Detailed information for compound 913928

Basic information

Technical information
  • TDR Targets ID: 913928
  • Name: (2E,4E,6E)-7-[5-[(4E,6E)-8-[[(2R)-2-[(2S,4S,6 S)-2,4-dihydroxy-5,5-dimethyl-6-[(1E,3Z)-pent a-1,3-dienyl]oxan-2-yl]propanoyl]amino]-3-hyd roxy-4-methylocta-4,6-dien-2-yl]-3-hydroxyoxo lan-2-yl]hepta-2,4,6-trienoic acid
  • MW: 629.781 | Formula: C35H51NO9
  • H donors: 6 H acceptors: 7 LogP: 4.3 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 3
  • SMILES: C/C=C\C=C\[C@@H]1O[C@@](O)(C[C@@H](C1(C)C)O)[C@H](C(=O)NC/C=C/C=C(/C(C(C1OC(C(C1)O)/C=C/C=C/C=C/C(=O)O)C)O)\C)C
  • InChi: 1S/C35H51NO9/c1-7-8-11-18-30-34(5,6)29(38)22-35(43,45-30)25(4)33(42)36-20-15-14-16-23(2)32(41)24(3)28-21-26(37)27(44-28)17-12-9-10-13-19-31(39)40/h7-19,24-30,32,37-38,41,43H,20-22H2,1-6H3,(H,36,42)(H,39,40)/b8-7-,10-9+,15-14+,17-12+,18-11+,19-13+,23-16+/t24?,25-,26?,27?,28?,29-,30-,32?,35-/m0/s1
  • InChiKey: WZDFAVLMGCBSJM-VOGZSAAZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2E,4E,6E)-7-[5-[(3E,5E)-7-[[(2R)-2-[(2S,4S,6S)-2,4-dihydroxy-5,5-dimethyl-6-[(1E,3Z)-penta-1,3-dienyl]tetrahydropyran-2-yl]propanoyl]amino]-2-hydroxy-1,3-dimethyl-hepta-3,5-dienyl]-3-hydroxy-tetrahydrofuran-2-yl]hepta-2,4,6-trienoic acid
  • (2E,4E,6E)-7-[5-[(3E,5E)-7-[[(2R)-2-[(2S,4S,6S)-2,4-dihydroxy-5,5-dimethyl-6-[(1E,3Z)-penta-1,3-dienyl]-2-tetrahydropyranyl]-1-oxopropyl]amino]-2-hydroxy-1,3-dimethylhepta-3,5-dienyl]-3-hydroxy-2-tetrahydrofuranyl]hepta-2,4,6-trienoic acid
  • (2E,4E,6E)-7-[5-[(4E,6E)-8-[[(2R)-2-[(2S,4S,6S)-2,4-dihydroxy-5,5-dimethyl-6-[(1E,3Z)-penta-1,3-dienyl]oxan-2-yl]propanoyl]amino]-3-hydroxy-4-methyl-octa-4,6-dien-2-yl]-3-hydroxy-oxolan-2-yl]hepta-2,4,6-trienoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Onchocerca volvulus 0.0119 0.2522 0.5574
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0108 0.0093
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0789 0.3124
Echinococcus granulosus tyrosine protein kinase 0.0033 0.0108 0.0108
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0184 0.4362 0.4362
Schistosoma mansoni sorting nexin 0.011 0.2288 0.2288
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Echinococcus granulosus tyrosine kinase 0.0152 0.3464 0.3464
Echinococcus granulosus tyrosine protein kinase ABL1 0.0152 0.3464 0.3464
Loa Loa (eye worm) protein kinase domain-containing protein 0.0033 0.0108 0.0093
Echinococcus granulosus epidermal growth factor receptor kinase 0.011 0.2288 0.2288
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0083 0.1505 0.6411
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0229 0.5645 0.7529
Echinococcus granulosus tyrosine kinase 0.0184 0.4362 0.4362
Brugia malayi Protein kinase domain containing protein 0.0152 0.3464 0.4601
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Echinococcus multilocularis activin receptor type 0.0036 0.0177 0.0177
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0108 0.0093
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0119 0.2522 0.2522
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Echinococcus granulosus SH2 motif 0.0119 0.2522 0.2522
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Trypanosoma brucei rac serine-threonine kinase, putative 0.0048 0.0508 0.1836
Schistosoma mansoni tyrosine kinase 0.0294 0.7485 0.7485
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0789 0.1007
Echinococcus granulosus protein kinase c epsilon type 0.0031 0.0039 0.0039
Echinococcus granulosus endophilin A3 0.011 0.2288 0.2288
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Brugia malayi Protein kinase c protein 2 0.0053 0.0673 0.0852
Brugia malayi Variant SH3 domain containing protein 0.011 0.2288 0.3021
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0294 0.7485 0.7485
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Receptor family ligand binding region containing protein 0.0033 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0549 0.0549
Schistosoma mansoni tensin-related 0.0119 0.2522 0.2522
Entamoeba histolytica protein kinase, putative 0.011 0.2288 0.6495
Schistosoma mansoni hypothetical protein 0.0119 0.2522 0.2522
Echinococcus granulosus tyrosine protein kinase HCK 0.0065 0.1005 0.1005
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.011 0.2288 0.3021
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi SRC-1 0.0294 0.7485 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.011 0.2288 0.2288
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0294 0.7485 0.7485
Loa Loa (eye worm) hypothetical protein 0.0046 0.0479 0.0591
Loa Loa (eye worm) STAT protein 0.0119 0.2522 0.3335
