Detailed information for compound 919815

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.598 | Formula: C27H36N4O6
  • H donors: 3 H acceptors: 5 LogP: 1.47 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N2[C@@H](C(=O)N[C@H]1CCCCCC(=O)[C@@H]1CO1)CCC2
  • InChi: 1S/C27H36N4O6/c1-17-24(33)30-20(15-18-9-4-2-5-10-18)27(36)31-14-8-12-21(31)26(35)29-19(25(34)28-17)11-6-3-7-13-22(32)23-16-37-23/h2,4-5,9-10,17,19-21,23H,3,6-8,11-16H2,1H3,(H,28,34)(H,29,35)(H,30,33)/t17-,19-,20-,21+,23-/m0/s1
  • InChiKey: QMNUPNOLDLHVTB-IWDBHXEASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Brugia malayi excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Brugia malayi Histone deacetylase 1 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus multilocularis microtubule associated protein 2 0.2103 0.919 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Schistosoma mansoni nuclear receptor nhr-48 0.0089 0.0321 0.0317
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Echinococcus multilocularis dna polymerase eta 0.0021 0.0021 0.0018
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0007 0.0017
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0072 0.0354
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.1101
Schistosoma mansoni flap endonuclease-1 0.0026 0.0041 0.0037
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0185 0.0742 1
Echinococcus multilocularis histone deacetylase 7 0.0452 0.192 0.2086
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Trypanosoma brucei histone deacetylase 4 0.0452 0.192 1
Plasmodium vivax histone deacetylase, putative 0.0197 0.0797 0.4139
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Brugia malayi hypothetical protein 0.0148 0.0578 0.2998
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Schistosoma mansoni acetylcholine receptor-related 0.0023 0.0028 0.0024
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Onchocerca volvulus 0.0059 0.0188 0.0773
Echinococcus multilocularis histone deacetylase 1 0.0417 0.1765 0.1917
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0646 0.0699
Schistosoma mansoni histone deacetylase hda2 0.0197 0.0797 0.0793
Loa Loa (eye worm) hypothetical protein 0.0255 0.1051 0.5465
Loa Loa (eye worm) BRM protein 0.0047 0.0134 0.068
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Plasmodium falciparum glutathione reductase 0.0037 0.0092 0.0462
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0345 0.6164
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Onchocerca volvulus 0.0089 0.0321 0.141
Loa Loa (eye worm) hypothetical protein 0.0048 0.0141 0.0714
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Leishmania major hypothetical protein, conserved 0.0052 0.0158 0.0802
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0187 0.0199
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0042 0.0111 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0007 0.0017
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus multilocularis nuclear receptor nhr 48 0.0089 0.0321 0.0345
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.0311 0.1731
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0053 0.0257
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.0311 0.1604
Echinococcus granulosus tar DNA binding protein 0.0123 0.0471 0.0508
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0471 0.2436
Brugia malayi Peptidase family M28 containing protein 0.0262 0.1081 0.5618
Loa Loa (eye worm) hypothetical protein 0.0197 0.0797 0.4139
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Onchocerca volvulus Glutaminyl cyclase homolog 0.0262 0.1081 0.507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0188 0.0201
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0059 0.0188 0.0963
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0085 0.0089
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0185 0.0742 0.3504
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.0983
Entamoeba histolytica histone deacetylase, putative 0.0417 0.1765 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.003 0.0237
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0094 0.0098
Echinococcus multilocularis dual specificity 0.0087 0.0311 0.0335
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Echinococcus granulosus flap endonuclease 1 0.0028 0.0053 0.0054
Schistosoma mansoni hypothetical protein 0.0071 0.0238 0.0235
Brugia malayi nuclear hormone receptor 0.0189 0.0761 0.3948
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0416 0.1758 0.1909
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus microtubule associated protein 2 0.2103 0.919 1
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0042 0.0111 0.15
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Onchocerca volvulus 0.0048 0.0141 0.0544
Brugia malayi ecdysone receptor 0.0089 0.0321 0.1653
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Echinococcus multilocularis histone deacetylase 0.0452 0.192 0.2086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Toxoplasma gondii hypothetical protein 0.0042 0.0111 0.0561
Echinococcus granulosus geminin 0.0164 0.0651 0.0704
Toxoplasma gondii histone deacetylase HDAC5 0.0197 0.0797 0.4139
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Brugia malayi TAR-binding protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Leishmania major DNA polymerase eta, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) nuclear hormone receptor 0.0089 0.0321 0.1653
