575 0.2952
Schistosoma mansoni cathepsin C 0.0314 0.0575 0.0563
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0019 0.0009
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.0575 0.0563
Schistosoma mansoni cathepsin F (C01 family) 0.0732 0.1364 0.1352
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0599 0.1113 0.1101
Toxoplasma gondii preprocathepsin c precursor, putative 0.0314 0.0575 0.1616
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0059 0.0059
Toxoplasma gondii cathepsin B 0.1859 0.349 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0034 0.0024
Loa Loa (eye worm) DR-78 0.0019 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.1017 0.1902 0.1891
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0059 0.0049
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0059 0.0059
Schistosoma mansoni zinc finger protein 0.0019 0.0019 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0244 0.0234
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0314 0.0575 0.2975
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0059 0.0059
Loa Loa (eye worm) ctsf protein 0.1017 0.1902 0.1902
Schistosoma mansoni patched 1 0.0042 0.0063 0.005
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.531 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0006
Brugia malayi cathepsin F-like cysteine proteinase 0.0285 0.0521 0.0511
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0019
Echinococcus granulosus high affinity choline transporter 1 0.0347 0.0637 0.0637
Brugia malayi Papain family cysteine protease containing protein 0.0314 0.0575 0.0565
Schistosoma mansoni cpg binding protein 0.003 0.004 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0059 0.0049
Trypanosoma cruzi cruzipain precursor, putative 0.0285 0.0521 0.0509
Echinococcus multilocularis cysteine protease 0.1017 0.1902 0.1902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0059 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0059 0.0059
Schistosoma mansoni high-affinity choline transporter 0.0347 0.0637 0.0625
Loa Loa (eye worm) hypothetical protein 0.1017 0.1902 0.1902
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0172 0.0159
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0023 0.0023
Brugia malayi GH02984p 0.0347 0.0637 0.0627
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0019 0.0019
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0462 0.0854 0.0854
Schistosoma mansoni lamin 0.0027 0.0034 0.0021
Plasmodium falciparum serine repeat antigen 6 0.0314 0.0575 0.2975
Brugia malayi Cathepsin L-like precursor 0.0732 0.1364 0.1355
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0098 0.0084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1859 0.349 0.3481
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0802 0.1496 0.1485
Leishmania major cathepsin L-like protease 0.1017 0.1902 0.5431
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0059 0.0213
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0059 0.0059
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0059 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0034 0.0034
Treponema pallidum fructose-bisphosphate aldolase 0.0579 0.1075 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Schistosoma mansoni cathepsin s 0.0285 0.0521 0.0509
Brugia malayi nuclear hormone receptor 0.004 0.0059 0.0049
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0059 0.0049
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0314 0.0575 0.2975
Loa Loa (eye worm) hypothetical protein 0.0052 0.0081 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0059 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0059 0.0049
Brugia malayi Cathepsin L-like precursor 0.1017 0.1902 0.1893
Brugia malayi nuclear receptor RXR 0.0019 0.0019 0.0009
Onchocerca volvulus 0.1017 0.1902 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0059 0.0059
Echinococcus multilocularis cathepsin L 0.0314 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus granulosus cathepsin L 0.0599 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.0575 0.1601
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0189
Leishmania major cathepsin L-like protease 0.1087 0.2034 0.5813
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1859 0.349 0.3481
Entamoeba histolytica cysteine proteinase, putative 0.0732 0.1364 0.7143
Plasmodium vivax unspecified product 0.0314 0.0575 0.2975
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.0863 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0732 0.1364 0.3874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0314 0.0575 0.0563
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0249 0.0249
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0055 0.0045
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1859 0.349 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0059 0.0059
Plasmodium vivax serine-repeat antigen (SERA) 0.0314 0.0575 0.2975
Entamoeba histolytica cysteine proteinase 2 0.0599 0.1113 0.5809
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0019 0.0019
Echinococcus multilocularis cathepsin b 0.531 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0249 0.0249
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1017 0.1902 0.1902
Brugia malayi hypothetical protein 0.0021 0.0023 0.0013
Schistosoma mansoni hypothetical protein 0.0179 0.032 0.0308
Loa Loa (eye worm) hypothetical protein 0.0138 0.0244 0.0244
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.0863 0.0863
Entamoeba histolytica hypothetical protein 0.0038 0.0055 0.0189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0019 0.0019