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK/ALK protein kinase 0.0033 0.0108 0.0093
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.011 0.2288 0.2288
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1252 0.1252
Brugia malayi Protein kinase domain containing protein 0.0152 0.3464 0.4601
Schistosoma mansoni dynamin-associated protein 0.011 0.2288 0.2288
Trypanosoma brucei cdc2-related kinase 3 0.0049 0.0549 0.2022
Echinococcus multilocularis expressed protein 0.011 0.2288 0.2288
Brugia malayi Variant SH3 domain containing protein 0.0122 0.2624 0.3472
Echinococcus multilocularis activated cdc42 kinase 1 0.0033 0.0108 0.0108
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0549 0.0685
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Onchocerca volvulus 0.011 0.2288 0.5034
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0125 0.2708 0.2708
Echinococcus multilocularis kinase suppressor of Ras 1 0.0033 0.0108 0.0108
Brugia malayi Fes/CIP4 homology domain containing protein 0.011 0.2288 0.3021
Echinococcus granulosus SH2 domain containing protein 7 0.0119 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Toxoplasma gondii AGC kinase 0.0045 0.0445 0.4951
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0229 0.5645 0.5645
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0151 0.342 0.342
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0049 0.0549 0.2022
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0033 0.0108 0.0108
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Raf kinase 0.0033 0.0108 0.0093
Echinococcus multilocularis fch and double sh3 domains protein 2 0.011 0.2288 0.2288
Echinococcus granulosus RNA directed DNA polymerase 0.0043 0.0379 0.0379
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.011 0.2288 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Schistosoma mansoni suppressor of cytokine signaling 0.0119 0.2522 0.2522
Echinococcus granulosus fch and double sh3 domains protein 2 0.011 0.2288 0.2288
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0549 0.2022
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Brugia malayi Furin-like cysteine rich region family protein 0.0033 0.0108 0.0093
Echinococcus granulosus nostrin 0.011 0.2288 0.2288
Echinococcus multilocularis receptor type guanylyl cyclase 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0033 0.0108 0.0093
Brugia malayi Variant SH3 domain containing protein 0.011 0.2288 0.3021
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0113 0.2351 0.2351
Schistosoma mansoni apoptosis stimulating of P53 0.011 0.2288 0.2288
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0263 0.6587 0.6587
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2288 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0033 0.0108 0.0093
Echinococcus granulosus fibroblast growth factor receptor 4 0.0033 0.0108 0.0108
Schistosoma mansoni tensin 0.0119 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.005 0.0565 0.0707
Echinococcus multilocularis intersectin 2 0.0112 0.2327 0.2327
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0152 0.3464 0.3464
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0125 0.2708 0.2708
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0119 0.2522 0.2522
Echinococcus multilocularis protein kinase 0.0033 0.0108 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0549 0.2022
Onchocerca volvulus 0.011 0.2288 0.5034
Loa Loa (eye worm) TK/CSK protein kinase 0.0068 0.1082 0.1402
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0033 0.0108 0.0108
Echinococcus multilocularis c src tyrosine kinase 0.0297 0.7562 0.7562
Brugia malayi p70 ribosomal S6 kinase beta 0.0045 0.0445 0.0546
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Echinococcus granulosus c src tyrosine kinase 0.0297 0.7562 0.7562
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0294 0.7485 0.7485
Loa Loa (eye worm) TK protein kinase 0.0184 0.4362 0.5806
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Entamoeba histolytica hypothetical protein, conserved 0.011 0.2288 0.6495
Brugia malayi cell division control protein 2 homolog 0.0049 0.0549 0.0685
Loa Loa (eye worm) SH2 domain-containing protein 0.0153 0.3497 0.4644
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Echinococcus multilocularis protein kinase c epsilon type 0.0031 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0119 0.2522 0.3335
Schistosoma mansoni eps8-related protein 0.011 0.2288 0.2288
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Schistosoma mansoni protein tyrosine kinase 0.0033 0.0108 0.0108