Loa Loa (eye worm) steroid hormone receptor 0.0189 0.0761 0.3948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0185 0.0742 0.4181
Loa Loa (eye worm) leucyl aminopeptidase 0.0042 0.0111 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0037 0.0141
Schistosoma mansoni coup transcription factor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0139 0.0541 0.7289
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0185 0.0742 0.0804
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.2206 0.2397
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0059 0.0188 0.0963
Giardia lamblia DINP protein human, muc B family 0.0021 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Onchocerca volvulus 0.0036 0.0088 0.0292
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0321 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Schistosoma mansoni steroid hormone receptor ad4bp 0.0189 0.0761 0.0757
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0059 0.0188 0.0185
Brugia malayi histone deacetylase 11 0.0197 0.0797 0.4139
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0017
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.184 0.9581
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0186 0.0747 0.3878
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.003 0.0404
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0018
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0018
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Loa Loa (eye worm) glutaminase 2 0.0265 0.1094 0.5688
Onchocerca volvulus 0.0494 0.2104 1
Plasmodium vivax histone deacetylase, putative 0.0452 0.192 1
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0072 0.0074
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Trypanosoma brucei glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Echinococcus multilocularis tumor protein p63 0.033 0.1383 0.1501
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.0077
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi nuclear receptor NHR-88 0.0189 0.0761 0.3948
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0185 0.0742 0.3852
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0037 0.0036
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0189 0.0761 0.0824
Brugia malayi nuclear hormone receptor family member nhr-6 0.0089 0.0321 0.1653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Echinococcus multilocularis FTZ F1 alpha 0.0189 0.0761 0.0824
Echinococcus granulosus histone deacetylase 0.0452 0.192 0.2086
Loa Loa (eye worm) hypothetical protein 0.0234 0.0956 0.4969
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0502 0.2599
Echinococcus multilocularis histone deacetylase 6 0.046 0.1953 0.2122
Loa Loa (eye worm) nuclear receptor NHR-67 0.0089 0.0321 0.1653
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0416 0.1758 0.1909
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Loa Loa (eye worm) histone deacetylase 3 0.0417 0.1765 0.9188
Loa Loa (eye worm) histone deacetylase 7A 0.0452 0.192 1
Mycobacterium ulcerans glutaminase 0.0265 0.1094 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0031 0.0029
Loa Loa (eye worm) glutaminase 0.0265 0.1094 0.5688
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Schistosoma mansoni kinase 0.0095 0.0345 0.0341
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0186 0.0747 0.0809
Brugia malayi nuclear receptor NHR-88 0.0089 0.0321 0.1653
Trypanosoma brucei histone deacetylase 2 0.0197 0.0797 0.4139
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0382 0.1974
Brugia malayi Muscleblind-like protein 0.0163 0.0646 0.3352
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis histone deacetylase 8 0.0197 0.0797 0.0863
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0202 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.0761 0.0757
Brugia malayi glutaminase DH11.1 0.0265 0.1094 0.5688
Onchocerca volvulus Bile acid receptor homolog 0.0189 0.0761 0.3529
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0037 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0103 0.0382 0.1974
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0028 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0189 0.0761 0.0824
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0141 0.0137
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0036 0.0088 0.0441
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0185 0.0742 0.3439
Plasmodium falciparum eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0088 0.0085
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0021 0.0279
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus FTZ F1 alpha 0.0189 0.0761 0.0824
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.003 0.0404
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0345 0.4648
Onchocerca volvulus Histone deacetylase 10 homolog 0.0197 0.0797 0.3704
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Brugia malayi Matrixin family protein 0.0276 0.1145 0.5953
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0028 0.0125
Onchocerca volvulus 0.0148 0.0578 0.2651
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni Fxna peptidase (M28 family) 0.0042 0.0111 0.0107
Onchocerca volvulus Matrix metalloproteinase homolog 0.0253 0.1044 0.4894
Treponema pallidum ATP-dependent RNA helicase 0.0185 0.0742 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0303 0.4084