Plasmodium falciparum cysteine proteinase falcipain 1 0.0599 0.1113 0.5823
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0059 0.0046
Trypanosoma cruzi cysteine protease, putative 0.0599 0.1113 0.1101
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.0364 0.0364
Schistosoma mansoni cpg binding protein 0.003 0.004 0.0027
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0314 0.0575 0.0563
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0003
Onchocerca volvulus 0.1017 0.1902 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0314 0.0575 0.2975
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0059 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Trichomonas vaginalis conserved hypothetical protein 0.0314 0.0575 0.1601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0059 0.0059
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0314 0.0575 0.1601
Trypanosoma cruzi cysteine peptidase, putative 0.1087 0.2034 0.2024
Echinococcus granulosus cathepsin l1 0.0732 0.1364 0.1364
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0059 0.0049
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0599 0.1113 0.1101
Echinococcus granulosus cathepsin L 0.0314 0.0575 0.0575
Brugia malayi Papain family cysteine protease containing protein 0.0599 0.1113 0.1103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Schistosoma mansoni cathepsin S (C01 family) 0.0314 0.0575 0.0563
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0098 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0034 0.0034
Schistosoma mansoni inositol transporter 0.0038 0.0055 0.0042
Schistosoma mansoni hypothetical protein 0.0041 0.006 0.0047
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0019 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0384 0.0708 0.0695
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.0575 0.1601
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0007
Onchocerca volvulus 0.0732 0.1364 0.7143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0285 0.0521 0.0521
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0055 0.0042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Echinococcus granulosus cathepsin l1 0.1017 0.1902 0.1902
Echinococcus granulosus FTZ F1 alpha 0.004 0.0059 0.0059
Plasmodium vivax vivapain-2 0.1017 0.1902 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Brugia malayi Cathepsin L-like precursor 0.1017 0.1902 0.1893
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0006
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0019 0.0019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Entamoeba histolytica cysteine protease, putative 0.0314 0.0575 0.2952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0006
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0314 0.0575 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0019 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0019 0.0006
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0314 0.0575 0.2952
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.531 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0023 0.0013
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Loa Loa (eye worm) fibroinase 0.1017 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0202 0.0364 0.0364
Plasmodium falciparum serine repeat antigen 5 0.0314 0.0575 0.2975
Brugia malayi Papain family cysteine protease containing protein 0.1017 0.1902 0.1893
Leishmania major cathepsin L-like protease 0.1017 0.1902 0.5431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0599 0.1113 0.3163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0285 0.0521 0.0521
Echinococcus granulosus cysteine protease 0.0599 0.1113 0.1113
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0314 0.0575 0.2952
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0059 0.0046
Brugia malayi hypothetical protein 0.0462 0.0854 0.0844
Giardia lamblia Cathepsin B precursor 0.1859 0.349 1
Plasmodium falciparum serine repeat antigen 8 0.0314 0.0575 0.2975
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.017 0.017
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0019 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Schistosoma mansoni cathepsin F (C01 family) 0.1017 0.1902 0.1891
Brugia malayi hypothetical protein 0.0038 0.0055 0.0044
Echinococcus granulosus solute carrier family 5 0.0038 0.0055 0.0055
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0055 0.0055
Brugia malayi Cathepsin L-like precursor 0.1017 0.1902 0.1893
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0104 0.0093
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0019 0.0009
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0019 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.0575 0.0563
Schistosoma mansoni cathepsin F (C01 family) 0.1017 0.1902 0.1891
Trypanosoma brucei cysteine peptidase C (CPC) 0.1859 0.349 1
Leishmania major cathepsin L-like protease 0.1017 0.1902 0.5431
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0314 0.0575 0.0563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0019 0.0019
Echinococcus granulosus cathepsin L cysteine protease 0.0599 0.1113 0.1113
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0038 0.0055 0.0042
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0059 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0209 0.0209
Brugia malayi Cathepsin L-like precursor 0.1017 0.1902 0.1893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0314 0.0575 0.1601
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0314 0.0575 0.1601