Brugia malayi Tyrosine-protein kinase abl-1 0.0263 0.6587 0.8795
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0033 0.0108 0.0108
Entamoeba histolytica protein kinase, putative 0.0121 0.2592 0.74
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0119 0.2522 0.2522
Plasmodium falciparum protein kinase 5 0.0049 0.0549 1
Onchocerca volvulus 0.0152 0.3464 0.7749
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) AGC/AKT protein kinase 0.0048 0.0508 0.063
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Echinococcus granulosus activated cdc42 kinase 1 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0049 0.0549 0.2022
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0033 0.0108 0.0093
Echinococcus granulosus tyrosine protein kinase Lyn 0.0297 0.7554 0.7554
Echinococcus granulosus tyrosine protein kinase Src42A 0.0151 0.342 0.342
Echinococcus multilocularis protein KINase family member (kin 25) 0.0033 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Onchocerca volvulus 0.0119 0.2522 0.5574
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0049 0.0549 0.0685
Trichomonas vaginalis STE family protein kinase 0.0083 0.1505 0.6411
Echinococcus granulosus tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase 0.0033 0.0108 0.0108
Onchocerca volvulus 0.0187 0.4439 1
Brugia malayi MAP kinase sur-1 0.0057 0.0789 0.1007
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Echinococcus multilocularis integrin linked protein kinase 0.0033 0.0108 0.0108
Echinococcus granulosus kinase suppressor of Ras 1 0.0033 0.0108 0.0108
Echinococcus granulosus integrin linked protein kinase 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0033 0.0108 0.0108
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0122 0.2624 0.3472
Brugia malayi Spectrin alpha chain 0.011 0.2288 0.3021
Schistosoma mansoni SH2A 0.0119 0.2522 0.2522
Echinococcus granulosus NCK adaptor protein 0.0229 0.5645 0.5645
Echinococcus multilocularis serine threonine protein kinase 0.0067 0.1066 0.1066
Schistosoma mansoni protein kinase 0.0036 0.0177 0.0177
Schistosoma mansoni tensin-related 0.0119 0.2522 0.2522
Echinococcus multilocularis endophilin A3 0.011 0.2288 0.2288
Entamoeba histolytica protein kinase, putative 0.0045 0.0445 0.1005
Echinococcus multilocularis ephrin type A receptor 4 A 0.0033 0.0108 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis growth factor receptor bound protein 2 0.0229 0.5645 0.5645
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Brugia malayi Tyrosine-protein kinase PR2 0.0033 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0229 0.5645 0.7529
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0125 0.2708 0.3585
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0177 0.0319
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.3231 0.3231
Echinococcus granulosus insulin receptor 0.0033 0.0108 0.0108
Onchocerca volvulus 0.011 0.2288 0.5034
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.011 0.2288 0.2288
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0119 0.2522 0.2522
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0033 0.0108 0.0108
Echinococcus granulosus retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0119 0.2522 0.5574
Echinococcus multilocularis tyrosine protein kinase Blk 0.0184 0.4362 0.4362
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0033 0.0108 0.0108
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Echinococcus granulosus tyrosine protein kinase Src42A 0.0294 0.7485 0.7485
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0789 1
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) serine/threonine protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni run and tbc1 domain containing 0.011 0.2288 0.2288
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0549 0.2022
Brugia malayi STAT protein, DNA binding domain containing protein 0.0119 0.2522 0.3335
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0033 0.0108 0.0093
Schistosoma mansoni tyrosine kinase 0.0152 0.3464 0.3464
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Echinococcus multilocularis RNA directed DNA polymerase 0.0043 0.0379 0.0379
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0294 0.7485 0.7485
Echinococcus multilocularis SH2 motif 0.0119 0.2522 0.2522
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0119 0.2522 0.2522
Echinococcus multilocularis transfer RNA-Thr 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/EPH protein kinase 0.0033 0.0108 0.0093
Onchocerca volvulus 0.0152 0.3464 0.7749
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0119 0.2522 0.5574