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0042 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0163 0.0646 0.3352
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.2206 0.2397
Loa Loa (eye worm) matrixin family protein 0.0276 0.1145 0.5953
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0192 0.0205
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Onchocerca volvulus 0.0059 0.0188 0.0773
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi hypothetical protein 0.0052 0.0158 0.0802
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni histone deacetylase hda2 0.046 0.1953 0.195
Onchocerca volvulus 0.0189 0.0761 0.3529
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0354
Schistosoma mansoni nicalin (M28 family) 0.0042 0.0111 0.0107
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0189 0.0761 0.3948
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus multilocularis histone deacetylase 3 0.0417 0.1765 0.1917
Brugia malayi steroid hormone receptor 0.0189 0.0761 0.3948
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Onchocerca volvulus Protein ultraspiracle homolog 0.0189 0.0761 0.3529
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0004 0.0056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0187 0.2519
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0053 0.0262
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0238 0.1224
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.0311 0.1604
Onchocerca volvulus 0.0059 0.0188 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0187 0.1677
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0187 0.0955
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0898 0.388 0.5
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Echinococcus granulosus neuropeptide s receptor 0.0517 0.2206 0.2397
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0215 0.1182
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0053 0.0054
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Brugia malayi hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus histone deacetylase 6 0.0452 0.192 0.2086
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0202 0.0216
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus granulosus nAChR subunit 0.0036 0.0088 0.0092
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0017
Brugia malayi Thioredoxin reductase 0.0037 0.0092 0.0462
Brugia malayi Pre-SET motif family protein 0.0062 0.0202 0.1035
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Schistosoma mansoni zinc finger protein 0.0089 0.0321 0.0317
Plasmodium falciparum histone deacetylase 1 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Leishmania major histone deacetylase, putative 0.0417 0.1765 0.9188
Schistosoma mansoni nuclear receptor 0.0089 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Brugia malayi nuclear receptor RXR 0.0089 0.0321 0.1653
Loa Loa (eye worm) histone deacetylase 0.0452 0.192 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Mycobacterium tuberculosis Conserved protein 0.0042 0.0111 0.15
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0053 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Plasmodium vivax histone deacetylase 2, putative 0.0452 0.192 1
Loa Loa (eye worm) histone deacetylase 11 0.0197 0.0797 0.4139
Brugia malayi histone deacetylase 1 (HD1) 0.0417 0.1765 0.9188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0089 0.0321 0.1653
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0092 0.0462
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0021 0.0279
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0092
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.003 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0028 0.0026
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Onchocerca volvulus 0.0059 0.0188 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0747 0.0744
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0471 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0471 0.0467
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0085 0.0082
Trypanosoma cruzi histone deacetylase, putative 0.0452 0.192 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Schistosoma mansoni histone deacetylase 0.0417 0.1765 0.1762
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Mycobacterium tuberculosis Probable reductase 0.0085 0.0303 0.4084
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Echinococcus multilocularis nAChR subunit 0.0036 0.0088 0.0092
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Trypanosoma cruzi histone deacetylase 1, putative 0.0417 0.1765 0.9188
Trypanosoma brucei unspecified product 0.0021 0.0021 0.0088
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Brugia malayi Hemopexin family protein 0.0162 0.0641 0.3327
Loa Loa (eye worm) hypothetical protein 0.0062 0.0202 0.1035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0185 0.0742 0.3852
Leishmania major trypanothione reductase 0.0037 0.0092 0.0462
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0059 0.0188 0.0963
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Brugia malayi conserved hypotetical protein 0.0089 0.0321 0.1653
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Loa Loa (eye worm) hypothetical protein 0.0263 0.1084 0.5636
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0215 0.1101
Loa Loa (eye worm) LGC-31 protein 0.0059 0.0188 0.0963
Onchocerca volvulus Matrilysin homolog 0.0114 0.0431 0.1942