Plasmodium vivax unspecified product 0.0285 0.0521 0.269
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0059 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Brugia malayi Cathepsin L-like precursor 0.0732 0.1364 0.1355
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0019 0.0019
Giardia lamblia Cathepsin B precursor 0.1859 0.349 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0314 0.0575 0.1601
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0599 0.1113 0.3151
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0019 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0314 0.0575 0.0563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0579 0.1075 0.5611
Echinococcus multilocularis cathepsin L cysteine protease 0.1017 0.1902 0.1902
Entamoeba histolytica cysteine proteinase, putative 0.1017 0.1902 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0059 0.0046
Leishmania major cathepsin L-like protease 0.1017 0.1902 0.5431
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1017 0.1902 0.1902
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0314 0.0575 0.1601
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0023 0.0013
Brugia malayi cathepsin Z-like cysteine proteinase 0.0314 0.0575 0.0565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0059 0.0059
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.531 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0059 0.0049
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0019 0.0019
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0019 0.0019
Onchocerca volvulus 0.1017 0.1902 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0019 0.0006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0059 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Echinococcus granulosus cpg binding protein 0.003 0.004 0.004
Brugia malayi cathepsin L precursor 0.0314 0.0575 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0059 0.0049
Brugia malayi PXA domain containing protein 0.0019 0.0019 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0599 0.1113 0.5809
Plasmodium vivax vivapain-3 0.0599 0.1113 0.5823
Brugia malayi steroid hormone receptor 0.004 0.0059 0.0049
Brugia malayi intermediate filament protein 0.0027 0.0034 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0599 0.1113 0.3163
Plasmodium falciparum serine repeat antigen 4 0.0314 0.0575 0.2975
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0055 0.0055
Echinococcus multilocularis expressed protein 0.0372 0.0685 0.0685
Entamoeba histolytica cysteine protease, putative 0.0599 0.1113 0.5809
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0019 0.0006
Schistosoma mansoni coup transcription factor 0.004 0.0059 0.0046
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0179 0.032 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0314 0.0575 0.1601
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0059 0.0059
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0019 0.0009
Leishmania major cysteine peptidase A (CPA) 0.1017 0.1902 0.5431
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0059 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0314 0.0575 0.1601
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1017 0.1902 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0074 0.0074
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0314 0.0575 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0314 0.0575 0.1601
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0059 0.0046
Toxoplasma gondii cathepsin CPC2 0.0314 0.0575 0.1616
Brugia malayi Cathepsin L-like cysteine proteinase 0.0732 0.1364 0.1355
Brugia malayi hypothetical protein 0.0019 0.0019 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1087 0.2034 0.5813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0579 0.1075 0.3043
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0283 0.0517 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0314 0.0575 0.1601
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0019 0.0019
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0314 0.0575 0.2975
Brugia malayi Cathepsin L-like precursor 0.1017 0.1902 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0314 0.0575 0.1601
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0314 0.0575 0.0565
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0063 0.0063
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0599 0.1113 0.1101
Schistosoma mansoni hypothetical protein 0.0064 0.0104 0.0091
Echinococcus multilocularis musashi 0.0027 0.0034 0.0034
Schistosoma mansoni nuclear receptor 0.0019 0.0019 0.0006
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0055 0.0121
Onchocerca volvulus Cathepsin F homolog 0.1017 0.1902 1
Toxoplasma gondii cathepsin CPL 0.1017 0.1902 0.5431
Loa Loa (eye worm) hypothetical protein 0.0347 0.0637 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0059 0.0059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0019 0.0019
Plasmodium falciparum serine repeat antigen 3 0.0314 0.0575 0.2975
Giardia lamblia Fructose-bisphosphate aldolase 0.0579 0.1075 0.1717
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0023 0.001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0023 0.001
Brugia malayi nuclear hormone receptor 0.0019 0.0019 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1017 0.1902 0.5423
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1017 0.1902 0.5423

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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