Brugia malayi cytokine inducible SH2-containing protein 5 0.0119 0.2522 0.3335
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0033 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0108
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0049 0.0549 0.6472
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2288 1
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0294 0.0294
Loa Loa (eye worm) p53BP2 0.011 0.2288 0.3021
Echinococcus granulosus tyrosine protein kinase csk 0.0068 0.1082 0.1082
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0125 0.2708 0.2708
Onchocerca volvulus 0.0119 0.2522 0.5574
Brugia malayi Protein kinase domain containing protein 0.0048 0.0508 0.063
Onchocerca volvulus 0.0113 0.2358 0.5194
Schistosoma mansoni dreadlocks/dock 0.011 0.2288 0.2288
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0119 0.2522 0.2522
Schistosoma mansoni tyrosine kinase 0.0297 0.7562 0.7562
Giardia lamblia Kinase, STE STE20 0.0083 0.1505 1
Echinococcus multilocularis tensin 0.0119 0.2522 0.2522
Plasmodium falciparum protein kinase, putative 0.0036 0.0177 0.1577
Echinococcus granulosus receptor type guanylyl cyclase 0.0033 0.0108 0.0108
Onchocerca volvulus Putative cortactin 0.011 0.2288 0.5034
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0549 0.0549
Schistosoma mansoni protein kinase 0.0083 0.1505 0.1505
Trypanosoma brucei cdc2-related kinase 1 0.0049 0.0549 0.2022
Echinococcus multilocularis tyrosine protein kinase csk 0.0068 0.1082 0.1082
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0033 0.0108 0.0093
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0033 0.0108 0.0093
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0549 0.3154
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0119 0.2522 0.2522
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Brugia malayi Tensin 0.0119 0.2522 0.3335
Entamoeba histolytica unconventional myosin IB 0.011 0.2288 0.6495
Loa Loa (eye worm) TK/FAK protein kinase 0.0033 0.0108 0.0093
Giardia lamblia Kinase, CMGC CDK 0.0049 0.0549 0.3154
Loa Loa (eye worm) TK/EGFR protein kinase 0.0033 0.0108 0.0093
Entamoeba histolytica protein kinase, putative 0.0048 0.0508 0.1193
Echinococcus granulosus tyrosine protein kinase Srms 0.0152 0.3464 0.3464
Schistosoma mansoni C-fyn 0.011 0.2288 0.2288
Loa Loa (eye worm) TK/ABL protein kinase 0.0152 0.3464 0.4601
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Schistosoma mansoni signal transduction protein lnk-related 0.0119 0.2522 0.2522
Entamoeba histolytica hypothetical protein, conserved 0.011 0.2288 0.6495
Schistosoma mansoni slit-robo rho gtpase activating protein 0.011 0.2288 0.2288
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0789 0.3124
Onchocerca volvulus 0.0119 0.2522 0.5574
Echinococcus multilocularis NCK adaptor protein 0.0229 0.5645 0.5645
Brugia malayi RhoGAP domain containing protein 0.0125 0.2708 0.3585
Brugia malayi Protein kinase domain containing protein 0.0049 0.0549 0.0685
Trypanosoma brucei protein kinase, putative 0.0036 0.0177 0.0319
Brugia malayi Variant SH3 domain containing protein 0.011 0.2288 0.3021
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Schistosoma mansoni signal transducing adapter molecule (stam) 0.011 0.2288 0.2288
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0789 0.0789
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis transfer RNA-Ala 0.011 0.2288 0.2288
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0789 0.3124
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0265 0.6643 0.6643
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Brugia malayi Guanylate kinase family protein 0.011 0.2288 0.3021
Schistosoma mansoni serine/threonine RGC 0.0033 0.0108 0.0108
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0033 0.0108 0.0093
Trichomonas vaginalis STE family protein kinase 0.0083 0.1505 0.6411
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0119 0.2522 0.2522
Schistosoma mansoni ephrin receptor 0.0033 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase Src64B 0.0294 0.7485 0.7485
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0113 0.2351 0.2351
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0033 0.0108 0.0108
Onchocerca volvulus 0.0152 0.3464 0.7749
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Entamoeba histolytica protein kinase domain containing protein 0.0036 0.0177 0.0207
Echinococcus multilocularis tyrosine protein kinase Srms 0.0184 0.4362 0.4362
Brugia malayi SH3 domain containing protein 0.011 0.2288 0.3021
Brugia malayi hypothetical protein 0.0119 0.2522 0.3335