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0007 0.0017
Trypanosoma brucei histone deacetylase 1 0.0417 0.1765 0.9188
Echinococcus multilocularis ecdysone induced protein 78C 0.0189 0.0761 0.0824
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0037 0.0171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Schistosoma mansoni hypothetical protein 0.0036 0.0085 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.2206 0.2397
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0053 0.0257
Brugia malayi orphan nuclear receptor NR2E1 0.0089 0.0321 0.1653
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0215 0.1101
Schistosoma mansoni DNA polymerase eta 0.0021 0.0021 0.0017
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0262 0.1081 0.1172
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0158 0.0802
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0059 0.0188 0.0201
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0188 0.0201
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0092 0.0462
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.003 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0189 0.0761 0.3948
Loa Loa (eye worm) matrix metalloproteinase 0.0114 0.0431 0.223
Onchocerca volvulus 0.0036 0.0088 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Schistosoma mansoni histone deacetylase 1 2 3 0.0197 0.0797 0.0793
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Giardia lamblia Histone deacetylase 0.0417 0.1765 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0189 0.0761 0.0824
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Brugia malayi Nuclear hormone receptor E75 0.0089 0.0321 0.1653
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0088 0.0441
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1059 0.5505
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0023 0.0028 0.0026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Plasmodium vivax SET domain protein, putative 0.0062 0.0202 0.1035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Toxoplasma gondii histone deacetylase HDAC3 0.0417 0.1765 0.9188
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0028 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.0761 0.3948
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0037 0.0033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0037 0.0171
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0059 0.0188 0.0963
Onchocerca volvulus 0.0059 0.0188 0.0773
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0202 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Brugia malayi leucyl aminopeptidase 0.0042 0.0111 0.0561
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0158 0.0802
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0345 0.4648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Plasmodium vivax RNA helicase-1, putative 0.0185 0.0742 0.3852
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0321 0.0345
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0262 0.1081 0.1077
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0092 0.0462
Brugia malayi BRM protein 0.0073 0.0251 0.1289
Plasmodium falciparum histone deacetylase 2 0.0452 0.192 1
Loa Loa (eye worm) RNA binding protein 0.0123 0.0471 0.2436
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0502 0.2599
Brugia malayi Nuclear hormone receptor-like 1 0.01 0.0368 0.1899
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Schistosoma mansoni microtubule-associated protein tau 0.2103 0.919 0.919
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0085 0.0089
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0471 0.2436
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0023 0.0028 0.0026
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0004 0.0052
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Plasmodium falciparum thioredoxin reductase 0.0037 0.0092 0.0462
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Trichomonas vaginalis histone deacetylase, putative 0.0417 0.1765 0.8381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Echinococcus granulosus thyroid hormone receptor alpha 0.0089 0.0321 0.0345
Echinococcus granulosus histone deacetylase 6 0.046 0.1953 0.2122
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0003
Echinococcus granulosus dual specificity 0.0087 0.0311 0.0335
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0188 0.0963
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trypanosoma brucei polo-like protein kinase 0.0186 0.0747 0.3878
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0059 0.0188 0.0963
Schistosoma mansoni helicase 0.0073 0.0251 0.0247
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0086 0.0307 0.158
Schistosoma mansoni nuclear hormone receptor 0.0189 0.0761 0.0757
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0189 0.0761 0.0824
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0042 0.0111 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0189 0.0761 0.3948
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0185 0.0742 0.4181
Plasmodium vivax histone deacetylase 1, putative 0.0417 0.1765 0.9188
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0185 0.0742 0.0738
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0303 0.4084
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0088 0.0441
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.003 0.0237
Onchocerca volvulus 0.0162 0.0641 0.2955
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0059 0.0188 0.0185
Onchocerca volvulus Matrilysin homolog 0.0253 0.1044 0.4894
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Onchocerca volvulus Serine\/threonine kinase homolog 0.0186 0.0747 0.3464
Loa Loa (eye worm) glutathione reductase 0.0037 0.0092 0.0462
Echinococcus granulosus muscleblind protein 0.0163 0.0646 0.0699
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0059 0.0188 0.0963
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0072 0.0074
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0059 0.0188 0.0201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0092 0.1245
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) matrixin family protein 0.0253 0.1044 0.5428
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.01 0.0368 0.0396
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0036 0.0088 0.0085
Loa Loa (eye worm) hypothetical protein 0.0139 0.0541 0.2802
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0004 0.0002
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0053 0.0262
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0059 0.0188 0.0963
Echinococcus multilocularis GPCR, family 2 0.0033 0.0072 0.0074
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Schistosoma mansoni glutaminase 0.0265 0.1094 0.1091
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0089 0.0321 0.141
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0007 0.0017
Brugia malayi Pre-SET motif family protein 0.0434 0.184 0.9581
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.0404 0.04
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0158 0.0802
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Echinococcus granulosus global transcription activator snf2l2 0.0073 0.0251 0.0269
Loa Loa (eye worm) BRM protein 0.0038 0.0095 0.0475
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) acetylcholine receptor protein 0.0023 0.0028 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0417 0.1765 0.8381
Schistosoma mansoni RAR-like nuclear receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0187 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0189 0.0761 0.0757
Loa Loa (eye worm) DR-78 0.0089 0.0321 0.1653
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0189 0.0761 0.0757
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0017
Brugia malayi Histone deacetylase family protein 0.0452 0.192 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0262 0.1081 0.5618
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0037 0.0171
Brugia malayi glutathione reductase 0.0037 0.0092 0.0462
Giardia lamblia Kinase, PLK 0.0186 0.0747 0.421
Brugia malayi nuclear hormone receptor 0.0089 0.0321 0.1653
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.071 0.3351
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.067 0.3092
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0018
Echinococcus granulosus dna polymerase eta 0.0021 0.0021 0.0018
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0059 0.0188 0.0201
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0186 0.0747 0.3878
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Echinococcus granulosus GPCR family 2 0.0033 0.0072 0.0074
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Onchocerca volvulus 0.0023 0.003 0.001
Brugia malayi Protein kinase domain containing protein 0.0087 0.0311 0.1604
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0053 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0334 0.1561
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0042 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Brugia malayi ecdysteroid receptor 0.0189 0.0761 0.3948
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0215 0.1101
Brugia malayi hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trypanosoma brucei histone deacetylase 3 0.0452 0.192 1
Brugia malayi Cation transporter family protein 0.0059 0.0188 0.0963
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0189 0.0761 0.0824
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0303 0.5345
Toxoplasma gondii histone deacetylase HDAC1 0.0452 0.192 1
Loa Loa (eye worm) histone deacetylase 1 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0125 0.048 0.2486
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0963
Loa Loa (eye worm) GABA receptor subunit 0.0036 0.0088 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.0088
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.003 0.0237
Plasmodium falciparum flap endonuclease 1 0.0028 0.0053 0.0257
Echinococcus granulosus tumor protein p63 0.033 0.1383 0.1501
Leishmania major eukaryotic initiation factor 4a, putative 0.0185 0.0742 0.3852
Echinococcus granulosus histone deacetylase 8 0.0197 0.0797 0.0863
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Trypanosoma brucei histone deacetylase, putative 0.0452 0.192 1
Brugia malayi nicalin 0.0042 0.0111 0.0561
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0189 0.0761 0.3948
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0088
Onchocerca volvulus 0.0114 0.0431 0.1942
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0004 0.0002
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0185 0.0742 0.3852
Brugia malayi Matrixin family protein 0.0114 0.0431 0.223
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Trichomonas vaginalis glutaminase, putative 0.0265 0.1094 0.5183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0382 0.1974