Loa Loa (eye worm) TK/RYK protein kinase 0.0033 0.0108 0.0093
Echinococcus granulosus ephrin type A receptor 4 A 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Brugia malayi Variant SH3 domain containing protein 0.0229 0.5645 0.7529
Brugia malayi tRNA modification GTPase TrmE family protein 0.0119 0.2522 0.3335
Schistosoma mansoni adapter molecule crk 0.0229 0.5645 0.5645
Echinococcus multilocularis SH2 domain containing protein 7 0.0119 0.2522 0.2522
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0036 0.0177 0.1021
Entamoeba histolytica BAR/SH3 domain containing protein 0.011 0.2288 0.6495
Schistosoma mansoni protein kinase 0.0036 0.0177 0.0177
Echinococcus granulosus Spectrin alpha actinin 0.011 0.2288 0.2288
Schistosoma mansoni tyrosine protein kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0043 0.0379 0.0457
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.011 0.2288 1
Echinococcus granulosus N chimaerin 0.0125 0.2708 0.2708
Echinococcus granulosus retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Brugia malayi hypothetical protein 0.0152 0.3464 0.4601
Echinococcus multilocularis dual specificity mitogen activated protein 0.0083 0.1505 0.1505
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Echinococcus multilocularis insulin receptor 0.0033 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase csk 0.0068 0.1082 0.1082
Brugia malayi Variant SH3 domain containing protein 0.011 0.2288 0.3021
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0789 0.3124
Brugia malayi bone morphogenetic protein type 1 receptor 0.0033 0.0108 0.0093
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0108 0.0093
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) SH2 domain-containing protein 0.0119 0.2522 0.3335
Echinococcus granulosus tensin 0.0119 0.2522 0.2522
Echinococcus multilocularis tyrosine protein kinase Abl 0.0263 0.6587 0.6587
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0074 0.1252 0.1252
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Onchocerca volvulus LIM and SH3 domain protein homolog 0.011 0.2288 0.5034
Brugia malayi ephrin receptor 1 precursor 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Echinococcus multilocularis cyclin dependent kinase 0.0049 0.0549 0.0549
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0294 0.7485 0.7485
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Brugia malayi Variant SH3 domain containing protein 0.011 0.2288 0.3021
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase csk 0.0068 0.1082 0.1082
Echinococcus granulosus tyrosine protein kinase csk 0.0068 0.1082 0.1082
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0047 0.0487 0.0602
Echinococcus granulosus Protein kinase C brain isozyme 0.0074 0.1252 0.1252
Echinococcus granulosus cyclin dependent kinase 5 0.0049 0.0549 0.0549
Echinococcus multilocularis natriuretic peptide receptor 1 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK protein kinase 0.0065 0.1005 0.1298
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0119 0.2522 0.2522
Leishmania major protein kinase, putative 0.0036 0.0177 0.0319
Echinococcus granulosus SH2 motif 0.0119 0.2522 0.2522
Echinococcus multilocularis heat shock protein 70 0.0033 0.0108 0.0108
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2708 0.3585
Schistosoma mansoni ephrin receptor 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0789 0.3124
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0049 0.0549 0.0685
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.011 0.2288 0.2288
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2288 1
Schistosoma mansoni hypothetical protein 0.011 0.2288 0.2288
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Echinococcus multilocularis tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus granulosus protein kinase 0.0033 0.0108 0.0108
Schistosoma mansoni formin binding protein and related proteins 0.011 0.2288 0.2288
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Echinococcus granulosus tyrosine protein kinase Blk 0.0184 0.4362 0.4362
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0043 0.0379 0.0379
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0152 0.3464 0.3464
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Loa Loa (eye worm) protein-tyrosine kinase 0.011 0.2288 0.3021
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0789 0.0789
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0045 0.0445 0.0546
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0033 0.0108 0.0093
Echinococcus multilocularis tyrosine kinase 0.0152 0.3464 0.3464
Echinococcus granulosus tyrosine protein kinase pr2 0.0033 0.0108 0.0108
Echinococcus multilocularis cyclin dependent kinase 5 0.0049 0.0549 0.0549
Brugia malayi Guanylyl cyclase protein 23 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Trypanosoma brucei protein kinase, putative 0.0057 0.0789 0.3124
Echinococcus granulosus signal transduction protein lnk realted 0.0119 0.2522 0.2522
Schistosoma mansoni tyrosine kinase 0.0263 0.6587 0.6587
Echinococcus multilocularis epidermal growth factor receptor 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0113 0.2351 0.2351
Echinococcus multilocularis tyrosine protein kinase HCK 0.0065 0.1005 0.1005
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Echinococcus granulosus protein kinase C gamma type 0.0067 0.1066 0.1066
Schistosoma mansoni tensin 0.0119 0.2522 0.2522
Brugia malayi SH2 domain containing protein 0.0152 0.3464 0.4601
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0152 0.3464 0.3464
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.011 0.2288 0.2288
Echinococcus granulosus hematopoietic lineage cell specific protein 0.011 0.2288 0.2288
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0263 0.6587 0.6587
Loa Loa (eye worm) RGC/RGC protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK/ACK protein kinase 0.0033 0.0108 0.0093
Entamoeba histolytica BAR/SH3 domain containing protein 0.011 0.2288 0.6495
Schistosoma mansoni vav2 0.0128 0.2771 0.2771
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Schistosoma mansoni growth factor receptor-bound protein 0.0229 0.5645 0.5645
Echinococcus multilocularis protein kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0036 0.0177 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0152 0.3464 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0119 0.2522 0.2522
Schistosoma mansoni GTPase activating protein 0.0119 0.2522 0.2522
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Loa Loa (eye worm) TK/FER protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni cell polarity protein 0.011 0.2288 0.2288
Brugia malayi Myosin tail family protein 0.011 0.2288 0.3021
Schistosoma mansoni hypothetical protein 0.0119 0.2522 0.2522
Echinococcus granulosus suppressor of cytokine signaling 6 0.0119 0.2522 0.2522
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Echinococcus granulosus natriuretic peptide receptor 1 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis Spectrin alpha actinin 0.011 0.2288 0.2288
Echinococcus multilocularis epidermal growth factor receptor 0.0033 0.0108 0.0108
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.011 0.2288 0.2288
Loa Loa (eye worm) thyroid receptor interactor 0.011 0.2288 0.3021
Echinococcus granulosus expressed conserved protein 0.0119 0.2522 0.2522
Loa Loa (eye worm) SRC-1 0.0294 0.7485 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Brugia malayi Protein kinase domain containing protein 0.0152 0.3464 0.4601
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Entamoeba histolytica hypothetical protein 0.0113 0.2351 0.6684
Brugia malayi hypothetical protein 0.0033 0.0108 0.0093
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.011 0.2288 0.2288
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Entamoeba histolytica protein kinase, putative 0.0048 0.0508 0.1193
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0789 0.3124
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0177 0.0319
Echinococcus multilocularis FL cytokine receptor 0.0033 0.0108 0.0108
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0152 0.3464 0.4601
Brugia malayi Variant SH3 domain containing protein 0.0229 0.5645 0.7529
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0083 0.1505 0.197
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Leishmania major hypothetical protein, conserved 0.011 0.2288 1
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Echinococcus granulosus raf serine:threonine protein kinase 0.004 0.0294 0.0294
Echinococcus multilocularis tyrosine protein kinase csk 0.0068 0.1082 0.1082
Echinococcus granulosus expressed protein 0.011 0.2288 0.2288
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus granulosus dual specificity mitogen activated protein 0.0083 0.1505 0.1505
Brugia malayi Variant SH3 domain containing protein 0.011 0.2288 0.3021
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0108 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0549 0.2022
Schistosoma mansoni protein kinase 0.0036 0.0177 0.0177