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0303 0.4084
Entamoeba histolytica hypothetical protein 0.0087 0.0311 0.1731
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Toxoplasma gondii histone deacetylase HDAC2 0.0417 0.1765 0.9188
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0345 0.4648
Loa Loa (eye worm) ACC-1 protein 0.0059 0.0188 0.0963
Mycobacterium ulcerans hypothetical protein 0.0042 0.0111 0.0983
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0059 0.0188 0.0963
Loa Loa (eye worm) hypothetical protein 0.0114 0.0431 0.223
Entamoeba histolytica hypothetical protein 0.0025 0.0037 0.0168
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Brugia malayi nuclear hormone receptor family member odr-7 0.0089 0.0321 0.1653
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0215 0.023
Schistosoma mansoni hypothetical protein 0.0162 0.0641 0.0638
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0303 0.4084
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0188 0.0963
Leishmania major glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0059 0.0188 0.0963
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0166 0.0658 0.0654
Brugia malayi tailless protein 0.0089 0.0321 0.1653
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0059 0.0188 0.0201
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0189 0.0761 0.0757
Brugia malayi Steroid receptor seven-up type 2 0.0189 0.0761 0.3948
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0089 0.0321 0.0345
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0202 0.0216
Trypanosoma cruzi polo-like protein kinase, putative 0.0186 0.0747 0.3878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0189 0.0761 0.3948
Schistosoma mansoni hypothetical protein 0.0023 0.0031 0.0027
Schistosoma mansoni acetylcholine receptor subunit beta 0.0023 0.0028 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0189 0.0761 0.0824
Echinococcus granulosus nAChR subunit 0.0059 0.0188 0.0201
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.003 0.0237
Loa Loa (eye worm) hypothetical protein 0.0063 0.0204 0.1043
Schistosoma mansoni histone deacetylase 4 5 0.0452 0.192 0.1917
Toxoplasma gondii peptidase, M28 family protein 0.0042 0.0111 0.0561
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0189 0.0761 0.3948
Schistosoma mansoni polycystin 1-related 0.0079 0.0275 0.0272
Mycobacterium ulcerans hydrolase 0.0139 0.0541 0.4924
Trypanosoma cruzi histone deacetylase, putative 0.0197 0.0797 0.4139
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0042 0.0111 0.0497
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Leishmania major hypothetical protein, conserved 0.0042 0.0111 0.0561
Brugia malayi photoreceptor-specific nuclear receptor 0.0189 0.0761 0.3948
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Entamoeba histolytica serine/threonine protein kinase, putative 0.0186 0.0747 0.421
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0215 0.0211
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi hypothetical protein 0.0034 0.0076 0.0377
Schistosoma mansoni retinoid-x-receptor (RXR) 0.01 0.0368 0.0364
Onchocerca volvulus 0.0042 0.0111 0.0402
Brugia malayi nuclear receptor NHR-67 0.0089 0.0321 0.1653
Entamoeba histolytica hypothetical protein 0.0036 0.0085 0.0446
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0053 0.0257
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Brugia malayi hypothetical protein 0.01 0.0368 0.1899
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0311 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0088
Entamoeba histolytica protein kinase, putative 0.0087 0.0311 0.1731
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0202 0.0198
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0023 0.0028 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0202 0.1035
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0089 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0136
Loa Loa (eye worm) hypothetical protein 0.0071 0.0238 0.1224
Mycobacterium ulcerans hypothetical protein 0.0023 0.003 0.0237
Schistosoma mansoni hypothetical protein 0.0033 0.0072 0.0068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0189 0.0761 0.3948
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Brugia malayi serine/threonine-protein kinase plk-2 0.0186 0.0747 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1059 0.5015
Echinococcus multilocularis histone deacetylase 6 0.0452 0.192 0.2086
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0007 0.0017
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0189 0.0761 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0158 0.0802
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0114 0.0431 0.0427
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0187 0.0199
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Brugia malayi hypothetical protein 0.0036 0.0085 0.0426
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus granulosus nuclear receptor nhr 48 0.0089 0.0321 0.0345
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0023 0.0028 0.0125
Trichomonas vaginalis set domain proteins, putative 0.0494 0.2104 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0095 0.0099
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0059 0.0188 0.0963
Echinococcus multilocularis global transcription activator snf2l2 0.0073 0.0251 0.0269