Echinococcus multilocularis tyrosine protein kinase pr2 0.0033 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0294 0.7485 0.7485
Loa Loa (eye worm) TK/INSR protein kinase 0.0033 0.0108 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0789 0.0789
Echinococcus granulosus tyrosine protein kinase Fyn 0.0294 0.7485 0.7485
Trichomonas vaginalis p67phox protein, putative 0.011 0.2288 1
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0049 0.0549 0.0549
Brugia malayi protein-tyrosine kinase 0.0184 0.4362 0.5806
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0033 0.0108 0.0108
Brugia malayi hypothetical protein 0.0033 0.0108 0.0093
Onchocerca volvulus 0.011 0.2288 0.5034
Echinococcus multilocularis nostrin 0.011 0.2288 0.2288
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.004 0.0294 0.0294
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0789 0.3124
Echinococcus multilocularis N chimaerin 0.0125 0.2708 0.2708
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0119 0.2522 0.2522
Echinococcus multilocularis epidermal growth factor receptor kinase 0.011 0.2288 0.2288
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0033 0.0108 0.0108
Onchocerca volvulus 0.0119 0.2522 0.5574
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0263 0.6587 0.6587
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Echinococcus multilocularis SHC transforming protein 3 0.0119 0.2522 0.2522
Trypanosoma cruzi cdc2-related kinase 3 0.0049 0.0549 0.2022
Echinococcus granulosus epidermal growth factor receptor 0.0033 0.0108 0.0108
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0033 0.0108 0.0093
Schistosoma mansoni sorbin 0.011 0.2288 0.2288
Echinococcus granulosus activin receptor type 0.0036 0.0177 0.0177
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.2288 0.3021
Trypanosoma cruzi cdc2-related kinase 1 0.0049 0.0549 0.2022
Onchocerca volvulus 0.0152 0.3464 0.7749
Schistosoma mansoni tensin 0.0119 0.2522 0.2522
Echinococcus granulosus epidermal growth factor receptor 0.0033 0.0108 0.0108
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0033 0.0108 0.0108
Echinococcus granulosus activated cdc42 kinase 1 0.0033 0.0108 0.0108
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0789 0.3124
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0508 0.1836
Brugia malayi Sex muscle abnormal protein 5 0.0229 0.5645 0.7529
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Plasmodium vivax protein kinase Crk2 0.0049 0.0549 1
Schistosoma mansoni shc transforming protein 0.0119 0.2522 0.2522
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.011 0.2288 0.2288
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0789 0.3124
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0119 0.2522 0.2522
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0033 0.0108 0.0093
Echinococcus multilocularis 0.0119 0.2522 0.2522
Trypanosoma brucei conserved protein 0.011 0.2288 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0789 0.3124
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0083 0.1505 0.6411
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0108 0.0093
Loa Loa (eye worm) SH2 domain-containing protein 0.0119 0.2522 0.3335
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0549 0.2022
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 1
Schistosoma mansoni Dab2-interacting protein-like 0.011 0.2288 0.2288
Echinococcus granulosus hypothetical protein 0.0119 0.2522 0.2522
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0119 0.2522 0.2522
Echinococcus granulosus SHC transforming protein 3 0.0119 0.2522 0.2522
Schistosoma mansoni nck2/grb4 0.0229 0.5645 0.5645
Loa Loa (eye worm) TK/ROR protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0549 0.0549
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni tyrosine kinase 0.0294 0.7485 0.7485
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0294 0.7485 0.7485
Echinococcus multilocularis protein tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0083 0.1505 0.197
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0294 0.7485 0.7485
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0294 0.7485 0.7485
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0549 0.1313
Onchocerca volvulus 0.0119 0.2522 0.5574
Entamoeba histolytica cell division protein kinase 2, putative 0.0049 0.0549 0.1313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0294 0.7485 0.7485
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0184 0.4362 0.4362
Onchocerca volvulus 0.0152 0.3464 0.7749
Brugia malayi protein-tyrosine kinase 0.011 0.2288 0.3021
Brugia malayi SH2 domain containing protein 0.0119 0.2522 0.3335
Entamoeba histolytica hypothetical protein 0.011 0.2288 0.6495
Echinococcus granulosus tyrosine protein kinase Fyn 0.0294 0.7485 0.7485
Echinococcus multilocularis cyclin dependent kinase 1 0.0049 0.0549 0.0549
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0033 0.0108 0.0108
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0033 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0119 0.2522 0.2522
Loa Loa (eye worm) TK protein kinase 0.0033 0.0108 0.0093
Echinococcus granulosus growth factor receptor bound protein 2 0.0229 0.5645 0.5645
Loa Loa (eye worm) TK/DDR protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni growth factor receptor-bound protein 0.0229 0.5645 0.5645
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0033 0.0108 0.0093
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0121 0.2592 0.74
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0229 0.5645 0.7529
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0033 0.0108 0.0108
Brugia malayi C-terminal src kinase protein 1 0.0033 0.0108 0.0093
Echinococcus granulosus cyclin dependent kinase 1 0.0049 0.0549 0.0549
Loa Loa (eye worm) TK/Met protein kinase 0.0033 0.0108 0.0093
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0033 0.0108 0.0108
Echinococcus multilocularis tensin 0.0119 0.2522 0.2522
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0033 0.0108 0.0108
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0789 0.4874
Loa Loa (eye worm) hypothetical protein 0.0119 0.2522 0.3335
Schistosoma mansoni hypothetical protein 0.011 0.2288 0.2288
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0033 0.0108 0.0108
Entamoeba histolytica SH2 domain containing protein 0.0119 0.2522 0.7192
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0119 0.2522 0.3335
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0036 0.0177 0.0177
Echinococcus granulosus src region 0.011 0.2288 0.2288
Schistosoma mansoni tyrosine kinase 0.0383 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0119 0.2522 0.2522
Echinococcus granulosus intersectin 2 0.0112 0.2327 0.2327
Loa Loa (eye worm) TK/FER protein kinase 0.0152 0.3464 0.4601
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0121 0.2585 0.342
Echinococcus granulosus tyrosine protein kinase Fyn 0.0294 0.7485 0.7485
Echinococcus granulosus SH2 domain containing adapter protein F 0.0119 0.2522 0.2522
Echinococcus granulosus tyrosine protein kinase csk 0.0068 0.1082 0.1082
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0033 0.0108 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0789 0.3124
Brugia malayi integrin-linked kinase 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0177 0.0319
Brugia malayi Protein kinase domain containing protein 0.0152 0.3464 0.4601
Echinococcus granulosus cyclin dependent kinase 0.0049 0.0549 0.0549
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0083 0.1505 0.6411
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0125 0.2708 0.2708
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Echinococcus multilocularis SH2 motif 0.0119 0.2522 0.2522
Loa Loa (eye worm) guanylate kinase 0.011 0.2288 0.3021
Brugia malayi SH2 domain containing protein 0.0187 0.4439 0.591
Schistosoma mansoni suppressor of cytokine signaling 0.0119 0.2522 0.2522
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0039 0.0039
Trichomonas vaginalis STE family protein kinase 0.0083 0.1505 0.6411
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0033 0.0108 0.0108
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Peripheral plasma membrane protein CASK 0.011 0.2288 0.3021
Schistosoma mansoni tyrosine kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis SH2 motif 0.0119 0.2522 0.2522
Schistosoma mansoni protein kinase 0.0033 0.0108 0.0108
Echinococcus multilocularis tyrosine protein kinase shark 0.0383 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.3464 0.4601
Loa Loa (eye worm) hypothetical protein 0.011 0.2288 0.3021
Entamoeba histolytica protein kinase, putative 0.0065 0.1005 0.2674
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1252 0.1252
Brugia malayi Src substrate cortactin 0.011 0.2288 0.3021
Echinococcus granulosus protein tyrosine kinase 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0093
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0119 0.2522 0.3335
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0294 0.7485 0.7485
Brugia malayi Protein kinase domain containing protein 0.0033 0.0108 0.0093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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