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0188 0.0201
Onchocerca volvulus Putative nachr subunit 0.0059 0.0188 0.0773
Onchocerca volvulus 0.0062 0.0202 0.0839
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0382 0.1974
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0089 0.0321 0.1653
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.003 0.0136
Echinococcus granulosus eukaryotic initiation factor 4A 0.0185 0.0742 0.0804
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0089 0.0321 0.0345
Trypanosoma cruzi glutaminyl cyclase, putative 0.0042 0.0111 0.0561
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0021 0.0092
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0561
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0189 0.0761 0.0824
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Brugia malayi RNA binding protein 0.0123 0.0471 0.2436
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0059 0.0188 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0111 0.0497
Leishmania major histone deacetylase, putative 0.0452 0.192 1
Brugia malayi Flap endonuclease-1 0.0028 0.0053 0.0257
Echinococcus multilocularis geminin 0.0164 0.0651 0.0704
Toxoplasma gondii thioredoxin reductase 0.0037 0.0092 0.0462
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0189 0.0761 0.0757
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Echinococcus multilocularis nAChR subunit 0.0059 0.0188 0.0201
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.0747 0.3529
Trypanosoma brucei trypanothione reductase 0.0037 0.0092 0.0462
Toxoplasma gondii histone deacetylase HDAC4 0.0197 0.0797 0.4139
Onchocerca volvulus Fxna peptidase homolog 0.0042 0.0111 0.0402
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.0311 0.1604
Brugia malayi nuclear receptor RXR 0.01 0.0368 0.1899
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0441
Onchocerca volvulus 0.0089 0.0321 0.141
Echinococcus multilocularis muscleblind protein 0.0163 0.0646 0.0699
Schistosoma mansoni retinoic acid receptor RXR 0.0189 0.0761 0.0757
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0189 0.0761 0.3529
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.01 0.0368 0.1899
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0158 0.0802
Plasmodium vivax glutathione reductase, putative 0.0037 0.0092 0.0462
Brugia malayi AMP-binding enzyme family protein 0.0023 0.003 0.0136
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0004
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Echinococcus granulosus histone deacetylase 7 0.0452 0.192 0.2086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0089 0.0321 0.0345
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0296 0.1233 0.6413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.003 0.013
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0088 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0189 0.0761 0.3948
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0059 0.0188 0.0201
Schistosoma mansoni hypothetical protein 0.0164 0.0651 0.0647
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.0088
Plasmodium falciparum histone deacetylase, putative 0.0452 0.192 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0004 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.067 0.3161
Brugia malayi MH2 domain containing protein 0.013 0.0502 0.2599
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0125
Brugia malayi FXNA 0.0042 0.0111 0.0561
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0059 0.0188 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0189 0.0761 0.3948
Brugia malayi histone deacetylase 3 (HD3) 0.0417 0.1765 0.9188
Onchocerca volvulus 0.0059 0.0188 0.0773
Echinococcus granulosus histone deacetylase 1 0.0417 0.1765 0.1917
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0021 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0189 0.0761 0.3948
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0139 0.0541 0.2802
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Schistosoma mansoni nAChR subunit 0.0059 0.0188 0.0185
Echinococcus granulosus histone deacetylase 3 0.0417 0.1765 0.1917
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.01 0.0368 0.0364
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0188 0.0201
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0303 0.4084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0072 0.0354
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0187 0.0955
Schistosoma mansoni nAChR subunit 0.0023 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0148 0.0578 0.2998
Mycobacterium leprae PROBABLE HYDROLASE 0.0139 0.0541 1
Entamoeba histolytica hypothetical protein 0.0036 0.0088 0.0463
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0072 0.0354
Loa Loa (eye worm) hypothetical protein 0.0417 0.1765 0.9188
Loa Loa (eye worm) hypothetical protein 0.0089 0.0321 0.1653
Brugia malayi eukaryotic initiation factor 4A 0.0185 0.0742 0.3852
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0188 0.0185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0189 0.0761 0.3948
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0094 0.0098

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.4 nM Inhibition of HDAC in human HeLa cell lysates after 30 mins by fluorescence based assay ChEMBL. 24999749

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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